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Research Article May 28 2025

Differentiation-dependent EBF1 Activity Determines CD22 Transcription and Leukemia Sensitivity to Inotuzumab Ozogamicin

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Research Article May 28 2025

RBM15-MKL1 fusion protein promotes leukemia via m6A methylation and WNT pathway activation

Madeline Y Mayday,Giulia Biancon,Manyi Wei,Christian Ramirez,Irene Moratti,Andreas P Pintado-Urbanc,Jether Amos Espinosa,Mi Chen,Lin Wang,Matthew D Simon,Yaara Ofir-Rosenfeld,Oliver Rausch,Toma Tebaldi,Stephanie Halene,Diane S Krause

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Research Article May 28 2025

PERK Maintains Hematopoietic Stem Cell Pool Integrity under Endoplasmic Reticulum Stress by Promoting Proliferation

Manxi Zheng,Qinlu Peng,Erin M Kropp,Zhejuan Shen,Suxuan Liu,Zhengyou Yin,Sho Matono,Takao Iwawaki,Xiang Wang,Ken Inoki,Yang Mei,Qing Li,Lu Liu

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Research Article May 22 2025

Sequential combinations of rapid immunoassays for prompt recognition of heparin-induced thrombocytopenia

Thomas Steinauer,Elena Matthey-Guirao,Francisco Javier Gomez,Luana Rittener-Ruf,Matteo Marchetti,Matthew Goodyer,Mitja Nabergoj,Stefano Barelli,Francesco Grandoni,Maxime Grégoire Zermatten,Lorenzo Alberio

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Research Article May 22 2025

Imaging Mass Cytometry Reveals the Order of Events in the Pathogenesis of Immune-Mediated Aplastic Anemia

Emma S. Pool,Sietse J. Luk,Marieke E. IJsselsteijn,Vincent van Unen,Noel F.C.C. de Miranda,J.H. Frederik Falkenburg,Frits Koning,Mirjam H.M. Heemskerk,Jennifer M-L. Tjon

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Research Article May 22 2025

CRISPR-Cas13d functional transcriptomics reveals widespread isoform-selective cancer dependencies on lncRNAs

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Research Article May 22 2025

Type 2 calreticulin mutations activate ATF6 to promote BCL-xL-mediated survival in myeloproliferative neoplasms

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Research Article May 22 2025

Plasminogen activation and plasmin activity are not required to prevent venous thrombosis/thromboembolism

Yaqiu Sang,Marzia Menegatti,Jennifer A Brody,Kerri L Wiggins,Brian C. Cooley,Katheryn Natalya Kapfer,Kadri Kangro,Bas de Laat,Flora Peyvandi,Matthew J. Flick,Nicholas Smith,Amy D. Shapiro,Alisa S. Wolberg

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Brief Report May 22 2025

Ultrasensitive detection of circulating multiple myeloma cells by next-generation flow after immunomagnetic enrichment

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Research Article May 19 2025

Ruxolitinib Targets JAK-STAT Signaling to Modulate Neutrophil Activation in Refractory Macrophage Activation Syndrome

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Brief Report May 19 2025

Inhibition of terminal complement complex formation alleviates murine antibody-mediated TRALI

Dawei Chen,Huaqin Liang,Xiuzhang Xu,Wenjie Xia,Xin Ye,Yalin Luo,Jiansen He,Yaori Xu,Jing Liu,Hui Ren,Shengxue Luo,Trent M. Woodruff,Wioleta M. Zelek,Bryan Paul Morgan,Rick Kapur,Sentot Santoso,Yongshui Fu

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Review Article May 15 2025

An Updated Understanding of Follicular Lymphoma Transformation

Erin M. Parry,Jessica Okosun

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Research Article May 15 2025

Defective neutrophil clearance in JAK2V617F myeloproliferative neoplasms drives myelofibrosis via immune checkpoint CD24

Eman Khatib-Massalha,Christian Andrea Di Buduo,Agathe L Chédeville,Ya-Hsuan Ho,Yexuan Zhu,Elodie Grockowiak,Yuki Date,Lam Tan Khuat,Zijian Fang,Jose Quesada-Salas,Eva Carrillo Félez,Matteo Migliavacca,Isabel Montero,José Antonio Pérez-Simón,Alessandra Balduini,Simón Méndez-Ferrer

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Research Article May 15 2025

Platelet NLRP6 protects from microvascular thrombosis in sepsis

Huimin Jiang,Shuang Chen,Xiang Gui,Yingying Li,Yueyue Sun,Hui Zhu,Yue Dai,Jie Zhang,Xiaoqian Li,Wen Ju,Zhenyu Li,Lingyu Zeng,Kailin Xu,Jianlin Qiao

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Review Article May 15 2025

How I Evaluate and Treat Resistance and Relapse in CML

Simona Soverini,Fausto Castagnetti

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Research Article May 15 2025

A phase 2 Trial of CHOP with Anti-CCR4 Antibody Mogamulizumab for older Patients with Adult T-Cell Leukemia/Lymphoma

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Research Article May 15 2025

Efficacy and safety of azacitidine for VEXAS syndrome: a large-scale retrospective study from the FRENVEX group

Vincent Jachiet,Olivier Kosmider,Maxime Beydon,Jerome Hadjadj,Lin-Pierre Zhao,Vincent Grobost,Valentin Lacombe,Guillaume Le Guenno,Yann Nguyen,Jean Benoit Arlet,Jeremie Dion,Mael Heiblig,Alice Garnier,Maxime Samson,Achille Aouba,Sylvain Thepot,Sophie Dimicoli-Salazar,Fabien Dutasta,Benoit Faucher,Estibaliz Lazaro, Pr,Veronique Morel,Antoine Neel,Roderau Outh,Holy Bezanahary,Julien Rossignol,Anne-Sophie Alary,Audrey Bidet,Pauline Blateau,Anne Bouvier,Guilaine Boursier,Matthieu Decamp,Benjamin Lebecque,Yannick Le Bris,Pierre Sujobert,Alice Marceau-Renaut,Cedric Pastoret,David Rizzo,Nathalie Boiret-Dupré,Lara Boucher,Stéphanie Dulucq,Franck Genevieve,Cassandra Jadeau,Pierre Lemaire,Romain Vazquez,Jean Baptiste Rieu,Olivier Fain,Sophie Anne Georgin-Lavialle, Pr,Lucie Rigolot,Lise Larcher,Pierre Hirsch,Benjamin Terrier,Pierre Fenaux,Arsène M Mékinian,Thibault Comont

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Research Article May 13 2025

A Multi-Omics Approach Reveals Novel Regulators of Plasma Factor V Levels: highlight on CLEC4M as a Clearance Receptor

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Brief Report May 13 2025

Shear-Dependent Platelet Aggregation by ChAdOx1 nCoV-19 Vaccine: A Novel Biophysical Mechanism for Arterial Thrombosis

Yiyao Catherine Chen,Naveen Eugene Louis Richard Louis,Angela Huang,Allan Sun,Alexander Dupuy,Laura Moldovan,Tiana Pelaia,Jianfang Ren,Taylor S Cohen,Sarah Gilbert,Huyen A Tran,Karlheinz Peter,James D McFadyen,Lining Arnold Ju

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Research Article May 13 2025

Transcriptional remodeling shapes therapeutic vulnerability to necroptosis in acute lymphoblastic leukemia

Anna Saorin,Anna Dehler,Bartimée Galvan,Fabio Daniel Steffen,Marine Ray,Dong Lu,Xin Yu,James Kim,Aneta Drakul,Samanta Kisele,Jin Wang,Jean-Pierre Bourquin,Beat Bornhauser

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Research Article May 13 2025

Targeting high-risk multiple myeloma genotypes with optimized anti-CD70 CAR-T cells

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Research Article May 13 2025

Modeling the HLH immune synapse uncovers critical roles for IS termination, cytokine intensity, and target cell death

Anastasia M. Frank-Kamenetskii,Hannah Klinghoffer,Jemy Anna Varghese,Vinh Dang,Jeremy Morrissette,Joseph A. Fraietta,Caroline Diorio,Janis K. Burkhardt,Scott Canna

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Research Article May 13 2025

A Comprehensive Genetic Study of Classical Hodgkin Lymphoma Using Circulating Tumor DNA

Maria Cristina Pirosa,Alessio Bruscaggin,Lodovico Terzi di Bergamo,Matin Salehi,Federico Jauk,Gabriela Forestieri,Simone Bocchetta,Deborah Piffaretti,Riccardo Moia,Vanessa Cristaldi,Martina di Trani,Georgia Alice Galimberti,Katia Pini,Valeria Spina,Claudia Giordano,Adalgisa Condoluci,Ilaria Romano,Salvatore Annunziata,Fabrizio Bergesio,Renzo Boldorini,Eugenio Borsatti,Pietro Bulian,Eleonora Calabretta,Stephane Chauvie,Francesco Corrado,Stefania Crisci,Marco Cuzzocrea,Rosaria De Filippi,Bernhard Gerber,Michał Kurlapski,Luigi Maria Larocca,Elisabetta Merlo,Andrea Rinaldi,Marcello Rodari,Grzegorz Romanowicz,Gian Mauro Sacchetti,Anastasios Stathis,Georg Stussi,Ilaria Zangrilli,Antonio Pinto,Luca Mazzucchelli,Valter Gattei,Jan Maciej Zaucha,Armando Santoro,Stefan Hohaus,Franco Cavalli,Alexandar Tzankov,Carmelo Carlo-Stella,Gianluca Gaidano,Luca Ceriani, Prof,Emanuele Zucca,Davide Rossi

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Research Article May 13 2025

Large B-cell lymphoma imprints a dysfunctional immune phenotype that persists years after treatment

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Review Article May 12 2025

How I approach hematopoietic stem cell transplantation for CML in a TKI world

Yves Chalandon,Federico Simonetta,Stavroula Masouridi-Levrat

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Review Article May 12 2025

How I Treat: Revisiting the myth of second remission in acute lymphoblastic leukemia in the era of immunotherapy

Ibrahim Aldoss,Mary C Clark,Stephen J Forman

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Letter May 7 2025

ANKRD26-related Thrombocytopenia 2 with a Baseline Increase in Blasts: Implications for Clinical Surveillance

Lara Wahlster,Lucy A Godley,Jason X Cheng,Michael W Drazer,Christopher R. Reilly,Geraldine S Pinkus,Jared H Rowe,Nina Weichert-Leahey,Robert Grant Rowe,Lev Gorfinkel,Karyn Jean Brundige,Franziska Wachter,Luana Miria Messa,Alan D Michelson,Alan B. Cantor,Akiko Shimamura,Jacob R Bledsoe

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Brief Report May 7 2025

Phase 1/2 Study of High-Dose Palifermin for GVHD Prophylaxis in Patients Undergoing HLA-Matched Unrelated Donor HCT

Eduard Schulz,Lauren M. Curtis,Noa G. Holtzman,Jennifer Sponaugle,Kaska Wloka,Alen Ostojic,Alain Mina,Najla El Jurdi,Filip Pirsl,Ashley Carpenter,Mahshid Golagha,Arlene Sirajuddin,Theo Heller,Brian C. Shaffer,Frances T. Hakim,Jeffrey Steven Rubin,Ronald E. Gress,Steven Z. Pavletic

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Letter May 7 2025

Targeting CD38 with Daratumumab for Platelet Transfusion Refractoriness in Aplastic Anemia

Zhen Gao,Hong Pan,Lele Zhang,Weiwang Li,Ruonan Li,Jingyu Zhao,Yuechen Luo,Yu Lian,Xiao Yu,Zhexiang Kuang,Neng Nie,Jianping Li,Jinbo Huang,Xin Zhao,Yuan Li,Liwei Fang,Meili Ge,Yizhou Zheng,Jun Shi

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Research Article May 7 2025

Novel, potent, and orally bioavailable LSD1 inhibitors induce fetal hemoglobin synthesis in a sickle cell disease mouse model

Yu Wang,Lei Yu,Kaiwen Deng,Mathivanan Packiarajan,Angelo Aguilar,Sojin An,Greggory Myers,Hoon Oh,Sharon A. Singh,Uhn-soo Cho,Shaomeng Wang,Yuanfang Guan,Andrew White,Rami Khoriaty,James Douglas Engel

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Research Article May 7 2025

Delineating Mpl-dependent and -independent phenotypes of Jak2 V617F- positive MPNs in vivo

Nicolas Papadopoulos,Audrey Nédélec,Yacine Rahmani,Hosuk Ryou,Jean-Philippe Defour,Jens Rittscher,Daniel Royston,Stefan N. Constantinescu

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Research Article May 7 2025

Menin inhibition with revumenib for NPM1-mutated relapsed or refractory acute myeloid leukemia: the AUGMENT-101 study

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Research Article May 7 2025

Augmented CD47 expression impairs alloreactive T-cell clearance after allo-HCT

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Research Article May 7 2025

BLAST: A Globally Applicable and Molecularly Versatile Survival Model for Chronic Myelomonocytic Leukemia

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Research Article May 7 2025

A multiomic analysis of Waldenström macroglobulinemia defines distinct disease subtypes

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Research Article April 29 2025

The mitochondrial protease ClpP is a metabolic vulnerability and an immunogenic trigger against multiple myeloma.

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Research Article April 29 2025

High Incidence of Severe TA-TMA Increases Mortality in adult Allogeneic Transplant recipients: A prospective MIDAS Consortium study

Sumithira Vasu,Qiuhong Zhao,Elizabeth Greer Miller,Patrick Elder,Lucille Langenberg,Spero R. Cataland,Stella M Davies,Nelli Bejanyan,Theresa Hahn

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Discussion April 29 2025