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Review Article January 24 2025

The Fit Older Adult with Acute Myeloid Leukemia: Clinical Challenges to Providing Evidence-Based Frontline Treatment

Sameem M Abedin,Geoffrey L Uy,Laura C. Michaelis

Research Article January 24 2025

One hundred thirty-four germ line PU.1 variants and the agammaglobulinemic patients carrying them

Ainsley V.C. Knox,Lauren Y. Cominsky,Di Sun,Emylette Cruz Cabrera,Brian E. Nolan,Edann Ofray,Elisa Benetti,Camilla Visconti,Federica Barzaghi,Sergio D. Rosenzweig,Monica Ghei Lawrence,Kathleen E. Sullivan,Samuel Yoon,Suzanna Rachimi,Nurcicek Padem,Erin Conboy,Maja Stojanovic,Gordana Petrovic,Srdjan Pasic,Joseph A. Church,Ronald M. Ferdman,Fabio Candotti,Tiphaine Arlabosse,Katerina Theodoropoulou,Cullen M. Dutmer,László Maródi,Gabriella Szücs,Arnon Broides,Amit Nahum,Jacov Levy,Kaisa Maria Kettunen,Ravindra Daddali, Ravi,Mikko R J Seppänen,Markku Vänttinen,Timi Martelius,Juha Grönholm,Matilde Peri,Chiara Azzari,Silvia Ricci,Samar Ojaimi,Emily SJ Edwards,Menno C. van Zelm,Jinqiao Sun,Hassan Abolhassani,Qiang Pan-Hammarström,Hakon Hakonarson,Daniel Mayr,Kaan Boztug,Bertrand Boisson,Jean-Laurent Casanova,Carole Le Coz,Gregory M.K. Poon,Neil Romberg

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Research Article January 24 2025

DDAVP response and its determinants in bleeding disorders: a systematic review and meta-analysis

Sebastiaan N.J. Laan,Jessica Del Castillo,Suzanne C Cannegieter,Karin Fijnvandraat, Prof,Marieke J H A Kruip,Saskia le Cessie,Ruben Bierings,Jeroen C.J. Eikenboom,Iris van Moort

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Research Article January 22 2025

Aging platelets shift their hemostatic properties to inflammatory functions

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Research Article January 22 2025

IL-1R1 and IL-18 Signals Regulate Mesenchymal Stromal Cells in an Aged Murine Model of Myelodysplastic Syndromes

Yuko Kawano,Hiroki Kawano,Mark W. LaMere,Elizabeth A. LaMere,Daniel K. Byun,Kathleen McGrath,James Palis,Jeevisha Bajaj,Jane L. Liesveld,Yoshio Katayama,Satoshi Yamazaki,Reuben Kapur,Laura M. Calvi,Tzu-Chieh Ho,Michael W Becker

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Research Article January 22 2025

FLT3 is genetically essential for ITD-mutated leukemic stem cells but dispensable for human hematopoietic stem cells

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Research Article January 22 2025

CpG island methylator phenotype classification improves risk assessment in pediatric T-cell Acute Lymphoblastic Leukemia

Fernanda Schäfer Hackenhaar,Nina Refhagen,Melanie M Hagleitner,Frank N. van Leeuwen,Hanne Vibeke Marquart,Hans Ole Madsen,Mattias Landfors,Pia Osterman,Kjeld Schmiegelow,Trond Flaegstad,Olafur G Jonsson,Jukka Kanerva,Jonas Abrahamsson,Mats Heyman,Ulrika Noren-Nystrom,Magnus Hultdin,Sofie Degerman

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Research Article January 22 2025

Functional assessment of genetic variants in thrombomodulin detected in patients with bleeding and thrombosis

Christine Van Laer,Renaud Lavend'homme,Sarissa Baert,Koenraad De Wispelaere,Chantal Thys,Cyrielle Kint,Sam Noppen,Kathelijne Peerlinck,Chris Van Geet,Dominique Schols,Thomas Vanassche,Veerle Labarque,Peter Verhamme,Marc G Jacquemin,Kathleen Freson

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Research Article January 22 2025

NETs persisting in vasculature undergo self-renewal with consequences for subsequent infection: a mouse model study

Michal Santocki,Anna Such,Dominika Drab,Gabriela Burczyk,Elzbieta Kolaczkowska

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Research Article January 22 2025

CD44-Mediated Metabolic Rewiring is A Targetable Dependency of IDH-Mutant Leukemia

Junhua Lyu,Yuxuan Liu,Ningning Liu,Hieu Vu,Feng Cai,Hui Cao,Pranita Kaphle,Zheng Wu,Giovanni A Botten,Yuannyu Zhang,Jin Wang,Sarada Achyutuni,Xiaofei Gao,Ilaria Iacobucci,Charles G. Mullighan,Stephen S Chung,Min Ni,Ralph J DeBerardinis,Jian Xu

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Research Article January 22 2025

Dual Biological Role and Clinical Impact of De Novo Chromatin Activation in Chronic Lymphocytic Leukemia

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Research Article January 22 2025

GATA2 links stemness to chemotherapy resistance in acute myeloid leukemia.

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Research Article January 22 2025

Evaluating the impact of CRBN mutations on response to immunomodulatory drugs and novel CRBN-binding agents in myeloma

Yakinthi Chrisochoidou,Andrea Scarpino, Dr,Salomon Morales,Shannon Martin,Sarah Anne Bird,Yigen Li, Dr,Brian A Walker,John Caldwell,Yann-Vai Le Bihan, Dr,Charlotte Pawlyn, Dr

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Research Article January 22 2025

Isatuximab, Carfilzomib, Lenalidomide, and Dexamethasone Induction in Newly Diagnosed Myeloma: Analysis of the MIDAS Trial

Aurore Perrot,Cyrille Touzeau,Jerome Lambert,Cyrille Hulin,Denis Caillot,Lionel Karlin,Bertrand Arnulf,Philippe Rey,Laurent Garderet,Margaret Macro, Dr,Martine Escoffre-Barbe,Julie Gay,Thomas Chalopin,Romain Gounot,Jean Marc Schiano de Colella,Mourad Tiab,Mohamad Mohty,Frédérique Kuhnowski,Jean Fontan,Salomon Manier,Frederique Orsini Piocelle,Laure Vincent,Sophie Rigaudeau,Xavier Leleu,Benjamin Hébraud,Laurent Flet,Jean-Valère Malfuson,Caroline Jacquet,Driss Chaoui,Nathalie Meuleman,Wajed Abarah,Lydia Montes,Riad Benramdane,Cécile Sonntag,Hacene Zerazhi,Alina Danu,Olivier Allangba,Mamoun Dib,Murielle Roussel,Sophie Cereja,Julien Depaus,Nicolas Branche,Hélène Demarquette,Valentine Richez,Cherel Bruiec,Laurent Frenzel,Marie-Christiane MB Vekemans,Noemie Bigot,Hervé Avet-Loiseau,Jill Corre,Philippe Moreau

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Research Article January 22 2025

HSP-CAR30 WITH A HIGH PROPORTION OF LESS-DIFFERENTIATED T CELLS PROMOTES DURABLE RESPONSES IN REFRACTORY CD30+ LYMPHOMA

Ana Carolina Caballero Gonzalez,Cristina Ujaldón-Miró,Paula Pujol-Fernández,Rosanna Montserrat-Torres,Maria Guardiola-Perello,Eva Escudero-López,Irene Garcia-Cadenas,Albert Esquirol,Rodrigo Martino,Paola Jara-Bustamante,Pol Ezquerra Condeminas,Jose Manuel Soria,Eva Iranzo Ribera,Maria-Estela Moreno-Martinez,Mireia Riba,Jorge Sierra,Carmen Alvarez-Fernández,Laura Escribà-Garcia,Javier Briones

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Research Article January 21 2025

Two-layered immune escape in AML is overcome by Fcγ receptor activation and inhibition of PGE2 signaling in NK cells

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Research Article January 15 2025

Defining 2 Biologically and Clinically Distinct Groups in Acute Leukemia with a Mixed Phenotype

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Research Article January 15 2025

A phase 1 trial of prizloncabtagene autoleucel, a CD19/CD20 CAR T-cell therapy for relapsed/refractory B-cell non-Hodgkin lymphoma

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Research Article January 15 2025

Common Hereditary Variants of the APOE Gene and Posttransplant Outcome in Acute Myeloid Leukemia

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Review Article January 14 2025

How I Treat Anemia in Myelofibrosis

Akriti G. Jain,Aaron T. Gerds

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Review Article January 14 2025

How I diagnose and treat systemic mastocytosis with an associated hematologic neoplasm

Deepti H. Radia

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Review Article January 14 2025

How I Treat Higher-Risk MDS

Alain Mina,Rami S. Komrokji

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Review Article January 14 2025

Precision Medicine for High-Risk Gene Fusions in Paediatric AML: a focus on KMT2A, NUP98, and GLIS2 Rearrangements

Grace Egan,Sarah K Tasian

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Review Article January 14 2025

Novel Mechanisms of Resistance in CLL: Variant BTK Mutations in Second-Generation and Noncovalent BTK Inhibitors

Constantine S. Tam,Shalini Balendran,Piers Blombery

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Research Article January 14 2025

Development of the Lee Symptom Scale-Skin Sclerosis for chronic GVHD-associated sclerosis

Emily Baumrin,Joseph A Pidala,Sandra Mitchell,Lynn Onstad,Stephanie J. Lee

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Brief Report January 14 2025

Salvage Autologous Transplant in Relapsed Multiple Myeloma: Long-Term Follow-Up of the Phase 3 GMMG ReLApsE Trial

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Research Article January 10 2025

Targeting DOT1L and EZH2 synergizes in breaking the germinal center identity of Diffuse Large B-cell Lymphoma

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Research Article January 10 2025

High-throughput drug screening identifies SMAC mimetics as enhancers of NK cell cytotoxicity in chronic myeloid leukemia

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Research Article January 10 2025

Donor Regulatory T-Cell Therapy to Prevent Graft-Versus-Host Disease

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Research Article January 10 2025

Epcoritamab plus GemOx in transplant-ineligible relapsed/refractory DLBCL: results from the EPCORE NHL-2 trial

Joshua D. Brody,Judit Meszaros Jørgensen, Dr,David Belada,Régis Costello,Marek Trněný,Umberto Vitolo,David John Lewis,Yasmin H. Karimi,Anna Sureda,Marc Andre,Björn E. Wahlin,Pieternella J. Lugtenburg,Tony Jiang,Kubra Karagoz,Andrew J Steele,Aqeel Abbas,Liwei Wang,Malene Risum,Raul Cordoba

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Discussion January 8 2025

Introduction to a review series on reflections on a quarter century of TKIs in CML

Brian J Druker

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Research Article January 7 2025

Potentiating CD20 monoclonal antibody therapy by targeting complement C3 fragment covalently deposited on lymphoma cells

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Research Article January 7 2025

Selenoprotein-Mediated Redox Regulation Shapes the Cell Fate of HSCs and Mature Lineages

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Research Article January 7 2025

Measurable residual disease and posttransplantation gilteritinib maintenance for patients with FLT3-ITD-mutated AML

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Research Article January 7 2025

Targeting Senescent Stemlike Subpopulations in Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia

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Research Article January 6 2025

Glucarpidase for Treatment of High-Dose Methotrexate Toxicity

Shruti Gupta,Sarah Allison Kaunfer,Kevin L Chen,Julie-Alexia Dias,Anitha Vijayan,Arun Rajasekaran,Jason Prosek,Huong L. Truong,Anthony Wood,Claude Bassil,Amanda DeMauro Renaghan,Chintan V Shah,Jingjing Zhang,Ilya Glezerman,Christopher Carlos,Katherine Kelly,Christopher J Passero,Jan Drappatz,Ala Abudayyeh,Daniel Shin,C. John Sperati,Bradley J Yelvington,Swetha Rani Kanduri,Javier A Neyra,Daniel Edmonston,Anushree C Shirali,Anip Bansal,Abdallah Geara,Zain Mithani,Susan L Ziolkowski,Arash Rashidi,Jonathan Jakubowski,Ashwini Pujari,David A Bond,Emily K Dotson,Sarah A Wall,John T. Patton,Jason N Barreto,Sandra M Hermann,Mohammad Salman Sheikh,Rachid C Baz,Jae Hui Lee,Nicholas Lucchesi,Michael Kolman,Muhammad Ahsan Rasheed,Afsheen Afzal,Dasol Kang,Amrita Mahesh,Raymond Hsu,Anthony Nicolaysen,Kibrewessen Tefera,Claire Schretlen,Ryan M Miller,Juan Carlos Q Velez,Alexander H Flannery,Abinet M Aklilu,Shuchi Anand,Soniya Chandrasekhara,Vicki Donley,Ashka Patel,Jian Ni,Shobana Krishnamurthy,Rafia Ali,Osman A Yilmam,Sophia L Wells,Jessica L Ortega,Olivia L Green-Lingren,Rebecca Karp Leaf,Meghan E Sise,Lakshmi Nayak,Ann S. LaCasce,Nelson Leung,David E Leaf

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Review Article January 6 2025

The Evolution of Treatment-Free Remission

Timothy P Hughes,Agnes SM Yong,David M Ross

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Review Article December 30 2024

High-Risk MCL: Recognition and Treatment

Preetesh Jain,Michael L Wang

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Review Article December 30 2024

How I use noninvasive prenatal testing for red blood cell and platelet antigens

Renske Marijke van 't Oever,E.J.T. (Joanne) Verweij,Masja De Haas

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Review Article December 30 2024

Genetic subtypes of B-cell acute lymphoblastic leukemia in adults

Marie Passet,Rathana Kim,Emmanuelle Clappier

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Review Article December 30 2024

How I Diagnose and Treat Acute Infection-associated Purpura Fulminans

Pavan K Bendapudi,Julie-Aurore Losman

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Research Article December 30 2024

Targeting Enterobacter cloacae attenuates osteolysis by reducing ammonium in multiple myeloma

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Review Article December 30 2024

How I Manage Patients with Unexplained Cytopenia

Luca Malcovati,Mario Cazzola

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Research Article December 30 2024

Prognostic and therapeutic implications of measurable residual disease levels during remission induction of childhood ALL

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Review Article December 30 2024

FDA-approved therapies for chronic GVHD

Stephanie J. Lee,Robert Zeiser

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Research Article December 30 2024

Odronextamab monotherapy in R/R DLBCL after progression with CAR T-cell therapy: Primary analysis of the ELM-1 study

Max S. Topp,Matthew J. Matasar,John N. Allan,Stephen M. Ansell,Jeffrey A. Barnes,Jon E. Arnason,Jean-Marie Michot,Neta Goldschmidt,Susan M. O'Brien, M.D.,Uri Abadi,Irit Avivi,Yuan Cheng,Dina M. Flink,Min Zhu,Jurriaan Brouwer-Visser,Aafia Chaudhry,Hesham Mohamed,Srikanth Ambati,Jennifer L. Crombie

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Research Article December 27 2024

Targeting WDR5/ATAD2 signaling by the CK2/Ikaros axis demonstrates therapeutic efficacy in T-ALL

Qi Han,Yan Gu,Huimin Xiang,Linyao Zhang,Yan Wang,Chan Yang,Jun Li,Chelsea Steiner,Rosa Lapalombella,Jennifer A. Woyach,Yiping Yang,Sinisa Dovat,Chunhua Song,Zheng Ge

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Research Article December 27 2024

α-Ketoglutarate dehydrogenase is a therapeutic vulnerability in acute myeloid leukemia

Scott Evan Millman,Almudena Chaves-Perez,Sudha Janaki-Raman,Yu-Jui Ho,John P Morris IV,Varun Narendra,Chi-Chao Chen,Benjamin T Jackson,Jossie J Yashinskie,Riccardo Mezzadra,Tessa I Devine,Valentin J. A. Barthet,Michelle Saoi,Timour Baslan,Sha Tian,Zohar Sachs,Lydia WS Finley,Justin R Cross,Scott W Lowe

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Research Article December 27 2024

Cullin-5 controls the number of megakaryocyte-committed stem cells to prevent thrombocytosis in mice

Maria Katariina Kauppi,Craig D Hyland,Elizabeth M Viney,Christine Anne White,Carolyn A de Graaf,AnneMarie E Welch,Jumana Yousef,Laura F Dagley,Samantha J Emery-Corbin,Ladina Di Rago,Andrew J Kueh,Marco J Herold,Douglas J. Hilton,Jeffrey J Babon,Nicos A. Nicola,Kira Behrens,Warren S Alexander

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Research Article December 27 2024

Population dynamics modeling reveals that myeloid bias involves both HSC differentiation and progenitor proliferation biases

Apeksha Singh,Jennifer J Chia,Dinesh S. Rao,Alexander Hoffmann

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