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Marina Konopleva
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Journal Articles

A weekly low-dose regimen of decitabine and venetoclax is efficacious and less myelotoxic in a racially diverse cohort

Clinical Trials & Observations
Mendel Goldfinger, Ioannis Mantzaris, Aditi Shastri, Yogen Saunthararajah, Kira Gritsman, R. Alejandro Sica, Noah Kornblum, Nishi Shah, David Levitz, Bradley Rockwell, Lauren C. Shapiro, Ridhi Gupta, Kith Pradhan, Xiaonan Xue, Anne Munoz, Aradhika Dhawan, Karen Fehn, Monica Comas, Jhannine Alyssa Verceles, Brian A. Jonas, Suman Kambhampati, Yang Shi, Ira Braunschweig, Dennis L. Cooper, Marina Konopleva, Eric J. Feldman, Amit Verma
Journal: Blood
Blood (2024) 144 (22): 2360–2363.
https://doi.org/10.1182/blood.2024025834
Published: 2024
Includes: Supplemental data
Journal Articles

A Multi-Site Break through Cancer Trial: Phase II Study Investigating Dual Inhibition of BCL2 and Menin in AML MRD Using the Combination of Venetoclax and Revumenib (Trial In Progress)

Ghayas C. Issa, Alexander J. Ambinder, Wenbin Xiao, Scott Manalis, Alex K Shalek, Lukasz P. Gondek, Alex Kentsis, Nicholas J. Short, Naval Daver, Jing Ning, Lianchun Xiao, Michael Hemann, Ken Chen, Keyur P. Patel, Pavan Bachireddy, Andrew A. Lane, Marina Konopleva, Omar Abdel-Wahab, Jeffrey J. Molldrem, Ross L Levine, Mark J. Levis, Richard M Stone, Michael Andreeff, Farhad Ravandi, Aaron D. Goldberg, Jacqueline S. Garcia
Journal: Blood
Blood (2024) 144 (Supplement 1): 4265.2.
https://doi.org/10.1182/blood-2024-201582
Published: 2024
Journal Articles

Decitabine-Venetoclax Treatment Reactivates Endogenous Retrovirus RNA Signaling in AML Cells and Induces T Cell Activation

Kotoko Yamatani, Kaori Saito, Abhishek Maiti, Abdullah Khasawneh, Faith Jessica Paran, Tastuya Suzuki, Toru Okamoto, Kala Hayes, Zhihong Zeng, Courtney D. DiNardo, Michael Andreeff, Marina Konopleva, Yoko Tabe
Journal: Blood
Blood (2024) 144 (Supplement 1): 1389.
https://doi.org/10.1182/blood-2024-202722
Published: 2024
Journal Articles

Efficacy of a Novel BCL-XL Degrader, DT2216, in Preclinical Models of Post-Myeloproliferative Neoplasm Secondary AML

Zhe Wang, Anna Skwarska, Gowri Poigailwar, Sovira Chaudhry, Alba Rodriguez-Meira, Pinpin Sui, Emmanuel Olivier, Yannan Jia, Cassandra L. Ramage, Guangrong Zheng, Alexandra Schurer, Kira Gritsman, Eirini Papapetrou, Kapil N. Bhalla, Daohong Zhou, Adam J Mead, Raajit Rampal, Jeffrey W Tyner, Hussein A. Abbas, Naveen Pemmaraju, Qi Zhang Tatarata, Marina Konopleva
Journal: Blood
Blood (2024) 144 (Supplement 1): 2749.
https://doi.org/10.1182/blood-2024-194031
Published: 2024
Journal Articles

EBF1 Activity Controls Leukemia Sensitivity to Inotuzumab Ozogamicin

Carolin S. Escherich, Zhenhua Li, Kelly R. Barnett, Yizhen Li, Megan Walker, Wenjian Yang, Xin Huang, Jiyang Yu, Wendy Stock, Elisabeth Paietta, Marina Konopleva, Steven M. Kornblau, Mark R. Litzow, Hiroto Inaba, Ching-Hon Pui, Mignon L. Loh, Daniel Savic, Jun J. Yang
Journal: Blood
Blood (2024) 144 (Supplement 1): 830.
https://doi.org/10.1182/blood-2024-198800
Published: 2024
Journal Articles

Enhancing Macrophage Mediated Phagocytosis in AML: The Complementary Mechanisms of Venetoclax and Azacitidine Combination Therapy

Zhe WANG, Xufeng Chen, Simone Sidoli, Anna Skwarska, Yannan Jia, Lei Yang, Varun Gupta, Shikhar Sharma, Iannis Aifantis, Hussein A. Abbas, Naval Daver, Qi Zhang Tatarata, Marina Konopleva
Journal: Blood
Blood (2024) 144 (Supplement 1): 207.
https://doi.org/10.1182/blood-2024-198057
Published: 2024
Journal Articles

Updated Results from a Phase II Study Hyper-CVAD, with or without Inotuzumab Ozogamicin, and Sequential Blinatumomab in Patients with Newly Diagnosed B-Cell Acute Lymphoblastic Leukemia

Daniel Nguyen, Hagop Kantarjian, Nicholas J. Short, Nitin Jain, Fadi G. Haddad, Musa Yilmaz, Alessandra Ferrajoli, Tapan M. Kadia, Yesid Alvarado Valero, Abhishek Maiti, Marianne Zoghbi, Jayastu Senapati, Rebecca Garris, Min Zhao, Marina Konopleva, Farhad Ravandi, Elias Jabbour
Journal: Blood
Blood (2024) 144 (Supplement 1): 1439.
https://doi.org/10.1182/blood-2024-208854
Published: 2024
Journal Articles

Venetoclax Combined with “7+3” Induction Chemotherapy Induces High MRD-Negative Response Rates in Newly Diagnosed AML Patients Fit for Intensive Chemotherapy across Ages

Ioannis Mantzaris, Matan Uriel, Mendel Goldfinger, Aditi Shastri, Nishi Shah, Kira Gritsman, Noah Kornblum, Lauren Shapiro, R. Alejandro Sica, Annemarie Munoz, Nicole Chambers, Aradhika Dhawan, Karen Fehn, Balda Tirone, Lamisha Shah, Shaunmonique Clark, Mimi Kim, Chenxin Zhang, Dennis L Cooper, Amit Verma, Marina Konopleva, Eric J. Feldman
Journal: Blood
Blood (2024) 144 (Supplement 1): 57.
https://doi.org/10.1182/blood-2024-211685
Published: 2024
Journal Articles

Venetoclax Alone or in Combination Shows Promising Activity in Preclinical Models and Clinical Cases of Relapsed/Refractory North American Adult T-Cell Leukemia Lymphoma

Ankit Tanwar, Emma Cordover, Shikhar Sharma, Zixuan Tong, Kith Pradhan, Latoya S Townsend, Ioannis Mantzaris, Mendel Goldfinger, Nishi Shah, Aditi Shastri, Noah Kornblum, Dennis L Cooper, Ridhi Gupta, Simon Zhen, Nechama Dreyfus, Julie Nguyen, Lauren Shapiro, Eric J. Feldman, Ira Braunschweig, Beth McLellan, Alyssa de Castro, Xingxing Zang, Ali Bazarbachi, Murali Janakiram, Erik Guillen, Gregoire Lauvau, Eric Liu, Kira Gritsman, B. Hilda Ye, Amit Verma, Marina Konopleva, R. Alejandro Sica
Journal: Blood
Blood (2024) 144 (Supplement 1): 2791.
https://doi.org/10.1182/blood-2024-206160
Published: 2024
Journal Articles

Long-Term Survival Outcomes and Cytogenetic/Molecular Patterns of Relapse in Adults with FLT3 -Mutated AML Receiving Frontline Triplet Therapy with a Hypomethylating Agent, Venetoclax and FLT3 Inhibitor

Nicholas J. Short, Sanam Loghavi, Musa Yilmaz, Omer Karrar, Joseph E. Jabbour, Courtney D. DiNardo, Tapan M. Kadia, Gautam Borthakur, Ghayas C. Issa, Hussein A. Abbas, Marina Konopleva, Farhad Ravandi, Hagop M. Kantarjian, Naval Daver
Journal: Blood
Blood (2024) 144 (Supplement 1): 220.
https://doi.org/10.1182/blood-2024-210891
Published: 2024
Journal Articles

Transcriptomic Signature of Resistance to Decitabine/Venetoclax in AML Patients

Abdullah Khasawneh, Faith Jessica Paran, Abhishek Maiti, Bofei Wang, Kala Hayes, Courtney D. DiNardo, Michael Andreeff, Hussein A. Abbas, Marina Konopleva, Yoko Tabe
Journal: Blood
Blood (2024) 144 (Supplement 1): 2766.
https://doi.org/10.1182/blood-2024-202806
Published: 2024
Journal Articles

Anti-Leukemia Combinatorial Efficacy of ABBV155, a B7H3-BCL-XL Inhibitor Antibody-Drug Conjugate, in Combination with Venetoclax through BCL-XL/BIM and BCL-2/BIM Complex Dissociations

Zhe Wang, Cassandra L. Ramage, Helen Ma, Haichao Zhang, Andrew Souers, Darren C Phillips, Marina Konopleva, Qi Zhang Tatarata
Journal: Blood
Blood (2024) 144 (Supplement 1): 2760.
https://doi.org/10.1182/blood-2024-193405
Published: 2024
Journal Articles

Elucidating Transcriptional Heterogeneity in Venetoclax Resistant AMLs

Vakul Mohanty, Natalia Baran, Yuefan Huang, Cassandra L. Ramage, Laurie Cooper, Sarah Gwen Pelletier, Shan He, Ramiz Iqbal, May Daher, MD, Jeffrey W. Tyner, Gordon B Mills, Marina Konopleva, Ken Chen
Journal: Blood
Blood (2024) 144 (Supplement 1): 2753.
https://doi.org/10.1182/blood-2024-204333
Published: 2024
Journal Articles

Assessing the Performance of the Iceland Screens, Treats, or Prevents Multiple Myeloma (iStopMM) Model in a Multicultural Bronx Cohort: Implications for Monoclonal Gammopathy of Undetermined Significance (MGUS) Risk Stratification

Rajvi Gor, Jeevan Shivakumar, Pallavi Surana, John X Wei, Irina Murakhovskaya, Mendel Goldfinger, Noah Kornblum, Lauren Shapiro, Aditi Shastri, Ridhi Gupta, David Levitz, Marina Konopleva, Eric J. Feldman, Kira Gritsman, R. Alejandro Sica, Ioannis Mantzaris, Amit Verma, Dennis L Cooper, Murali Janakiram, Nishi Shah
Journal: Blood
Blood (2024) 144 (Supplement 1): 3307.
https://doi.org/10.1182/blood-2024-201590
Published: 2024
Journal Articles

Targeting PERK Arm of Unfolded Protein Response Helps to Eliminate Therapy-Induced Residual Senescent-like Acute Myeloid Leukemia Cells

Gowri Poigaialwar, Sumiko Takao, Sovira Chaudhry, Laura K. Schmalbrock, Varun Gupta, Alex Kentsis, Julio A. Aguirre-Ghiso, Marina Konopleva, Maria S. Sosa, Anna Skwarska
Journal: Blood
Blood (2024) 144 (Supplement 1): 4137.
https://doi.org/10.1182/blood-2024-203451
Published: 2024
Journal Articles

Developments in Therapeutics and Impact on AML Survival in Older Patients: A Populational Analysis

John X Wei, Mendel Goldfinger, Marina Konopleva, Ioannis Mantzaris, Amit Verma, Eric J. Feldman
Journal: Blood
Blood (2024) 144 (Supplement 1): 3802.
https://doi.org/10.1182/blood-2024-206488
Published: 2024
Journal Articles

A Phase I/II Study of Mini-Hyper-CVD, Venetoclax and Navitoclax in Patients with Relapsed/Refractory Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia

Nicholas J. Short, Hagop Kantarjian, Nitin Jain, Jayastu Senapati, Fadi G. Haddad, Omer Karrar, Kelly S. Chien, Eitan Kugler, Adaeze Elechi, Regina Abramova, Min Zhao, Rebecca Garris, Marina Konopleva, Farhad Ravandi, Elias Jabbour
Journal: Blood
Blood (2024) 144 (Supplement 1): 4198.
https://doi.org/10.1182/blood-2024-206487
Published: 2024
Journal Articles

Tagraxofusp Achieves Anti-Tumor Activity with Rapid Restoration of Normal Hematopoiesis in Treatment-Naïve Patients with Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN): Subanalysis of a Pivotal Trial

Marina Konopleva, Naveen Pemmaraju, Kendra L. Sweet, Anthony S. Stein, David A. Rizzieri, Eunice S. Wang, Sumithira Vasu, Todd Rosenblat, Michael Zuurman, Ira Gupta, Andrew A. Lane
Journal: Blood
Blood (2024) 144 (Supplement 1): 1515.
https://doi.org/10.1182/blood-2024-200230
Published: 2024
Journal Articles

Promising Safety and Efficacy Data for Peginterferon Alfa-2a (PEG-IFN) and Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy) in a North American Adult T-Cell Leukemia Lymphoma (NA-ATLL) Cohort of Patients

Nechama Dreyfus, Emma Cordover, Kith Pradhan, Latoya S Townsend, Mendel Goldfinger, Ioannis Mantzaris, Nishi Shah, Aditi Shastri, Noah Kornblum, Dennis L Cooper, Ridhi Gupta, Lauren Shapiro, Kira Gritsman, Marina Konopleva, Beth McLellan, Simon Zhen, Alyssa de Castro, Salvatore Lia, Virleny Garcia, Roy Browne, Eric Meyerowitz, Yoram Puius, Margaret McCort, Yang Shi, Yanhua Wang, Amit Verma, B. Hilda Ye, Murali Janakiram, Abdul-Hamid Bazarbachi, R. Alejandro Sica
Journal: Blood
Blood (2024) 144 (Supplement 1): 3067.
https://doi.org/10.1182/blood-2024-208199
Published: 2024
Journal Articles

Phase I/II Study of Quizartinib, Venetoclax, and Decitabine Triple Combination in FLT3-ITD Mutated AML

Musa Yilmaz, Muharrem Muftuoglu, Nicholas J. Short, Sanam Loghavi, Tapan M. Kadia, Courtney D. DiNardo, Gautam Borthakur, Naveen Pemmaraju, Yesid Alvarado Valero, Abhishek Maiti, Marina Konopleva, Lucia Masarova, Guillermo Montalban-Bravo, Carissa Jurisprudencia, Allison Pike, Keyur P. Patel, Guilin Tang, Jairo Matthews, Steven M. Kornblau, Elias Jabbour, Guillermo Garcia-Manero, Koichi Takahashi, Michael Andreeff, Farhad Ravandi, Hagop M. Kantarjian, Naval Daver
Journal: Blood
Blood (2024) 144 (Supplement 1): 4263.
https://doi.org/10.1182/blood-2024-204296
Published: 2024