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Lachlin Vaughan
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Journal Articles

Clinical Response to Azacitidine in Myelodysplastic Neoplasms Is Associated with Distinct DNA Methylation Changes in Haematopoietic Stem and Progenitor Cells In Vivo

Julie A.I. Thoms, Feng Yan, Henry R. Hampton, Sarah Davidson, Swapna Joshi, Jesslyn Saw, Chowdhury H. Sarowar, Xin Ying Lim, Andrea C Nunez, Purvi M. Kakadia, Golam Sarower Bhuyan, Xiaoheng Zou, Mary Nguyen, Elaheh S Ghodousi, Forrest C Koch, Fatemeh Vafaee, I. Richard Thompson, Mohammad M. Karimi, Russell Pickford, Mark J Raftery, Sally Hough, Griselda Buckland, Michelle Bailey, Yuvaraj Ghodke, Noorul Absar, Lachlin Vaughan, Leonardo Pasalic, Chun Yew Fong, Melita Kenealy, Devendra Hiwase, Rohanna Stoddart, Soma Mohammed, Linda Lee, Freda H Passam, Stephen Robert Larsen, Kevin J Spring, Kristen K Skarratt, Patricia Rebeiro, Peter Presgrave, William S Stevenson, Silvia Ling, Campbell Tiley, Stephen Fuller, Fernando Roncolato, Anoop K Enjeti, Dirk Hoenemann, Charlotte Lemech, Christopher J Jolly, Stefan K. Bohlander, David J. Curtis, Jason Wong, Ashwin Unnikrishnan, Mark S. Hertzberg, Jake Olivier, Mark N Polizzotto, John E Pimanda
Journal: Blood
Blood (2024) 144 (Supplement 1): 3223.
https://doi.org/10.1182/blood-2024-201216
Published: 2024
Journal Articles

Revumenib As Pre-Emptive Therapy for Measurable Residual Disease in NPM1 mutated or KMT2A- rearranged Acute Myeloid Leukemia: A Domain of the Multi-Arm ALLG AMLM26 Intercept Platform Trial

Sun Loo, Harry Iland, Ing Soo Tiong, David Westerman, Jad Othman, Paula Marlton, Chong Chyn Chua, Duncan Purtill, Hannah Rose, Shaun Fleming, Deepak Singhal, Anoop K Enjeti, William S. Stevenson, Teng Fong Ng, McCulloch Derek, Lachlin Vaughan, Robin Gasiorowski, Adam Ivey, Amanda Souza, Revati Pattani, Natasha S. Anstee, Rachel Koldej, David S. Ritchie, Sanam Loghavi, Naval Daver, Courtney D. DiNardo, Andrew W. Roberts, Carolyn S. Grove, John Reynolds, Andrew H Wei
Journal: Blood
Blood (2024) 144 (Supplement 1): 223.
https://doi.org/10.1182/blood-2024-202895
Published: 2024
Journal Articles

Phase 1b Study of Menin-KMT2A Inhibitor Bleximenib in Combination with Intensive Chemotherapy in Newly Diagnosed Acute Myeloid Leukemia with KMT2Ar or NPM1 Alterations

Christian Recher, Jenny O'Nions, Ibrahim Aldoss, Ana Alfonso Pierola, Alicia Allred, Juan Manuel Alonso-Dominguez, Laura Barreyro, Pierre Bories, Martin Curtis, Nikki Daskalakis, Matteo Giovanni Della Porta, Hartmut Döhner, Amber D'Souza, James P. Dugan, Jordi Esteve Reyner, Matthew Exum, Amir T. Fathi, Pasquale L. Fedele, Lucille Ferrante, Stan Gaj, Sylvain Garciaz, Ana Garrido, Sara Garrido Paniagua, Christina Guttke, Emmanuel Gyan, Brett Hiebert, Elias Jabbour, Madlen Jentzsch, Hagop M. Kantarjian, Marina Konopleva, Jan Krönke, Min Chul Kwon, Christina Loefgren, Oliver Lomas, Valentina Mancini, Ioannis Mantzaris, Giovanni Martinelli, Daniel Morillo Giles, Joseph Murphy, Kathryn Packman, Cristina Papayannidis, Ulrike Philippar, Uwe Platzbecker, Sravanti Rangaraju, Christoph Röllig, Olga Salamero, Madhu Sanga, Tim Sauer, Emma Searle, Natalia Tovar, Trevor Tucker, Nicolas Vallet, Lachlin Vaughan, Gala Vega, Paresh Vyas, Andrew Wei
Journal: Blood
Blood (2024) 144 (Supplement 1): 215.
https://doi.org/10.1182/blood-2024-207072
Published: 2024
Journal Articles

Seeing MDS through the lens of genomics

Lachlin Vaughan, John E. Pimanda
Journal: Blood
Blood (2024) 144 (15): 1552–1554.
https://doi.org/10.1182/blood.2024025676
Published: 2024
Journal Articles

Contribution of mutant HSC clones to immature and mature cells in MDS and CMML, and variations with AZA therapy

Brief Report
Annatina S. Schnegg-Kaufmann, Julie A. I. Thoms, Golam Sarower Bhuyan, Henry R. Hampton, Lachlin Vaughan, Kayleigh Rutherford, Purvi M. Kakadia, Hui Mei Lee, Emma M. V. Johansson, Timothy W. Failes, Greg M. Arndt, Jason Koval, Robert Lindeman, Pauline Warburton, Alba Rodriguez-Meira, Adam J. Mead, Ashwin Unnikrishnan, Sarah Davidson, Mark N. Polizzotto, Mark Hertzberg, Elli Papaemmanuil, Stefan K. Bohlander, Omid R. Faridani, Christopher J. Jolly, Fabio Zanini, John E. Pimanda
Journal: Blood
Blood (2023) 141 (11): 1316–1321.
https://doi.org/10.1182/blood.2022018602
Published: 2023
Includes: Supplemental data
Journal Articles

In Vivo Drug Incorporation and Intracellular Dynamics of Injectable Versus Oral Azacytidine: A Phase II Open Label Multicentre Trial

John E. Pimanda, Julie A.I. Thoms, Henry R. Hampton, Sarah Davidson, Swapna Joshi, Chowdhury H. Sarowar, Xin Ying Lim, Andrea C. Nunez, Purvi M. Kakadia, Russell Pickford, Mark Raftery, Sally Hough, Griselda Buckland, Michelle Bailey, Yuvaraj Ghodke, Noorul Absar, Lachlin Vaughan, Leonardo Pasalic, Chun Yew Fong, Melita Kenealy, Devendra Hiwase, Rohanna Stoddart, Soma Mohammed, Linda Lee, Freda H. Passam, Kevin Spring, Kristy K. Skarratt, Patricia Rebeiro, Stephen R Larsen, Peter Presgrave, William S Stevenson, Silvia Ling, Campbell Tiley, Stephen Fuller, Fernando Roncolato, Anoop Kumar Enjeti, Dirk Hoenemann, Charlotte Lemech, Stefan K. Bohlander, Jake Olivier, Mark Hertzberg, Ashwin Unnikrishnan, Mark N. Polizzotto
Journal: Blood
Blood (2022) 140 (Supplement 1): 6927–6929.
https://doi.org/10.1182/blood-2022-157634
Published: 2022
Journal Articles

Clinical Response to Azacytidine (AZA) Is Associated with Increased Contribution from Mutated Blood Progenitors: Insights from Single Cell Genotyping of Matched Stem/Progenitor and Mature Blood Cells from MDS/CMML Patients Pre- and Post-AZA Treatment

Julie A.I. Thoms, Annatina Schnegg-Kaufmann, Golam Sarower Bhuyan, Henry R. Hampton, Lachlin Vaughan, Kayleigh Rutherford, Purvi M. Kakadia, Hui Mei Lee, Emma Johansson, Tim W. Failes, Greg M. Arndt, Jason Koval, Sarah Davidson, Robert Lindeman, Pauline Warburton, Alba Rodriguez-Meira, Adam J Mead, Ashwin Unnikrishnan, Mark Hertzberg, Mark N. Polizzotto, Elli Papaemmanuil, Stefan K. Bohlander, Omid Faridani, Christopher J. Jolly, Fabio Zanini, John E. Pimanda
Journal: Blood
Blood (2022) 140 (Supplement 1): 9751–9752.
https://doi.org/10.1182/blood-2022-163158
Published: 2022
Journal Articles

In Vivo Assessment of Intracellular Dynamics Comparing Injection Versus Oral Azacitidine in a Phase IIb Investigator Initiated Clinical Trial

Ashwin Unnikrishnan, PhD, Xin Ying Lim, PhD, Swapna Joshi, Andrea C. Nunez, PhD, Lachlin Vaughan, MBBS, BSc, FRACP, FRCPA, Russell Pickford, PhD, Sally Hough, Sarah Davidson, Chun Fong, Melita Kenealy, MD, Devendra K Hiwase, MBBS, MD FRACP, FRCPA, PhD, Leonardo Pasalic, MBBS, PhD, Soma Mohammed, Linda Lee, PhD, Freda H. Passam, MD PhD, Kevin Spring, PhD, Patricia Rebeiro, MD, Silvia Ling, MBBS, PhD, Stephen Fuller, MBBS, PhD, Peter Presgrave, MBBS, Fernando Roncolato, BMed, FRACP, FRCPA, Stephen Larsen, MBBS, PhD FRACP, FRCPA, Anoop K Enjeti, MBBS,FRCPA, FRACP,PhDMD,MRCP, William S. Stevenson, MBBS, PhD, Campbell Tiley, MBBS, FRACP, Peter J Campbell, Charlotte Lemech, MD FRACP, Jake Olivier, PhD, Mark Hertzberg, MD MBBS, PhD, Mark N. Polizzotto, MBBS, FRACP, FRCPA, John Pimanda, MBBS, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4247.
https://doi.org/10.1182/blood-2019-123921
Published: 2019