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John E. Pimanda
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Journal Articles

Seeing MDS through the lens of genomics

Lachlin Vaughan, John E. Pimanda
Journal: Blood
Blood (2024) 144 (15): 1552–1554.
https://doi.org/10.1182/blood.2024025676
Published: 2024
Journal Articles

Genome-wide transcription factor–binding maps reveal cell-specific changes in the regulatory architecture of human HSPCs

Shruthi Subramanian, Julie A. I. Thoms, Yizhou Huang, Paola Cornejo-Páramo, Forrest C. Koch, Sebastien Jacquelin, Sylvie Shen, Emma Song, Swapna Joshi, Chris Brownlee, Petter S. Woll, Diego Chacon-Fajardo, Dominik Beck, David J. Curtis, Kenneth Yehson, Vicki Antonenas, Tracey O'Brien, Annette Trickett, Jason A. Powell, Ian D. Lewis, Stuart M. Pitson, Maher K. Gandhi, Steven W. Lane, Fatemeh Vafaee, Emily S. Wong, Berthold Göttgens, Hamid Alinejad-Rokny, Jason W. H. Wong, John E. Pimanda
Journal: Blood
Blood (2023) 142 (17): 1448–1462.
https://doi.org/10.1182/blood.2023021120
Published: 2023
Includes: Supplemental data
Journal Articles

Contribution of mutant HSC clones to immature and mature cells in MDS and CMML, and variations with AZA therapy

Brief Report
Annatina S. Schnegg-Kaufmann, Julie A. I. Thoms, Golam Sarower Bhuyan, Henry R. Hampton, Lachlin Vaughan, Kayleigh Rutherford, Purvi M. Kakadia, Hui Mei Lee, Emma M. V. Johansson, Timothy W. Failes, Greg M. Arndt, Jason Koval, Robert Lindeman, Pauline Warburton, Alba Rodriguez-Meira, Adam J. Mead, Ashwin Unnikrishnan, Sarah Davidson, Mark N. Polizzotto, Mark Hertzberg, Elli Papaemmanuil, Stefan K. Bohlander, Omid R. Faridani, Christopher J. Jolly, Fabio Zanini, John E. Pimanda
Journal: Blood
Blood (2023) 141 (11): 1316–1321.
https://doi.org/10.1182/blood.2022018602
Published: 2023
Includes: Supplemental data
Journal Articles

DDX41: the poster child for familial MDS/AML grows up

Peter Truong, John E. Pimanda
Journal: Blood
Blood (2023) 141 (5): 447–449.
https://doi.org/10.1182/blood.2022018787
Published: 2023
Journal Articles

Comparative Analysis of Genome-Scale Gene Regulatory Networks in Human Hematopoietic Stem and Myeloid Progenitor Fractions

Shruthi Subramanian, Julie A.I. Thoms, Yizhou Huang, Sebastien Jacquelin, Sylvie Shen, Emma Song, Swapna Joshi, Chris Brownlee, Petter S Woll, Diego Chacon Fajardo, Dominik Beck, David J. Curtis, Kenneth Yehson, Vicki Antonenas, Tracey O' Brien, Annette Trickett, Jason Powell, Stuart M Pitson, Maher K. Gandhi, Paola Cornejo, Emily Wong, Steven W Lane, Bertie Gottgens, Hamid Alinejad Rokny, Jason W.H Wong, John E. Pimanda
Journal: Blood
Blood (2022) 140 (Supplement 1): 2846–2848.
https://doi.org/10.1182/blood-2022-165620
Published: 2022
Journal Articles

Clinical Response to Azacytidine (AZA) Is Associated with Increased Contribution from Mutated Blood Progenitors: Insights from Single Cell Genotyping of Matched Stem/Progenitor and Mature Blood Cells from MDS/CMML Patients Pre- and Post-AZA Treatment

Julie A.I. Thoms, Annatina Schnegg-Kaufmann, Golam Sarower Bhuyan, Henry R. Hampton, Lachlin Vaughan, Kayleigh Rutherford, Purvi M. Kakadia, Hui Mei Lee, Emma Johansson, Tim W. Failes, Greg M. Arndt, Jason Koval, Sarah Davidson, Robert Lindeman, Pauline Warburton, Alba Rodriguez-Meira, Adam J Mead, Ashwin Unnikrishnan, Mark Hertzberg, Mark N. Polizzotto, Elli Papaemmanuil, Stefan K. Bohlander, Omid Faridani, Christopher J. Jolly, Fabio Zanini, John E. Pimanda
Journal: Blood
Blood (2022) 140 (Supplement 1): 9751–9752.
https://doi.org/10.1182/blood-2022-163158
Published: 2022
Journal Articles

In Vivo Drug Incorporation and Intracellular Dynamics of Injectable Versus Oral Azacytidine: A Phase II Open Label Multicentre Trial

John E. Pimanda, Julie A.I. Thoms, Henry R. Hampton, Sarah Davidson, Swapna Joshi, Chowdhury H. Sarowar, Xin Ying Lim, Andrea C. Nunez, Purvi M. Kakadia, Russell Pickford, Mark Raftery, Sally Hough, Griselda Buckland, Michelle Bailey, Yuvaraj Ghodke, Noorul Absar, Lachlin Vaughan, Leonardo Pasalic, Chun Yew Fong, Melita Kenealy, Devendra Hiwase, Rohanna Stoddart, Soma Mohammed, Linda Lee, Freda H. Passam, Kevin Spring, Kristy K. Skarratt, Patricia Rebeiro, Stephen R Larsen, Peter Presgrave, William S Stevenson, Silvia Ling, Campbell Tiley, Stephen Fuller, Fernando Roncolato, Anoop Kumar Enjeti, Dirk Hoenemann, Charlotte Lemech, Stefan K. Bohlander, Jake Olivier, Mark Hertzberg, Ashwin Unnikrishnan, Mark N. Polizzotto
Journal: Blood
Blood (2022) 140 (Supplement 1): 6927–6929.
https://doi.org/10.1182/blood-2022-157634
Published: 2022
Journal Articles

Genome-Wide CRISPR-Cas9 Screening Identifies a Synergy between Hypomethylating Agents and Sumoylation Blockade in Myelodysplastic Syndromes and Acute Myeloid Leukemia

Peter Truong, Sylvie Shen, Swapna Joshi, Ali Afrasiabi, Ling Zhong, Mark J. Raftery, Jonas Larsson, Richard B. Lock, Carl R. Walkley, Hamid Alinejad Rokny, Julie A.I. Thoms, Christopher J. Jolly, John E. Pimanda
Journal: Blood
Blood (2022) 140 (Supplement 1): 220–221.
https://doi.org/10.1182/blood-2022-165713
Published: 2022
Journal Articles

p57Kip2 regulates embryonic blood stem cells by controlling sympathoadrenal progenitor expansion

Chrysa Kapeni, Leslie Nitsche, Alastair M. Kilpatrick, Nicola K. Wilson, Kankan Xia, Bahar Mirshekar-Syahkal, Vashe Chandrakanthan, Camille Malouf, John E. Pimanda, Berthold Göttgens, Kristina Kirschner, Simon R. Tomlinson, Katrin Ottersbach
Journal: Blood
Blood (2022) 140 (5): 464–477.
https://doi.org/10.1182/blood.2021014853
Published: 2022
Includes: Supplemental data
Journal Articles

Disruption of a GATA2-TAL1-ERG regulatory circuit promotes erythroid transition in healthy and leukemic stem cells

Julie A. I. Thoms, Peter Truong, Shruthi Subramanian, Kathy Knezevic, Gregory Harvey, Yizhou Huang, Janith A. Seneviratne, Daniel R. Carter, Swapna Joshi, Joanna Skhinas, Diego Chacon, Anushi Shah, Ineke de Jong, Dominik Beck, Berthold Göttgens, Jonas Larsson, Jason W. H. Wong, Fabio Zanini, John E. Pimanda
Journal: Blood
Blood (2021) 138 (16): 1441–1455.
https://doi.org/10.1182/blood.2020009707
Published: 2021
Includes: Supplemental data
Journal Articles

To switch or not to switch: PU.1 expression is the question

Julie A. I. Thoms, John E. Pimanda, Olaf Heidenreich
Journal: Blood
Blood (2021) 138 (15): 1289–1291.
https://doi.org/10.1182/blood.2021012112
Published: 2021
Journal Articles

The EMT modulator SNAI1 contributes to AML pathogenesis via its interaction with LSD1

Catherine L. Carmichael, Jueqiong Wang, Thao Nguyen, Oluseyi Kolawole, Aissa Benyoucef, Charlotte De Mazière, Anna R. Milne, Sona Samuel, Kevin Gillinder, Soroor Hediyeh-zadeh, Anh N. Q. Vo, Yizhou Huang, Kathy Knezevic, William R. L. McInnes, Benjamin J. Shields, Helen Mitchell, Matthew E. Ritchie, Tim Lammens, Beatrice Lintermans, Pieter Van Vlierberghe, Nicholas C. Wong, Katharina Haigh, Julie A. I. Thoms, Emma Toulmin, David J. Curtis, Ethan P. Oxley, Ross A. Dickins, Dominik Beck, Andrew Perkins, Matthew P. McCormack, Melissa J. Davis, Geert Berx, Johannes Zuber, John E. Pimanda, Benjamin T. Kile, Steven Goossens, Jody J. Haigh
Journal: Blood
Blood (2020) 136 (8): 957–973.
https://doi.org/10.1182/blood.2019002548
Published: 2020
Includes: Supplemental data
Journal Articles

Titans awake: HMAs for virus-driven ATL

Christopher J. Jolly, John E. Pimanda
Journal: Blood
Blood (2020) 136 (7): 777–779.
https://doi.org/10.1182/blood.2020006488
Published: 2020
Journal Articles

Shared roles for Scl and Lyl1 in murine platelet production and function

Sung K. Chiu, Stephanie L. Orive, Mitchell J. Moon, Jesslyn Saw, Sarah Ellis, Benjamin T. Kile, Yizhou Huang, Diego Chacon, John E. Pimanda, Dominik Beck, Justin R. Hamilton, Cedric S. Tremblay, David J. Curtis
Journal: Blood
Blood (2019) 134 (10): 826–835.
https://doi.org/10.1182/blood.2019896175
Published: 2019
Includes: Supplemental data
Journal Articles

Jak2V617F and Dnmt3a loss cooperate to induce myelofibrosis through activated enhancer-driven inflammation

Sebastien Jacquelin, Jasmin Straube, Leanne Cooper, Therese Vu, Axia Song, Megan Bywater, Eva Baxter, Matthew Heidecker, Brad Wackrow, Amy Porter, Victoria Ling, Joanne Green, Rebecca Austin, Stephen Kazakoff, Nicola Waddell, Luke B. Hesson, John E. Pimanda, Frank Stegelmann, Lars Bullinger, Konstanze Döhner, Raajit K. Rampal, Dirk Heckl, Geoffrey R. Hill, Steven W. Lane
Journal: Blood
Blood (2018) 132 (26): 2707–2721.
https://doi.org/10.1182/blood-2018-04-846220
Published: 2018
Includes: Supplemental data
Journal Articles

Srsf2 P95H initiates myeloid bias and myelodysplastic/myeloproliferative syndrome from hemopoietic stem cells

Monique F. Smeets, Shuh Ying Tan, Jane Jialu Xu, Govardhan Anande, Ashwin Unnikrishnan, Alistair M. Chalk, Scott R. Taylor, John E. Pimanda, Meaghan Wall, Louise E. Purton, Carl R. Walkley
Journal: Blood
Blood (2018) 132 (6): 608–621.
https://doi.org/10.1182/blood-2018-04-845602
Published: 2018
Includes: Supplemental data
Journal Articles

Identification of novel regulators of developmental hematopoiesis using Endoglin regulatory elements as molecular probes

Rabab Nasrallah, Eva M. Fast, Parham Solaimani, Kathy Knezevic, Alexia Eliades, Rahima Patel, Roshana Thambyrajah, Ashwin Unnikrishnan, Julie Thoms, Dominik Beck, Chris S. Vink, Aileen Smith, Jason Wong, Mairi Shepherd, David Kent, Rahul Roychoudhuri, Fabian Paul, Julia Klippert, Annette Hammes, Thomas Willnow, Bertie Göttgens, Elaine Dzierzak, Leonard I. Zon, George Lacaud, Valerie Kouskoff, John E. Pimanda
Journal: Blood
Blood (2016) 128 (15): 1928–1939.
https://doi.org/10.1182/blood-2016-02-697870
Published: 2016
Includes: Supplemental data
Journal Articles

An Integrative Genomics Approach Uncovers the Basis of Resistance to AZA Therapy in MDS and CMML

Ashwin Unnikrishnan, PhD, Elli Papaemmanuil, PhD, Dominik Beck, PhD, Arjun Verma, B.Sc., Ashu Kumari, PhD, Laura A. Richards, Kathy Knezevic, Vashe Chandrakanthan, PhD, Julie A.I. Thoms, PhD, Melinda L. Tursky, PhD, Yizhou Huang, Sally Galbraith, PhD, Austin G. Kulasekararaj, MBBS, MD MRCP, FRCPath, Magnus Tobiasson, MD, Petter S. Woll, PhD, Andrea Pellagatti, PhD, Susan R. Wilson, PhD, Robert Lindeman, MD, Jacqueline Boultwood, PhD, Kevin Lynch, MBBS, Sten Eirik Jacobsen, Ghulam J Mufti, FRCP, FRCPath, Eva Hellstrom-Lindberg, MD PhD, Karen Lee Mackenzie, PhD, Jason W.H. Wong, PhD, Peter J Campbell, MD PhD, John E. Pimanda, MDPhD
Journal: Blood
Blood (2015) 126 (23): 710.
https://doi.org/10.1182/blood.V126.23.710.710
Published: 2015
Journal Articles

A Tissue-Specific Transcriptional Element for C/ebpa Is Required for HSC Maintenance and Neutrophil Development

Roberto Avellino, Marije Havermans, Claudia Erpelinck, Mathijs Sanders, Stefan Groeschel, Harmen Vandewerken, Remco M. Hoogenboezem, M.Sc., Elwin Rombouts, Kirsten Van Lom, Paulette Van Strien, Hans De Looper, Claudia Christine Gebhard, Michael Rehli, Dominik Beck, PhD, Julie A.I. Thoms, PhD, Stefan Erkeland, Ivo Touw, John E. Pimanda, MDPhD, Eric JM Bindels, Ruud Delwel
Journal: Blood
Blood (2015) 126 (23): 301.
https://doi.org/10.1182/blood.V126.23.301.301
Published: 2015
Journal Articles

Opposing regulation of BIM and BCL2 controls glucocorticoid-induced apoptosis of pediatric acute lymphoblastic leukemia cells

Duohui Jing, Vivek A. Bhadri, Dominik Beck, Julie A. I. Thoms, Nurul A. Yakob, Jason W. H. Wong, Kathy Knezevic, John E. Pimanda, Richard B. Lock
Journal: Blood
Blood (2015) 125 (2): 273–283.
https://doi.org/10.1182/blood-2014-05-576470
Published: 2015
Includes: Supplemental data