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Journal Articles

The glycosaminoglycan oncofetal chondroitin sulfate represents a novel target for antibody drug-conjugate therapy for AML

Blood blood.2024028147.

https://doi.org/10.1182/blood.2024028147

Published: 2025

Includes: Supplemental data

Journal Articles

Fusion gene depletion eliminates stemness and induces bidirectional differentiation of acute myeloid leukemia

Polina K. Derevyanko, Laura E. Swart, L. Daniel Mata Casimiro, Anita van Oort, Manisha du Plessis, Luca van den Brink, Minoo Ashtiani, C. Michel Zwaan, Anja Krippner-Heidenreich, Constanze Bonifer, Raymond Schiffelers, Josef Vormoor, Sophie G. Kellaway, Olaf Heidenreich

Blood (2025) 146 (24): 2963–2978.

https://doi.org/10.1182/blood.2025028988

Published: 2025

Includes: Supplemental data

Journal Articles

Double trouble for a blurry foe: precision strike on BCL11B

Olaf Heidenreich

Blood (2025) 146 (19): 2280–2281.

https://doi.org/10.1182/blood.2025030748

Published: 2025

Journal Articles

Multi-omics single-cell spatial profiling of paediatric and adult acute myeloid leukaemia links spatial organization, molecular genetics and microenvironmental interactions

Merel van der Meulen, Joost Koedijk, Emma Pool, Eva Argiro, Marijn Scheijde-Vermeulen, Livius Penter, Jana Ihlow, Andrej Lissat, Marieke Griffioen, Jennifer Tjon, Erik Van Den Akker, David Horst, Hendrik Veelken, Bianca Goemans, Wim De Jonge, Thanasis Margaritis, C. Zwaan, Olaf Heidenreich

Blood (2025) 146 (Supplement 1): 860.

https://doi.org/10.1182/blood-2025-860

Published: 2025

Journal Articles

Molecular characterization of pediatric acute myeloid leukemia treated under the NOPHO-DBH-2012 protocol in the Netherlands

Elizabeth Schweighart, Maaike Luesink, Milad Rasouli, Gertjan Kaspers, Olaf Heidenreich, C. Zwaan, Lennart Kester, Bianca Goemans

Blood (2025) 146 (Supplement 1): 445.

https://doi.org/10.1182/blood-2025-445

Published: 2025

Journal Articles

Pediatric AML blasts drive immunosuppressive reprogramming and metabolic adaptation in macrophages, impairing T cell activation and anti-leukemic immunity

Alicia Perzolli, Farah Massaoudi, Joost Koedijk, Elizabeth Schweighart, Lennart Kester, Bianca Goemans, C. Zwaan, Olaf Heidenreich

Blood (2025) 146 (Supplement 1): 5282.

https://doi.org/10.1182/blood-2025-5282

Published: 2025

Journal Articles

Optimization of Targeted Lipid Nanoparticle for the Treatment of RUNX1::ETO Driven AML

Luis Daniel Daniel Mata Casimiro, Manisha du Plessis, Dennis Unthan, Heyang Zhang, Matthias Barz, Raymond M. Schiffelers, Olaf Heidenreich

Blood (2024) 144 (Supplement 1): 2199.

https://doi.org/10.1182/blood-2024-204969

Published: 2024

Journal Articles

The Interplay between Macrophages and Pediatric AML Blasts

Alicia Perzolli, Joost B. Koedijk, Elizabeth K Schweighart, Bianca F. Goemans, Christian Michel Zwaan, Olaf Heidenreich

Blood (2024) 144 (Supplement 1): 5653.

https://doi.org/10.1182/blood-2024-204948

Published: 2024

Journal Articles

The Nanoparticle-Mediated Delivery of Therapeutic Sirnas Targeting the KMT2A::Afdn Fusion Gene in AML

Manisha du Plessis, Luis Daniel Mata Casimiro, Irmela Jeremias, Olaf Heidenreich

Blood (2024) 144 (Supplement 1): 4963.

https://doi.org/10.1182/blood-2024-202373

Published: 2024

Journal Articles

Characterizing the Bone Marrow Stromal Niche in Pediatric Acute Myeloid Leukemia

Elizabeth K Schweighart, Cristoforo Grasso, Brigit M. te Pas, Mirjam E. Belderbos, Christian Michel Zwaan, Hendrik G. Stunnenberg, Olaf Heidenreich, Bianca F. Goemans

Blood (2024) 144 (Supplement 1): 4062.

https://doi.org/10.1182/blood-2024-204988

Published: 2024

Journal Articles

Single-Cell Dissection of the B-ALL Niche Reveals Distinct Mesenchymal Stromal Cell Subtypes with Differential Leukemic Cell Support and Relapse Implications

Mauricio Nicolás Ferrao Blanco, Bexultan Kazybay, Olaf Heidenreich, Josef Vormoor

Blood (2024) 144 (Supplement 1): 1299.

https://doi.org/10.1182/blood-2024-205911

Published: 2024

Journal Articles

Acute myeloid leukemias with UBTF tandem duplications are sensitive to menin inhibitors

Blood (2024) 143 (7): 619–630.

https://doi.org/10.1182/blood.2023021359

Published: 2024

Includes: Supplemental data

Journal Articles

Transcriptional Heterogeneity and Clonal Evolution between Diagnosis and Relapse in Pediatric Acute Myeloid Leukemia

Cristoforo Grasso, Peter Brazda, Brigit M. te Pas, Gitanjali Dharmadhikari, Joost B. Koedijk, Bianca F. Goemans, Olaf Heidenreich, Mirjam E. Belderbos, C. Michel Zwaan, Hendrik G. Stunnenberg, Wout Megchelenbrink

Blood (2023) 142 (Supplement 1): 2746.

https://doi.org/10.1182/blood-2023-182852

Published: 2023

Journal Articles

RUNX1::RUNX1T1 Impairs the Differentiation Potential of Primary AML Cells

Polina K Derevianko, Laura E. Swart, Minoo Ashtiani, Sophie Kellaway, Anja Krippner-Heidenreich, Raymond M. Schiffelers, Josef Vormoor, Olaf Heidenreich

Blood (2023) 142 (Supplement 1): 1573.

https://doi.org/10.1182/blood-2023-182804

Published: 2023

Journal Articles

Oncogenic RAS Signaling Promotes an Immunosuppressive Niche in Acute Lymphoblastic Leukemia

Mauricio Nicolás Ferrao Blanco, Elizabeth Schweighart, Lennart Kester, Jayne Hehir-Kwa, Mirjam E. Belderbos, Monique L. den Boer, Olaf Heidenreich, Josef Vormoor

Blood (2023) 142 (Supplement 1): 4080.

https://doi.org/10.1182/blood-2023-188899

Published: 2023

Journal Articles

Identification of Epigenetic Modifiers Essential for Growth and Survival of AML1/ETO-Positive Leukemia

Jesus Duque Afonso, Veratti Pia, Usama-Ur Rehman, Heike Herzog, Jan Mitschke, Gabriele Greve, Julian Eble, Bettina Berberich, Johanna Thomas, Milena Pantic, Miguel Waterhouse, Gaia Gentile, Olaf Heidenreich, Cornelius Miething, Michael Lübbert

Blood (2023) 142 (Supplement 1): 5687.

https://doi.org/10.1182/blood-2023-187372

Published: 2023

Journal Articles

Spatial Technologies Reveal the Immune Landscape of Pediatric Acute Myeloid Leukemia

Joost B. Koedijk, Inge Van Der Werf, Marijn A. Vermeulen, Alicia Perzolli, Marta F. Fiocco, Hester A. de Groot-Kruseman, Rubina Moeniralam, Kristina B. Christensen, Henrik Hasle, Stefan Nierkens, Mirjam E. Belderbos, Michel C. Zwaan, Olaf Heidenreich

Blood (2023) 142 (Supplement 1): 2959.

https://doi.org/10.1182/blood-2023-177932

Published: 2023

Journal Articles

Inhibition of the Menin-MLL1 Interaction in MLL -Rearranged Primary Mixed-Phenotype Acute Leukemia Samples Promotes Leukemic Differentiation

Katarzyna Szoltysek, Rachel L. Cameron, Anja Krippner-Heidenreich, Milad Rasouli, Jayne Y. Hehir-Kwa, Elizabeth K. Schweighart, Minoo Ashtiani, Janine Stutterheim, Josef Vormoor, Olaf Heidenreich

Blood (2022) 140 (Supplement 1): 9191.

https://doi.org/10.1182/blood-2022-166326

Published: 2022

Journal Articles

Dual Targeting of MDM2 and BCL2/Bclxl Demonstrates Potent Synergistic Activity in High-Risk Adult Acute Lymphoblastic Leukemia

Hayden L Bell, Mankaran Singh, Helen J Blair, Olaf Heidenreich, Frederik W. van Delft, Anthony V. Moorman, John Lunec, Julie Irving

Blood (2022) 140 (Supplement 1): 9181–9182.

https://doi.org/10.1182/blood-2022-159573

Published: 2022

Journal Articles

Epigenetic regulator genes direct lineage switching in MLL/AF4 leukemia

Ricky Tirtakusuma, Katarzyna Szoltysek, Paul Milne, Vasily V. Grinev, Anetta Ptasinska, Paulynn S. Chin, Claus Meyer, Sirintra Nakjang, Jayne Y. Hehir-Kwa, Daniel Williamson, Pierre Cauchy, Peter Keane, Salam A. Assi, Minoo Ashtiani, Sophie G. Kellaway, Maria R. Imperato, Fotini Vogiatzi, Elizabeth K. Schweighart, Shan Lin, Mark Wunderlich, Janine Stutterheim, Alexander Komkov, Elena Zerkalenkova, Paul Evans, Hesta McNeill, Alex Elder, Natalia Martinez-Soria, Sarah E. Fordham, Yuzhe Shi, Lisa J. Russell, Deepali Pal, Alex Smith, Zoya Kingsbury, Jennifer Becq, Cornelia Eckert, Oskar A. Haas, Peter Carey, Simon Bailey, Roderick Skinner, Natalia Miakova, Matthew Collin, Venetia Bigley, Muzlifah Haniffa, Rolf Marschalek, Christine J. Harrison, Catherine A. Cargo, Denis Schewe, Yulia Olshanskaya, Michael J. Thirman, Peter N. Cockerill, James C. Mulloy, Helen J. Blair, Josef Vormoor, James M. Allan, Constanze Bonifer, Olaf Heidenreich, Simon Bomken

Blood (2022) 140 (17): 1875–1890.

https://doi.org/10.1182/blood.2021015036

Published: 2022

Includes: Supplemental data

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The glycosaminoglycan oncofetal chondroitin sulfate represents a novel target for antibody drug-conjugate therapy for AML

Fusion gene depletion eliminates stemness and induces bidirectional differentiation of acute myeloid leukemia

Double trouble for a blurry foe: precision strike on BCL11B

Multi-omics single-cell spatial profiling of paediatric and adult acute myeloid leukaemia links spatial organization, molecular genetics and microenvironmental interactions

Molecular characterization of pediatric acute myeloid leukemia treated under the NOPHO-DBH-2012 protocol in the Netherlands

Pediatric AML blasts drive immunosuppressive reprogramming and metabolic adaptation in macrophages, impairing T cell activation and anti-leukemic immunity

Optimization of Targeted Lipid Nanoparticle for the Treatment of RUNX1::ETO Driven AML

The Interplay between Macrophages and Pediatric AML Blasts

The Nanoparticle-Mediated Delivery of Therapeutic Sirnas Targeting the KMT2A::Afdn Fusion Gene in AML

Characterizing the Bone Marrow Stromal Niche in Pediatric Acute Myeloid Leukemia

Single-Cell Dissection of the B-ALL Niche Reveals Distinct Mesenchymal Stromal Cell Subtypes with Differential Leukemic Cell Support and Relapse Implications

Acute myeloid leukemias with UBTF tandem duplications are sensitive to menin inhibitors

Transcriptional Heterogeneity and Clonal Evolution between Diagnosis and Relapse in Pediatric Acute Myeloid Leukemia

RUNX1::RUNX1T1 Impairs the Differentiation Potential of Primary AML Cells

Oncogenic RAS Signaling Promotes an Immunosuppressive Niche in Acute Lymphoblastic Leukemia

Identification of Epigenetic Modifiers Essential for Growth and Survival of AML1/ETO-Positive Leukemia

Spatial Technologies Reveal the Immune Landscape of Pediatric Acute Myeloid Leukemia

Inhibition of the Menin-MLL1 Interaction in MLL -Rearranged Primary Mixed-Phenotype Acute Leukemia Samples Promotes Leukemic Differentiation

Dual Targeting of MDM2 and BCL2/Bclxl Demonstrates Potent Synergistic Activity in High-Risk Adult Acute Lymphoblastic Leukemia

Epigenetic regulator genes direct lineage switching in MLL/AF4 leukemia

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