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Volume 145,

Issue 24,

June 12 2025

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Issue Highlights

Tet3 DNA demethylation and Ig class switching in chronic GVHD
Blood Spotlight Series: acute myeloid leukemia
Rovadicitinib for refractory chronic GVHD
Inhibition of EZH2 and DOTL1 for B-cell lymphoma
Coinhibition of pre-TCR and IL17R in the treatment of T-ALL
Rilzabrutinib for chronic ITP
Diabetes mellitus and risk of kidney disease in SCD
NOTCH dimeric signaling in T-cell ALL

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Free Articles

A small B-cell leukemia/lymphoma with weak to negative expression of CD5

Shamini Selvarajah; Daniel Xia

https://doi.org/10.1182/blood.2025028974

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Plenary Papers

Deficiency of T follicular helper cell Tet3 DNA demethylation inhibits pathogenic IgG2c class switching and chronic GVHD

Michael C. Zaiken; Sujeong Jin; Cameron S. McDonald-Hyman; Christina R. Hartigan; Peter T. Sage; Keli L. Hippen; Brent H. Koehn; Angela Panoskaltsis-Mortari; Megan J. Riddle; Cindy R. Eide; Jakub Tolar; Geoffrey R. Hill; Leo Luznik; Corey S. Cutler; Jerome R. Ritz; Leslie S. Kean; Ageliki Tsagaratou; Anjana Rao; Bruce R. Blazar

https://doi.org/10.1182/blood.2024025036

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First Edition

TNFα signaling restores steady-state hematopoiesis in a TNFαKO mouse model of anemia of inflammation

Amaliris Guerra; Vania Lo Presti; Ding-Wen Chen; Ana C. Martins; Ariel Rivera; Nolan Hamilton; Pankaj Sharma; Yelena Z Ginzburg; Carlo Castruccio Castracani; Carla Casu; Ritama Gupta; Raffaella Gozzelino; Edward M Behrens; Laura Bennett; Robert F. Paulson; Peter Kurre; Stefano Rivella

https://doi.org/10.1182/blood.2025029352

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Clinical Trials and Observations

TP53 -mutated acute myeloid leukemia: how can we improve outcomes?

David A. Sallman; Maximilian Stahl

https://doi.org/10.1182/blood.2024024245

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Year in review: Blood's ten most read articles published in 2024

170,000 citations
earned in 2023

Acknowledgement of Reviewers for 2024

Issue Highlights

170,000 citations
earned in 2023

Featured Content

A key role for T-cell TET3 in chronic GVHD; a BTK inhibitor for ITP; co-inhibition of pre-TCR and IL-7R pathways in a T-ALL patient subset

Deficiency of T follicular helper cell Tet3 DNA demethylation inhibits pathogenic IgG2c class switching and chronic GVHD

Safety and efficacy of rilzabrutinib vs placebo in adults with immune thrombocytopenia: the phase 3 LUNA3 study

Surface pTα expression predicts LCK activation and preclinical synergy of LCK and JAK coinhibition in adult T-ALL

A first-in-class JAK/ROCK inhibitor, rovadicitinib, for glucocorticoid-refractory or -dependent chronic GVHD

Synergistic antitumor effect of combined EZH2 and DOT1L inhibition in B-cell lymphoma

ASH Publications

American Society of Hematology

Issue Highlights

170,000 citations earned in 2023

Featured Content

A key role for T-cell TET3 in chronic GVHD; a BTK inhibitor for ITP; co-inhibition of pre-TCR and IL-7R pathways in a T-ALL patient subset

Deficiency of T follicular helper cell Tet3 DNA demethylation inhibits pathogenic IgG2c class switching and chronic GVHD

Safety and efficacy of rilzabrutinib vs placebo in adults with immune thrombocytopenia: the phase 3 LUNA3 study

Surface pTα expression predicts LCK activation and preclinical synergy of LCK and JAK coinhibition in adult T-ALL

A first-in-class JAK/ROCK inhibitor, rovadicitinib, for glucocorticoid-refractory or -dependent chronic GVHD

Synergistic antitumor effect of combined EZH2 and DOT1L inhibition in B-cell lymphoma

ASH Publications

American Society of Hematology

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170,000 citations
earned in 2023