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Ti-Cheng Chang
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Journal Articles

Assessment of Outcomes of Allogeneic Stem Cell Transplantation By Treatment Arm in Newly Diagnosed Measurable Residual Disease Negative Patients with B-Lineage Acute Lymphoblastic Leukemia Randomized to Conventional Chemotherapy +/- Blinatumomab in the ECOG-ACRIN E1910 Phase III National Clinical Trials Network Trial

Michaela Liedtke, Zhuoxin Sun, Mark R. Litzow, Ryan J Mattison, Elisabeth Paietta, Kathryn G. Roberts, Yanming Zhang, Janis Racevskis, Hillard M. Lazarus, Jacob M. Rowe, Daniel A. Arber, Julie Bergeron, Brent L. Wood, Yaqi Zhao, Gang Wu, Ti-Cheng Chang, Wenchao Zhang, Keith W. Pratz, Shira N. Dinner, Noelle Frey, Steven D. Gore, Bhavana Bhatnagar, Ehab L. Atallah, Geoffrey L. Uy, Deepa Jeyakumar, Tara L. Lin, Cheryl L. Willman, Daniel J. DeAngelo, Shejal B. Patel, Michelle A Elliott, Anjali S. Advani, Dimitrios Tzachanis, Pankit Vachhani, Rupali Bhave, Elad Sharon, Richard Little, Harry P. Erba, Richard M. Stone, Selina Luger, Charles G. Mullighan, Martin S. Tallman, Matthew J. Wieduwilt
Journal: Blood
Blood (2024) 144 (Supplement 1): 779.
https://doi.org/10.1182/blood-2024-207557
Published: 2024
Journal Articles

Identification of Breakpoints of RHD Hybrid Alleles By Long-Read Sequencing

Ti-Cheng Chang, Jing Yu, Bensheng Ju, Melanie Loyd, Granger Ridout, Geoffrey A.M. Neale, Jane S Hankins, Mitchell J Weiss, Gorka Ochoa, Sunitha Vege, Stella T. Chou, John Easton, Yan Zheng
Journal: Blood
Blood (2024) 144 (Supplement 1): 4031.
https://doi.org/10.1182/blood-2024-198223
Published: 2024
Journal Articles

Addition of Blinatumomab to Consolidation Therapy Among Older Newly Diagnosed Patients (pts) with BCR::ABL1 Negative B-Lineage Acute Lymphoblastic Leukemia (ALL) in the ECOG-ACRIN E1910 Randomized Phase III Trial

Nikolai A. Podoltsev, Zhuoxin Sun, Mark R. Litzow, Elisabeth Paietta, Kathryn G. Roberts, Yanming Zhang, Janis Racevskis, Hillard M. Lazarus, Jacob M. Rowe, Daniel A. Arber, Matthew J. Wieduwilt, Michaela Liedtke, Julie Bergeron, Brent L. Wood, Yaqi Zhao, Gang Wu, Ti-Cheng Chang, Wenchao Zhang, Keith W. Pratz, Shira N. Dinner, Noelle Frey, Steven D. Gore, Bhavana Bhatnagar, Ehab L. Atallah, Geoffrey L. Uy, Deepa Jeyakumar, Tara L. Lin, Cheryl L. Willman, Daniel J. DeAngelo, Shejal B. Patel, Michelle A Elliott, Anjali S. Advani, Dimitrios Tzachanis, Pankit Vachhani, Rupali Roy, Elad Sharon, Richard Little, Harry Erba, Richard M. Stone, Charles G. Mullighan, Martin S. Tallman, Selina Luger, Ryan J Mattison
Journal: Blood
Blood (2024) 144 (Supplement 1): 4211.
https://doi.org/10.1182/blood-2024-207143
Published: 2024
Journal Articles

Genomic determinants of response and resistance to inotuzumab ozogamicin in B-cell ALL

Yaqi Zhao, Nicholas J. Short, Hagop M. Kantarjian, Ti-Cheng Chang, Pankaj S. Ghate, Chunxu Qu, Walid Macaron, Nitin Jain, Beenu Thakral, Aaron H. Phillips, Joseph Khoury, Guillermo Garcia-Manero, Wenchao Zhang, Yiping Fan, Hui Yang, Rebecca S. Garris, Lewis F. Nasr, Richard W. Kriwacki, Kathryn G. Roberts, Marina Konopleva, Elias J. Jabbour, Charles G. Mullighan
Journal: Blood
Blood (2024) 144 (1): 61–73.
https://doi.org/10.1182/blood.2024023930
Published: 2024
Includes: Supplemental data
Journal Articles

Acute myeloid leukemias with UBTF tandem duplications are sensitive to menin inhibitors

Juan M. Barajas, Milad Rasouli, Masayuki Umeda, Ryan Hiltenbrand, Sherif Abdelhamed, Rebecca Mohnani, Bright Arthur, Tamara Westover, Melvin E. Thomas, III, Minoo Ashtiani, Laura J. Janke, Beisi Xu, Ti-Cheng Chang, Wojciech Rosikiewicz, Emily Xiong, Chandra Rolle, Jonathan Low, Reethu Krishan, Guangchun Song, Michael P. Walsh, Jing Ma, Jeffrey E. Rubnitz, Ilaria Iacobucci, Taosheng Chen, Anja Krippner-Heidenreich, Christian M. Zwaan, Olaf Heidenreich, Jeffery M. Klco
Journal: Blood
Blood (2024) 143 (7): 619–630.
https://doi.org/10.1182/blood.2023021359
Published: 2024
Includes: Supplemental data
Journal Articles

Assessment of Outcomes of Consolidation Therapy By Number of Cycles of Blinatumomab Received in Newly Diagnosed Measurable Residual Disease Negative Patients with B-Lineage Acute Lymphoblastic Leukemia: In the ECOG-ACRIN E1910 Randomized Phase III National Clinical Trials Network Trial

Selina M Luger, Zhuoxin Sun, Ryan J Mattison, Elisabeth Paietta, Kathryn G. Roberts, Yanming Zhang, Janis Racevckis, Hillard M. Lazarus, Jacob M. Rowe, Daniel A. Arber, Matthew J. Wieduwilt, Michaela Liedtke, Julie Bergeron, Brent L. Wood, Yaqi Zhao, Gang Wu, Ti-Cheng Chang, Wenchao Zhang, Keith W Pratz, Shira N. Dinner, Noelle V. Frey, Steven D. Gore, Bhavana Bhatnagar, Ehab L. Atallah, Geoffrey L Uy, Deepa Jeyakumar, Tara L Lin, Cheryl L. Willman, Daniel J. DeAngelo, Elad Sharon, Richard F. Little, Harry P. Erba, Richard M Stone, Charles G. Mullighan, Mark R. Litzow, Martin S. Tallman
Journal: Blood
Blood (2023) 142 (Supplement 1): 2877.
https://doi.org/10.1182/blood-2023-189648
Published: 2023
Journal Articles

Cancer Genomic Profiling and Minimal Residual Disease Monitoring By Cell-Free DNA Sequencing in Pediatric Leukemia

Shaohua Lei, Sujuan Jia, Sunitha Takalkar, Ti-Cheng Chang, Gang Wu, Xiaotu Ma, Selene C. Koo, Paul E. Mead, Jeffery M. Klco, Ruth G. Tatevossian, Charles G. Mullighan
Journal: Blood
Blood (2023) 142 (Supplement 1): 1604.
https://doi.org/10.1182/blood-2023-188158
Published: 2023
Journal Articles

Optimization of RH Genotyping from Whole Exon Sequencing Data By Machine Learning

Ti-Cheng Chang, Jing Yu, Zhaoming Wang, Jane S Hankins, Mitchell Weiss, Gang Wu, Connie M. Westhoff, Sunitha Vege, Stella Chou, Yan Zheng
Journal: Blood
Blood (2023) 142 (Supplement 1): 4034.
https://doi.org/10.1182/blood-2023-182089
Published: 2023
Journal Articles

The genomic landscape of acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21

Qingsong Gao, Sarra L. Ryan, Ilaria Iacobucci, Pankaj S. Ghate, Ruth E. Cranston, Claire Schwab, Abdelrahman H. Elsayed, Lei Shi, Stanley Pounds, Shaohua Lei, Pradyuamna Baviskar, Deqing Pei, Cheng Cheng, Matthew Bashton, Paul Sinclair, David R. Bentley, Mark T. Ross, Zoya Kingsbury, Terena James, Kathryn G. Roberts, Meenakshi Devidas, Yiping Fan, Wenan Chen, Ti-Cheng Chang, Gang Wu, Andrew Carroll, Nyla Heerema, Virginia Valentine, Marcus Valentine, Wenjian Yang, Jun J. Yang, Anthony V. Moorman, Christine J. Harrison, Charles G. Mullighan
Journal: Blood
Blood (2023) 142 (8): 711–723.
https://doi.org/10.1182/blood.2022019094
Published: 2023
Includes: Supplemental data
Journal Articles

Genomic landscape of Down syndrome–associated acute lymphoblastic leukemia

Zhenhua Li, Ti-Cheng Chang, Jacob J. Junco, Meenakshi Devidas, Yizhen Li, Wenjian Yang, Xin Huang, Dale J. Hedges, Zhongshan Cheng, Mary Shago, Andrew J. Carroll, Nyla A. Heerema, Julie Gastier-Foster, Brent L. Wood, Michael J. Borowitz, Lauren Sanclemente, Elizabeth A. Raetz, Stephen P. Hunger, Eleanor Feingold, Tracie C. Rosser, Stephanie L. Sherman, Mignon L. Loh, Charles G. Mullighan, Jiyang Yu, Gang Wu, Philip J. Lupo, Karen R. Rabin, Jun J. Yang
Journal: Blood
Blood (2023) 142 (2): 172–184.
https://doi.org/10.1182/blood.2023019765
Published: 2023
Includes: Supplemental data
Journal Articles

Discovery of novel predisposing coding and noncoding variants in familial Hodgkin lymphoma

Jamie E. Flerlage, Jason R. Myers, Jamie L. Maciaszek, Ninad Oak, Sara R. Rashkin, Yawei Hui, Yong-Dong Wang, Wenan Chen, Gang Wu, Ti-Cheng Chang, Kayla Hamilton, Saima S. Tithi, Lynn R. Goldin, Melissa Rotunno, Neil Caporaso, Aurélie Vogt, Deborah Flamish, Kathleen Wyatt, Jia Liu, Margaret Tucker, Christopher N. Hahn, Anna L. Brown, Hamish S. Scott, Charles Mullighan, Kim E. Nichols, Monika L. Metzger, Mary L. McMaster, Jun J. Yang, Evadnie Rampersaud
Journal: Blood
Blood (2023) 141 (11): 1293–1307.
https://doi.org/10.1182/blood.2022016056
Published: 2023
Includes: Supplemental data
Journal Articles

Mutational Permutations of a Single Amino Acid Exert Divergent Phenotypic Effects in Human, Mice, and Cellular Models of SAMD9L Bone Marrow Failure Disorder

Sushree S Sahoo, Charnise Goodings-Harris, Shondra Miller, Maria Angeles Lillo Osuna, Baranda S Hansen, Lei Han, Ti-Cheng Chang, Tim Lammens, Mattias Hofmans, Marta Derecka, Barbara De Moerloose, Marcin W Wlodarski
Journal: Blood
Blood (2022) 140 (Supplement 1): 2216–2217.
https://doi.org/10.1182/blood-2022-169400
Published: 2022
Journal Articles

Comprehensive Genome Characterization of Childhood T-ALL Links Oncogene Activation Mechanism and Subtypes to Prognosis

Petri Pölönen, Abdelrahman Elsayed, Danika Di Giacomo, Lindsey Montefiori, Shunsuke Kimura, Jason Myers, Dale Hedges, Jason Xu, Yawei Hui, Zhongshan Cheng, Yiping Fan, Ilaria Iacobucci, Yunchao Chang, Rawan Shraim, Meenakshi Devidas, Stuart S. Winter, Kimberly P. Dunsmore, Jun J.J. Yang, Tiffaney L. Vincent, Kai Tan, Changya Chen, Haley Newman, Mignon L. Loh, Elizabeth A. Raetz, Stephen P. Hunger, Evadnie Rampersaud, Ti-Cheng Chang, Gang Wu, Stanley B. Pounds, Charles G. Mullighan, David T. Teachey
Journal: Blood
Blood (2022) 140 (Supplement 1): 1727–1729.
https://doi.org/10.1182/blood-2022-167157
Published: 2022
Journal Articles

Gain-of-function mutations in RPA1 cause a syndrome with short telomeres and somatic genetic rescue

Clinical Trials & Observations
Richa Sharma, Sushree S. Sahoo, Masayoshi Honda, Sophie L. Granger, Charnise Goodings, Louis Sanchez, Axel Künstner, Hauke Busch, Fabian Beier, Shondra M. Pruett-Miller, Marcus B. Valentine, Alfonso G. Fernandez, Ti-Cheng Chang, Vincent Géli, Dmitri Churikov, Sandrine Hirschi, Victor B. Pastor, Melanie Boerries, Melchior Lauten, Charikleia Kelaidi, Megan A. Cooper, Sarah Nicholas, Jill A. Rosenfeld, Sophia Polychronopoulou, Caroline Kannengiesser, Carole Saintomé, Charlotte M. Niemeyer, Patrick Revy, Marc S. Wold, Maria Spies, Miriam Erlacher, Stéphane Coulon, Marcin W. Wlodarski
Journal: Blood
Blood (2022) 139 (7): 1039–1051.
https://doi.org/10.1182/blood.2021011980
Published: 2022
Includes: Supplemental data
Journal Articles

Precision Medicine for Sickle Cell Disease through Whole Genome Sequencing

Evadnie Rampersaud, PhD, Lance E. Palmer, PhD, Jane S. Hankins, MD MS, Vivien A Sheehan, MD PhD, Wenjian Bi, PhD, Heather Mulder, BS, Guolian Kang, PhD, Jeremie H. Estepp, MD, Shuoguo Wang, PhD, Andrew Thrasher, PhD, Martha Villavicencio, PhD, Jason R Hodges, PhD MA, Wenan Chen, PhD, Ti-Cheng Chang, PhD, Yong Cheng, PhD, Michael Rusch, BS, Yadav Sapkota, PhD, Akshay Sharma, MBBS, Pavel Sumazin, PhD, Xing Tang, PhD, Amanda M. Brandow, DO, MS, Shawn Levy, Nidal Boulos, PhD, Celeste Rosencrance, BS, Donald Yergeau, PhD, Jeffrey Lebensburger, DO, MSPH, Winfred Wang, MD, Yutaka Yasui, PhD, John Easton, PhD, Michael R. DeBaun, MD, James R. Downing, MD, Jinghui Zhang, Gang Wu, PhD, Mitchell J. Weiss, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3641.
https://doi.org/10.1182/blood-2018-99-117606
Published: 2018
Journal Articles

Accurate Prediction of RH Genotypes Using Whole Genome Sequencing Data

Yan Zheng, MD PhD, Ti-Cheng Chang, PhD, Gang Wu, PhD, Jane S. Hankins, MD MS, Mitchell J. Weiss, MD PhD, Connie M. Westhoff, PhD, Stella T. Chou, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2332.
https://doi.org/10.1182/blood-2018-99-119681
Published: 2018