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Journal Articles

Multimodal Single-Cell Profiling of Minimal Residual Disease in B Acute Lymphoblastic Leukemia Reveals Genetic and Non-Genetic Factors of Early Drug Resistance

Rushabh Mehta, Changya Chen, Fatemeh Alikarami, Steven Foltz, Avi Loren, Elizabeth Li, Jason Xu, Marilyn M. Li, Kathrin M. Bernt, Kai Tan
Journal: Blood
Blood (2024) 144 (Supplement 1): 316.
https://doi.org/10.1182/blood-2024-210504
Published: 2024
Journal Articles

Changes in Glycosylation on the Cell Surface Result in Highly Potent and Long-Lasting Allogeneic CAR-T Therapy in Patients

Zeguang Wu, Jinhong Shi, Qiezhong Lamao, Jinxin Yang, Yuanyuan Qiu, Yang Liu, Feifei Liang, Changya Chen, Qingming Yang, Chunmeng Wang, Haixia Zhang, Zhonghan Yang, Yunyi Zhang, Yuting Yi, Xufen Zheng, Yun Sun, Kuiying Ma, Lingling Yu, Huihui Yang, Yongjian Zhang, Zhiqiang Wu, Yao Wang, Zhenguang Wang, Catherine CL Wong, Pengfei Yuan, Weidong Han, Wensheng Wei
Journal: Blood
Blood (2024) 144 (Supplement 1): 3405.
https://doi.org/10.1182/blood-2024-204568
Published: 2024
Journal Articles

Aberrant Stemness Transcription Signature Unveils a Mechanism of Chemotherapy Resistance through Blunting p53-Mediated Response in Acute Myeloid Leukemia

Fatemeh Alikarami, Hongbo Xie, Simone Stefanie Riedel, Haley Goodrow, Declan Barrett, Leila Mahdavi, Alexandra Lenard, Changya Chen, Taylor Yamauchi, Etienne Danis, Zhendong Cao, Vu L. Tran, Mabel M. Jung, Yapeng Li, Hua Huang, Junwei Shi, Kai Tan, David T. Teachey, Emery H. Bresnick, Tobias Neff, Kathrin M. Bernt
Journal: Blood
Blood (2024) 144 (Supplement 1): 725.
https://doi.org/10.1182/blood-2024-199215
Published: 2024
Journal Articles

Interferon-Activated Gene Signatures Associate with Chemotherapy Resistance and Sensitivity to JAK-Inhibition in Refractory ETP-ALL

Jason Xu, Jonathan Sussman, Austin Yang, Satoshi Yoshimura, Changya Chen, Omar Elghawy, Tiffaney Vincent, Caroline Diorio, Shovik Bandyopadyay, Jianzhong Hu, Alexander Lai Li, Gregory M. Chen, Chia-Hui Chen, Rawan Shraim, Haley Newman, Yang Ding, Elizabeth Li, Wenbao Yu, Anusha Thadi, Kyung Jin Ahn, Petri Pölönen, Abdelrahman Elsayed, David Frank, Elizabeth A. Raetz, Mignon L. Loh, Brent L. Wood, Stuart S. Winter, Kimberly P. Dunsmore, Meenakshi Devidas, Chunxu Qu, Stanley Pounds, Stephen P. Hunger, Charles G. Mullighan, Jun J. Yang, Kai Tan, David T. Teachey
Journal: Blood
Blood (2024) 144 (Supplement 1): 1464.
https://doi.org/10.1182/blood-2024-211090
Published: 2024
Journal Articles

Mapping the Cellular Biogeography of Human Bone Marrow Niches Using Single-Cell Transcriptomics and Proteomic Imaging

Shovik Bandyopadhyay, Michael Duffy, Kyung Jin Ahn, Minxing Pang, David Smith, Gwendolyn Duncan, Jonathan Sussman, Jihan Zhang, Jeffrey Huang, Yulieh Lin, Barbara Xiong, Tamjid Imtiaz, Chia Hui Chen, Anusha Thadi, Changya Chen, Jason Xu, Melissa Reichart, Vinodh Pillai, Oraine Snaith, Derek Oldridge, Siddharth Bhattacharyya, Ivan Maillard, Martin Carroll, Charles Nelson, Ling Qin, Kai Tan
Journal: Blood
Blood (2023) 142 (Supplement 1): 4072.
https://doi.org/10.1182/blood-2023-179280
Published: 2023
Journal Articles

The Role of GATA2 in Drug Resistance in AML

Fatemeh Alikarami, Simone S. Riedel, Qinglan Li, Changya Chen, Taylor Yamauchi, Etienne Danis, Kai Tan, Liling Wan, Tobias Neff, Kathrin M. Bernt
Journal: Blood
Blood (2022) 140 (Supplement 1): 97–98.
https://doi.org/10.1182/blood-2022-166666
Published: 2022
Journal Articles

Single-Cell Pan-Cancer Analysis Reveals Treatment Resistance Stem/Progenitor-like Subpopulation in the High-Risk Pediatric Leukemia

Changya Chen, Jason Xu, Tiffaney L. Vincent, Wenbao Yu, Yang Y Ding, Chia-hui Chen, Samuel Kim, Elizabeth Li, Shovik Bandyopadhyay, Petri Pölönen, Abdelrahman Elsayed, Haley Newman, Brent L. Wood, Jianzhong Hu, Rawan Shraim, Mignon L. Loh, Elizabeth A. Raetz, Stephen P. Hunger, Stanley B. Pounds, Jun J. Yang, Charles G. Mullighan, David Frank, Kathrin M. Bernt, David T. Teachey, Kai Tan
Journal: Blood
Blood (2022) 140 (Supplement 1): 1273–1274.
https://doi.org/10.1182/blood-2022-167057
Published: 2022
Journal Articles

The Influence of Genetic Ancestry on Disease Biology in Pediatric T-Cell Acute Lymphoblastic Leukemia

Haley Newman, Shawn Lee, Petri Pölönen, Rawan Shraim, Yimei Li, Hongyan Liu, Tiffaney L. Vincent, Richard Aplenc, Changya Chen, Zhiguo Chen, Caroline Diorio, Kimberly P. Dunsmore, Sumit Gupta, Gang Wu, Kai Tan, Meenakshi Devidas, Stuart S. Winter, Brent L. Wood, Lena E. Winestone, Jason Xu, Elizabeth A. Raetz, Mignon L. Loh, Stephen P. Hunger, Stanley B. Pounds, Kira O Bona, Charles G. Mullighan, Jun J. Yang, David T. Teachey
Journal: Blood
Blood (2022) 140 (Supplement 1): 3458–3460.
https://doi.org/10.1182/blood-2022-159159
Published: 2022
Journal Articles

Comprehensive Genome Characterization of Childhood T-ALL Links Oncogene Activation Mechanism and Subtypes to Prognosis

Petri Pölönen, Abdelrahman Elsayed, Danika Di Giacomo, Lindsey Montefiori, Shunsuke Kimura, Jason Myers, Dale Hedges, Jason Xu, Yawei Hui, Zhongshan Cheng, Yiping Fan, Ilaria Iacobucci, Yunchao Chang, Rawan Shraim, Meenakshi Devidas, Stuart S. Winter, Kimberly P. Dunsmore, Jun J.J. Yang, Tiffaney L. Vincent, Kai Tan, Changya Chen, Haley Newman, Mignon L. Loh, Elizabeth A. Raetz, Stephen P. Hunger, Evadnie Rampersaud, Ti-Cheng Chang, Gang Wu, Stanley B. Pounds, Charles G. Mullighan, David T. Teachey
Journal: Blood
Blood (2022) 140 (Supplement 1): 1727–1729.
https://doi.org/10.1182/blood-2022-167157
Published: 2022
Journal Articles

Progenitor Sub-Populations in Treatment Resistant T-ALL

Jason Xu, Changya Chen, Tiffaney L. Vincent, Petri Pölönen, Abdelrahman Elsayed, Jianzhong Hu, Satoshi Yoshimura, Wenbao Yu, Chia-hui Chen, Elizabeth Li, Rawan Shraim, Marieke Lavaert, Haley Newman, Yang-yang Ding, Anusha Thadi, Kyung Jin Ahn, Jacqueline Peng, Chujie Gong, Yusha Sun, Shovik Bandyopadhyay, David Frank, Mignon L. Loh, Elizabeth A. Raetz, Zhiguo Chen, Brent L. Wood, Meenakshi Devidas, Kimberly P. Dunsmore, Stuart S. Winter, Gang Wu, Avinash Bhandoola, Stanley B. Pounds, Stephen P. Hunger, Jun J. Yang, Charles G. Mullighan, David T. Teachey, Kai Tan
Journal: Blood
Blood (2022) 140 (Supplement 1): 1724–1726.
https://doi.org/10.1182/blood-2022-166521
Published: 2022
Journal Articles

Single-cell multiomics reveals increased plasticity, resistant populations, and stem-cell–like blasts in KMT2A -rearranged leukemia

Changya Chen, Wenbao Yu, Fatemeh Alikarami, Qi Qiu, Chia-hui Chen, Jennifer Flournoy, Peng Gao, Yasin Uzun, Li Fang, James W. Davenport, Yuxuan Hu, Qin Zhu, Kai Wang, Clara Libbrecht, Alex Felmeister, Isaiah Rozich, Yang-yang Ding, Stephen P. Hunger, Carolyn A. Felix, Hao Wu, Patrick A. Brown, Erin M. Guest, David M. Barrett, Kathrin M. Bernt, Kai Tan
Journal: Blood
Blood (2022) 139 (14): 2198–2211.
https://doi.org/10.1182/blood.2021013442
Published: 2022
Includes: Supplemental data
Journal Articles

Single-Cell Multiomics Reveals Increased Plasticity, Resistant Populations and Stem-Cell-like Blasts in KMT2A-Rearranged Leukemia

Changya Chen, Wenbao Yu, Fatemeh Alikarami, Qi Qiu, Chia-hui Chen, Jennifer Flournoy, Peng Gao, Yasin Uzun, Li Fang, Yuxuan Hu, Qin Zhu, Kai Wang, Clara Libbrecht, Alex Felmeister, Isaiah Rozich, Yang-yang Ding, Stephen P Hunger, Hao Wu, Patrick A. Brown, Erin Guest, David M Barrett, Kathrin M. Bernt, Kai Tan
Journal: Blood
Blood (2021) 138 (Supplement 1): 2203.
https://doi.org/10.1182/blood-2021-146102
Published: 2021
Journal Articles

Reference Mapping Pediatric Leukemia Using Single Cell Multiomic Atlas of Pediatric Hematopoiesis

Jason Xu, Changya Chen, Tiffaney Vincent, Elizabeth Li, Yusha Sun, Chia-hui Chen, David Frank, David T. Teachey, Kai Tan
Journal: Blood
Blood (2021) 138 (Supplement 1): 3265.
https://doi.org/10.1182/blood-2021-153428
Published: 2021
Journal Articles

Treatment Resistance in ETP-ALL Is Associated with Progenitor-like Arrest State

Changya Chen, Jason Xu, Tiffaney Vincent, Chia-hui Chen, Elizabeth Li, Yusha Sun, Jackie Peng, Rawan Shraim, Anusha Thadi, Sydney D'Amaddio, David Teachey, Kai Tan
Journal: Blood
Blood (2021) 138 (Supplement 1): 618.
https://doi.org/10.1182/blood-2021-153291
Published: 2021
Journal Articles

Developmental trajectory of prehematopoietic stem cell formation from endothelium

Qin Zhu, Peng Gao, Joanna Tober, Laura Bennett, Changya Chen, Yasin Uzun, Yan Li, Elizabeth D. Howell, Melanie Mumau, Wenbao Yu, Bing He, Nancy A. Speck, Kai Tan
Journal: Blood
Blood (2020) 136 (7): 845–856.
https://doi.org/10.1182/blood.2020004801
Published: 2020
Includes: Supplemental data
Journal Articles

Developmental Biology of the Blood System

Nancy Speck, PhD, Qin Zhu, Peng Gao, Joanna Tober, PhD, Laura Bennett, PhD, Changya Chen, Yasin Uzun, PhD, Yan Li, PhD, Kai Tan
Journal: Blood
Blood (2019) 134 (Supplement_1): SCI-29.
https://doi.org/10.1182/blood-2019-121283
Published: 2019
Journal Articles

Dynamic HoxB4-regulatory network during embryonic stem cell differentiation to hematopoietic cells

e-blood
Rong Fan, Sabrina Bonde, Peng Gao, Brendan Sotomayor, Changya Chen, Tyler Mouw, Nicholas Zavazava, Kai Tan
Journal: Blood
Blood (2012) 119 (19): e139–e147.
https://doi.org/10.1182/blood-2011-12-396754
Published: 2012
Includes: Supplemental data