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Journal Articles

KMT2A -Rearranged ALL Requires DYRK1A for Regulation of ERK Signaling and Cell Proliferation

Venkata Sesha Sai Abhinav Ayyadevara, Gerald Wertheim, John Chukinas, Joseph Loftus, Sung June Lee, Anil Kumar, Srividya Swaminathan, Rahul S Bhansali, Wayne Childers, Huimin Geng, Thomas A Milne, Xianxin Hua, Kathrin M. Bernt, Thierry Besson, Junwei Shi, John D. Crispino, Martin P Carroll, Sarah K. Tasian, Christian Hurtz

Blood (2024) 144 (Supplement 1): 1455.

https://doi.org/10.1182/blood-2024-206134

Published: 2024

Journal Articles

A Novel Genome-Scale CRISPR-Cas12a Screen Identifies Ptpa As a Fetal Hemoglobin Regulator Via BCL11A

Elizabeth A. Traxler, Chad Komar, Megan Saari, Quynn Hotan, A Josephine Thrasher, Eugene Khandros, Kunhua Qin, Osheiza Abdulmalik, Claire Shao, Qingzhou Chen, Andy J. Minn, Cheryl A. Keller, Junwei Shi, Gerd A. Blobel

Blood (2024) 144 (Supplement 1): 412.

https://doi.org/10.1182/blood-2024-210117

Published: 2024

Journal Articles

CBL Loss or Mutations Reduces MHCII Expression through Downregulating ERG in Myeloid Malignancies

Rouxing Wang, Mohammed Alhusayan, Bowen Xing, Emma Hedgepeth, Yan Liu, Hamid Band, Laurence Eisenlohr, Junwei Shi, Irfan Asangani, Wei Tong

Blood (2024) 144 (Supplement 1): 2730.

https://doi.org/10.1182/blood-2024-208798

Published: 2024

Journal Articles

CBL Loss or Mutations Upregulates AXL to Promote Cytokine-Independent Growth in Myeloid Malignancies: AXL Upregulation Promotes Cytokine-Independent Growth in CBL -Mutant CMML

Rouxing Wang, Shiwei Chen, Mohammed Alhusayan, Bowen Xing, Yan Liu, Hamid Band, Irfan Asangani, Junwei Shi, Wei Tong

Blood (2024) 144 (Supplement 1): 4574.

https://doi.org/10.1182/blood-2024-209140

Published: 2024

Journal Articles

Systematic Evaluation of GAPs and Gefs Identifies ARHGAP45 As a Targetable Leukemia-Specific Dependency

Blood (2024) 144 (Supplement 1): 950.

https://doi.org/10.1182/blood-2024-198954

Published: 2024

Journal Articles

Aberrant Stemness Transcription Signature Unveils a Mechanism of Chemotherapy Resistance through Blunting p53-Mediated Response in Acute Myeloid Leukemia

Blood (2024) 144 (Supplement 1): 725.

https://doi.org/10.1182/blood-2024-199215

Published: 2024

Journal Articles

let-7 miRNAs repress HIC2 to regulate BCL11A transcription and hemoglobin switching

Peng Huang, Scott A. Peslak, Vanessa Shehu, Cheryl A. Keller, Belinda Giardine, Junwei Shi, Ross C. Hardison, Gerd A. Blobel, Eugene Khandros

Blood (2024) 143 (19): 1980–1991.

https://doi.org/10.1182/blood.2023023399

Published: 2024

Includes: Supplemental data

Journal Articles

Protein Phosphatase 6 Complex: Novel Regulator of Fetal Hemoglobin and Potential Therapeutic Target in Sickle Cell Disease

Scott A. Peslak, Talla Abbas, Eugene Khandros, Elizabeth A. Traxler, Osheiza Abdulmalik, Belinda M. Giardine, Cheryl A. Keller, Ross C. Hardison, Junwei Shi, Gerd A. Blobel

Blood (2023) 142 (Supplement 1): 13.

https://doi.org/10.1182/blood-2023-181989

Published: 2023

Journal Articles

Genome-Scale CRISPR-Cas12a Screen Identifies Novel Fetal Hemoglobin Regulators

Elizabeth A. Traxler, Chad Komar, Megan Saari, A Josephine Thrasher, Kunhua Qin, Eugene Khandros, Quynn Hotan, Osheiza Abdulmalik, Claire Shao, Qingzhou Chen, Andy J. Minn, Cheryl A. Keller, Junwei Shi, Gerd A. Blobel

Blood (2023) 142 (Supplement 1): 1101.

https://doi.org/10.1182/blood-2023-189547

Published: 2023

Journal Articles

Selective Globin Gene Regulation By the Non-Canonical Baf Chromatin Remodeling Complex

Sindhu Billakanti, Vanessa Shehu, Kathryn M. Farrell, Osheiza Abdulmalik, Belinda M. Giardine, Cheryl A. Keller, Ross C. Hardison, Junwei Shi, Gerd A. Blobel, Eugene Khandros

Blood (2023) 142 (Supplement 1): 553.

https://doi.org/10.1182/blood-2023-179001

Published: 2023

Journal Articles

DLBCL-associated NOTCH2 mutations escape ubiquitin-dependent degradation and promote chemoresistance

Nan Zhou, Jaewoo Choi, Grant Grothusen, Bang-Jin Kim, Diqiu Ren, Zhendong Cao, Yiman Liu, Qinglan Li, Arati Inamdar, Thomas Beer, Hsin-Yao Tang, Eric Perkey, Ivan Maillard, Roberto Bonasio, Junwei Shi, Marco Ruella, Liling Wan, Luca Busino

Blood (2023) 142 (11): 973–988.

https://doi.org/10.1182/blood.2022018752

Published: 2023

Includes: Supplemental data

Journal Articles

Molecular basis of polycomb group protein–mediated fetal hemoglobin repression

Kunhua Qin, Xianjiang Lan, Peng Huang, Megan S. Saari, Eugene Khandros, Cheryl A. Keller, Belinda Giardine, Osheiza Abdulmalik, Junwei Shi, Ross C. Hardison, Gerd A. Blobel

Blood (2023) 141 (22): 2756–2770.

https://doi.org/10.1182/blood.2022019578

Published: 2023

Includes: Supplemental data

Journal Articles

Mechanisms of Polycomb Group Protein-Mediated Fetal Hemoglobin Silencing

Kunhua Qin, Peng Huang, Xianjiang Lan, Megan S. Saari, Eugene Khandros, Osheiza Y. Abdulmalik, Cheryl A. Keller, Belinda M. Giardine, Ross C. Hardison, Junwei Shi, Gerd A. Blobel

Blood (2022) 140 (Supplement 1): 5382–5383.

https://doi.org/10.1182/blood-2022-165560

Published: 2022

Journal Articles

Examining the Role of Individual Baf Chromatin Remodeling Complex Components in Globin Gene Regulation

Kathryn M. Farrell, Peng Huang, Osheiza Y. Abdulmalik, Belinda M. Giardine, Cheryl A. Keller, Ross C. Hardison, Junwei Shi, Gerd A. Blobel, Eugene Khandros

Blood (2022) 140 (Supplement 1): 1943.

https://doi.org/10.1182/blood-2022-159347

Published: 2022

Journal Articles

Regulation of Fetal Hemoglobin Production in Adult Erythroid Cells By Protein Phosphatase 6C (PPP6C)

Scott A. Peslak, Eugene Khandros, Peng Huang, Aoi Wakabayashi, Talla Abbas, Osheiza Y. Abdulmalik, Cheryl A. Keller, Ross C. Hardison, Junwei Shi, Gerd A. Blobel

Blood (2022) 140 (Supplement 1): 2502–2503.

https://doi.org/10.1182/blood-2022-165286

Published: 2022

Journal Articles

Pharmacologic Inhibition of DYRK1A Results in Hyperactivation and Hyperphosphorylation of MYC and ERK Rendering KMT2A-R ALL Cells Sensitive to BCL2 Inhibition

V. S. S. Abhinav Ayyadevara, Gerald Wertheim, John Chukinas, Joseph Patrick Loftus, Sung June Lee, Anil Kumar, Rahul S. Bhansali, Srividya Swaminathan, Thierry Besson, Junwei Shi, John D. Crispino, Sarah K Tasian, Martin P. Carroll, Christian Hurtz

Blood (2022) 140 (Supplement 1): 3486–3488.

https://doi.org/10.1182/blood-2022-162782

Published: 2022

Journal Articles

Pharmacologic Inhibition of DYRK1A Results in Hyperactivation and Hyperphosphorylation of MYC and ERK Rendering KMT2A-R ALL Cells Sensitive to BCL2 Inhibition

Christian Hurtz, Gerald Wertheim, John Chukinas, Joseph Patrick Loftus, Sung June Lee, Anil Kumar, Rahul S. Bhansali, Srividya Swaminathan, Thierry Besson, Junwei Shi, John D. Crispino, Sarah K Tasian, Martin P. Carroll

Blood (2021) 138 (Supplement 1): 506.

https://doi.org/10.1182/blood-2021-144476

Published: 2021

Journal Articles

Interrogating Post-Transcriptional Mechanisms of Fetal Hemoglobin Regulation

Aoi Wakabayashi, Maryanne Kihiu, Malini Sharma, Mathieu Quesnel-Vallieres, Osheiza Abdulmalik, Scott A. Peslak, Cheryl A. Keller, Belinda Giardine, Ross C. Hardison, Junwei Shi, Gerd A. Blobel

Blood (2021) 138 (Supplement 1): 3079.

https://doi.org/10.1182/blood-2021-151488

Published: 2021

Journal Articles

HIC2 Controls Developmental Hemoglobin Switching By Repressing BCL11A Transcription

Peng Huang, Scott A. Peslak, Eugene Khandros, Xianjiang Lan, Kunhua Qin, Malini Sharma, Cheryl A. Keller, Belinda Giardine, Osheiza Abdulmalik, Stella T. Chou, Junwei Shi, Ross C. Hardison, Gerd A. Blobel

Blood (2021) 138 (Supplement 1): 571.

https://doi.org/10.1182/blood-2021-146637

Published: 2021

Journal Articles

Protein Phosphatase 6C (PPP6C) Loss Significantly Raises Fetal Hemoglobin Levels and Reduces Cell Sickling

Scott A. Peslak, Eugene Khandros, Peng Huang, Maryanne Kihiu, Osheiza Abdulmalik, Cheryl A. Keller, Ross C. Hardison, Junwei Shi, Gerd A. Blobel

Blood (2021) 138 (Supplement 1): 2031.

https://doi.org/10.1182/blood-2021-147275

Published: 2021

NARROW

KMT2A -Rearranged ALL Requires DYRK1A for Regulation of ERK Signaling and Cell Proliferation

A Novel Genome-Scale CRISPR-Cas12a Screen Identifies Ptpa As a Fetal Hemoglobin Regulator Via BCL11A

CBL Loss or Mutations Reduces MHCII Expression through Downregulating ERG in Myeloid Malignancies

CBL Loss or Mutations Upregulates AXL to Promote Cytokine-Independent Growth in Myeloid Malignancies: AXL Upregulation Promotes Cytokine-Independent Growth in CBL -Mutant CMML

Systematic Evaluation of GAPs and Gefs Identifies ARHGAP45 As a Targetable Leukemia-Specific Dependency

Aberrant Stemness Transcription Signature Unveils a Mechanism of Chemotherapy Resistance through Blunting p53-Mediated Response in Acute Myeloid Leukemia

let-7 miRNAs repress HIC2 to regulate BCL11A transcription and hemoglobin switching

Protein Phosphatase 6 Complex: Novel Regulator of Fetal Hemoglobin and Potential Therapeutic Target in Sickle Cell Disease

Genome-Scale CRISPR-Cas12a Screen Identifies Novel Fetal Hemoglobin Regulators

Selective Globin Gene Regulation By the Non-Canonical Baf Chromatin Remodeling Complex

DLBCL-associated NOTCH2 mutations escape ubiquitin-dependent degradation and promote chemoresistance

Molecular basis of polycomb group protein–mediated fetal hemoglobin repression

Mechanisms of Polycomb Group Protein-Mediated Fetal Hemoglobin Silencing

Examining the Role of Individual Baf Chromatin Remodeling Complex Components in Globin Gene Regulation

Regulation of Fetal Hemoglobin Production in Adult Erythroid Cells By Protein Phosphatase 6C (PPP6C)

Pharmacologic Inhibition of DYRK1A Results in Hyperactivation and Hyperphosphorylation of MYC and ERK Rendering KMT2A-R ALL Cells Sensitive to BCL2 Inhibition

Pharmacologic Inhibition of DYRK1A Results in Hyperactivation and Hyperphosphorylation of MYC and ERK Rendering KMT2A-R ALL Cells Sensitive to BCL2 Inhibition

Interrogating Post-Transcriptional Mechanisms of Fetal Hemoglobin Regulation

HIC2 Controls Developmental Hemoglobin Switching By Repressing BCL11A Transcription

Protein Phosphatase 6C (PPP6C) Loss Significantly Raises Fetal Hemoglobin Levels and Reduces Cell Sickling

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American Society of Hematology

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ASH Publications

American Society of Hematology

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