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Journal Articles

A novel LRF degrader induces fetal hemoglobin expression in adult erythroblasts

Sisi Zheng, Abhirup Bagchi, Ke Li, Peng Huang, John Hines, Mackenzie Krone, Arseniy Butrin, Michael Bond, Belinda Giardine, Cheryl Keller, Zhuangzhuang Geng, Bailey Godfrey, Sarah Cotteta, Osheiza Abdulmalik, Ross Hardison, George Burslem, Eugene Khandros, Craig Crews, Gerd Blobel

Blood (2025) 146 (Supplement 1): 836.

https://doi.org/10.1182/blood-2025-836

Published: 2025

Journal Articles

LDB1-dependent enhancer networks drive high-risk transcriptional programs in T-cell acute lymphoblastic leukemia

Rahul Bhansali, Juan Long, Petri Polonen, Shuo Zhang, Mariah Antopia, Siqing Wang, Nicholas Aboreden, Ahnaf Tausif, Zhuangzhuang Geng, Cheryl Keller, Belinda Giardine, Ross Hardison, Charles Mullighan, Gerd Blobel

Blood (2025) 146 (Supplement 1): 3251.

https://doi.org/10.1182/blood-2025-3251

Published: 2025

Journal Articles

let-7 miRNAs repress HIC2 to regulate BCL11A transcription and hemoglobin switching

Peng Huang, Scott A. Peslak, Vanessa Shehu, Cheryl A. Keller, Belinda Giardine, Junwei Shi, Ross C. Hardison, Gerd A. Blobel, Eugene Khandros

Blood (2024) 143 (19): 1980–1991.

https://doi.org/10.1182/blood.2023023399

Published: 2024

Includes: Supplemental data

Journal Articles

Molecular basis of polycomb group protein–mediated fetal hemoglobin repression

Kunhua Qin, Xianjiang Lan, Peng Huang, Megan S. Saari, Eugene Khandros, Cheryl A. Keller, Belinda Giardine, Osheiza Abdulmalik, Junwei Shi, Ross C. Hardison, Gerd A. Blobel

Blood (2023) 141 (22): 2756–2770.

https://doi.org/10.1182/blood.2022019578

Published: 2023

Includes: Supplemental data

Journal Articles

Interrogating Post-Transcriptional Mechanisms of Fetal Hemoglobin Regulation

Aoi Wakabayashi, Maryanne Kihiu, Malini Sharma, Mathieu Quesnel-Vallieres, Osheiza Abdulmalik, Scott A. Peslak, Cheryl A. Keller, Belinda Giardine, Ross C. Hardison, Junwei Shi, Gerd A. Blobel

Blood (2021) 138 (Supplement 1): 3079.

https://doi.org/10.1182/blood-2021-151488

Published: 2021

Journal Articles

Isolated Changes in Chromatin Accessibility and Enhancer-Promoter Contacts at the β-Globin Locus Distinguish Fetal Hemoglobin Producing F-Cells from a-Cells

Eugene Khandros, Peng Huang, Scott A. Peslak, Malini Sharma, Osheiza Abdulmalik, Belinda Giardine, Zhe Zhang, Cheryl A. Keller, Ross C. Hardison, Gerd A. Blobel

Blood (2021) 138 (Supplement 1): 855.

https://doi.org/10.1182/blood-2021-149877

Published: 2021

Journal Articles

HIC2 Controls Developmental Hemoglobin Switching By Repressing BCL11A Transcription

Peng Huang, Scott A. Peslak, Eugene Khandros, Xianjiang Lan, Kunhua Qin, Malini Sharma, Cheryl A. Keller, Belinda Giardine, Osheiza Abdulmalik, Stella T. Chou, Junwei Shi, Ross C. Hardison, Gerd A. Blobel

Blood (2021) 138 (Supplement 1): 571.

https://doi.org/10.1182/blood-2021-146637

Published: 2021

Journal Articles

Control of Fetal Hemoglobin Levels By NFI Transcription Factors

Kunhua Qin, Peng Huang, PhD, Anran Huang, BS, Ruopeng Feng, PhD, Thiyagaraj Mayuranathan, Cheryl A. Keller, PhD, Belinda Giardine, Ross C. Hardison, PhD, Mitchell J. Weiss, MD PhD, Junwei Shi, PhD, Gerd A. Blobel, MDPhD

Blood (2020) 136 (Supplement 1): 54.

https://doi.org/10.1182/blood-2020-136167

Published: 2020

Journal Articles

ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression

Blood (2020) 136 (Supplement 1): 54.

https://doi.org/10.1182/blood-2020-137564

Published: 2020

Journal Articles

A β-Globin Locus-Intrinsic Epigenetic Mechanism Underlies Fetal Globin Production in F-Cells

Eugene Khandros, MD PhD, Peng Huang, PhD, Scott A. Peslak, MD PhD, Malini Sharma, BS, Osheiza Abdulmalik, DVM, Belinda Giardine, Zhe Zhang, PhD, Cheryl A. Keller, PhD, Ross C. Hardison, PhD, Gerd A. Blobel, MDPhD

Blood (2020) 136 (Supplement 1): 16–17.

https://doi.org/10.1182/blood-2020-137646

Published: 2020

Journal Articles

The HRI-regulated transcription factor ATF4 activates BCL11A transcription to silence fetal hemoglobin expression

Peng Huang, Scott A. Peslak, Xianjiang Lan, Eugene Khandros, Jennifer A. Yano, Malini Sharma, Cheryl A. Keller, Belinda Giardine, Kunhua Qin, Osheiza Abdulmalik, Ross C. Hardison, Junwei Shi, Gerd A. Blobel

Blood (2020) 135 (24): 2121–2132.

https://doi.org/10.1182/blood.2020005301

Published: 2020

Includes: Supplemental data

Journal Articles

Understanding Heterogeneity of Fetal Hemoglobin Induction through Comparative Analysis of Stage-Matched F- and a-Cells

Eugene Khandros, MD PhD, Peng Huang, PhD, Scott A. Peslak, MD PhD, Belinda Giardine, Zhe Zhang, PhD, Cheryl A Keller, PhD, Ross C. Hardison, PhD, Gerd A. Blobel, MD PhD

Blood (2019) 134 (Supplement_1): 981.

https://doi.org/10.1182/blood-2019-124099

Published: 2019

Journal Articles

Heme-Regulated Inhibitor (HRI) Activates Transcription Factor ATF4 to Promote BCL11A Transcription and Fetal Hemoglobin Silencing

Peng Huang, PhD, Scott A. Peslak, MD PhD, Xianjiang Lan, PhD, Eugene Khandros, MD PhD, Malini Sharma, BS, Kunhua Qin, PhD, Cheryl A Keller, PhD, Belinda Giardine, Junwei Shi, PhD, Ross C. Hardison, PhD, Gerd A. Blobel, MD PhD

Blood (2019) 134 (Supplement_1): 814.

https://doi.org/10.1182/blood-2019-123837

Published: 2019

Journal Articles

Mouse Erythroid Cells Originate from a Megakaryocyte Precursor in Common Myeloid Progenitors

Elisabeth F Heuston, PhD, Bethan Psaila, MD PhD, Cheryl A Keller, PhD, NISC Comparative SequencingProgram, Stacie M Anderson, Martha Kirby, Lauren C Murphy, Alexander Q Wixom, PhD, Belinda Giardine, Ross C. Hardison, PhD, David M. Bodine, PhD

Blood (2019) 134 (Supplement_1): 337.

https://doi.org/10.1182/blood-2019-121631

Published: 2019

Journal Articles

Domain-Focused CRISPR-Cas9 Screen Identifies the E3 Ubiquitin Ligase Substrate Adaptor Protein SPOP as a Novel Repressor of Fetal Hemoglobin

Xianjiang Lan, PhD, Eugene Khandros, MD PhD, Jeremy D. Grevet, BA, Scott A. Peslak, MD, Saurabh Bhardwaj, PhD, Cheryl A. Keller, PhD, Belinda Giardine, Ben A. Garcia, PhD, Ross C. Hardison, PhD, Junwei Shi, PhD, Gerd A. Blobel, MD PhD

Blood (2018) 132 (Supplement 1): 414.

https://doi.org/10.1182/blood-2018-99-119518

Published: 2018

Journal Articles

Epigenetic and Single Cell Analyses Reveal Dual Fate Decision Points in Pre-Primed Hematopoietic Stem Cells during Erythro-Megakaryopoiesis

Elisabeth F Heuston, PhD, Cheryl A. Keller, PhD, Jens Lichtenberg, Belinda Giardine, Stacie M Anderson, Bethan Psaila, MD PhD, NISC Comparative Sequencing Program, Ross C Hardison, PhD, David M. Bodine, PhD

Blood (2017) 130 (Supplement 1): 3764.

https://doi.org/10.1182/blood.V130.Suppl_1.3764.3764

Published: 2017

Journal Articles

Domain-Focused CRISPR-Cas9 Screen Identifies Hri Kinase As a Regulator of Fetal Hemoglobin in Adult Human Erythroid Cells

Jeremy D. Grevet, Nicole Hamagami, Xianjiang Lan, PhD, Laavanya Sankaranarayanan, MS, Saurabh Bhardwaj, PhD, Carolyne Face, David Posocco, Osheiza Abdulmalik, DVM, Cheryl A. Keller, PhD, Belinda Giardine, Simone Sidoli, PhD, Ben Garcia, PhD, Stella T Chou, MD, Ross C Hardison, PhD, Chris Vakoc, MD PhD, Junwei Shi, PhD, Gerd A. Blobel, MD PhD

Blood (2017) 130 (Supplement 1): 536.

https://doi.org/10.1182/blood.V130.Suppl_1.536.536

Published: 2017

Journal Articles

Comparison of Fetal and Adult Erythroid Chromosomal Architectures Identifies a Novel Fetal Hemoglobin Regulatory Region

Peng Huang, PhD, Cheryl A. Keller, PhD, Belinda Giardine, James O.J. Davies, Jim R. Hughes, Ross C Hardison, PhD, Gerd Blobel, MD PhD

Blood (2017) 130 (Supplement 1): 774.

https://doi.org/10.1182/blood.V130.Suppl_1.774.774

Published: 2017

Journal Articles

The BET Protein BRD2 Cooperates with CTCF to Enforce a Transcriptional Boundary in Erythroid Cells

Sarah C. Hsu, Caroline Bartman, Aaron J Stonestrom, MD PhD, Christopher R Edwards, PhD, Thomas Gilgenast, Daniel Emerson, Peng Huang, PhD, Michael T. Werner, Kristen Jahn, Cheryl A. Keller, PhD, Belinda Giardine, Ross C. Hardison, PhD, Arjun Raj, PhD, Jennifer E. Phillips-Cremins, PhD, Gerd A. Blobel, MD PhD

Blood (2016) 128 (22): 1034.

https://doi.org/10.1182/blood.V128.22.1034.1034

Published: 2016

Journal Articles

A Hyperactive Transcriptional State Marks Genome Reactivation during Mitotic Exit

Gerd A. Blobel, MD PhD, Chris C.S. Hsiung, B.A., Peng Huang, PhD, Cheryl Keller, PhD, Paul Ginart, Kristen Jahn, Caroline Bartman, Aaron James Stonestrom, BS, Perry Evans, Belinda Giardine, Ross C. Hardison, PhD, Arjun Raj, PhD

Blood (2015) 126 (23): 48.

https://doi.org/10.1182/blood.V126.23.48.48

Published: 2015

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A novel LRF degrader induces fetal hemoglobin expression in adult erythroblasts

LDB1-dependent enhancer networks drive high-risk transcriptional programs in T-cell acute lymphoblastic leukemia

let-7 miRNAs repress HIC2 to regulate BCL11A transcription and hemoglobin switching

Molecular basis of polycomb group protein–mediated fetal hemoglobin repression

Interrogating Post-Transcriptional Mechanisms of Fetal Hemoglobin Regulation

Isolated Changes in Chromatin Accessibility and Enhancer-Promoter Contacts at the β-Globin Locus Distinguish Fetal Hemoglobin Producing F-Cells from a-Cells

HIC2 Controls Developmental Hemoglobin Switching By Repressing BCL11A Transcription

Control of Fetal Hemoglobin Levels By NFI Transcription Factors

ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression

A β-Globin Locus-Intrinsic Epigenetic Mechanism Underlies Fetal Globin Production in F-Cells

The HRI-regulated transcription factor ATF4 activates BCL11A transcription to silence fetal hemoglobin expression

Understanding Heterogeneity of Fetal Hemoglobin Induction through Comparative Analysis of Stage-Matched F- and a-Cells

Heme-Regulated Inhibitor (HRI) Activates Transcription Factor ATF4 to Promote BCL11A Transcription and Fetal Hemoglobin Silencing

Mouse Erythroid Cells Originate from a Megakaryocyte Precursor in Common Myeloid Progenitors

Domain-Focused CRISPR-Cas9 Screen Identifies the E3 Ubiquitin Ligase Substrate Adaptor Protein SPOP as a Novel Repressor of Fetal Hemoglobin

Epigenetic and Single Cell Analyses Reveal Dual Fate Decision Points in Pre-Primed Hematopoietic Stem Cells during Erythro-Megakaryopoiesis

Domain-Focused CRISPR-Cas9 Screen Identifies Hri Kinase As a Regulator of Fetal Hemoglobin in Adult Human Erythroid Cells

Comparison of Fetal and Adult Erythroid Chromosomal Architectures Identifies a Novel Fetal Hemoglobin Regulatory Region

The BET Protein BRD2 Cooperates with CTCF to Enforce a Transcriptional Boundary in Erythroid Cells

A Hyperactive Transcriptional State Marks Genome Reactivation during Mitotic Exit

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