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Journal Articles

Inhibition of Hypoxia Inducible Factor Prolyl Hydroxylase By FG-4592 (Roxadustat) Increases Erythropoietic Stimulation in a Mouse Model of Sickle Cell Disease

Malini Sharma, Timothy Lequang, Brian J Philips, Fabliha A Chowdhury, Katherine C Wood, Adam C Straub, Julia Z Xu
Journal: Blood
Blood (2022) 140 (Supplement 1): 5391–5392.
https://doi.org/10.1182/blood-2022-164803
Published: 2022
Journal Articles

Preclinical Development and Screening of a Quinone-Nitroalkene Molecule for Sickle Cell Anemia

Fabliha A Chowdhury, Megan P Miller, Katherine C Wood, Malini Sharma, Shuai Yuan, Stefanie N Taiclet, Derek J Sinchar, Elizabeth R Rochon, Francisco J Schopfer, Bruce A Freeman, Adam C Straub
Journal: Blood
Blood (2022) 140 (Supplement 1): 957–958.
https://doi.org/10.1182/blood-2022-160188
Published: 2022
Journal Articles

Interrogating Post-Transcriptional Mechanisms of Fetal Hemoglobin Regulation

Aoi Wakabayashi, Maryanne Kihiu, Malini Sharma, Mathieu Quesnel-Vallieres, Osheiza Abdulmalik, Scott A. Peslak, Cheryl A. Keller, Belinda Giardine, Ross C. Hardison, Junwei Shi, Gerd A. Blobel
Journal: Blood
Blood (2021) 138 (Supplement 1): 3079.
https://doi.org/10.1182/blood-2021-151488
Published: 2021
Journal Articles

HIC2 Controls Developmental Hemoglobin Switching By Repressing BCL11A Transcription

Peng Huang, Scott A. Peslak, Eugene Khandros, Xianjiang Lan, Kunhua Qin, Malini Sharma, Cheryl A. Keller, Belinda Giardine, Osheiza Abdulmalik, Stella T. Chou, Junwei Shi, Ross C. Hardison, Gerd A. Blobel
Journal: Blood
Blood (2021) 138 (Supplement 1): 571.
https://doi.org/10.1182/blood-2021-146637
Published: 2021
Journal Articles

Isolated Changes in Chromatin Accessibility and Enhancer-Promoter Contacts at the β-Globin Locus Distinguish Fetal Hemoglobin Producing F-Cells from a-Cells

Eugene Khandros, Peng Huang, Scott A. Peslak, Malini Sharma, Osheiza Abdulmalik, Belinda Giardine, Zhe Zhang, Cheryl A. Keller, Ross C. Hardison, Gerd A. Blobel
Journal: Blood
Blood (2021) 138 (Supplement 1): 855.
https://doi.org/10.1182/blood-2021-149877
Published: 2021
Journal Articles

A β-Globin Locus-Intrinsic Epigenetic Mechanism Underlies Fetal Globin Production in F-Cells

Eugene Khandros, MD PhD, Peng Huang, PhD, Scott A. Peslak, MD PhD, Malini Sharma, BS, Osheiza Abdulmalik, DVM, Belinda Giardine, Zhe Zhang, PhD, Cheryl A. Keller, PhD, Ross C. Hardison, PhD, Gerd A. Blobel, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 16–17.
https://doi.org/10.1182/blood-2020-137646
Published: 2020
Journal Articles

The HRI-regulated transcription factor ATF4 activates BCL11A transcription to silence fetal hemoglobin expression

Peng Huang, Scott A. Peslak, Xianjiang Lan, Eugene Khandros, Jennifer A. Yano, Malini Sharma, Cheryl A. Keller, Belinda Giardine, Kunhua Qin, Osheiza Abdulmalik, Ross C. Hardison, Junwei Shi, Gerd A. Blobel
Journal: Blood
Blood (2020) 135 (24): 2121–2132.
https://doi.org/10.1182/blood.2020005301
Published: 2020
Includes: Supplemental data
Journal Articles

Understanding heterogeneity of fetal hemoglobin induction through comparative analysis of F and A erythroblasts

Eugene Khandros, Peng Huang, Scott A. Peslak, Malini Sharma, Osheiza Abdulmalik, Belinda M. Giardine, Zhe Zhang, Cheryl A. Keller, Ross C. Hardison, Gerd A. Blobel
Journal: Blood
Blood (2020) 135 (22): 1957–1968.
https://doi.org/10.1182/blood.2020005058
Published: 2020
Includes: Supplemental data
Journal Articles

Interrogating RNA Binding Proteins as Novel Regulators of Fetal Hemoglobin Expression

Aoi Wakabayashi, BS, Jeremy D. Grevet, PhD, Xianjiang Lan, PhD, Malini Sharma, BS, Junwei Shi, PhD, Gerd A. Blobel, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 966.
https://doi.org/10.1182/blood-2019-125901
Published: 2019
Journal Articles

Heme-Regulated Inhibitor (HRI) Activates Transcription Factor ATF4 to Promote BCL11A Transcription and Fetal Hemoglobin Silencing

Peng Huang, PhD, Scott A. Peslak, MD PhD, Xianjiang Lan, PhD, Eugene Khandros, MD PhD, Malini Sharma, BS, Kunhua Qin, PhD, Cheryl A Keller, PhD, Belinda Giardine, Junwei Shi, PhD, Ross C. Hardison, PhD, Gerd A. Blobel, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 814.
https://doi.org/10.1182/blood-2019-123837
Published: 2019