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Journal Articles

A Novel Genome-Scale CRISPR-Cas12a Screen Identifies Ptpa As a Fetal Hemoglobin Regulator Via BCL11A

Elizabeth A. Traxler, Chad Komar, Megan Saari, Quynn Hotan, A Josephine Thrasher, Eugene Khandros, Kunhua Qin, Osheiza Abdulmalik, Claire Shao, Qingzhou Chen, Andy J. Minn, Cheryl A. Keller, Junwei Shi, Gerd A. Blobel

Blood (2024) 144 (Supplement 1): 412.

https://doi.org/10.1182/blood-2024-210117

Published: 2024

Journal Articles

Elevating fetal hemoglobin: recently discovered regulators and mechanisms

Eugene Khandros, Gerd A. Blobel

Blood (2024) 144 (8): 845–852.

https://doi.org/10.1182/blood.2023022190

Published: 2024

Journal Articles

let-7 miRNAs repress HIC2 to regulate BCL11A transcription and hemoglobin switching

Peng Huang, Scott A. Peslak, Vanessa Shehu, Cheryl A. Keller, Belinda Giardine, Junwei Shi, Ross C. Hardison, Gerd A. Blobel, Eugene Khandros

Blood (2024) 143 (19): 1980–1991.

https://doi.org/10.1182/blood.2023023399

Published: 2024

Includes: Supplemental data

Journal Articles

Selective Globin Gene Regulation By the Non-Canonical Baf Chromatin Remodeling Complex

Sindhu Billakanti, Vanessa Shehu, Kathryn M. Farrell, Osheiza Abdulmalik, Belinda M. Giardine, Cheryl A. Keller, Ross C. Hardison, Junwei Shi, Gerd A. Blobel, Eugene Khandros

Blood (2023) 142 (Supplement 1): 553.

https://doi.org/10.1182/blood-2023-179001

Published: 2023

Journal Articles

Protein Phosphatase 6 Complex: Novel Regulator of Fetal Hemoglobin and Potential Therapeutic Target in Sickle Cell Disease

Scott A. Peslak, Talla Abbas, Eugene Khandros, Elizabeth A. Traxler, Osheiza Abdulmalik, Belinda M. Giardine, Cheryl A. Keller, Ross C. Hardison, Junwei Shi, Gerd A. Blobel

Blood (2023) 142 (Supplement 1): 13.

https://doi.org/10.1182/blood-2023-181989

Published: 2023

Journal Articles

Genome-Scale CRISPR-Cas12a Screen Identifies Novel Fetal Hemoglobin Regulators

Elizabeth A. Traxler, Chad Komar, Megan Saari, A Josephine Thrasher, Kunhua Qin, Eugene Khandros, Quynn Hotan, Osheiza Abdulmalik, Claire Shao, Qingzhou Chen, Andy J. Minn, Cheryl A. Keller, Junwei Shi, Gerd A. Blobel

Blood (2023) 142 (Supplement 1): 1101.

https://doi.org/10.1182/blood-2023-189547

Published: 2023

Journal Articles

Molecular basis of polycomb group protein–mediated fetal hemoglobin repression

Kunhua Qin, Xianjiang Lan, Peng Huang, Megan S. Saari, Eugene Khandros, Cheryl A. Keller, Belinda Giardine, Osheiza Abdulmalik, Junwei Shi, Ross C. Hardison, Gerd A. Blobel

Blood (2023) 141 (22): 2756–2770.

https://doi.org/10.1182/blood.2022019578

Published: 2023

Includes: Supplemental data

Journal Articles

Let-7 Inhibits HIC2 to Control BCL11A Transcription and Hemoglobin Switching

Peng Huang, Eugene Khandros, Scott A. Peslak, Cheryl A. Keller, Belinda M. Giardine, Ross C. Hardison, Gerd A. Blobel

Blood (2022) 140 (Supplement 1): 1937–1938.

https://doi.org/10.1182/blood-2022-157978

Published: 2022

Journal Articles

Mechanisms of Polycomb Group Protein-Mediated Fetal Hemoglobin Silencing

Kunhua Qin, Peng Huang, Xianjiang Lan, Megan S. Saari, Eugene Khandros, Osheiza Y. Abdulmalik, Cheryl A. Keller, Belinda M. Giardine, Ross C. Hardison, Junwei Shi, Gerd A. Blobel

Blood (2022) 140 (Supplement 1): 5382–5383.

https://doi.org/10.1182/blood-2022-165560

Published: 2022

Journal Articles

Examining the Role of Individual Baf Chromatin Remodeling Complex Components in Globin Gene Regulation

Kathryn M. Farrell, Peng Huang, Osheiza Y. Abdulmalik, Belinda M. Giardine, Cheryl A. Keller, Ross C. Hardison, Junwei Shi, Gerd A. Blobel, Eugene Khandros

Blood (2022) 140 (Supplement 1): 1943.

https://doi.org/10.1182/blood-2022-159347

Published: 2022

Journal Articles

Regulation of Fetal Hemoglobin Production in Adult Erythroid Cells By Protein Phosphatase 6C (PPP6C)

Scott A. Peslak, Eugene Khandros, Peng Huang, Aoi Wakabayashi, Talla Abbas, Osheiza Y. Abdulmalik, Cheryl A. Keller, Ross C. Hardison, Junwei Shi, Gerd A. Blobel

Blood (2022) 140 (Supplement 1): 2502–2503.

https://doi.org/10.1182/blood-2022-165286

Published: 2022

Journal Articles

Protein Phosphatase 6C (PPP6C) Loss Significantly Raises Fetal Hemoglobin Levels and Reduces Cell Sickling

Scott A. Peslak, Eugene Khandros, Peng Huang, Maryanne Kihiu, Osheiza Abdulmalik, Cheryl A. Keller, Ross C. Hardison, Junwei Shi, Gerd A. Blobel

Blood (2021) 138 (Supplement 1): 2031.

https://doi.org/10.1182/blood-2021-147275

Published: 2021

Journal Articles

HIC2 Controls Developmental Hemoglobin Switching By Repressing BCL11A Transcription

Peng Huang, Scott A. Peslak, Eugene Khandros, Xianjiang Lan, Kunhua Qin, Malini Sharma, Cheryl A. Keller, Belinda Giardine, Osheiza Abdulmalik, Stella T. Chou, Junwei Shi, Ross C. Hardison, Gerd A. Blobel

Blood (2021) 138 (Supplement 1): 571.

https://doi.org/10.1182/blood-2021-146637

Published: 2021

Journal Articles

Isolated Changes in Chromatin Accessibility and Enhancer-Promoter Contacts at the β-Globin Locus Distinguish Fetal Hemoglobin Producing F-Cells from a-Cells

Eugene Khandros, Peng Huang, Scott A. Peslak, Malini Sharma, Osheiza Abdulmalik, Belinda Giardine, Zhe Zhang, Cheryl A. Keller, Ross C. Hardison, Gerd A. Blobel

Blood (2021) 138 (Supplement 1): 855.

https://doi.org/10.1182/blood-2021-149877

Published: 2021

Journal Articles

A β-Globin Locus-Intrinsic Epigenetic Mechanism Underlies Fetal Globin Production in F-Cells

Eugene Khandros, MD PhD, Peng Huang, PhD, Scott A. Peslak, MD PhD, Malini Sharma, BS, Osheiza Abdulmalik, DVM, Belinda Giardine, Zhe Zhang, PhD, Cheryl A. Keller, PhD, Ross C. Hardison, PhD, Gerd A. Blobel, MDPhD

Blood (2020) 136 (Supplement 1): 16–17.

https://doi.org/10.1182/blood-2020-137646

Published: 2020

Journal Articles

The HRI-regulated transcription factor ATF4 activates BCL11A transcription to silence fetal hemoglobin expression

Peng Huang, Scott A. Peslak, Xianjiang Lan, Eugene Khandros, Jennifer A. Yano, Malini Sharma, Cheryl A. Keller, Belinda Giardine, Kunhua Qin, Osheiza Abdulmalik, Ross C. Hardison, Junwei Shi, Gerd A. Blobel

Blood (2020) 135 (24): 2121–2132.

https://doi.org/10.1182/blood.2020005301

Published: 2020

Includes: Supplemental data

Journal Articles

Understanding heterogeneity of fetal hemoglobin induction through comparative analysis of F and A erythroblasts

Eugene Khandros, Peng Huang, Scott A. Peslak, Malini Sharma, Osheiza Abdulmalik, Belinda M. Giardine, Zhe Zhang, Cheryl A. Keller, Ross C. Hardison, Gerd A. Blobel

Blood (2020) 135 (22): 1957–1968.

https://doi.org/10.1182/blood.2020005058

Published: 2020

Includes: Supplemental data

Journal Articles

Heme-Regulated Inhibitor (HRI) Depletion Cooperates with Pharmacologic Inducers to Strongly Elevate Fetal Hemoglobin and Reduce Sickle Cell Formation

Scott A. Peslak, MD PhD, Xianjiang Lan, PhD, Eugene Khandros, MD PhD, Peng Huang, PhD, Jennifer A. Yano, BA, Jeremy D. Grevet, PhD, Osheiza Abdulmalik, DVM, Cheryl A Keller, PhD, Ross C. Hardison, PhD, Junwei Shi, PhD, Gerd A. Blobel, MD PhD

Blood (2019) 134 (Supplement_1): 3557.

https://doi.org/10.1182/blood-2019-125664

Published: 2019

Journal Articles

Heme-Regulated Inhibitor (HRI) Activates Transcription Factor ATF4 to Promote BCL11A Transcription and Fetal Hemoglobin Silencing

Peng Huang, PhD, Scott A. Peslak, MD PhD, Xianjiang Lan, PhD, Eugene Khandros, MD PhD, Malini Sharma, BS, Kunhua Qin, PhD, Cheryl A Keller, PhD, Belinda Giardine, Junwei Shi, PhD, Ross C. Hardison, PhD, Gerd A. Blobel, MD PhD

Blood (2019) 134 (Supplement_1): 814.

https://doi.org/10.1182/blood-2019-123837

Published: 2019

Journal Articles

Understanding Heterogeneity of Fetal Hemoglobin Induction through Comparative Analysis of Stage-Matched F- and a-Cells

Eugene Khandros, MD PhD, Peng Huang, PhD, Scott A. Peslak, MD PhD, Belinda Giardine, Zhe Zhang, PhD, Cheryl A Keller, PhD, Ross C. Hardison, PhD, Gerd A. Blobel, MD PhD

Blood (2019) 134 (Supplement_1): 981.

https://doi.org/10.1182/blood-2019-124099

Published: 2019

NARROW

A Novel Genome-Scale CRISPR-Cas12a Screen Identifies Ptpa As a Fetal Hemoglobin Regulator Via BCL11A

Elevating fetal hemoglobin: recently discovered regulators and mechanisms

let-7 miRNAs repress HIC2 to regulate BCL11A transcription and hemoglobin switching

Selective Globin Gene Regulation By the Non-Canonical Baf Chromatin Remodeling Complex

Protein Phosphatase 6 Complex: Novel Regulator of Fetal Hemoglobin and Potential Therapeutic Target in Sickle Cell Disease

Genome-Scale CRISPR-Cas12a Screen Identifies Novel Fetal Hemoglobin Regulators

Molecular basis of polycomb group protein–mediated fetal hemoglobin repression

Let-7 Inhibits HIC2 to Control BCL11A Transcription and Hemoglobin Switching

Mechanisms of Polycomb Group Protein-Mediated Fetal Hemoglobin Silencing

Examining the Role of Individual Baf Chromatin Remodeling Complex Components in Globin Gene Regulation

Regulation of Fetal Hemoglobin Production in Adult Erythroid Cells By Protein Phosphatase 6C (PPP6C)

Protein Phosphatase 6C (PPP6C) Loss Significantly Raises Fetal Hemoglobin Levels and Reduces Cell Sickling

HIC2 Controls Developmental Hemoglobin Switching By Repressing BCL11A Transcription

Isolated Changes in Chromatin Accessibility and Enhancer-Promoter Contacts at the β-Globin Locus Distinguish Fetal Hemoglobin Producing F-Cells from a-Cells

A β-Globin Locus-Intrinsic Epigenetic Mechanism Underlies Fetal Globin Production in F-Cells

The HRI-regulated transcription factor ATF4 activates BCL11A transcription to silence fetal hemoglobin expression

Understanding heterogeneity of fetal hemoglobin induction through comparative analysis of F and A erythroblasts

Heme-Regulated Inhibitor (HRI) Depletion Cooperates with Pharmacologic Inducers to Strongly Elevate Fetal Hemoglobin and Reduce Sickle Cell Formation

Heme-Regulated Inhibitor (HRI) Activates Transcription Factor ATF4 to Promote BCL11A Transcription and Fetal Hemoglobin Silencing

Understanding Heterogeneity of Fetal Hemoglobin Induction through Comparative Analysis of Stage-Matched F- and a-Cells

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American Society of Hematology

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American Society of Hematology

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