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Tobias Neff
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Journal Articles

Aberrant Stemness Transcription Signature Unveils a Mechanism of Chemotherapy Resistance through Blunting p53-Mediated Response in Acute Myeloid Leukemia

Fatemeh Alikarami, Hongbo Xie, Simone Stefanie Riedel, Haley Goodrow, Declan Barrett, Leila Mahdavi, Alexandra Lenard, Changya Chen, Taylor Yamauchi, Etienne Danis, Zhendong Cao, Vu L. Tran, Mabel M. Jung, Yapeng Li, Hua Huang, Junwei Shi, Kai Tan, David T. Teachey, Emery H. Bresnick, Tobias Neff, Kathrin M. Bernt
Journal: Blood
Blood (2024) 144 (Supplement 1): 725.
https://doi.org/10.1182/blood-2024-199215
Published: 2024
Journal Articles

The Role of GATA2 in Drug Resistance in AML

Fatemeh Alikarami, Simone S. Riedel, Qinglan Li, Changya Chen, Taylor Yamauchi, Etienne Danis, Kai Tan, Liling Wan, Tobias Neff, Kathrin M. Bernt
Journal: Blood
Blood (2022) 140 (Supplement 1): 97–98.
https://doi.org/10.1182/blood-2022-166666
Published: 2022
Journal Articles

Updated Results from the Phase 2 Centaurus Study of Daratumumab (DARA) Monotherapy in Patients with Intermediate-Risk or High-Risk Smoldering Multiple Myeloma (SMM)

Ola Landgren, MD PhD, Michele Cavo, MD, Ajai Chari, MD, Yael C Cohen, MD, Andrew Spencer, MBBS, FRACP, FRCPA, DM, Peter M. Voorhees, MD, Jane Estell, FRACP, Irwindeep Sandhu, MDFRCPC, Matthew Jenner, Catherine Williams, Niels WCJ van de Donk, MD PhD, Meral Beksac, MD, Hartmut Goldschmidt, MD, Philippe Moreau, Steven Kuppens, Rajesh Bandekar, Tobias Neff, Annelore Cortoos, MD, Pamela L Clemens, PhD, Ming Qi, Homer Adams, III, PhD, Craig C Hofmeister, MDMPH
Journal: Blood
Blood (2018) 132 (Supplement 1): 1994.
https://doi.org/10.1182/blood-2018-99-113467
Published: 2018
Journal Articles

Daratumumab Monotherapy for Patients with Intermediate or High-Risk Smoldering Multiple Myeloma (SMM): Centaurus, a Randomized, Open-Label, Multicenter Phase 2 Study

Craig C Hofmeister, MDMPH, Ajai Chari, Yael Cohen, Andrew Spencer, MD, Peter M. Voorhees, MD, Jane Estell, Christopher P. Venner, Irwindeep Sandhu, Matthew W Jenner, Cathy Williams, Michele Cavo, MD, Niels WCJ Van De Donk, Meral Beksac, Steven Kuppens, Rajesh Bandekar, Tobias Neff, Christoph Heuck, Ming Qi, Hartmut Goldschmidt, MD, Ola Landgren, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 510.
https://doi.org/10.1182/blood.V130.Suppl_1.510.510
Published: 2017
Journal Articles

The Role of Gata2 in Murine Models of Acute Myeloid Leukemia

Taylor Yamauchi, B.A., Etienne Danis, PhD, Xi Zhang, B.A., Simone Riedel, PhD, Hua Huang, MD, PhD, Kathrin M Bernt, MD, Tobias Neff, MD
Journal: Blood
Blood (2016) 128 (22): 1516.
https://doi.org/10.1182/blood.V128.22.1516.1516
Published: 2016
Journal Articles

The Role of MLL1 and MLL2 in MLL Fusion Oncoprotein-Initiated Leukemia

Patricia Ernst, PhD, Konstantinos Anastassiadis, PhD, Andrea Kranz, PhD, A. Francis Stewart, PhD, Kathrin Arndt, PhD, Claudia Waskow, PhD, Akihiko Yokoyama, PhD, Kenneth Jones, PhD, Tobias Neff, MD, Yufei Chen
Journal: Blood
Blood (2016) 128 (22): 573.
https://doi.org/10.1182/blood.V128.22.573.573
Published: 2016
Journal Articles

Meningeoma-1 Cooperates with MLL and DOT1L to Induce Leukemia

Simone Riedel, PhD, Jessica Haladyna, BA, Brett Stevens, Craig T Jordan, PhD, Daniel Pollyea, MD MS, Scott A. Armstrong, MD PhD, Qi Wei, PhD, Patricia Ernst, PhD, Tobias Neff, MD, Kathrin M Bernt, MD
Journal: Blood
Blood (2015) 126 (23): 2428.
https://doi.org/10.1182/blood.V126.23.2428.2428
Published: 2015
Journal Articles

Targeting Meningeoma-1 Driven AML through Epigenetic Modulation of the Cell of Origin

Simone Riedel, PhD, Kathrin M Bernt, MD, Jessica Haladyna, BA, Matthew Bezzant, Brett Stevens, PhD, Daniel A. Pollyea, MD MS, Amit U. Sinha, PhD, Scott A. Armstrong, MD PhD, Qi Wei, PhD, Craig T. Jordan, PhD, Tobias Neff, MD
Journal: Blood
Blood (2014) 124 (21): 838.
https://doi.org/10.1182/blood.V124.21.838.838
Published: 2014
Journal Articles

Context Dependent Role of Polycomb Repressive Complex 2 in Acute Leukemia

Etienne Danis, PhD, Taylor Yamauchi, BA, Kristen Echanique, BS, Jessica Haladyna, BA, Huafeng Xie, PhD, Nan Zhu, PhD, Simone Riedel, PhD, Kathrin M Bernt, MD, Stuart H. Orkin, MD, Scott A. Armstrong, MD PhD, Tobias Neff, MD
Journal: Blood
Blood (2014) 124 (21): 610.
https://doi.org/10.1182/blood.V124.21.610.610
Published: 2014
Journal Articles

MDR1 Mediated Drug Resistance to a Histone Methyltansferase Inhibitor (KMT)

Jessica Haladyna, BA, Taylor Yamauchi, BA, Tobias Neff, MD, Kathrin M Bernt, MD
Journal: Blood
Blood (2014) 124 (21): 3622.
https://doi.org/10.1182/blood.V124.21.3622.3622
Published: 2014
Journal Articles

Recent progress toward epigenetic therapies: the example of mixed lineage leukemia

Tobias Neff, Scott A. Armstrong
Journal: Blood
Blood (2013) 121 (24): 4847–4853.
https://doi.org/10.1182/blood-2013-02-474833
Published: 2013
Journal Articles

Long-term polyclonal and multilineage engraftment of methylguanine methyltransferase P140K gene-modified dog hematopoietic cells in primary and secondary recipients

Brian C. Beard, Reeteka Sud, Kirsten A. Keyser, Christina Ironside, Tobias Neff, Sabine Gerull, Grant D. Trobridge, Hans-Peter Kiem
Journal: Blood
Blood (2009) 113 (21): 5094–5103.
https://doi.org/10.1182/blood-2008-09-176412
Published: 2009
Includes: Supplemental data
Journal Articles

Sustained Stable Engraftment of MGMT Gene-Modified Long-Term Repopulating Cells in Primary and Secondary Canine Recipients.

Brian C. Beard, PhD, Reeteka Sud, PhD, Sabine Gerull, MD, Laura J. Peterson, BS, Tobias Neff, MD, Hans-Peter Kiem, MD
Journal: Blood
Blood (2006) 108 (11): 202.
https://doi.org/10.1182/blood.V108.11.202.202
Published: 2006
Journal Articles

Survival of the fittest: in vivo selection and stem cell gene therapy

Tobias Neff, Brian C. Beard, Hans-Peter Kiem
Journal: Blood
Blood (2006) 107 (5): 1751–1760.
https://doi.org/10.1182/blood-2005-06-2335
Published: 2006
Journal Articles

Genomic Mapping of Retrovirus Integration Profiles after In Vivo Selection of Chemo-Protected Stem Cells in the Clinically Relevant Canine Model.

Brian C. Beard, PhD, Pau Mezquita, MD, PhD, Grant Trobridge, PhD, Laura J. Peterson, MS, Tobias Neff, MD, Alixandra A. Knapp, BA, Hans-Peter Kiem, MD
Journal: Blood
Blood (2005) 106 (11): 1293.
https://doi.org/10.1182/blood.V106.11.1293.1293
Published: 2005
Journal Articles

Polyclonal chemoprotection against temozolomide in a large-animal model of drug resistance gene therapy

Tobias Neff, Brian C. Beard, Laura J. Peterson, Ponni Anandakumar, Jesse Thompson, Hans-Peter Kiem
Journal: Blood
Blood (2005) 105 (3): 997–1002.
https://doi.org/10.1182/blood-2004-08-3169
Published: 2005
Journal Articles

Molecular Characterization of Stem Cell Populations and Specific Clone Tracking of Retrovirally-Marked Chemoprotected Stem Cells before and after Dose-Escalating Chemotherapy.

Brian C. Beard, PhD, Pau Mezquita, MD, PhD, Laura J. Peterson, BS, Tobias Neff, MD, Ponni Anandakumar, MS, Alixandra A. Knapp, BA, Hans-Peter Kiem, MD
Journal: Blood
Blood (2004) 104 (11): 291.
https://doi.org/10.1182/blood.V104.11.291.291
Published: 2004
Journal Articles

Direct Intramarrow Injection of CD34+ Cells May Improve Long-Term Engraftment in Nonhuman Primates.

Chul W. Jung, MD, Julia C. Morris, Brian Beard, PhD, Tobias Neff, MD, PhD, Kate Beebe, Hans-Peter Kiem, MD, PhD
Journal: Blood
Blood (2004) 104 (11): 2103.
https://doi.org/10.1182/blood.V104.11.2103.2103
Published: 2004
Journal Articles

Efficient lentiviral gene transfer to canine repopulating cells using an overnight transduction protocol

Peter A. Horn, Kirsten A. Keyser, Laura J. Peterson, Tobias Neff, Bobbie M. Thomasson, Jesse Thompson, Hans-Peter Kiem
Journal: Blood
Blood (2004) 103 (10): 3710–3716.
https://doi.org/10.1182/blood-2003-07-2414
Published: 2004
Journal Articles

Pharmacologically regulated in vivo selection in a large animal

Tobias Neff, Peter A. Horn, Victor E. Valli, Allen M. Gown, Scott Wardwell, Brent L. Wood, Christof von Kalle, Manfred Schmidt, Laura J. Peterson, Julia C. Morris, Robert E. Richard, Tim Clackson, Hans-Peter Kiem, C. Anthony Blau
Journal: Blood
Blood (2002) 100 (6): 2026–2031.
https://doi.org/10.1182/blood-2002-03-0792
Published: 2002