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Journal Articles

Pooled CAR-T screening in pig-tailed macaques identifies designs with enhanced proliferation, trafficking, and persistence

Blood (2025) 146 (21): 2531–2543.

https://doi.org/10.1182/blood.2025028683

Published: 2025

Includes: Supplemental data

Journal Articles

CD90-targeted multiplex virus-like particles (MVPs) for concomitant In Vivo gene editing, transduction, and transcription factor delivery into HSCs

Justin Thomas, Stefan Radtke, Dnyanada Pande, Mark Enstrom, Heather Mack, Carl Worf, Alvin Tong, Mitch Egan, Jay Squire, Hans-Peter Kiem

Blood (2025) 146 (Supplement 1): 2543.

https://doi.org/10.1182/blood-2025-2543

Published: 2025

Journal Articles

In Vivo hematopoietic stem cell (HSC) engineering and selection with CD90-targeted multiplexed virus-like particles (MVPs) for HSC gene therapy and cancer immunotherapy

Stefan Radtke, Justin Thomas, Seunga Choo, Nicholas Petty, Peter Rupert, Greta Kanestrom, Alvin Tong, Kyle Swing, Heather Mack, Carl Worf, Mitch Egan, Malia Callier, Roland Strong, Hans-Peter Kiem

Blood (2025) 146 (Supplement 1): 1065.

https://doi.org/10.1182/blood-2025-1065

Published: 2025

Journal Articles

TNFα Apoptotic Signaling By Antigen-Engaged CAR T-Cells Mediates Clearance of Target Antigen-Negative Acute Myeloid Leukemia

Erik L Kimble, Salvatore Fiorenza, Alexandre V. Vinaud Hirayama, Austin M Gabel, Jordan Gauthier, Aiko Torkelson, Abigail Chutnik, Henna Di, Jocelyn H Wright, Barbara Pender, Stefan Radtke, Roland B. Walter, Hans-Peter Kiem, David G. Maloney, Robert K. Bradley, Cameron J. Turtle

Blood (2024) 144 (Supplement 1): 3422.

https://doi.org/10.1182/blood-2024-207966

Published: 2024

Journal Articles

Vivovec™ Surface-Engineered Lentiviral Particles Mediate In Vivo CAR T Generation with Potent and Highly Durable Activity in Non-Human Primates

Blood (2024) 144 (Supplement 1): 502.

https://doi.org/10.1182/blood-2024-206328

Published: 2024

Journal Articles

CD45-Directed Radioimmunotherapy with the Alpha-Emitter Astatine-211 As Conditioning for Autologous Hematopoietic Stem/Progenitor Cell Gene Therapy: Results from a Nonhuman Primate Model

Stefan Radtke, Kyle Swing, George S. Laszlo, Andrea Repele, Greta N. Kanestrom, Nicholas E Petty, Donald K. Hamlin, D. Scott Wilbur, Brenda M. Sandmaier, Hans-Peter Kiem, Roland B. Walter

Blood (2024) 144 (Supplement 1): 2014.

https://doi.org/10.1182/blood-2024-205992

Published: 2024

Journal Articles

In vivo CAR T-cell generation in nonhuman primates using lentiviral vectors displaying a multidomain fusion ligand

Blood (2024) 144 (9): 977–987.

https://doi.org/10.1182/blood.2024024523

Published: 2024

Includes: Supplemental data

Journal Articles

Alloengraftment without significant toxicity or GVHD in CD45 antibody-drug conjugate–conditioned Fanconi anemia mice

Blood (2024) 143 (21): 2201–2216.

https://doi.org/10.1182/blood.2023023549

Published: 2024

Includes: Supplemental data

Journal Articles

CD90-Targeted Cocal-Pseudotyped Lentivirus As a Robust Platform for Human HSC Gene Therapy

Justin Thomas, Kurt Burkmueller, Greta Kanestrom, Stefan Radtke, Hans-Peter Kiem

Blood (2023) 142 (Supplement 1): 2254.

https://doi.org/10.1182/blood-2023-187488

Published: 2023

Journal Articles

Lisocabtagene Maraleucel Versus Axicabtagene Ciloleucel: Efficacy and Toxicity in a Real-World Setting

Andrew J Portuguese, Aya Albittar, Emily C Liang, Jennifer J. Huang, Alexandre V Hirayama, Erik L Kimble, Lorenzo Iovino, Christina Poh, Ajay K Gopal, Mazyar Shadman, Brian G Till, Hans-Peter Kiem, Filippo Milano, Aude G Chapuis, Folashade Otegbeye, Ryan D Cassaday, David G Maloney, Jordan Gauthier

Blood (2023) 142 (Supplement 1): 2131.

https://doi.org/10.1182/blood-2023-172978

Published: 2023

Journal Articles

Efficient and Stable Makassar Base Editing in Nonhuman Primates

Stefan Radtke, Emily Fields, Gregory A. Newby, Jonathan S Yen, Mitchell Weiss, Olivier Humbert, Dnyanada Pande, Mark Enstrom, David Liu, Hans-Peter Kiem

Blood (2023) 142 (Supplement 1): 484.

https://doi.org/10.1182/blood-2023-178732

Published: 2023

Journal Articles

Stochastic fate decisions of HSCs after transplantation: early contribution, symmetric expansion, and pool formation

Stefan Radtke, Mark Enstrom, Dnyanada Pande, Elizabeth R. Duke, E. Fabian Cardozo-Ojeda, Ravishankar Madhu, Staci Owen, Greta Kanestrom, Margaret Cui, Anai M. Perez, Joshua T. Schiffer, Hans-Peter Kiem

Blood (2023) 142 (1): 33–43.

https://doi.org/10.1182/blood.2022018564

Published: 2023

Includes: Supplemental data

Journal Articles

In vivo HSC prime editing rescues sickle cell disease in a mouse model

Chang Li, Aphrodite Georgakopoulou, Gregory A. Newby, Peter J. Chen, Kelcee A. Everette, Kiriaki Paschoudi, Efthymia Vlachaki, Sucheol Gil, Anna K. Anderson, Theodore Koob, Lishan Huang, Hongjie Wang, Hans-Peter Kiem, David R. Liu, Evangelia Yannaki, André Lieber

Blood (2023) 141 (17): 2085–2099.

https://doi.org/10.1182/blood.2022018252

Published: 2023

Includes: Supplemental data

Journal Articles

HSCs Engraft in a Stochastic Pattern and Form Clonal Pools after Transplantation

Stefan Radtke, Mark Enstrom, Dnyanada Pande, Ravishankar Madhu, Staci Owen, Greta Kanestrom, Margaret Cui, Anai M Perez, Hans-Peter Kiem

Blood (2022) 140 (Supplement 1): 5719–5720.

https://doi.org/10.1182/blood-2022-158535

Published: 2022

Journal Articles

Timing of PD-L1 Blockade with Durvalumab May Affect Outcomes of CD19 CAR-T Cell Therapy for Relapsed/Refractory Large B-Cell Lymphoma

Alexandre Vinaud Hirayama, Salvatore Fiorenza, Jordan Gauthier, Jenna M. Voutsinas, Qian Vicky Wu, Erik L. Kimble, Barbara S. Pender, Delaney R. Kirchmeier, Henna A. Di, Ryan D. Cassaday, Aude G. Chapuis, Damian J. Green, Hans-Peter Kiem, Filippo Milano, Mazyar Shadman, Brian G. Till, Stanley R. Riddell, David G. Maloney, Cameron J. Turtle

Blood (2022) 140 (Supplement 1): 7447–7449.

https://doi.org/10.1182/blood-2022-168185

Published: 2022

Journal Articles

A CD45-targeted antibody-drug conjugate successfully conditions for allogeneic hematopoietic stem cell transplantation in mice

Asim Saha, Sharon Hyzy, Tahirih Lamothe, Katelyn Hammond, Nicholas Clark, Leanne Lanieri, Prashant Bhattarai, Rahul Palchaudhuri, Geoffrey O. Gillard, Jennifer Proctor, Megan J. Riddle, Angela Panoskaltsis-Mortari, Margaret L. MacMillan, John E. Wagner, Hans-Peter Kiem, Lisa M. Olson, Bruce R. Blazar

Blood (2022) 139 (11): 1743–1759.

https://doi.org/10.1182/blood.2021012366

Published: 2022

Includes: Supplemental data

Journal Articles

Efficient Nanoparticle-Mediated Delivery of Gene Editing Reagents into Human Hematopoietic Stem and Progenitor Cells

Rkia El Kharrag, Kurt Berckmueller, Margaret Cui, Ravishankar Madhu, Anai M Perez, Olivier Humbert, Hans-Peter Kiem, Stefan Radtke

Blood (2021) 138 (Supplement 1): 2933.

https://doi.org/10.1182/blood-2021-150924

Published: 2021

Journal Articles

High-Density Clonal Analysis Reveals Highly Active Contribution of Multipotent Hematopoietic Stem Cells during Early Phases of Hematopoietic Recovery after Transplantation

Stefan Radtke, Mark Enstrom, Dnyanada Pande, Margaret Cui, Hans-Peter Kiem

Blood (2021) 138 (Supplement 1): 3258.

https://doi.org/10.1182/blood-2021-150701

Published: 2021

Journal Articles

Myeloid-Biased HSC Require Semaphorin4a from the Bone Marrow Niche for Self-Renewal Under Stress and Life-Long Persistence

Blood (2021) 138 (Supplement 1): 3283.

https://doi.org/10.1182/blood-2021-153831

Published: 2021

Journal Articles

Persistent Control of SIV Infection in Rhesus Macaques By Expressing a Highly Potent SIV Decoy Receptor after In Vivo HSC Transduction

Chang Li, Hongjie Wang, Sucheol Gil, Veronica Nelson, Hans-Peter Kiem, Andre Lieber

Blood (2021) 138 (Supplement 1): 1855.

https://doi.org/10.1182/blood-2021-153808

Published: 2021

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Pooled CAR-T screening in pig-tailed macaques identifies designs with enhanced proliferation, trafficking, and persistence

CD90-targeted multiplex virus-like particles (MVPs) for concomitant In Vivo gene editing, transduction, and transcription factor delivery into HSCs

In Vivo hematopoietic stem cell (HSC) engineering and selection with CD90-targeted multiplexed virus-like particles (MVPs) for HSC gene therapy and cancer immunotherapy

TNFα Apoptotic Signaling By Antigen-Engaged CAR T-Cells Mediates Clearance of Target Antigen-Negative Acute Myeloid Leukemia

Vivovec™ Surface-Engineered Lentiviral Particles Mediate In Vivo CAR T Generation with Potent and Highly Durable Activity in Non-Human Primates

CD45-Directed Radioimmunotherapy with the Alpha-Emitter Astatine-211 As Conditioning for Autologous Hematopoietic Stem/Progenitor Cell Gene Therapy: Results from a Nonhuman Primate Model

In vivo CAR T-cell generation in nonhuman primates using lentiviral vectors displaying a multidomain fusion ligand

Alloengraftment without significant toxicity or GVHD in CD45 antibody-drug conjugate–conditioned Fanconi anemia mice

CD90-Targeted Cocal-Pseudotyped Lentivirus As a Robust Platform for Human HSC Gene Therapy

Lisocabtagene Maraleucel Versus Axicabtagene Ciloleucel: Efficacy and Toxicity in a Real-World Setting

Efficient and Stable Makassar Base Editing in Nonhuman Primates

Stochastic fate decisions of HSCs after transplantation: early contribution, symmetric expansion, and pool formation

In vivo HSC prime editing rescues sickle cell disease in a mouse model

HSCs Engraft in a Stochastic Pattern and Form Clonal Pools after Transplantation

Timing of PD-L1 Blockade with Durvalumab May Affect Outcomes of CD19 CAR-T Cell Therapy for Relapsed/Refractory Large B-Cell Lymphoma

A CD45-targeted antibody-drug conjugate successfully conditions for allogeneic hematopoietic stem cell transplantation in mice

Efficient Nanoparticle-Mediated Delivery of Gene Editing Reagents into Human Hematopoietic Stem and Progenitor Cells

High-Density Clonal Analysis Reveals Highly Active Contribution of Multipotent Hematopoietic Stem Cells during Early Phases of Hematopoietic Recovery after Transplantation

Myeloid-Biased HSC Require Semaphorin4a from the Bone Marrow Niche for Self-Renewal Under Stress and Life-Long Persistence

Persistent Control of SIV Infection in Rhesus Macaques By Expressing a Highly Potent SIV Decoy Receptor after In Vivo HSC Transduction

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