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Journal Articles

TNFα Apoptotic Signaling By Antigen-Engaged CAR T-Cells Mediates Clearance of Target Antigen-Negative Acute Myeloid Leukemia

Erik L Kimble, Salvatore Fiorenza, Alexandre V. Vinaud Hirayama, Austin M Gabel, Jordan Gauthier, Aiko Torkelson, Abigail Chutnik, Henna Di, Jocelyn H Wright, Barbara Pender, Stefan Radtke, Roland B. Walter, Hans-Peter Kiem, David G. Maloney, Robert K. Bradley, Cameron J. Turtle

Blood (2024) 144 (Supplement 1): 3422.

https://doi.org/10.1182/blood-2024-207966

Published: 2024

Journal Articles

CD45-Directed Radioimmunotherapy with the Alpha-Emitter Astatine-211 As Conditioning for Autologous Hematopoietic Stem/Progenitor Cell Gene Therapy: Results from a Nonhuman Primate Model

Stefan Radtke, Kyle Swing, George S. Laszlo, Andrea Repele, Greta N. Kanestrom, Nicholas E Petty, Donald K. Hamlin, D. Scott Wilbur, Brenda M. Sandmaier, Hans-Peter Kiem, Roland B. Walter

Blood (2024) 144 (Supplement 1): 2014.

https://doi.org/10.1182/blood-2024-205992

Published: 2024

Journal Articles

CD90-Targeted Cocal-Pseudotyped Lentivirus As a Robust Platform for Human HSC Gene Therapy

Justin Thomas, Kurt Burkmueller, Greta Kanestrom, Stefan Radtke, Hans-Peter Kiem

Blood (2023) 142 (Supplement 1): 2254.

https://doi.org/10.1182/blood-2023-187488

Published: 2023

Journal Articles

Efficient and Stable Makassar Base Editing in Nonhuman Primates

Stefan Radtke, Emily Fields, Gregory A. Newby, Jonathan S Yen, Mitchell Weiss, Olivier Humbert, Dnyanada Pande, Mark Enstrom, David Liu, Hans-Peter Kiem

Blood (2023) 142 (Supplement 1): 484.

https://doi.org/10.1182/blood-2023-178732

Published: 2023

Journal Articles

Stochastic fate decisions of HSCs after transplantation: early contribution, symmetric expansion, and pool formation

Stefan Radtke, Mark Enstrom, Dnyanada Pande, Elizabeth R. Duke, E. Fabian Cardozo-Ojeda, Ravishankar Madhu, Staci Owen, Greta Kanestrom, Margaret Cui, Anai M. Perez, Joshua T. Schiffer, Hans-Peter Kiem

Blood (2023) 142 (1): 33–43.

https://doi.org/10.1182/blood.2022018564

Published: 2023

Includes: Supplemental data

Journal Articles

HSCs Engraft in a Stochastic Pattern and Form Clonal Pools after Transplantation

Stefan Radtke, Mark Enstrom, Dnyanada Pande, Ravishankar Madhu, Staci Owen, Greta Kanestrom, Margaret Cui, Anai M Perez, Hans-Peter Kiem

Blood (2022) 140 (Supplement 1): 5719–5720.

https://doi.org/10.1182/blood-2022-158535

Published: 2022

Journal Articles

Efficient Nanoparticle-Mediated Delivery of Gene Editing Reagents into Human Hematopoietic Stem and Progenitor Cells

Rkia El Kharrag, Kurt Berckmueller, Margaret Cui, Ravishankar Madhu, Anai M Perez, Olivier Humbert, Hans-Peter Kiem, Stefan Radtke

Blood (2021) 138 (Supplement 1): 2933.

https://doi.org/10.1182/blood-2021-150924

Published: 2021

Journal Articles

High-Density Clonal Analysis Reveals Highly Active Contribution of Multipotent Hematopoietic Stem Cells during Early Phases of Hematopoietic Recovery after Transplantation

Stefan Radtke, Mark Enstrom, Dnyanada Pande, Margaret Cui, Hans-Peter Kiem

Blood (2021) 138 (Supplement 1): 3258.

https://doi.org/10.1182/blood-2021-150701

Published: 2021

Journal Articles

Myeloid-Biased HSC Require Semaphorin4a from the Bone Marrow Niche for Self-Renewal Under Stress and Life-Long Persistence

Blood (2021) 138 (Supplement 1): 3283.

https://doi.org/10.1182/blood-2021-153831

Published: 2021

Journal Articles

Multiplex CRISPR/Cas9 Genome Editing Targeting the BCL11A/HBG Axis Maximizes Fetal Hemoglobin Reinduction but Generates Chromosomal Translocations Which Persist In Vivo

Clare Samuelson, Olivier Humbert, PhD, Stefan Radtke, PhD, Haiying Zhu, Mallory J Llewellyn, BS, Emily Fields, BS, Savannah Cook, BS, Meei-Li W Huang, Olivier Negre, PhD, Keith Jerome, MDPhD, Hans-Peter Kiem, MDPhD

Blood (2020) 136 (Supplement 1): 47–48.

https://doi.org/10.1182/blood-2020-138539

Published: 2020

Journal Articles

In Vivo HSC Gene Therapy for Hemoglobinopathies: A Proof of Concept Evaluation in Rhesus Macaques

Chang Li, Hongjie Wang, PhD, Sucheol Gil, Afrodite Georgakopoulou, PhDstudent, Stefan Radtke, PhD, Evangelia Yannaki, MD, Thalia Papayannopoulou, MD DrSci, Hans-Peter Kiem, MDPhD, Andre Lieber, MD PhD

Blood (2020) 136 (Supplement 1): 46–47.

https://doi.org/10.1182/blood-2020-141468

Published: 2020

Journal Articles

The evolution of viral integration site analysis

Stefan Radtke, Hans-Peter Kiem

Blood (2020) 135 (15): 1192–1193.

https://doi.org/10.1182/blood.2020005115

Published: 2020

Journal Articles

Fully Closed, Large-Scale, and Clinical Grade Cell Sorting of Hematopoietic Stem Cell (HSC)-Enriched CD90 + Cells for Transplantation and Gene Therapy

Stefan Radtke, PhD, Margaret Cui, Anai M Perez, Yan-Yi Chan, Stefanie Schmuck, BS, Andrew J Berger, PhD, Thomas Eunson, BSc, Hans-Peter Kiem, MD PhD

Blood (2019) 134 (Supplement_1): 3246.

https://doi.org/10.1182/blood-2019-125969

Published: 2019

Journal Articles

Persistence of CRISPR/Cas9-Edited Hematopoietic Stem and Progenitor Cells and Reactivation of Fetal Hemoglobin in Nonhuman Primates

Olivier Humbert, PhD, Stefan Radtke, PhD, Ray R Carillo, Anai M Perez, Sowmya Somashekar Reddy, Lauren E Schefter, Christopher Lux, MDPhD, Sowmya Pattabhi, PhD, Olivier Negre, PhD, Ciaran M Lee, PhD, Jennifer Adair, PhD, Christopher Peterson, PhD, Gang Bao, PhD, David J. Rawlings, MD, Andrew M. Scharenberg, MD, Hans-Peter Kiem, MD PhD

Blood (2018) 132 (Supplement 1): 806.

https://doi.org/10.1182/blood-2018-99-112996

Published: 2018

Journal Articles

Pharmacological Inhibition of Luteinizing Hormone Signaling Promotes HSC Quiescence and Hematopoietic Regeneration

Enrico Velardi, PhD BS, Jennifer Tsai, MD PhD, Stefan Radtke, PhD, Kirsten Cooper, Kimon Argyropoulos, MD, Shieh Jae-Hung, PhD, Yusuke Shono, MD PhD, Robert R. Jenq, MD, Alan M. Hanash, Malcolm A.S. Moore, DPhil, Hans-Peter Kiem, MD PhD, Marcel R.M. van den Brink, MD PhD, Jarrod A Dudakov, PhD

Blood (2017) 130 (Supplement 1): 1139.

https://doi.org/10.1182/blood.V130.Suppl_1.1139.1139

Published: 2017

Journal Articles

A Novel Highly Conserved Hematopoietic Stem/Progenitor Cell Population for Stem Cell Transplantation and Gene Therapy

Stefan Radtke, PhD, Yan-Yi Chan, Morgan A. Giese, Anthony Rongvaux, PhD, Jennifer Adair, PhD, Hans-Peter Kiem, MD PhD

Blood (2017) 130 (Supplement 1): 3339.

https://doi.org/10.1182/blood.V130.Suppl_1.3339.3339

Published: 2017

Journal Articles

Identification and Characterization of a Distinct, Evolutionarily Conserved HSC Phenotype Associated with and Predicting Multi-Lineage Engraftment

Stefan Radtke, PhD, Morgan A. Giese, BA, Yan-Yi Chan, BA, Zachary K. Norgaard, MSc, Jennifer E Adair, PhD, Hans-Peter Kiem, MD FACP

Blood (2016) 128 (22): 1153.

https://doi.org/10.1182/blood.V128.22.1153.1153

Published: 2016

Journal Articles

Conserved Lineage Development in Human and Nonhuman Primate Hematopoiesis

Stefan Radtke, PhD, Yan-Yi Chan, BA, Morgan A. Giese, BA, Zachary K. Norgaard, MSc, Lauren E Schefter, BA, Jennifer E Adair, PhD, Hans-Peter Kiem, MD FACP

Blood (2016) 128 (22): 2646.

https://doi.org/10.1182/blood.V128.22.2646.2646

Published: 2016

Journal Articles

CD133 + CD34 + HSPCs Are Not Significantly Increased in Fetal Liver Compared to Adult or Umbilical Cord HSPCs

Stefan Radtke, PhD, Kevin G Haworth, PhD, Hans-Peter Kiem, MD

Blood (2015) 126 (23): 2369.

https://doi.org/10.1182/blood.V126.23.2369.2369

Published: 2015

NARROW

TNFα Apoptotic Signaling By Antigen-Engaged CAR T-Cells Mediates Clearance of Target Antigen-Negative Acute Myeloid Leukemia

CD45-Directed Radioimmunotherapy with the Alpha-Emitter Astatine-211 As Conditioning for Autologous Hematopoietic Stem/Progenitor Cell Gene Therapy: Results from a Nonhuman Primate Model

CD90-Targeted Cocal-Pseudotyped Lentivirus As a Robust Platform for Human HSC Gene Therapy

Efficient and Stable Makassar Base Editing in Nonhuman Primates

Stochastic fate decisions of HSCs after transplantation: early contribution, symmetric expansion, and pool formation

HSCs Engraft in a Stochastic Pattern and Form Clonal Pools after Transplantation

Efficient Nanoparticle-Mediated Delivery of Gene Editing Reagents into Human Hematopoietic Stem and Progenitor Cells

High-Density Clonal Analysis Reveals Highly Active Contribution of Multipotent Hematopoietic Stem Cells during Early Phases of Hematopoietic Recovery after Transplantation

Myeloid-Biased HSC Require Semaphorin4a from the Bone Marrow Niche for Self-Renewal Under Stress and Life-Long Persistence

Multiplex CRISPR/Cas9 Genome Editing Targeting the BCL11A/HBG Axis Maximizes Fetal Hemoglobin Reinduction but Generates Chromosomal Translocations Which Persist In Vivo

In Vivo HSC Gene Therapy for Hemoglobinopathies: A Proof of Concept Evaluation in Rhesus Macaques

The evolution of viral integration site analysis

Fully Closed, Large-Scale, and Clinical Grade Cell Sorting of Hematopoietic Stem Cell (HSC)-Enriched CD90 + Cells for Transplantation and Gene Therapy

Persistence of CRISPR/Cas9-Edited Hematopoietic Stem and Progenitor Cells and Reactivation of Fetal Hemoglobin in Nonhuman Primates

Pharmacological Inhibition of Luteinizing Hormone Signaling Promotes HSC Quiescence and Hematopoietic Regeneration

A Novel Highly Conserved Hematopoietic Stem/Progenitor Cell Population for Stem Cell Transplantation and Gene Therapy

Identification and Characterization of a Distinct, Evolutionarily Conserved HSC Phenotype Associated with and Predicting Multi-Lineage Engraftment

Conserved Lineage Development in Human and Nonhuman Primate Hematopoiesis

CD133 + CD34 + HSPCs Are Not Significantly Increased in Fetal Liver Compared to Adult or Umbilical Cord HSPCs

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American Society of Hematology

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ASH Publications

American Society of Hematology

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