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Journal Articles

In vivo HSC prime editing rescues sickle cell disease in a mouse model

Chang Li, Aphrodite Georgakopoulou, Gregory A. Newby, Peter J. Chen, Kelcee A. Everette, Kiriaki Paschoudi, Efthymia Vlachaki, Sucheol Gil, Anna K. Anderson, Theodore Koob, Lishan Huang, Hongjie Wang, Hans-Peter Kiem, David R. Liu, Evangelia Yannaki, André Lieber
Journal: Blood
Blood (2023) 141 (17): 2085–2099.
https://doi.org/10.1182/blood.2022018252
Published: 2023
Includes: Supplemental data
Journal Articles

Persistent Control of SIV Infection in Rhesus Macaques By Expressing a Highly Potent SIV Decoy Receptor after In Vivo HSC Transduction

Chang Li, Hongjie Wang, Sucheol Gil, Veronica Nelson, Hans-Peter Kiem, Andre Lieber
Journal: Blood
Blood (2021) 138 (Supplement 1): 1855.
https://doi.org/10.1182/blood-2021-153808
Published: 2021
Journal Articles

Enhanced HbF reactivation by multiplex mutagenesis of thalassemic CD34 + cells in vitro and in vivo

Nikoletta Psatha, Aphrodite Georgakopoulou, Chang Li, Vivek Nandakumar, Grigorios Georgolopoulos, Reyes Acosta, Kiriaki Paschoudi, Jemma Nelson, Daniel Chee, Anastasia Athanasiadou, Anastasia Kouvatsi, Alister Peter William Funnell, André Lieber, Evangelia Yannaki, Thalia Papayannopoulou
Journal: Blood
Blood (2021) 138 (17): 1540–1553.
https://doi.org/10.1182/blood.2020010020
Published: 2021
Includes: Supplemental data
Journal Articles

In Vivo HSC Gene Therapy for Hemoglobinopathies: A Proof of Concept Evaluation in Rhesus Macaques

Chang Li, Hongjie Wang, PhD, Sucheol Gil, Afrodite Georgakopoulou, PhDstudent, Stefan Radtke, PhD, Evangelia Yannaki, MD, Thalia Papayannopoulou, MD DrSci, Hans-Peter Kiem, MDPhD, Andre Lieber, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 46–47.
https://doi.org/10.1182/blood-2020-141468
Published: 2020
Journal Articles

Mgta-145 / Plerixafor-Mediated HSC Mobilization and Intravenous HDAd5/35++ Vector Injection into Mice Allows for Efficient In Vivo HSC Transduction and Stable Gene Marking in Peripheral Blood Cells of CD46-Transgenic and Thalassemia Mice

Chang Li, Sucheol Gil, Kevin A. Goncalves, PhD, John C. Davis, Jr., MD MPH, MS, Hans-Peter Kiem, MDPhD, Andre Lieber, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 4–5.
https://doi.org/10.1182/blood-2020-141485
Published: 2020
Journal Articles

In Vivo HSC Gene Therapy with Base Editors Allows for Efficient Reactivation of Fetal Globin in Beta-Yac Mice

Chang Li, Afrodite Georgakopoulou, PhDstudent, Sucheol Gil, Andre Lieber, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 22.
https://doi.org/10.1182/blood-2020-141492
Published: 2020
Journal Articles

Combining HPFH Mutations in Human Adult HSCs to Enhance Reactivation of Fetal Hemoglobin

Nikoletta Psatha, Afrodite Georgakopoulou, PhDstudent, Chang Li, PhD, Pavel Sova, Hongjie Wang, PhD, Andre Lieber, MD PhD, Thalia Papayannopoulou, MD DrSci
Journal: Blood
Blood (2019) 134 (Supplement_1): 2246.
https://doi.org/10.1182/blood-2019-131487
Published: 2019
Journal Articles

Thalassemia Gene Therapy By In Vivo Transduction of Mobilized Hematopoietic Stem Cells (HSCs) with an Integrating Hybrid Adenovirus Vector System

Afrodite Georgakopoulou, PhDstudent, Hongjie Wang, PhD, Chrysi Kapsali, Undergraduate, Nikoleta Psatha, PhD, Angeliki Koufali, Graduate, Chang Li, PhD, Zsuzsanna Izsvak, PhD, Achilles Anagnostopoulos, Thalia Papayannopoulou, MD DrSci, Evangelia Yannaki, MD, Andre Lieber, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2193.
https://doi.org/10.1182/blood-2018-99-116787
Published: 2018
Journal Articles

Reactivation of γ-globin in adult β-YAC mice after ex vivo and in vivo hematopoietic stem cell genome editing

Chang Li, Nikoletta Psatha, Pavel Sova, Sucheol Gil, Hongjie Wang, Jiho Kim, Chandana Kulkarni, Cristina Valensisi, R. David Hawkins, George Stamatoyannopoulos, André Lieber
Journal: Blood
Blood (2018) 131 (26): 2915–2928.
https://doi.org/10.1182/blood-2018-03-838540
Published: 2018
Includes: Supplemental data
Journal Articles

Introduction of Two Simultaneous Mutations By Genome Editing Greatly Enhances the Accumulation of the Endogenous Fetal Hemoglobin in Human Normal Erythroid Cells

Nikoleta Psatha, PhD, Chang Li, PhD, Hongjie Wang, PhD, Demetri Dalas, George Stamatoyannopoulos, MD, Thalia Papayannopoulou, MD, Andre Lieber, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 947.
https://doi.org/10.1182/blood.V130.Suppl_1.947.947
Published: 2017
Journal Articles

In Vivo HSC Transduction and Selection Results in Long-Term, High-Level Expression of Human Gamma Globin in Peripheral Blood Erythrocytes of Mice

Andre Lieber, MD PhD, Hongjie Wang, PhD, Nikoleta Psatha, PhD, Chang Li, PhD, Kevin G Haworth, BS, PhD, Anja Ehrhardt, PhD, Zsuzsanna Izsvak, Hans-Peter Kiem, MD PhD, George Stamatoyannopoulos, MD, Thalia Papayannopoulou, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4616.
https://doi.org/10.1182/blood.V130.Suppl_1.4616.4616
Published: 2017
Journal Articles

OX40 costimulation turns off Foxp3 + Tregs

Minh Diem Vu, Xiang Xiao, Wenda Gao, Nicolas Degauque, Ming Chen, Alexander Kroemer, Nigel Killeen, Naoto Ishii, Xian Chang Li
Journal: Blood
Blood (2007) 110 (7): 2501–2510.
https://doi.org/10.1182/blood-2007-01-070748
Published: 2007
Journal Articles

Dendritic-cell-associated C-type lectin 2 (DCAL-2) alters dendritic-cell maturation and cytokine production

Chang-Hung Chen, Helen Floyd, N. Eric Olson, Dario Magaletti, Chang Li, Kevin Draves, Edward A. Clark
Journal: Blood
Blood (2006) 107 (4): 1459–1467.
https://doi.org/10.1182/blood-2005-08-3264
Published: 2006
Includes: Supplemental data