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Journal Articles

In vivo HSC prime editing rescues sickle cell disease in a mouse model

Chang Li, Aphrodite Georgakopoulou, Gregory A. Newby, Peter J. Chen, Kelcee A. Everette, Kiriaki Paschoudi, Efthymia Vlachaki, Sucheol Gil, Anna K. Anderson, Theodore Koob, Lishan Huang, Hongjie Wang, Hans-Peter Kiem, David R. Liu, Evangelia Yannaki, André Lieber

Blood (2023) 141 (17): 2085–2099.

https://doi.org/10.1182/blood.2022018252

Published: 2023

Includes: Supplemental data

Journal Articles

Persistent Control of SIV Infection in Rhesus Macaques By Expressing a Highly Potent SIV Decoy Receptor after In Vivo HSC Transduction

Chang Li, Hongjie Wang, Sucheol Gil, Veronica Nelson, Hans-Peter Kiem, Andre Lieber

Blood (2021) 138 (Supplement 1): 1855.

https://doi.org/10.1182/blood-2021-153808

Published: 2021

Journal Articles

Enhanced HbF reactivation by multiplex mutagenesis of thalassemic CD34 + cells in vitro and in vivo

Nikoletta Psatha, Aphrodite Georgakopoulou, Chang Li, Vivek Nandakumar, Grigorios Georgolopoulos, Reyes Acosta, Kiriaki Paschoudi, Jemma Nelson, Daniel Chee, Anastasia Athanasiadou, Anastasia Kouvatsi, Alister Peter William Funnell, André Lieber, Evangelia Yannaki, Thalia Papayannopoulou

Blood (2021) 138 (17): 1540–1553.

https://doi.org/10.1182/blood.2020010020

Published: 2021

Includes: Supplemental data

Journal Articles

In Vivo HSC Gene Therapy with Base Editors Allows for Efficient Reactivation of Fetal Globin in Beta-Yac Mice

Chang Li, Afrodite Georgakopoulou, PhDstudent, Sucheol Gil, Andre Lieber, MD PhD

Blood (2020) 136 (Supplement 1): 22.

https://doi.org/10.1182/blood-2020-141492

Published: 2020

Journal Articles

In Vivo HSC Gene Therapy for Hemoglobinopathies: A Proof of Concept Evaluation in Rhesus Macaques

Chang Li, Hongjie Wang, PhD, Sucheol Gil, Afrodite Georgakopoulou, PhDstudent, Stefan Radtke, PhD, Evangelia Yannaki, MD, Thalia Papayannopoulou, MD DrSci, Hans-Peter Kiem, MDPhD, Andre Lieber, MD PhD

Blood (2020) 136 (Supplement 1): 46–47.

https://doi.org/10.1182/blood-2020-141468

Published: 2020

Journal Articles

Mgta-145 / Plerixafor-Mediated HSC Mobilization and Intravenous HDAd5/35++ Vector Injection into Mice Allows for Efficient In Vivo HSC Transduction and Stable Gene Marking in Peripheral Blood Cells of CD46-Transgenic and Thalassemia Mice

Chang Li, Sucheol Gil, Kevin A. Goncalves, PhD, John C. Davis, Jr., MD MPH, MS, Hans-Peter Kiem, MDPhD, Andre Lieber, MD PhD

Blood (2020) 136 (Supplement 1): 4–5.

https://doi.org/10.1182/blood-2020-141485

Published: 2020

Journal Articles

Combining HPFH Mutations in Human Adult HSCs to Enhance Reactivation of Fetal Hemoglobin

Nikoletta Psatha, Afrodite Georgakopoulou, PhDstudent, Chang Li, PhD, Pavel Sova, Hongjie Wang, PhD, Andre Lieber, MD PhD, Thalia Papayannopoulou, MD DrSci

Blood (2019) 134 (Supplement_1): 2246.

https://doi.org/10.1182/blood-2019-131487

Published: 2019

Journal Articles

Thalassemia Gene Therapy By In Vivo Transduction of Mobilized Hematopoietic Stem Cells (HSCs) with an Integrating Hybrid Adenovirus Vector System

Afrodite Georgakopoulou, PhDstudent, Hongjie Wang, PhD, Chrysi Kapsali, Undergraduate, Nikoleta Psatha, PhD, Angeliki Koufali, Graduate, Chang Li, PhD, Zsuzsanna Izsvak, PhD, Achilles Anagnostopoulos, Thalia Papayannopoulou, MD DrSci, Evangelia Yannaki, MD, Andre Lieber, MD PhD

Blood (2018) 132 (Supplement 1): 2193.

https://doi.org/10.1182/blood-2018-99-116787

Published: 2018

Journal Articles

Reactivation of γ-globin in adult β-YAC mice after ex vivo and in vivo hematopoietic stem cell genome editing

Chang Li, Nikoletta Psatha, Pavel Sova, Sucheol Gil, Hongjie Wang, Jiho Kim, Chandana Kulkarni, Cristina Valensisi, R. David Hawkins, George Stamatoyannopoulos, André Lieber

Blood (2018) 131 (26): 2915–2928.

https://doi.org/10.1182/blood-2018-03-838540

Published: 2018

Includes: Supplemental data

Journal Articles

Introduction of Two Simultaneous Mutations By Genome Editing Greatly Enhances the Accumulation of the Endogenous Fetal Hemoglobin in Human Normal Erythroid Cells

Nikoleta Psatha, PhD, Chang Li, PhD, Hongjie Wang, PhD, Demetri Dalas, George Stamatoyannopoulos, MD, Thalia Papayannopoulou, MD, Andre Lieber, MD PhD

Blood (2017) 130 (Supplement 1): 947.

https://doi.org/10.1182/blood.V130.Suppl_1.947.947

Published: 2017

Journal Articles

In Vivo HSC Transduction and Selection Results in Long-Term, High-Level Expression of Human Gamma Globin in Peripheral Blood Erythrocytes of Mice

Andre Lieber, MD PhD, Hongjie Wang, PhD, Nikoleta Psatha, PhD, Chang Li, PhD, Kevin G Haworth, BS, PhD, Anja Ehrhardt, PhD, Zsuzsanna Izsvak, Hans-Peter Kiem, MD PhD, George Stamatoyannopoulos, MD, Thalia Papayannopoulou, MD

Blood (2017) 130 (Supplement 1): 4616.

https://doi.org/10.1182/blood.V130.Suppl_1.4616.4616

Published: 2017

Journal Articles

In vivo transduction of primitive mobilized hematopoietic stem cells after intravenous injection of integrating adenovirus vectors

Maximilian Richter, Kamola Saydaminova, Roma Yumul, Rohini Krishnan, Jing Liu, Eniko-Eva Nagy, Manvendra Singh, Zsuzsanna Izsvák, Roberto Cattaneo, Wolfgang Uckert, Donna Palmer, Philip Ng, Kevin G. Haworth, Hans-Peter Kiem, Anja Ehrhardt, Thalia Papayannopoulou, André Lieber

Blood (2016) 128 (18): 2206–2217.

https://doi.org/10.1182/blood-2016-04-711580

Published: 2016

Includes: Supplemental data

Journal Articles

Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors

Raul Alba, Angela C. Bradshaw, Lynda Coughlan, Laura Denby, Robert A. McDonald, Simon N. Waddington, Suzanne M. K. Buckley, Jenny A. Greig, Alan L. Parker, Ashley M. Miller, Hongjie Wang, Andre Lieber, Nico van Rooijen, John H. McVey, Stuart A. Nicklin, Andrew H. Baker

Blood (2010) 116 (15): 2656–2664.

https://doi.org/10.1182/blood-2009-12-260026

Published: 2010

Includes: Supplemental data

Journal Articles

A recombinant adenovirus type 35 fiber knob protein sensitizes lymphoma cells to rituximab therapy

Hongjie Wang, Ying Liu, Zong-Yi Li, Xiaolong Fan, Akseli Hemminki, André Lieber

Blood (2010) 115 (3): 592–600.

https://doi.org/10.1182/blood-2009-05-222463

Published: 2010

Includes: Supplemental data

Journal Articles

Toward a stem cell gene therapy for breast cancer

ZongYi Li, Ying Liu, Sebastian Tuve, Ye Xun, Xiaolong Fan, Liang Min, Qinghua Feng, Nancy Kiviat, Hans-Peter Kiem, Mary Leonora Disis, André Lieber

Blood (2009) 113 (22): 5423–5433.

https://doi.org/10.1182/blood-2008-10-187237

Published: 2009

Includes: Supplemental data

Journal Articles

Multiple vitamin K-dependent coagulation zymogens promote adenovirus-mediated gene delivery to hepatocytes

Alan L. Parker, Simon N. Waddington, Campbell G. Nicol, Dmitry M. Shayakhmetov, Suzanne M. Buckley, Laura Denby, Geoffrey Kemball-Cook, Shaoheng Ni, Andre Lieber, John H. McVey, Stuart A. Nicklin, Andrew H. Baker

Blood (2006) 108 (8): 2554–2561.

https://doi.org/10.1182/blood-2006-04-008532

Published: 2006

NARROW

In vivo HSC prime editing rescues sickle cell disease in a mouse model

Persistent Control of SIV Infection in Rhesus Macaques By Expressing a Highly Potent SIV Decoy Receptor after In Vivo HSC Transduction

Enhanced HbF reactivation by multiplex mutagenesis of thalassemic CD34 + cells in vitro and in vivo

In Vivo HSC Gene Therapy with Base Editors Allows for Efficient Reactivation of Fetal Globin in Beta-Yac Mice

In Vivo HSC Gene Therapy for Hemoglobinopathies: A Proof of Concept Evaluation in Rhesus Macaques

Mgta-145 / Plerixafor-Mediated HSC Mobilization and Intravenous HDAd5/35++ Vector Injection into Mice Allows for Efficient In Vivo HSC Transduction and Stable Gene Marking in Peripheral Blood Cells of CD46-Transgenic and Thalassemia Mice

Combining HPFH Mutations in Human Adult HSCs to Enhance Reactivation of Fetal Hemoglobin

Thalassemia Gene Therapy By In Vivo Transduction of Mobilized Hematopoietic Stem Cells (HSCs) with an Integrating Hybrid Adenovirus Vector System

Reactivation of γ-globin in adult β-YAC mice after ex vivo and in vivo hematopoietic stem cell genome editing

Introduction of Two Simultaneous Mutations By Genome Editing Greatly Enhances the Accumulation of the Endogenous Fetal Hemoglobin in Human Normal Erythroid Cells

In Vivo HSC Transduction and Selection Results in Long-Term, High-Level Expression of Human Gamma Globin in Peripheral Blood Erythrocytes of Mice

In vivo transduction of primitive mobilized hematopoietic stem cells after intravenous injection of integrating adenovirus vectors

Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors

A recombinant adenovirus type 35 fiber knob protein sensitizes lymphoma cells to rituximab therapy

Toward a stem cell gene therapy for breast cancer

Multiple vitamin K-dependent coagulation zymogens promote adenovirus-mediated gene delivery to hepatocytes

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American Society of Hematology

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ASH Publications

American Society of Hematology

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