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Journal Articles

In vivo HSC prime editing rescues sickle cell disease in a mouse model

Chang Li, Aphrodite Georgakopoulou, Gregory A. Newby, Peter J. Chen, Kelcee A. Everette, Kiriaki Paschoudi, Efthymia Vlachaki, Sucheol Gil, Anna K. Anderson, Theodore Koob, Lishan Huang, Hongjie Wang, Hans-Peter Kiem, David R. Liu, Evangelia Yannaki, André Lieber

Blood (2023) 141 (17): 2085–2099.

https://doi.org/10.1182/blood.2022018252

Published: 2023

Includes: Supplemental data

Journal Articles

Persistent Control of SIV Infection in Rhesus Macaques By Expressing a Highly Potent SIV Decoy Receptor after In Vivo HSC Transduction

Chang Li, Hongjie Wang, Sucheol Gil, Veronica Nelson, Hans-Peter Kiem, Andre Lieber

Blood (2021) 138 (Supplement 1): 1855.

https://doi.org/10.1182/blood-2021-153808

Published: 2021

Journal Articles

In Vivo HSC Gene Therapy for Hemoglobinopathies: A Proof of Concept Evaluation in Rhesus Macaques

Chang Li, Hongjie Wang, PhD, Sucheol Gil, Afrodite Georgakopoulou, PhDstudent, Stefan Radtke, PhD, Evangelia Yannaki, MD, Thalia Papayannopoulou, MD DrSci, Hans-Peter Kiem, MDPhD, Andre Lieber, MD PhD

Blood (2020) 136 (Supplement 1): 46–47.

https://doi.org/10.1182/blood-2020-141468

Published: 2020

Journal Articles

Combining HPFH Mutations in Human Adult HSCs to Enhance Reactivation of Fetal Hemoglobin

Nikoletta Psatha, Afrodite Georgakopoulou, PhDstudent, Chang Li, PhD, Pavel Sova, Hongjie Wang, PhD, Andre Lieber, MD PhD, Thalia Papayannopoulou, MD DrSci

Blood (2019) 134 (Supplement_1): 2246.

https://doi.org/10.1182/blood-2019-131487

Published: 2019

Journal Articles

Integrin Alphav-beta3 on Podocytes Orchestrates Coagulation Protease Signaling through Protease-Activated Receptors

Madhusudhan Thati, PhD, Sanchita Ghosh, MS, Hongjie Wang, MD PhD, Wolfram Ruf, MD, Berend H. Isermann, MD

Blood (2018) 132 (Supplement 1): 137.

https://doi.org/10.1182/blood-2018-99-114566

Published: 2018

Journal Articles

Thalassemia Gene Therapy By In Vivo Transduction of Mobilized Hematopoietic Stem Cells (HSCs) with an Integrating Hybrid Adenovirus Vector System

Afrodite Georgakopoulou, PhDstudent, Hongjie Wang, PhD, Chrysi Kapsali, Undergraduate, Nikoleta Psatha, PhD, Angeliki Koufali, Graduate, Chang Li, PhD, Zsuzsanna Izsvak, PhD, Achilles Anagnostopoulos, Thalia Papayannopoulou, MD DrSci, Evangelia Yannaki, MD, Andre Lieber, MD PhD

Blood (2018) 132 (Supplement 1): 2193.

https://doi.org/10.1182/blood-2018-99-116787

Published: 2018

Journal Articles

Reactivation of γ-globin in adult β-YAC mice after ex vivo and in vivo hematopoietic stem cell genome editing

Chang Li, Nikoletta Psatha, Pavel Sova, Sucheol Gil, Hongjie Wang, Jiho Kim, Chandana Kulkarni, Cristina Valensisi, R. David Hawkins, George Stamatoyannopoulos, André Lieber

Blood (2018) 131 (26): 2915–2928.

https://doi.org/10.1182/blood-2018-03-838540

Published: 2018

Includes: Supplemental data

Journal Articles

Introduction of Two Simultaneous Mutations By Genome Editing Greatly Enhances the Accumulation of the Endogenous Fetal Hemoglobin in Human Normal Erythroid Cells

Nikoleta Psatha, PhD, Chang Li, PhD, Hongjie Wang, PhD, Demetri Dalas, George Stamatoyannopoulos, MD, Thalia Papayannopoulou, MD, Andre Lieber, MD PhD

Blood (2017) 130 (Supplement 1): 947.

https://doi.org/10.1182/blood.V130.Suppl_1.947.947

Published: 2017

Journal Articles

In Vivo HSC Transduction and Selection Results in Long-Term, High-Level Expression of Human Gamma Globin in Peripheral Blood Erythrocytes of Mice

Andre Lieber, MD PhD, Hongjie Wang, PhD, Nikoleta Psatha, PhD, Chang Li, PhD, Kevin G Haworth, BS, PhD, Anja Ehrhardt, PhD, Zsuzsanna Izsvak, Hans-Peter Kiem, MD PhD, George Stamatoyannopoulos, MD, Thalia Papayannopoulou, MD

Blood (2017) 130 (Supplement 1): 4616.

https://doi.org/10.1182/blood.V130.Suppl_1.4616.4616

Published: 2017

Journal Articles

Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin-like function

Blood (2017) 130 (12): 1445–1455.

https://doi.org/10.1182/blood-2017-02-767921

Published: 2017

Includes: Supplemental data

Journal Articles

Activated Protein C Targets PI3K-p85/XBP1 Pathway to Inhibit Hyperglycemia Induced Endoplasmic Reticulum Stress in Diabetic Nephropathy

Berend H. Isermann, MD, Hongjie Wang, MD, Peter P. Nawroth, MD, Thati Madhusudhan, PhD

Blood (2012) 120 (21): 3354.

https://doi.org/10.1182/blood.V120.21.3354.3354

Published: 2012

Journal Articles

Cytoprotective signaling by activated protein C requires protease-activated receptor-3 in podocytes

Thati Madhusudhan, Hongjie Wang, Beate K. Straub, Elisabeth Gröne, Qianxing Zhou, Khurrum Shahzad, Sandra Müller-Krebs, Vedat Schwenger, Bruce Gerlitz, Brian W. Grinnell, John H. Griffin, Jochen Reiser, Hermann-Josef Gröne, Charles T. Esmon, Peter P. Nawroth, Berend Isermann

Blood (2012) 119 (3): 874–883.

https://doi.org/10.1182/blood-2011-07-365973

Published: 2012

Includes: Supplemental data

Journal Articles

Intermediate Thrombin Activation Is Associated with Reduced Cardiovascular Death Independently of Markers of Lipid Metabolism and Inflammation

Berend H. Isermann, MD, Jochen Schneider, MD, Marcus E Kleber, Ph.D., Hongjie Wang, Bernhard O Boehm, MD, Tanja B Grammer, MD, Florian Prüller, MD, Peter P Nawroth, MD, Winfried März, MD

Blood (2011) 118 (21): 31.

https://doi.org/10.1182/blood.V118.21.31.31

Published: 2011

Journal Articles

Activated Protein C Controls p66shc: A Novel Defense Mechanism in Diabetic Nephropathy

Fabian M Bock, Khurrum Shahzad, Ph.D., Thati Madhusudhan, Ph.D., Hongjie Wang, Peter P Nawroth, MD, Berend H. Isermann, MD

Blood (2011) 118 (21): 2204.

https://doi.org/10.1182/blood.V118.21.2204.2204

Published: 2011

Journal Articles

Low but sustained coagulation activation ameliorates glucose-induced podocyte apoptosis: protective effect of factor V Leiden in diabetic nephropathy

Hongjie Wang, Thati Madhusudhan, Tao He, Björn Hummel, Simone Schmidt, Ilya A. Vinnikov, Khurrum Shahzad, Muhammed Kashif, Sandra Muller-Krebs, Vedat Schwenger, Angelika Bierhaus, Gottfried Rudofsky, Peter P. Nawroth, Berend Isermann

Blood (2011) 117 (19): 5231–5242.

https://doi.org/10.1182/blood-2010-10-314773

Published: 2011

Includes: Supplemental data

Journal Articles

The Lectin-Like Domain of Thrombomodulin Protects Against Diabetic Nephropathy by Inhibiting Complement Activation

Hongjie Wang, Ilya Vinnikov, Qianxing Zhou, Thati Madhusudhan, Khurrum Shahzad, Muhammed Kashif, Juliane Wolter, Angelika Bierhaus, Peter Nawroth, Edward M. Conway, MD, PhD, FRCPC, MBA, Berend Isermann

Blood (2010) 116 (21): 654.

https://doi.org/10.1182/blood.V116.21.654.654

Published: 2010

Journal Articles

PAR-3 Activation by Activated Protein C: a Novel Podocyte Protective Signalling Pathway

Thati Madhusudhan, Hongjie Wang, Sandra Müller-Krebs, Vedat Schwenger, Martin G. Zeier, Peter Nawroth, Charles Esmon, PhD, Berend Isermann

Blood (2010) 116 (21): 329.

https://doi.org/10.1182/blood.V116.21.329.329

Published: 2010

Journal Articles

Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors

Raul Alba, Angela C. Bradshaw, Lynda Coughlan, Laura Denby, Robert A. McDonald, Simon N. Waddington, Suzanne M. K. Buckley, Jenny A. Greig, Alan L. Parker, Ashley M. Miller, Hongjie Wang, Andre Lieber, Nico van Rooijen, John H. McVey, Stuart A. Nicklin, Andrew H. Baker

Blood (2010) 116 (15): 2656–2664.

https://doi.org/10.1182/blood-2009-12-260026

Published: 2010

Includes: Supplemental data

Journal Articles

A recombinant adenovirus type 35 fiber knob protein sensitizes lymphoma cells to rituximab therapy

Hongjie Wang, Ying Liu, Zong-Yi Li, Xiaolong Fan, Akseli Hemminki, André Lieber

Blood (2010) 115 (3): 592–600.

https://doi.org/10.1182/blood-2009-05-222463

Published: 2010

Includes: Supplemental data

NARROW

In vivo HSC prime editing rescues sickle cell disease in a mouse model

Persistent Control of SIV Infection in Rhesus Macaques By Expressing a Highly Potent SIV Decoy Receptor after In Vivo HSC Transduction

In Vivo HSC Gene Therapy for Hemoglobinopathies: A Proof of Concept Evaluation in Rhesus Macaques

Combining HPFH Mutations in Human Adult HSCs to Enhance Reactivation of Fetal Hemoglobin

Integrin Alphav-beta3 on Podocytes Orchestrates Coagulation Protease Signaling through Protease-Activated Receptors

Thalassemia Gene Therapy By In Vivo Transduction of Mobilized Hematopoietic Stem Cells (HSCs) with an Integrating Hybrid Adenovirus Vector System

Reactivation of γ-globin in adult β-YAC mice after ex vivo and in vivo hematopoietic stem cell genome editing

Introduction of Two Simultaneous Mutations By Genome Editing Greatly Enhances the Accumulation of the Endogenous Fetal Hemoglobin in Human Normal Erythroid Cells

In Vivo HSC Transduction and Selection Results in Long-Term, High-Level Expression of Human Gamma Globin in Peripheral Blood Erythrocytes of Mice

Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin-like function

Activated Protein C Targets PI3K-p85/XBP1 Pathway to Inhibit Hyperglycemia Induced Endoplasmic Reticulum Stress in Diabetic Nephropathy

Cytoprotective signaling by activated protein C requires protease-activated receptor-3 in podocytes

Intermediate Thrombin Activation Is Associated with Reduced Cardiovascular Death Independently of Markers of Lipid Metabolism and Inflammation

Activated Protein C Controls p66shc: A Novel Defense Mechanism in Diabetic Nephropathy

Low but sustained coagulation activation ameliorates glucose-induced podocyte apoptosis: protective effect of factor V Leiden in diabetic nephropathy

The Lectin-Like Domain of Thrombomodulin Protects Against Diabetic Nephropathy by Inhibiting Complement Activation

PAR-3 Activation by Activated Protein C: a Novel Podocyte Protective Signalling Pathway

Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors

A recombinant adenovirus type 35 fiber knob protein sensitizes lymphoma cells to rituximab therapy

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American Society of Hematology

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ASH Publications

American Society of Hematology

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