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Journal Articles

Survival Advantage Associated with Heterozygous Factor V Leiden Mutation in Sars-Cov-2-Infected K18-hACE2 Mice

Roberto Aiolfi, Jose A. Fernandez, Hiroshi Deguchi, Xiao Xu, Jeanine Ahmed, Miriam Hauer-Jensen, John H. Griffin, Juan Carlos de la Torre, Hartmut Weiler, Laurent O. Mosnier

Blood (2023) 142 (Supplement 1): 2563.

https://doi.org/10.1182/blood-2023-190742

Published: 2023

Journal Articles

Heterobivalent Peptide Agonists Comprising Covalently Linked Protease Activated Receptor 1 and Protease Activated Receptor 3 Peptides Mimic the Cytoprotective Cell Signaling Activities of Activated Protein C

Jose A. Fernandez, Laura D. Healy, Laurent O. Mosnier, John H. Griffin

Blood (2023) 142 (Supplement 1): 3976.

https://doi.org/10.1182/blood-2023-185096

Published: 2023

Journal Articles

Sars-Cov-2 Infection Promotes Endothelial Dysfunction and Thrombosis in a Mouse Model of COVID-19

Roberto Aiolfi, Jeanine Ahmed, Juan Carlos de la Torre, John H. Griffin, Laurent O. Mosnier

Blood (2021) 138 (Supplement 1): 999.

https://doi.org/10.1182/blood-2021-148713

Published: 2021

Journal Articles

Skeletal Muscle Myosin Is Procoagulant By Binding Factor XI Via Its A3 Domain and Enhancing Factor XI Activation By Thrombin

Hiroshi Deguchi, Shravan Morla, Jevgenia Zilberman-Rudenko, Andras Gruber, Owen J T McCarty, Priyanka Srivastava, David Gailani, John H. Griffin

Blood (2021) 138 (Supplement 1): 441.

https://doi.org/10.1182/blood-2021-151372

Published: 2021

Journal Articles

Factor VIIa induces extracellular vesicles from the endothelium: a potential mechanism for its hemostatic effect

Kaushik Das, Shiva Keshava, Shabbir A. Ansari, Vijay Kondreddy, Charles T. Esmon, John H. Griffin, Usha R. Pendurthi, L. Vijaya Mohan Rao

Blood (2021) 137 (24): 3428–3442.

https://doi.org/10.1182/blood.2020008417

Published: 2021

Includes: Supplemental data

Journal Articles

Procoagulant activities of skeletal muscle and cardiac myosins require both myosin protein and myosin-associated anionic phospholipids

Shravan Morla, Hiroshi Deguchi, José A. Fernández, Wolfram Ruf, Rolf A. Brekken, John H. Griffin

Blood (2021) 137 (13): 1839–1842.

https://doi.org/10.1182/blood.2020008580

Published: 2021

Journal Articles

Biased PAR-1 Signaling Regulates Thrombo-Inflammation in a Mouse Model of Sickle Cell Disease

Erica Sparkenbaugh, PhD, John H. Griffin, PhD, Laurent O Mosnier, Rafal Pawlinski, PhD

Blood (2020) 136 (Supplement 1): 16–17.

https://doi.org/10.1182/blood-2020-139862

Published: 2020

Journal Articles

Procoagulant Activity of Skeletal Muscle Myosin Is Not Caused By Contaminating Phosphatidylserine-Vesicles

Shravan Morla, Hiroshi Deguchi, MD PhD, Rolf Brekken, PhD, John H. Griffin, PhD

Blood (2020) 136 (Supplement 1): 20–21.

https://doi.org/10.1182/blood-2020-139574

Published: 2020

Journal Articles

Platelet protein S limits venous but not arterial thrombosis propensity by controlling coagulation in the thrombus

Sara Calzavarini, Raja Prince-Eladnani, François Saller, Luca Bologna, Laurent Burnier, Anne C. Brisset, Claudia Quarroz, Maria Desiré Reina Caro, Vladimir Ermolayev, Yasuhiro Matsumura, José A. Fernández, Tilman M. Hackeng, John H. Griffin, Anne Angelillo-Scherrer

Blood (2020) 135 (22): 1969–1982.

https://doi.org/10.1182/blood.2019003630

Published: 2020

Includes: Multimedia, Supplemental data

Journal Articles

Factor VIIa Induces Biased Cytoprotective Signaling through the Cleavage of Protease Activated Receptor 1 at Canonical Arg41 Site

Vijay Kumar Reddy Kondreddy, MSc,PhD, Usha R. Pendurthi, PhD, Xiao Xu, John H. Griffin, PhD, L. Vijaya Mohan Rao, PhD

Blood (2019) 134 (Supplement_1): 481.

https://doi.org/10.1182/blood-2019-124976

Published: 2019

Journal Articles

Molecular Interaction Site on Procoagulant Skeletal Muscle Myosin for Factor Xa-Dependent Prothrombin Activation

Hiroshi Deguchi, MD PhD, Zihan Guo, Mohammed Hayat, Elsa Pflimlin, Weijun Shen, John H. Griffin, PhD

Blood (2019) 134 (Supplement_1): 3622.

https://doi.org/10.1182/blood-2019-129161

Published: 2019

Journal Articles

Cardiac Myosin Acts Is a Potent Procoagulant in Vitro and In Vivo

Jevgenia Zilberman-Rudenko, Hiroshi Deguchi, MD PhD, Mohammed Hayat, Meenal Shukla, PhD, Jennifer Nagrampa Orje, Zihan Guo, Tine Wyseure, PhD, Laurent O Mosnier, Owen J T McCarty, PhD, Zaverio M. Ruggeri, MD, John H. Griffin, PhD

Blood (2019) 134 (Supplement_1): 3632.

https://doi.org/10.1182/blood-2019-129312

Published: 2019

Journal Articles

Tissue factor pathway inhibitor primes monocytes for antiphospholipid antibody-induced thrombosis

Nadine Müller-Calleja, Anne Hollerbach, Svenja Ritter, Denise G. Pedrosa, Dennis Strand, Claudine Graf, Christoph Reinhardt, Susanne Strand, Philippe Poncelet, John H. Griffin, Karl J. Lackner, Wolfram Ruf

Blood (2019) 134 (14): 1119–1131.

https://doi.org/10.1182/blood.2019001530

Published: 2019

Journal Articles

Activated protein C ameliorates chronic graft-versus-host disease by PAR1-dependent biased cell signaling on T cells

Ranjeet K. Sinha, Ryan Flynn, Michael Zaiken, Katelyn Paz, Amanda L. Gavin, David Nemazee, José A. Fernández, Xiao Xu, John H. Griffin, Bruce R. Blazar

Blood (2019) 134 (9): 776–781.

https://doi.org/10.1182/blood.2019001259

Published: 2019

Journal Articles

Activated protein C, protease activated receptor 1, and neuroprotection

John H. Griffin, Berislav V. Zlokovic, Laurent O. Mosnier

Blood (2018) 132 (2): 159–169.

https://doi.org/10.1182/blood-2018-02-769026

Published: 2018

Journal Articles

Targeting anticoagulant protein S to improve hemostasis in hemophilia

Blood (2018) 131 (12): 1360–1371.

https://doi.org/10.1182/blood-2017-09-800326

Published: 2018

Includes: Supplemental data

Journal Articles

PAR1 biased signaling is required for activated protein C in vivo benefits in sepsis and stroke

Ranjeet K. Sinha, Yaoming Wang, Zhen Zhao, Xiao Xu, Laurent Burnier, Naveen Gupta, José A. Fernández, Greg Martin, Sergey Kupriyanov, Laurent O. Mosnier, Berislav V. Zlokovic, John H. Griffin

Blood (2018) 131 (11): 1163–1171.

https://doi.org/10.1182/blood-2017-10-810895

Published: 2018

Includes: Supplemental data

Journal Articles

Cytoprotective activated protein C averts Nlrp3 inflammasome–induced ischemia-reperfusion injury via mTORC1 inhibition

Sumra Nazir, Ihsan Gadi, Moh’d Mohanad Al-Dabet, Ahmed Elwakiel, Shrey Kohli, Sanchita Ghosh, Jayakumar Manoharan, Satish Ranjan, Fabian Bock, Ruediger C. Braun-Dullaeus, Charles T. Esmon, Tobias B. Huber, Eric Camerer, Chris Dockendorff, John H. Griffin, Berend Isermann, Khurrum Shahzad

Blood (2017) 130 (24): 2664–2677.

https://doi.org/10.1182/blood-2017-05-782102

Published: 2017

Includes: Supplemental data

Journal Articles

Blocking Protein S Improves Hemostasis in Hemophilia a and B

Luca Bologna, PhDstudent, Raja Prince, PhDstudent, Mirko Manetti, PhD, Daniela Melchiorre, MD, Irene Rosa, PhDstudent, Natacha Dewarrat, Poorya Amini, PhDstudent, Jose A Fernandez, Claudia Quarroz, Yasuhiro Matsumura, MD PhD, Johanna A Kremer Hovinga, MD PhD, Shida Yousefi, PhD, John H. Griffin, PhD, Simon Hans-Uwe, MD PhD, Lidia Ibba Manneschi, Francois Saller, PhD, Sara Calzavarini, PhD, Anne Angelillo-Scherrer, MD

Blood (2016) 128 (22): 79.

https://doi.org/10.1182/blood.V128.22.79.79

Published: 2016

Journal Articles

Novel R41Q- and R46Q-PAR1-Modified Mice Enable Proof-of-Concept Studies for In Vivo Protective Mechanisms of Action for Activated Protein C (APC) in Sepsis and Stroke

Ranjeet Kumar Sinha, PhD MSc, Yaoming Wang, PhD, Zhen Zhao, PhD, Jose A. Fernandez, MD PhD, Naveen Gupta, Xiao Xu, MSc, Greg Martin, MSc, Sergey Kupriyanov, PhD MSc, Laurent O Mosnier, PhD, Berislav Zlokovic, PhD, John H. Griffin, PhD

Blood (2016) 128 (22): 13.

https://doi.org/10.1182/blood.V128.22.13.13

Published: 2016

NARROW

Survival Advantage Associated with Heterozygous Factor V Leiden Mutation in Sars-Cov-2-Infected K18-hACE2 Mice

Heterobivalent Peptide Agonists Comprising Covalently Linked Protease Activated Receptor 1 and Protease Activated Receptor 3 Peptides Mimic the Cytoprotective Cell Signaling Activities of Activated Protein C

Sars-Cov-2 Infection Promotes Endothelial Dysfunction and Thrombosis in a Mouse Model of COVID-19

Skeletal Muscle Myosin Is Procoagulant By Binding Factor XI Via Its A3 Domain and Enhancing Factor XI Activation By Thrombin

Factor VIIa induces extracellular vesicles from the endothelium: a potential mechanism for its hemostatic effect

Procoagulant activities of skeletal muscle and cardiac myosins require both myosin protein and myosin-associated anionic phospholipids

Biased PAR-1 Signaling Regulates Thrombo-Inflammation in a Mouse Model of Sickle Cell Disease

Procoagulant Activity of Skeletal Muscle Myosin Is Not Caused By Contaminating Phosphatidylserine-Vesicles

Platelet protein S limits venous but not arterial thrombosis propensity by controlling coagulation in the thrombus

Factor VIIa Induces Biased Cytoprotective Signaling through the Cleavage of Protease Activated Receptor 1 at Canonical Arg41 Site

Molecular Interaction Site on Procoagulant Skeletal Muscle Myosin for Factor Xa-Dependent Prothrombin Activation

Cardiac Myosin Acts Is a Potent Procoagulant in Vitro and In Vivo

Tissue factor pathway inhibitor primes monocytes for antiphospholipid antibody-induced thrombosis

Activated protein C ameliorates chronic graft-versus-host disease by PAR1-dependent biased cell signaling on T cells

Activated protein C, protease activated receptor 1, and neuroprotection

Targeting anticoagulant protein S to improve hemostasis in hemophilia

PAR1 biased signaling is required for activated protein C in vivo benefits in sepsis and stroke

Cytoprotective activated protein C averts Nlrp3 inflammasome–induced ischemia-reperfusion injury via mTORC1 inhibition

Blocking Protein S Improves Hemostasis in Hemophilia a and B

Novel R41Q- and R46Q-PAR1-Modified Mice Enable Proof-of-Concept Studies for In Vivo Protective Mechanisms of Action for Activated Protein C (APC) in Sepsis and Stroke

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American Society of Hematology

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American Society of Hematology

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