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Journal Articles

Enhanced Thrombotic Susceptibility, Endotheliopathy, and Abnormal Cognitive Behavior for up to 5 Months after Sars-Cov-2 Infection in a Mouse Model of Long COVID

Roberto Aiolfi, Antonella Zampolli, Miriam Hauer-Jensen, Jose A. Fernandez, Xiao Xu, Angel Gandarilla, Julia C.O. Mosnier, Amanda J. Roberts, Juan Carlos de la Torre, Laurent O. Mosnier

Blood (2024) 144 (Supplement 1): 1230.

https://doi.org/10.1182/blood-2024-212054

Published: 2024

Journal Articles

Survival Advantage Associated with Heterozygous Factor V Leiden Mutation in Sars-Cov-2-Infected K18-hACE2 Mice

Roberto Aiolfi, Jose A. Fernandez, Hiroshi Deguchi, Xiao Xu, Jeanine Ahmed, Miriam Hauer-Jensen, John H. Griffin, Juan Carlos de la Torre, Hartmut Weiler, Laurent O. Mosnier

Blood (2023) 142 (Supplement 1): 2563.

https://doi.org/10.1182/blood-2023-190742

Published: 2023

Journal Articles

STI-8591, a Novel Tyrosine Kinase Inhibitor, Shows Excellent Antileukemic Activity in FLT3 -Mutated (mut) Acute Myeloid Leukemia (AML)

Yi Zhang, Wenwen Wei, Bin Zhang, Jie Sun, Dandan Zhao, Fang Chen, Yongfang Xu, Yu Qian, Yanchun Zhao, Yutong Zhou, Wanhong Xu, Xiaoying Zhang, Long Mao, Guido Marcucci, Xiao Xu, Jie Jin

Blood (2023) 142 (Supplement 1): 5010.

https://doi.org/10.1182/blood-2023-174745

Published: 2023

Journal Articles

Factor VIIa Induces Biased Cytoprotective Signaling through the Cleavage of Protease Activated Receptor 1 at Canonical Arg41 Site

Vijay Kumar Reddy Kondreddy, MSc,PhD, Usha R. Pendurthi, PhD, Xiao Xu, John H. Griffin, PhD, L. Vijaya Mohan Rao, PhD

Blood (2019) 134 (Supplement_1): 481.

https://doi.org/10.1182/blood-2019-124976

Published: 2019

Journal Articles

Activated protein C ameliorates chronic graft-versus-host disease by PAR1-dependent biased cell signaling on T cells

Ranjeet K. Sinha, Ryan Flynn, Michael Zaiken, Katelyn Paz, Amanda L. Gavin, David Nemazee, José A. Fernández, Xiao Xu, John H. Griffin, Bruce R. Blazar

Blood (2019) 134 (9): 776–781.

https://doi.org/10.1182/blood.2019001259

Published: 2019

Journal Articles

PAR1 biased signaling is required for activated protein C in vivo benefits in sepsis and stroke

Ranjeet K. Sinha, Yaoming Wang, Zhen Zhao, Xiao Xu, Laurent Burnier, Naveen Gupta, José A. Fernández, Greg Martin, Sergey Kupriyanov, Laurent O. Mosnier, Berislav V. Zlokovic, John H. Griffin

Blood (2018) 131 (11): 1163–1171.

https://doi.org/10.1182/blood-2017-10-810895

Published: 2018

Includes: Supplemental data

Journal Articles

Novel R41Q- and R46Q-PAR1-Modified Mice Enable Proof-of-Concept Studies for In Vivo Protective Mechanisms of Action for Activated Protein C (APC) in Sepsis and Stroke

Ranjeet Kumar Sinha, PhD MSc, Yaoming Wang, PhD, Zhen Zhao, PhD, Jose A. Fernandez, MD PhD, Naveen Gupta, Xiao Xu, MSc, Greg Martin, MSc, Sergey Kupriyanov, PhD MSc, Laurent O Mosnier, PhD, Berislav Zlokovic, PhD, John H. Griffin, PhD

Blood (2016) 128 (22): 13.

https://doi.org/10.1182/blood.V128.22.13.13

Published: 2016

Journal Articles

Activated Protein C (APC) Therapy Ameliorates Chronic Graft Versus Host Disease By Cell Signaling Mechanisms That Require Cleavage at Arg46 in PAR1 on T Cells

Ranjeet Kumar Sinha, PhD MSc, Ryan P Flynn, PhD, Jose A. Fernandez, MD PhD, Xiao Xu, MSc, Greg Martin, MSc, Sergey Kupriyanov, PhD MSc, John H. Griffin, PhD, Bruce R. Blazar, MD

Blood (2016) 128 (22): 808.

https://doi.org/10.1182/blood.V128.22.808.808

Published: 2016

Journal Articles

Novel R41Q-PAR1-Modified Mice Enable Proof-of-Concept Studies for in Vivo Mechanisms of Action for Thrombin (IIa) and Activated Protein C (APC)

Ranjeet Kumar Sinha, PhD, Laurent Burnier, PhD, Naveen Gupta, MD, Xiao Xu, MS, Sergey Kupriyanov, PhD, Greg Martin, MS, Laurent O. Mosnier, PhD, John H. Griffin, PhD

Blood (2014) 124 (21): 99.

https://doi.org/10.1182/blood.V124.21.99.99

Published: 2014

Journal Articles

Systematic analysis of microRNA fingerprints in thrombocythemic platelets using integrated platforms

Xiao Xu, Dmitri V. Gnatenko, Jingfang Ju, Ian S. Hitchcock, Dwight W. Martin, Wei Zhu, Wadie F. Bahou

Blood (2012) 120 (17): 3575–3585.

https://doi.org/10.1182/blood-2012-02-411264

Published: 2012

Includes: Supplemental data

Journal Articles

Class prediction models of thrombocytosis using genetic biomarkers

Dmitri V. Gnatenko, Wei Zhu, Xiao Xu, Edward T. Samuel, Melissa Monaghan, Mohammad H. Zarrabi, Christi Kim, Anil Dhundale, Wadie F. Bahou

Blood (2010) 115 (1): 7–14.

https://doi.org/10.1182/blood-2009-05-224477

Published: 2010

Includes: Supplemental data

Journal Articles

Molecular Characteristics of Platelet Formation Studied by Genetic Profiling.

Suraj H. Rambhia, B.S., B.E., Xiao Xu, M.S., Dmitri V. Gnatenko, Ph.D., Wei Zhu, Ph.D., Wadie F. Bahou, MD

Blood (2009) 114 (22): 4584.

https://doi.org/10.1182/blood.V114.22.4584.4584

Published: 2009

Journal Articles

Activation of the PI3K-Akt Pathway by Activated Protein C Occurs Via a Novel Receptor, Apolipoprotein E Receptor 2 (ApoER2)

Xia V. Yang, PhD, Yajnavalka Banerjee, PhD, Jose A. Fernandez, MD, PhD, Hiroshi Deguchi, MD, PhD, Xiao Xu, Laurent O. Mosnier, PhD, Rolf T Urbanus, MD, Phillip G deGroot, PhD, Tara C White, Owen J.T. McCarty, PhD, John H. Griffin, PhD

Blood (2008) 112 (11): 695.

https://doi.org/10.1182/blood.V112.11.695.695

Published: 2008

Journal Articles

Evaluation of the Relationship Between Venous Thromboembolism Risk Factors and the Use of Antithrombotic Prophylaxis in Multiple Myeloma Patients Treated with Thalidomide and Dexamethasone Combination Regimens

Nancy A Brandenburg, PhD, Thomas F Goss, PharmD, Tyler Knight, MS, Xiao Xu, PhD, Robert D. Knight, MD

Blood (2008) 112 (11): 2369.

https://doi.org/10.1182/blood.V112.11.2369.2369

Published: 2008

Journal Articles

Extensive Venous and Arterial Thrombosis Associated With an Inhibitor to Activated Protein C

Ariella Zivelin, Sanford Gitel, John H. Griffin, Xiao Xu, Jose A. Fernandez, Uri Martinowitz, Yael Cohen, Hillel Halkin, Uri Seligsohn, Aida Inbal

Blood (1999) 94 (3): 895–901.

https://doi.org/10.1182/blood.V94.3.895.415k01_895_901

Published: 1999

Journal Articles

A Single Genetic Origin for a Common Caucasian Risk Factor for Venous Thrombosis

Ariella Zivelin, John H. Griffin, Xiao Xu, Ingrid Pabinger, Michel Samama, Jacqueline Conard, Benjamin Brenner, Amiram Eldor, Uri Seligsohn

Blood (1997) 89 (2): 397–402.

https://doi.org/10.1182/blood.V89.2.397

Published: 1997

NARROW

Enhanced Thrombotic Susceptibility, Endotheliopathy, and Abnormal Cognitive Behavior for up to 5 Months after Sars-Cov-2 Infection in a Mouse Model of Long COVID

Survival Advantage Associated with Heterozygous Factor V Leiden Mutation in Sars-Cov-2-Infected K18-hACE2 Mice

STI-8591, a Novel Tyrosine Kinase Inhibitor, Shows Excellent Antileukemic Activity in FLT3 -Mutated (mut) Acute Myeloid Leukemia (AML)

Factor VIIa Induces Biased Cytoprotective Signaling through the Cleavage of Protease Activated Receptor 1 at Canonical Arg41 Site

Activated protein C ameliorates chronic graft-versus-host disease by PAR1-dependent biased cell signaling on T cells

PAR1 biased signaling is required for activated protein C in vivo benefits in sepsis and stroke

Novel R41Q- and R46Q-PAR1-Modified Mice Enable Proof-of-Concept Studies for In Vivo Protective Mechanisms of Action for Activated Protein C (APC) in Sepsis and Stroke

Activated Protein C (APC) Therapy Ameliorates Chronic Graft Versus Host Disease By Cell Signaling Mechanisms That Require Cleavage at Arg46 in PAR1 on T Cells

Novel R41Q-PAR1-Modified Mice Enable Proof-of-Concept Studies for in Vivo Mechanisms of Action for Thrombin (IIa) and Activated Protein C (APC)

Systematic analysis of microRNA fingerprints in thrombocythemic platelets using integrated platforms

Class prediction models of thrombocytosis using genetic biomarkers

Molecular Characteristics of Platelet Formation Studied by Genetic Profiling.

Activation of the PI3K-Akt Pathway by Activated Protein C Occurs Via a Novel Receptor, Apolipoprotein E Receptor 2 (ApoER2)

Evaluation of the Relationship Between Venous Thromboembolism Risk Factors and the Use of Antithrombotic Prophylaxis in Multiple Myeloma Patients Treated with Thalidomide and Dexamethasone Combination Regimens

Extensive Venous and Arterial Thrombosis Associated With an Inhibitor to Activated Protein C

A Single Genetic Origin for a Common Caucasian Risk Factor for Venous Thrombosis

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American Society of Hematology

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American Society of Hematology

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