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Journal Articles

Coagulation factor XI regulates endothelial cell permeability and barrier function in vitro and in vivo

Cristina Puy, Samantha A. Moellmer, Jiaqing Pang, Helen H. Vu, Alexander R. Melrose, Christina U. Lorentz, Erik I. Tucker, Joseph J. Shatzel, Ravi S. Keshari, Florea Lupu, David Gailani, Owen J. T. McCarty

Blood (2024) 144 (17): 1821–1833.

https://doi.org/10.1182/blood.2023022257

Published: 2024

Includes: Supplemental data

Journal Articles

Targeting factor XI and factor XIa to prevent thrombosis

David Gailani, Andras Gruber

Blood (2024) 143 (15): 1465–1475.

https://doi.org/10.1182/blood.2023020722

Published: 2024

Journal Articles

A mechanism for hereditary angioedema caused by a methionine-379–to–lysine substitution in kininogens

S. Kent Dickeson, Sunil Kumar, Mao-fu Sun, Maxim Litvak, Tracey Z. He, Dennis R. Phillips, Elijah T. Roberts, Edward P. Feener, Ruby H. P. Law, David Gailani

Blood (2024) 143 (7): 641–650.

https://doi.org/10.1182/blood.2023022254

Published: 2024

Includes: Supplemental data

Journal Articles

Forms of Hereditary Angioedema That Are Independent of Kallikrein and Factor XIIa System

Maxim Litvak, Stephen Kent Dickeson, Sunil Kumar, Dennis Phillips, Ruby Law, David Gailani

Blood (2023) 142 (Supplement 1): 2599.

https://doi.org/10.1182/blood-2023-189458

Published: 2023

Journal Articles

First Validated Model of Zymogen Factor XII Provides Insights into Protein Assembly and Activation

Aleksandr Shamanaev, Mao-Fu Sun, Michal Ponczek, Jonas Emsley, David Gailani

Blood (2023) 142 (Supplement 1): 23.

https://doi.org/10.1182/blood-2023-190006

Published: 2023

Journal Articles

Hereditary angioedema and thrombosis

David Gailani

Blood (2023) 141 (19): 2295–2297.

https://doi.org/10.1182/blood.2023019861

Published: 2023

Journal Articles

Factor XII contributes to thrombotic complications and vaso-occlusion in sickle cell disease

Blood (2023) 141 (15): 1871–1883.

https://doi.org/10.1182/blood.2022017074

Published: 2023

Includes: Multimedia, Supplemental data

Journal Articles

Antiplatelet Effects of Inhibiting Coagulation Factor XI in a Diet-Induced Obesity Model of Early Atherosclerosis

Tia CL Kohs, Iván Parra-Izquierdo, Helen Vu, Monica T Hinds, Joseph J Shatzel, Joseph E Aslan, Michael Wallisch, Erik I Tucker, Christina U Lorentz, Cristina Puy, David Gailani, Owen JT McCarty

Blood (2022) 140 (Supplement 1): 8437.

https://doi.org/10.1182/blood-2022-170472

Published: 2022

Journal Articles

A mechanism for hereditary angioedema caused by a lysine 311–to–glutamic acid substitution in plasminogen

S. Kent Dickeson, Sunil Kumar, Mao-Fu Sun, Bassem M. Mohammed, Dennis R. Phillips, James C. Whisstock, Adam J. Quek, Edward P. Feener, Ruby H. P. Law, David Gailani

Blood (2022) 139 (18): 2816–2829.

https://doi.org/10.1182/blood.2021012945

Published: 2022

Includes: Supplemental data

Journal Articles

The contact activation inhibitor AB023 in heparin-free hemodialysis: results of a randomized phase 2 clinical trial

Christina U. Lorentz, Erik I. Tucker, Norah G. Verbout, Joseph J. Shatzel, Sven R. Olson, Brandon D. Markway, Michael Wallisch, Martina Ralle, Monica T. Hinds, Owen J. T. McCarty, David Gailani, Jeffrey I. Weitz, András Gruber

Blood (2021) 138 (22): 2173–2184.

https://doi.org/10.1182/blood.2021011725

Published: 2021

Includes: Supplemental data

Journal Articles

Skeletal Muscle Myosin Is Procoagulant By Binding Factor XI Via Its A3 Domain and Enhancing Factor XI Activation By Thrombin

Hiroshi Deguchi, Shravan Morla, Jevgenia Zilberman-Rudenko, Andras Gruber, Owen J T McCarty, Priyanka Srivastava, David Gailani, John H. Griffin

Blood (2021) 138 (Supplement 1): 441.

https://doi.org/10.1182/blood-2021-151372

Published: 2021

Journal Articles

Factor XII plays a pathogenic role in organ failure and death in baboons challenged with Staphylococcus aureus

Robert Silasi, Ravi S. Keshari, Girija Regmi, Cristina Lupu, Constantin Georgescu, Joe H. Simmons, Michael Wallisch, Tia C. L. Kohs, Joseph J. Shatzel, Sven R. Olson, Christina U. Lorentz, Cristina Puy, Erik I. Tucker, David Gailani, Sidney Strickland, András Gruber, Owen J. T. McCarty, Florea Lupu

Blood (2021) 138 (2): 178–189.

https://doi.org/10.1182/blood.2020009345

Published: 2021

Includes: Supplemental data

Journal Articles

Safety and Efficacy of the Contact Activation Inhibitor AB023 in Patients with End-Stage Renal Disease on Chronic Hemodialysis: A Phase 2, Double-Blind, Randomized, Placebo-Controlled Trial

Christina U Lorentz, PhD, Norah G Verbout, PhD, Joseph J Shatzel, MD, Michael Wallisch, PhD, Brandon D Markway, PhD, Monica T Hinds, PhD, Owen J T McCarty, PhD, David Gailani, MD, Jeffrey I. Weitz, MDFRCPC, Erik I Tucker, PhD, András Gruber, MD

Blood (2020) 136 (Supplement 1): 23–24.

https://doi.org/10.1182/blood-2020-139948

Published: 2020

Journal Articles

Protease activity in single-chain prekallikrein

Ivan Ivanov, Ingrid M. Verhamme, Mao-fu Sun, Bassem Mohammed, Qiufang Cheng, Anton Matafonov, S. Kent Dickeson, Kusumam Joseph, Allen P. Kaplan, David Gailani

Blood (2020) 135 (8): 558–567.

https://doi.org/10.1182/blood.2019002224

Published: 2020

Includes: Supplemental data

Journal Articles

Factor IX for treating factor XI deficiency?

David Gailani

Blood (2019) 134 (6): 501–502.

https://doi.org/10.1182/blood.2019001826

Published: 2019

Journal Articles

A mechanism for hereditary angioedema with normal C1 inhibitor: an inhibitory regulatory role for the factor XII heavy chain

Ivan Ivanov, Anton Matafonov, Mao-fu Sun, Bassem M. Mohammed, Qiufang Cheng, S. Kent Dickeson, Suman Kundu, Ingrid M. Verhamme, Andras Gruber, Keith McCrae, David Gailani

Blood (2019) 133 (10): 1152–1163.

https://doi.org/10.1182/blood-2018-06-860270

Published: 2019

Includes: Supplemental data

Journal Articles

Peptidoglycan induces disseminated intravascular coagulation in baboons through activation of both coagulation pathways

Narcis I. Popescu, Robert Silasi, Ravi S. Keshari, Alanson Girton, Tarea Burgett, Sacha S. Zeerleder, David Gailani, Andras Gruber, Florea Lupu, K. Mark Coggeshall

Blood (2018) 132 (8): 849–860.

https://doi.org/10.1182/blood-2017-10-813618

Published: 2018

Includes: Supplemental data

Journal Articles

Making thrombolysis safer in stroke

David Gailani

Blood (2017) 129 (16): 2212–2213.

https://doi.org/10.1182/blood-2017-02-765610

Published: 2017

Journal Articles

Proteolytic properties of single-chain factor XII: a mechanism for triggering contact activation

Ivan Ivanov, Anton Matafonov, Mao-fu Sun, Qiufang Cheng, S. Kent Dickeson, Ingrid M. Verhamme, Jonas Emsley, David Gailani

Blood (2017) 129 (11): 1527–1537.

https://doi.org/10.1182/blood-2016-10-744110

Published: 2017

Includes: Supplemental data

Journal Articles

Discovery and Characterization of a Highly Specific Antibody Inhibitor of Factor XIIa, and the Subsequent Generation of a Factor XIIa/Plasma Kallikrein Bispecific Antibody

Blood (2015) 126 (23): 2268.

https://doi.org/10.1182/blood.V126.23.2268.2268

Published: 2015

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Coagulation factor XI regulates endothelial cell permeability and barrier function in vitro and in vivo

Targeting factor XI and factor XIa to prevent thrombosis

A mechanism for hereditary angioedema caused by a methionine-379–to–lysine substitution in kininogens

Forms of Hereditary Angioedema That Are Independent of Kallikrein and Factor XIIa System

First Validated Model of Zymogen Factor XII Provides Insights into Protein Assembly and Activation

Hereditary angioedema and thrombosis

Factor XII contributes to thrombotic complications and vaso-occlusion in sickle cell disease

Antiplatelet Effects of Inhibiting Coagulation Factor XI in a Diet-Induced Obesity Model of Early Atherosclerosis

A mechanism for hereditary angioedema caused by a lysine 311–to–glutamic acid substitution in plasminogen

The contact activation inhibitor AB023 in heparin-free hemodialysis: results of a randomized phase 2 clinical trial

Skeletal Muscle Myosin Is Procoagulant By Binding Factor XI Via Its A3 Domain and Enhancing Factor XI Activation By Thrombin

Factor XII plays a pathogenic role in organ failure and death in baboons challenged with Staphylococcus aureus

Safety and Efficacy of the Contact Activation Inhibitor AB023 in Patients with End-Stage Renal Disease on Chronic Hemodialysis: A Phase 2, Double-Blind, Randomized, Placebo-Controlled Trial

Protease activity in single-chain prekallikrein

Factor IX for treating factor XI deficiency?

A mechanism for hereditary angioedema with normal C1 inhibitor: an inhibitory regulatory role for the factor XII heavy chain

Peptidoglycan induces disseminated intravascular coagulation in baboons through activation of both coagulation pathways

Making thrombolysis safer in stroke

Proteolytic properties of single-chain factor XII: a mechanism for triggering contact activation

Discovery and Characterization of a Highly Specific Antibody Inhibitor of Factor XIIa, and the Subsequent Generation of a Factor XIIa/Plasma Kallikrein Bispecific Antibody

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