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Journal Articles

Factor XI Inhibition for the Prevention of Catheter-Associated Thrombosis in Cancer Patients Undergoing Central Line Placement: A Phase 2 Clinical Trial

Michael A Pfeffer, Helen Vu, Tia CL Kohs, Jenny Wang, Christina U Lorentz, Erik I Tucker, Sven R Olson, Thomas G Deloughery, Monica T Hinds, Owen JT McCarty, Joseph J Shatzel

Blood (2022) 140 (Supplement 1): 1247–1249.

https://doi.org/10.1182/blood-2022-170429

Published: 2022

Journal Articles

Antiplatelet Effects of Inhibiting Coagulation Factor XI in a Diet-Induced Obesity Model of Early Atherosclerosis

Tia CL Kohs, Iván Parra-Izquierdo, Helen Vu, Monica T Hinds, Joseph J Shatzel, Joseph E Aslan, Michael Wallisch, Erik I Tucker, Christina U Lorentz, Cristina Puy, David Gailani, Owen JT McCarty

Blood (2022) 140 (Supplement 1): 8437.

https://doi.org/10.1182/blood-2022-170472

Published: 2022

Journal Articles

The contact activation inhibitor AB023 in heparin-free hemodialysis: results of a randomized phase 2 clinical trial

Christina U. Lorentz, Erik I. Tucker, Norah G. Verbout, Joseph J. Shatzel, Sven R. Olson, Brandon D. Markway, Michael Wallisch, Martina Ralle, Monica T. Hinds, Owen J. T. McCarty, David Gailani, Jeffrey I. Weitz, András Gruber

Blood (2021) 138 (22): 2173–2184.

https://doi.org/10.1182/blood.2021011725

Published: 2021

Includes: Supplemental data

Journal Articles

A Phase 2 Trial of the Protein C Activator AB002 in End-Stage Renal Disease Patients on Chronic Hemodialysis

Norah G Verbout, Christina U Lorentz, Brandon D Markway, Michael Wallisch, Joseph J Shatzel, Andras Gruber, Erik I Tucker

Blood (2021) 138 (Supplement 1): 669.

https://doi.org/10.1182/blood-2021-148208

Published: 2021

Journal Articles

Factor XII plays a pathogenic role in organ failure and death in baboons challenged with Staphylococcus aureus

Robert Silasi, Ravi S. Keshari, Girija Regmi, Cristina Lupu, Constantin Georgescu, Joe H. Simmons, Michael Wallisch, Tia C. L. Kohs, Joseph J. Shatzel, Sven R. Olson, Christina U. Lorentz, Cristina Puy, Erik I. Tucker, David Gailani, Sidney Strickland, András Gruber, Owen J. T. McCarty, Florea Lupu

Blood (2021) 138 (2): 178–189.

https://doi.org/10.1182/blood.2020009345

Published: 2021

Includes: Supplemental data

Journal Articles

Safety and Efficacy of the Contact Activation Inhibitor AB023 in Patients with End-Stage Renal Disease on Chronic Hemodialysis: A Phase 2, Double-Blind, Randomized, Placebo-Controlled Trial

Christina U Lorentz, PhD, Norah G Verbout, PhD, Joseph J Shatzel, MD, Michael Wallisch, PhD, Brandon D Markway, PhD, Monica T Hinds, PhD, Owen J T McCarty, PhD, David Gailani, MD, Jeffrey I. Weitz, MDFRCPC, Erik I Tucker, PhD, András Gruber, MD

Blood (2020) 136 (Supplement 1): 23–24.

https://doi.org/10.1182/blood-2020-139948

Published: 2020

Journal Articles

The protein C activator AB002 rapidly interrupts thrombus development in baboons

Erik I. Tucker, Norah G. Verbout, Brandon D. Markway, Michael Wallisch, Christina U. Lorentz, Monica T. Hinds, Joseph J. Shatzel, Leslie A. Pelc, David C. Wood, Owen J. T. McCarty, Enrico Di Cera, András Gruber

Blood (2020) 135 (9): 689–699.

https://doi.org/10.1182/blood.2019002771

Published: 2020

Includes: Supplemental data

Journal Articles

Safety and Antithrombotic Efficacy of the Recombinant Protein C Activator AB002 (E-WE Thrombin) in End Stage Renal Disease Patients on Chronic Hemodialysis

Norah G Verbout, PhD, Christina U Lorentz, PhD, Brandon D Markway, PhD, Joseph J Shatzel, MD, Erik I Tucker, PhD, Andras Gruber, MD

Blood (2019) 134 (Supplement_1): 2433.

https://doi.org/10.1182/blood-2019-124999

Published: 2019

Journal Articles

The Anti-Factor XII Antibody AB052 Is Antithrombotic without Hemostatic Impairment in a Primate Model of Extracorporeal Membrane Oxygenation

Michael Wallisch, PhD, Erik I Tucker, PhD, Christina U Lorentz, PhD, Jennifer Johnson, RLATG, Marschelle R Carris, BA, Owen JT McCarty, PhD, Monica T Hinds, PhD, András Gruber, MD

Blood (2017) 130 (Supplement 1): 236.

https://doi.org/10.1182/blood.V130.Suppl_1.236.236

Published: 2017

Journal Articles

Inhibition of Factor XIIa-Mediated Factor XI Activation Reduces Infarct Size in a Mouse Model of Myocardial Ischemia and Reperfusion

Christina U Lorentz, PhD, Norah G Verbout, PhD, Zhiping Cao, Helen Liu, Owen J.T. McCarty, PhD, Erik I. Tucker, PhD, Andras Gruber, MD, Donna Van Winkle, PhD

Blood (2014) 124 (21): 2873.

https://doi.org/10.1182/blood.V124.21.2873.2873

Published: 2014

NARROW

Factor XI Inhibition for the Prevention of Catheter-Associated Thrombosis in Cancer Patients Undergoing Central Line Placement: A Phase 2 Clinical Trial

Antiplatelet Effects of Inhibiting Coagulation Factor XI in a Diet-Induced Obesity Model of Early Atherosclerosis

The contact activation inhibitor AB023 in heparin-free hemodialysis: results of a randomized phase 2 clinical trial

A Phase 2 Trial of the Protein C Activator AB002 in End-Stage Renal Disease Patients on Chronic Hemodialysis

Factor XII plays a pathogenic role in organ failure and death in baboons challenged with Staphylococcus aureus

Safety and Efficacy of the Contact Activation Inhibitor AB023 in Patients with End-Stage Renal Disease on Chronic Hemodialysis: A Phase 2, Double-Blind, Randomized, Placebo-Controlled Trial

The protein C activator AB002 rapidly interrupts thrombus development in baboons

Safety and Antithrombotic Efficacy of the Recombinant Protein C Activator AB002 (E-WE Thrombin) in End Stage Renal Disease Patients on Chronic Hemodialysis

The Anti-Factor XII Antibody AB052 Is Antithrombotic without Hemostatic Impairment in a Primate Model of Extracorporeal Membrane Oxygenation

Inhibition of Factor XIIa-Mediated Factor XI Activation Reduces Infarct Size in a Mouse Model of Myocardial Ischemia and Reperfusion

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American Society of Hematology

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American Society of Hematology

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