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Journal Articles

Treatment with a Novel Small Molecule Dual Factor IIa/Xa Inhibitor Protects Against Coagulopathy and Organ Dysfunction in a Baboon Model of Staphylococcus Aureus Sepsis

Robert Silasi, Ravi Shankar Keshari, Tomohiro Abe, Girija Regmi, Cristina Lupu, Joe Simmons, Nils Pfaff, Stefan Heitmeier, Florea Lupu

Blood (2024) 144 (Supplement 1): 3988.

https://doi.org/10.1182/blood-2024-203669

Published: 2024

Journal Articles

Disseminated intravascular coagulation and its immune mechanisms

Narcis I. Popescu, Cristina Lupu, Florea Lupu

Blood (2022) 139 (13): 1973–1986.

https://doi.org/10.1182/blood.2020007208

Published: 2022

Journal Articles

Factor XII plays a pathogenic role in organ failure and death in baboons challenged with Staphylococcus aureus

Robert Silasi, Ravi S. Keshari, Girija Regmi, Cristina Lupu, Constantin Georgescu, Joe H. Simmons, Michael Wallisch, Tia C. L. Kohs, Joseph J. Shatzel, Sven R. Olson, Christina U. Lorentz, Cristina Puy, Erik I. Tucker, David Gailani, Sidney Strickland, András Gruber, Owen J. T. McCarty, Florea Lupu

Blood (2021) 138 (2): 178–189.

https://doi.org/10.1182/blood.2020009345

Published: 2021

Includes: Supplemental data

Journal Articles

In vivo–generated thrombin and plasmin do not activate the complement system in baboons

Ravi S. Keshari, Robert Silasi, Cristina Lupu, Fletcher B. Taylor, Jr, Florea Lupu

Blood (2017) 130 (24): 2678–2681.

https://doi.org/10.1182/blood-2017-06-788216

Published: 2017

Includes: Supplemental data

Journal Articles

Synthetic Pentasaccharide Fondaparinux (Arixtra ® ) Reduces Sepsis Induced Coagulopathy and Promotes Survival in the Baboon Model of E. coli Sepsis

Ravi Shankar Keshari, PhD, Robert Silasi, PhD, Narcis Ioan Popescu, PhD, Cristina Lupu, PhD, Charles Esmon, PhD, Florea Lupu, PhD

Blood (2017) 130 (Supplement 1): 2375.

https://doi.org/10.1182/blood.V130.Suppl_1.2375.2375

Published: 2017

Journal Articles

Bacteremia, Not Coagulation Proteases Contribute to In Vivo Complement Activation in Sepsis

Ravi Shankar Keshari, PhD, Robert Silasi-Mansat, PhD, Cristina Lupu, PhD, Fletcher B. Taylor, Jr., MD, Florea Lupu, PhD

Blood (2016) 128 (22): 275.

https://doi.org/10.1182/blood.V128.22.275.275

Published: 2016

Journal Articles

Role of Androgen Dependent TFPI-Regulating Protein (ADTRP) in Vascular Development and Function

Maulin Mukeshchandra Patel, Robert Silasi-Mansat, PhD, Ravi Shankar Keshari, PhD, Christopher L. Sansam, PhD, David A. Jones, PhD, Cristina Lupu, PhD, Florea Lupu, PhD

Blood (2016) 128 (22): 556.

https://doi.org/10.1182/blood.V128.22.556.556

Published: 2016

Journal Articles

Complement C5 Inhibition Blocks the Cytokine Storm and Consumptive Coagulopathy By Decreasing Lipopolysaccharide (LPS) Release in E. coli Sepsis

Ravi Shankar Keshari, PhD, Robert Silasi-Mansat, PhD, Narcis I. Popescu, PhD, Marybeth Langer, PhD, Hala Chaaban, MD, Cristina Lupu, PhD, Mark K. Coggeshall, Steven DeMarco, PhD, Florea Lupu, PhD

Blood (2015) 126 (23): 765.

https://doi.org/10.1182/blood.V126.23.765.765

Published: 2015

Journal Articles

A Novel C5 Complement Inhibitor Protects Against Sepsis-Induced Activation of Complement, Coagulation and Inflammation and Provides Survival Benefit in E. coli Sepsis

Ravi Keshari, PhD, Robert Silasi-Mansat, PhD, Narcis I. Popescu, PhD, Hala Chaaban, MD, Cristina Lupu, PhD, Steven J DeMarco, PhD, Florea Lupu, PhD

Blood (2014) 124 (21): 112.

https://doi.org/10.1182/blood.V124.21.112.112

Published: 2014

Journal Articles

Novel protein ADTRP regulates TFPI expression and function in human endothelial cells in normal conditions and in response to androgen

Cristina Lupu, Hua Zhu, Narcis I. Popescu, Jonathan D. Wren, Florea Lupu

Blood (2011) 118 (16): 4463–4471.

https://doi.org/10.1182/blood-2011-05-355370

Published: 2011

Includes: Supplemental data

Journal Articles

Novel Protein Encoded by C6orf105 Regulates Tissue Factor Pathway Inhibitor Expression and Function In Human Endothelial Cells In Normal Conditions and During Androgen Stimulation

Cristina Lupu, PhD, Hua Zhu, PhD, Jonathan Wren, PhD, Florea Lupu, PhD

Blood (2010) 116 (21): 348.

https://doi.org/10.1182/blood.V116.21.348.348

Published: 2010

Journal Articles

Calcium Ionophore-Induced Tissue Factor (TF) Decryption Induces TF Immobilization Into Lipid Rafts and Negative Regulation of TF Procoagulant Activity.

Narcis I. Popescu, PhD, Cristina Lupu, PhD, Florea Lupu, PhD

Blood (2010) 116 (21): 1131.

https://doi.org/10.1182/blood.V116.21.1131.1131

Published: 2010

Journal Articles

Complement inhibition decreases the procoagulant response and confers organ protection in a baboon model of Escherichia coli sepsis

Robert Silasi-Mansat, Hua Zhu, Narcis I. Popescu, Glenn Peer, Georgia Sfyroera, Paola Magotti, Lacramioara Ivanciu, Cristina Lupu, Tom E. Mollnes, Fletcher B. Taylor, Gary Kinasewitz, John D. Lambris, Florea Lupu

Blood (2010) 116 (6): 1002–1010.

https://doi.org/10.1182/blood-2010-02-269746

Published: 2010

Includes: Supplemental data

Journal Articles

Extracellular protein disulfide isomerase regulates coagulation on endothelial cells through modulation of phosphatidylserine exposure

Narcis I. Popescu, Cristina Lupu, Florea Lupu

Blood (2010) 116 (6): 993–1001.

https://doi.org/10.1182/blood-2009-10-249607

Published: 2010

Includes: Supplemental data

Journal Articles

Caveolin-1 Deficiency in Mice Leads to Increased Protection Against Endotoxemia.

Lacramioara Ivanciu, PhD, Cristina Lupu, Ph.D., Florea Lupu, Ph.D

Blood (2006) 108 (11): 1814.

https://doi.org/10.1182/blood.V108.11.1814.1814

Published: 2006

Journal Articles

Functional Regulation of TFPI in Membrane Lipid Rafts.

Cristina Lupu, PhD, Florea Lupu, Ph.D.

Blood (2006) 108 (11): 1753.

https://doi.org/10.1182/blood.V108.11.1753.1753

Published: 2006

Journal Articles

Tissue Characterization of Hypoxia, Nitric Oxide and Apoptosis Pathways in a Baboon Model of E. coli Sepsis.

Lacramioara Ivanciu, PhD, Oana Herlea, MS, Hua Zhu, PhD, Fletcher B. Taylor, MD, Cristina Lupu, PhD, Florea Lupu, PhD

Blood (2005) 106 (11): 138.

https://doi.org/10.1182/blood.V106.11.138.138

Published: 2005

Journal Articles

Sepsis-Induced Coagulation in the Baboon Lung Is Associated with Decreased Endothelial Tissue Factor Pathway Inhibitor.

Haiwang Tang, MD, PhD, Lacramioara Ivanciu, PhD, Todd Hamm, Fletcher B. Taylor, MD, Cristina Lupu, PhD, Florea Lupu, PhD

Blood (2004) 104 (11): 803.

https://doi.org/10.1182/blood.V104.11.803.803

Published: 2004

NARROW

Treatment with a Novel Small Molecule Dual Factor IIa/Xa Inhibitor Protects Against Coagulopathy and Organ Dysfunction in a Baboon Model of Staphylococcus Aureus Sepsis

Disseminated intravascular coagulation and its immune mechanisms

Factor XII plays a pathogenic role in organ failure and death in baboons challenged with Staphylococcus aureus

In vivo–generated thrombin and plasmin do not activate the complement system in baboons

Synthetic Pentasaccharide Fondaparinux (Arixtra ® ) Reduces Sepsis Induced Coagulopathy and Promotes Survival in the Baboon Model of E. coli Sepsis

Bacteremia, Not Coagulation Proteases Contribute to In Vivo Complement Activation in Sepsis

Role of Androgen Dependent TFPI-Regulating Protein (ADTRP) in Vascular Development and Function

Complement C5 Inhibition Blocks the Cytokine Storm and Consumptive Coagulopathy By Decreasing Lipopolysaccharide (LPS) Release in E. coli Sepsis

A Novel C5 Complement Inhibitor Protects Against Sepsis-Induced Activation of Complement, Coagulation and Inflammation and Provides Survival Benefit in E. coli Sepsis

Novel protein ADTRP regulates TFPI expression and function in human endothelial cells in normal conditions and in response to androgen

Novel Protein Encoded by C6orf105 Regulates Tissue Factor Pathway Inhibitor Expression and Function In Human Endothelial Cells In Normal Conditions and During Androgen Stimulation

Calcium Ionophore-Induced Tissue Factor (TF) Decryption Induces TF Immobilization Into Lipid Rafts and Negative Regulation of TF Procoagulant Activity.

Complement inhibition decreases the procoagulant response and confers organ protection in a baboon model of Escherichia coli sepsis

Extracellular protein disulfide isomerase regulates coagulation on endothelial cells through modulation of phosphatidylserine exposure

Caveolin-1 Deficiency in Mice Leads to Increased Protection Against Endotoxemia.

Functional Regulation of TFPI in Membrane Lipid Rafts.

Tissue Characterization of Hypoxia, Nitric Oxide and Apoptosis Pathways in a Baboon Model of E. coli Sepsis.

Sepsis-Induced Coagulation in the Baboon Lung Is Associated with Decreased Endothelial Tissue Factor Pathway Inhibitor.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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