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Journal Articles

Targeting factor XI and factor XIa to prevent thrombosis

David Gailani, Andras Gruber

Blood (2024) 143 (15): 1465–1475.

https://doi.org/10.1182/blood.2023020722

Published: 2024

Journal Articles

Pharmacologic Reduction of Platelet Count Attenuates Whole Blood Hypofibrinolysis in a Mouse Model of Sickle Cell Disease

Anton Ilich, Karnsasin Seanoon, Fatima Trebak, Andras Gruber, Nigel S. Key, Rafal Pawlinski

Blood (2023) 142 (Supplement 1): 562.

https://doi.org/10.1182/blood-2023-187098

Published: 2023

Journal Articles

Endogenous Protein C Activation with AB002 Improves Outcomes in a Rat Model of Acute Ischemic Stroke

Norah G. Verbout, Wenri Zhang, Erik I. Tucker, Andras Gruber

Blood (2023) 142 (Supplement 1): 3949.

https://doi.org/10.1182/blood-2023-187448

Published: 2023

Journal Articles

Factor XII contributes to thrombotic complications and vaso-occlusion in sickle cell disease

Blood (2023) 141 (15): 1871–1883.

https://doi.org/10.1182/blood.2022017074

Published: 2023

Includes: Multimedia, Supplemental data

Journal Articles

The contact activation inhibitor AB023 in heparin-free hemodialysis: results of a randomized phase 2 clinical trial

Christina U. Lorentz, Erik I. Tucker, Norah G. Verbout, Joseph J. Shatzel, Sven R. Olson, Brandon D. Markway, Michael Wallisch, Martina Ralle, Monica T. Hinds, Owen J. T. McCarty, David Gailani, Jeffrey I. Weitz, András Gruber

Blood (2021) 138 (22): 2173–2184.

https://doi.org/10.1182/blood.2021011725

Published: 2021

Includes: Supplemental data

Journal Articles

Skeletal Muscle Myosin Is Procoagulant By Binding Factor XI Via Its A3 Domain and Enhancing Factor XI Activation By Thrombin

Hiroshi Deguchi, Shravan Morla, Jevgenia Zilberman-Rudenko, Andras Gruber, Owen J T McCarty, Priyanka Srivastava, David Gailani, John H. Griffin

Blood (2021) 138 (Supplement 1): 441.

https://doi.org/10.1182/blood-2021-151372

Published: 2021

Journal Articles

A Phase 2 Trial of the Protein C Activator AB002 in End-Stage Renal Disease Patients on Chronic Hemodialysis

Norah G Verbout, Christina U Lorentz, Brandon D Markway, Michael Wallisch, Joseph J Shatzel, Andras Gruber, Erik I Tucker

Blood (2021) 138 (Supplement 1): 669.

https://doi.org/10.1182/blood-2021-148208

Published: 2021

Journal Articles

Inhibition of Factor XII Attenuates Prothrombotic Complications in Sickle Cell Mice

Erica Sparkenbaugh, Christina M Abrams, Megan D Miller, Brian C Cooley, Anton Ilich, Shreya Yadav, Michael Wallisch, Nigel S Key, Andras Gruber, Felicity N. E. Gavins, Rafal Pawlinski

Blood (2021) 138 (Supplement 1): 189.

https://doi.org/10.1182/blood-2021-152753

Published: 2021

Journal Articles

Abelacimab Reduces Thrombus Propagation in a Baboon Model of Vascular Graft Thrombosis

Michael Wallisch, Yasser Khder, Monica T. Hinds, Erik I Tucker, Dan Bloomfield, Andras Gruber

Blood (2021) 138 (Supplement 1): 1027.

https://doi.org/10.1182/blood-2021-150535

Published: 2021

Journal Articles

Factor XII plays a pathogenic role in organ failure and death in baboons challenged with Staphylococcus aureus

Robert Silasi, Ravi S. Keshari, Girija Regmi, Cristina Lupu, Constantin Georgescu, Joe H. Simmons, Michael Wallisch, Tia C. L. Kohs, Joseph J. Shatzel, Sven R. Olson, Christina U. Lorentz, Cristina Puy, Erik I. Tucker, David Gailani, Sidney Strickland, András Gruber, Owen J. T. McCarty, Florea Lupu

Blood (2021) 138 (2): 178–189.

https://doi.org/10.1182/blood.2020009345

Published: 2021

Includes: Supplemental data

Journal Articles

Safety and Efficacy of the Contact Activation Inhibitor AB023 in Patients with End-Stage Renal Disease on Chronic Hemodialysis: A Phase 2, Double-Blind, Randomized, Placebo-Controlled Trial

Christina U Lorentz, PhD, Norah G Verbout, PhD, Joseph J Shatzel, MD, Michael Wallisch, PhD, Brandon D Markway, PhD, Monica T Hinds, PhD, Owen J T McCarty, PhD, David Gailani, MD, Jeffrey I. Weitz, MDFRCPC, Erik I Tucker, PhD, András Gruber, MD

Blood (2020) 136 (Supplement 1): 23–24.

https://doi.org/10.1182/blood-2020-139948

Published: 2020

Journal Articles

The protein C activator AB002 rapidly interrupts thrombus development in baboons

Erik I. Tucker, Norah G. Verbout, Brandon D. Markway, Michael Wallisch, Christina U. Lorentz, Monica T. Hinds, Joseph J. Shatzel, Leslie A. Pelc, David C. Wood, Owen J. T. McCarty, Enrico Di Cera, András Gruber

Blood (2020) 135 (9): 689–699.

https://doi.org/10.1182/blood.2019002771

Published: 2020

Includes: Supplemental data

Journal Articles

Safety and Antithrombotic Efficacy of the Recombinant Protein C Activator AB002 (E-WE Thrombin) in End Stage Renal Disease Patients on Chronic Hemodialysis

Norah G Verbout, PhD, Christina U Lorentz, PhD, Brandon D Markway, PhD, Joseph J Shatzel, MD, Erik I Tucker, PhD, Andras Gruber, MD

Blood (2019) 134 (Supplement_1): 2433.

https://doi.org/10.1182/blood-2019-124999

Published: 2019

Journal Articles

A mechanism for hereditary angioedema with normal C1 inhibitor: an inhibitory regulatory role for the factor XII heavy chain

Ivan Ivanov, Anton Matafonov, Mao-fu Sun, Bassem M. Mohammed, Qiufang Cheng, S. Kent Dickeson, Suman Kundu, Ingrid M. Verhamme, Andras Gruber, Keith McCrae, David Gailani

Blood (2019) 133 (10): 1152–1163.

https://doi.org/10.1182/blood-2018-06-860270

Published: 2019

Includes: Supplemental data

Journal Articles

Antisense Oligonucleotide Targeting of Thrombopoietin Synthesis Reduces Platelet Count within the Hemostatic Range and Slows Progression of De Novo Mammary Carcinogenesis in the Mmtv-Pymt Mouse

Toshiaki Shirai, PhD, Alexey Revenko, PhD, Justin Tibbits, MS, Lisa M Coussens, PhD, Owen JT McCarty, PhD, Brett P. Monia, PhD, Andras Gruber, MD

Blood (2018) 132 (Supplement 1): 989.

https://doi.org/10.1182/blood-2018-99-114157

Published: 2018

Journal Articles

Peptidoglycan induces disseminated intravascular coagulation in baboons through activation of both coagulation pathways

Narcis I. Popescu, Robert Silasi, Ravi S. Keshari, Alanson Girton, Tarea Burgett, Sacha S. Zeerleder, David Gailani, Andras Gruber, Florea Lupu, K. Mark Coggeshall

Blood (2018) 132 (8): 849–860.

https://doi.org/10.1182/blood-2017-10-813618

Published: 2018

Includes: Supplemental data

Journal Articles

The Anti-Factor XII Antibody AB052 Is Antithrombotic without Hemostatic Impairment in a Primate Model of Extracorporeal Membrane Oxygenation

Michael Wallisch, PhD, Erik I Tucker, PhD, Christina U Lorentz, PhD, Jennifer Johnson, RLATG, Marschelle R Carris, BA, Owen JT McCarty, PhD, Monica T Hinds, PhD, András Gruber, MD

Blood (2017) 130 (Supplement 1): 236.

https://doi.org/10.1182/blood.V130.Suppl_1.236.236

Published: 2017

Journal Articles

Selective factor VIII activation by the tissue factor–factor VIIa–factor Xa complex

Yuichi Kamikubo, G. Loredana Mendolicchio, Antonella Zampolli, Patrizia Marchese, Andrea S. Rothmeier, Jennifer Nagrampa Orje, Andrew J. Gale, Sriram Krishnaswamy, András Gruber, Henrik Østergaard, Lars C. Petersen, Wolfram Ruf, Zaverio M. Ruggeri

Blood (2017) 130 (14): 1661–1670.

https://doi.org/10.1182/blood-2017-02-767079

Published: 2017

Includes: Supplemental data

Journal Articles

E-WE Thrombin (ProCase) Inhibits Thrombin Mediated TAFI Activation and Accelerates TPA-Induced Thrombolysis

Erik I Tucker, PhD, Brandon Markway, PhD, Michael Wallisch, PhD, Norah Green Verbout, PhD, Christina Lorentz, PhD, Marschelle Carris, Owen J.T. McCarty, PhD, Andras Gruber, MD

Blood (2016) 128 (22): 1390.

https://doi.org/10.1182/blood.V128.22.1390.1390

Published: 2016

Journal Articles

FXIIa Differentially Regulates Thrombin Generation during Steady State and Vaso-Occlusive Crisis in Sickle Cell Mice

Erica M Sparkenbaugh, PhD, Camille Faes, PhD, Denis Noubouossie, MD PhD, Daniel K. Kirchhofer, PhD, András Gruber, MD, Nigel S. Key, MB, ChB, Rafal Pawlinski, PhD

Blood (2016) 128 (22): 162.

https://doi.org/10.1182/blood.V128.22.162.162

Published: 2016

NARROW

Targeting factor XI and factor XIa to prevent thrombosis

Pharmacologic Reduction of Platelet Count Attenuates Whole Blood Hypofibrinolysis in a Mouse Model of Sickle Cell Disease

Endogenous Protein C Activation with AB002 Improves Outcomes in a Rat Model of Acute Ischemic Stroke

Factor XII contributes to thrombotic complications and vaso-occlusion in sickle cell disease

The contact activation inhibitor AB023 in heparin-free hemodialysis: results of a randomized phase 2 clinical trial

Skeletal Muscle Myosin Is Procoagulant By Binding Factor XI Via Its A3 Domain and Enhancing Factor XI Activation By Thrombin

A Phase 2 Trial of the Protein C Activator AB002 in End-Stage Renal Disease Patients on Chronic Hemodialysis

Inhibition of Factor XII Attenuates Prothrombotic Complications in Sickle Cell Mice

Abelacimab Reduces Thrombus Propagation in a Baboon Model of Vascular Graft Thrombosis

Factor XII plays a pathogenic role in organ failure and death in baboons challenged with Staphylococcus aureus

Safety and Efficacy of the Contact Activation Inhibitor AB023 in Patients with End-Stage Renal Disease on Chronic Hemodialysis: A Phase 2, Double-Blind, Randomized, Placebo-Controlled Trial

The protein C activator AB002 rapidly interrupts thrombus development in baboons

Safety and Antithrombotic Efficacy of the Recombinant Protein C Activator AB002 (E-WE Thrombin) in End Stage Renal Disease Patients on Chronic Hemodialysis

A mechanism for hereditary angioedema with normal C1 inhibitor: an inhibitory regulatory role for the factor XII heavy chain

Antisense Oligonucleotide Targeting of Thrombopoietin Synthesis Reduces Platelet Count within the Hemostatic Range and Slows Progression of De Novo Mammary Carcinogenesis in the Mmtv-Pymt Mouse

Peptidoglycan induces disseminated intravascular coagulation in baboons through activation of both coagulation pathways

The Anti-Factor XII Antibody AB052 Is Antithrombotic without Hemostatic Impairment in a Primate Model of Extracorporeal Membrane Oxygenation

Selective factor VIII activation by the tissue factor–factor VIIa–factor Xa complex

E-WE Thrombin (ProCase) Inhibits Thrombin Mediated TAFI Activation and Accelerates TPA-Induced Thrombolysis

FXIIa Differentially Regulates Thrombin Generation during Steady State and Vaso-Occlusive Crisis in Sickle Cell Mice

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American Society of Hematology

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ASH Publications

American Society of Hematology

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