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Journal Articles

Selective factor VIII activation by the tissue factor–factor VIIa–factor Xa complex

Yuichi Kamikubo, G. Loredana Mendolicchio, Antonella Zampolli, Patrizia Marchese, Andrea S. Rothmeier, Jennifer Nagrampa Orje, Andrew J. Gale, Sriram Krishnaswamy, András Gruber, Henrik Østergaard, Lars C. Petersen, Wolfram Ruf, Zaverio M. Ruggeri

Blood (2017) 130 (14): 1661–1670.

https://doi.org/10.1182/blood-2017-02-767079

Published: 2017

Includes: Supplemental data

Journal Articles

Distinct Mechanism of Anti-Hemophilic FVIII Activation By Nascent FXa in the Tissue Factor-FVIIa Coagulation Initiation Complex Resistant to FXa-Directed Inhibition

Yuichi Kamikubo, PhD, Grazia Loredana Mendolicchio, MD PhD, Antonella Zampolli, PhD, Patrizia Marchese, PhD, Andrew J. Gale, PhD, Sriram Krishnaswamy, PhD, Andras Gruber, MD, Lars Christian Petersen, Wolfram Ruf, MD, Zaverio M Ruggeri, MD

Blood (2014) 124 (21): 2803.

https://doi.org/10.1182/blood.V124.21.2803.2803

Published: 2014

Journal Articles

Synergistic Effect in Bleed Reduction By super fva and Recombinant Human FVIIa in Vivo Suggests a Novel Bypassing Strategy for Hemophilia Patients with Inhibitors

Vikas Bhat, PhD, Annette von Drygalski, MD PharmD, Andrew J. Gale, PhD, John H. Griffin, PhD, Laurent O. Mosnier, PhD

Blood (2014) 124 (21): 692.

https://doi.org/10.1182/blood.V124.21.692.692

Published: 2014

Journal Articles

Reversal of Novel Oral Anticoagulant (NOAC)-Induced Bleeding in Mice By Engineered super factor Va

Vikas Bhat, PhD, Andrew J. Gale, PhD, John H. Griffin, PhD, Laurent O. Mosnier, PhD, Annette von Drygalski, MD PharmD

Blood (2014) 124 (21): 695.

https://doi.org/10.1182/blood.V124.21.695.695

Published: 2014

Journal Articles

Activation-Resistant Homozygous Protein C R229W Mutation Causing Familial Perinatal Intracranial Hemorrhage

Abdulrahman Alsultan, MD, Andrew J. Gale, PhD, Kadijah Kurban, MD, Mohammed Khalifah, MD, Fahad B. Albadr, MD, John H. Griffin, PhD

Blood (2013) 122 (21): 3587.

https://doi.org/10.1182/blood.V122.21.3587.3587

Published: 2013

Journal Articles

An Engineered Factor Fva Prevents Bleeding Induced By Anticoagulant Wild Type Activated Protein C

Annette Von Drygalski, MD, PharmD, Andrew J. Gale, PhD, Laurent Burnier, PhD, Thomas J. Cramer, PhD, John H. Griffin, PhD, Laurent O. Mosnier, PhD

Blood (2013) 122 (21): 203.

https://doi.org/10.1182/blood.V122.21.203.203

Published: 2013

Journal Articles

Superior in Vivo Hemostatic Properties of an Engineered Factor Va Variant for Hemophilia Mice

Annette Von Drygalski, MD, PharmD, Thomas J. Cramer, PhD, John H. Griffin, PhD, Andrew J. Gale, PhD, Laurent O. Mosnier, PhD

Blood (2012) 120 (21): 17.

https://doi.org/10.1182/blood.V120.21.17.17

Published: 2012

Journal Articles

Factor V as Anticoagulant Cofactor for Activated Protein C in Factor Va Inactivation

Thomas J Cramer, MSc., John H. Griffin, PhD, Andrew J. Gale, PhD

Blood (2008) 112 (11): 3075.

https://doi.org/10.1182/blood.V112.11.3075.3075

Published: 2008

Journal Articles

The Neutrophil Proteases, Elastase and Cathepsin G, May Modulate the Activity of Factor VIII.

Andrew J. Gale, PhD, Diana Rozenshteyn, Justin Riceberg

Blood (2006) 108 (11): 1716.

https://doi.org/10.1182/blood.V108.11.1716.1716

Published: 2006

Journal Articles

Whole Blood Thromboelastogram Assays Demonstrate Prolonged Factor VIIIa Potency for Recombinant Disulfide Bond-Stabilized Factor VIII Variants.

Klaus-Peter Radtke, Dean Chamberlain, John H. Griffin, Andrew J. Gale

Blood (2004) 104 (11): 2976.

https://doi.org/10.1182/blood.V104.11.2976.2976

Published: 2004

Journal Articles

Factor Xa Binding Sites on Factor Va in the Prothrombinase Complex.

Andrew J. Gale, PhD, John H. Griffin, PhD

Blood (2004) 104 (11): 1713.

https://doi.org/10.1182/blood.V104.11.1713.1713

Published: 2004

Journal Articles

Activated protein C variants with normal cytoprotective but reduced anticoagulant activity

Laurent O. Mosnier, Andrew J. Gale, Subramanian Yegneswaran, John H. Griffin

Blood (2004) 104 (6): 1740–1744.

https://doi.org/10.1182/blood-2004-01-0110

Published: 2004

Journal Articles

The autolysis loop of activated protein C interacts with factor Va and differentiates between the Arg506 and Arg306 cleavage sites

Andrew J. Gale, Mary J. Heeb, John H. Griffin

Blood (2000) 96 (2): 585–593.

https://doi.org/10.1182/blood.V96.2.585

Published: 2000

NARROW

Selective factor VIII activation by the tissue factor–factor VIIa–factor Xa complex

Distinct Mechanism of Anti-Hemophilic FVIII Activation By Nascent FXa in the Tissue Factor-FVIIa Coagulation Initiation Complex Resistant to FXa-Directed Inhibition

Synergistic Effect in Bleed Reduction By super fva and Recombinant Human FVIIa in Vivo Suggests a Novel Bypassing Strategy for Hemophilia Patients with Inhibitors

Reversal of Novel Oral Anticoagulant (NOAC)-Induced Bleeding in Mice By Engineered super factor Va

Activation-Resistant Homozygous Protein C R229W Mutation Causing Familial Perinatal Intracranial Hemorrhage

An Engineered Factor Fva Prevents Bleeding Induced By Anticoagulant Wild Type Activated Protein C

Superior in Vivo Hemostatic Properties of an Engineered Factor Va Variant for Hemophilia Mice

Factor V as Anticoagulant Cofactor for Activated Protein C in Factor Va Inactivation

The Neutrophil Proteases, Elastase and Cathepsin G, May Modulate the Activity of Factor VIII.

Whole Blood Thromboelastogram Assays Demonstrate Prolonged Factor VIIIa Potency for Recombinant Disulfide Bond-Stabilized Factor VIII Variants.

Factor Xa Binding Sites on Factor Va in the Prothrombinase Complex.

Activated protein C variants with normal cytoprotective but reduced anticoagulant activity

The autolysis loop of activated protein C interacts with factor Va and differentiates between the Arg506 and Arg306 cleavage sites

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American Society of Hematology

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ASH Publications

American Society of Hematology

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