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Journal Articles

Humanization of Clinically Used Murine CD45 Antibody for Optimized CD45-Targeted Radioimmunotherapy

George S. Laszlo, Brenda M. Sandmaier, David J. King, Allie R. Kehret, Kyle E. Nyberg, Jacob W. Barton, Frances M. Cole, Junyang Li, Margaret C. Lunn-Halbert, Donald K. Hamlin, D. Scott Wilbur, Johnnie J. Orozco, Shannon L. Dexter, Roland B. Walter

Blood (2024) 144 (Supplement 1): 4779.

https://doi.org/10.1182/blood-2024-201016

Published: 2024

Journal Articles

CD45-Directed Radioimmunotherapy with the Alpha-Emitter Astatine-211 As Conditioning for Autologous Hematopoietic Stem/Progenitor Cell Gene Therapy: Results from a Nonhuman Primate Model

Stefan Radtke, Kyle Swing, George S. Laszlo, Andrea Repele, Greta N. Kanestrom, Nicholas E Petty, Donald K. Hamlin, D. Scott Wilbur, Brenda M. Sandmaier, Hans-Peter Kiem, Roland B. Walter

Blood (2024) 144 (Supplement 1): 2014.

https://doi.org/10.1182/blood-2024-205992

Published: 2024

Journal Articles

BCMA-Directed Low Dose Alpha-Emitter Therapy Eliminates Minimal Residual Disease in a Multiple Myeloma Mouse Xenograft Model

Melissa L Comstock, Shyril O'Steen, Yukang Lin, Donald Hamlin, D Scott Wilbur, Johnnie J. Orozco, Rainer F. Storb, Roland B. Walter, Pinar Ataca Atilla, Brian G Till, Geoffrey R Hill, Brenda M. Sandmaier, Damian J Green

Blood (2023) 142 (Supplement 1): 53.

https://doi.org/10.1182/blood-2023-188055

Published: 2023

Journal Articles

Development of Astatine-211 ( 211 At)-Based Anti-CD123 Radioimmunotherapy for Acute Leukemias and Other CD123+ Hematologic Malignancies

George S. Laszlo, Johnnie J. Orozco, Allie R. Kehret, Margaret C. Lunn, Donald K. Hamlin, D. Scott Wilbur, Shannon L. Dexter, Melissa C. Comstock, Shyril O'Steen, Damian J. Green, Roland B. Walter

Blood (2021) 138 (Supplement 1): 3341.

https://doi.org/10.1182/blood-2021-152105

Published: 2021

Journal Articles

The α-emitter astatine-211 targeted to CD38 can eradicate multiple myeloma in a disseminated disease model

Shyril O’Steen, Melissa L. Comstock, Johnnie J. Orozco, Donald K. Hamlin, D. Scott Wilbur, Jon C. Jones, Aimee Kenoyer, Margaret E. Nartea, Yukang Lin, Brian W. Miller, Theodore A. Gooley, Sherilyn A. Tuazon, Brian G. Till, Ajay K. Gopal, Brenda M. Sandmaier, Oliver W. Press, Damian J. Green

Blood (2019) 134 (15): 1247–1256.

https://doi.org/10.1182/blood.2019001250

Published: 2019

Includes: Supplemental data

Journal Articles

The Alpha Emitter Astatine-211 Targeted to CD38 Can Eradicate Multiple Myeloma in Minimal Residual Disease Models

Shyril O'Steen, PhD, Melissa C. Comstock, BS, Johnnie J. Orozco, MD PhD, Donald K. Hamlin, BS, D. Scott Wilbur, PhD, Jon Jones, BS, Aimee Kenoyer, BS, Margaret E. Nartea, BS, Yukang Lin, PhD, Brian W. Miller, PhD, Sherilyn A. Tuazon, MD, Brian G. Till, MD, Ajay K. Gopal, MD, Brenda M. Sandmaier, MD, Oliver W. Press, MD PhD, Damian J. Green, MD

Blood (2018) 132 (Supplement 1): 1941.

https://doi.org/10.1182/blood-2018-99-119555

Published: 2018

Journal Articles

CD38-bispecific antibody pretargeted radioimmunotherapy for multiple myeloma and other B-cell malignancies

Damian J. Green, Shyril O’Steen, Yukang Lin, Melissa L. Comstock, Aimee L. Kenoyer, Donald K. Hamlin, D. Scott Wilbur, Darrell R. Fisher, Margaret Nartea, Mark D. Hylarides, Ajay K. Gopal, Theodore A. Gooley, Johnnie J. Orozco, Brian G. Till, Kelly D. Orcutt, K. Dane Wittrup, Oliver W. Press

Blood (2018) 131 (6): 611–620.

https://doi.org/10.1182/blood-2017-09-807610

Published: 2018

Includes: Supplemental data

Journal Articles

Novel Bispecific Antibody Targeting CD45 and 90 Y-DOTA Is Effective Therapy for Acute Myeloid Leukemia in Preclinical Murine Models

Johnnie J. Orozco, MD PhD, Aimee Kenoyer, BS, Yukang Lin, PhD, Darrell R. Fisher, PhD, Donald K. Hamlin, BS, D. Scott Wilbur, PhD, Alexandra Hernandez, BS, Rosario Guel, Margaret E. Nartea, Shyril O'Steen, PhD, Mark D Hylarides, PhD, Brian G Till, MD, Damian J. Green, MD, Ajay K. Gopal, MD, Kelly D Orcutt, PhD, Karl Dane Wittrup, PhD, Brenda M. Sandmaier, MD, John M. Pagel, MD PhD, Oliver W. Press, MD PhD

Blood (2017) 130 (Supplement 1): 1355.

https://doi.org/10.1182/blood.V130.Suppl_1.1355.1355

Published: 2017

Journal Articles

Addition of Astatine-211-Labeled Anti-CD45 Antibody to Total Body Irradiation (TBI) As Conditioning for DLA-Identical Marrow Transplantation: A Novel Strategy to Overcome Graft Rejection in a Canine Presensitization Model

Huiying Qiu, MD, Erlinda B Santos, Rainer F. Storb, MD, Donald K Hamlin, D Scott Wilbur, PhD, Brenda M Sandmaier, MD

Blood (2016) 128 (22): 2152.

https://doi.org/10.1182/blood.V128.22.2152.2152

Published: 2016

Journal Articles

Anti-CD45 radioimmunotherapy without TBI before transplantation facilitates persistent haploidentical donor engraftment

Johnnie J. Orozco, Aimee Kenoyer, Ethan R. Balkin, Ted A. Gooley, Donald K. Hamlin, D. Scott Wilbur, Mark D. Hylarides, Sofia H. L. Frost, Raya Mawad, Paul O’Donnell, Brenda M. Sandmaier, Ephraim J. Fuchs, Leo Luznik, Damian J. Green, Ajay K. Gopal, Oliver W. Press, John M. Pagel

Blood (2016) 127 (3): 352–359.

https://doi.org/10.1182/blood-2014-12-617019

Published: 2016

Includes: Supplemental data

Journal Articles

Astatine-211 conjugated to an anti-CD20 monoclonal antibody eradicates disseminated B-cell lymphoma in a mouse model

Blood (2015) 125 (13): 2111–2119.

https://doi.org/10.1182/blood-2014-11-612770

Published: 2015

Includes: Supplemental data

Journal Articles

Pre-Targeted Radioimmunotherapy Employing a Recombinant Bispecific Antibody Using a Murine Xenograft Model of Human Leukemia

Aimee L. Kenoyer, BS, Yukang Lin, PhD, Johnnie J. Orozco, MD PhD, Ethan Balkin, Don Hamlin, BS, Alexandra H. Hernandez, BS, Chen Fang, PhD, Kelly Laird, Sofia H.L. Frost, PhD, Mark Hylarides, PhD, Kelly D. Orcutt, PhD, D Scott Wilbur, PhD, K. Dane Wittrup, PhD, Oliver W. Press, MD PhD, John Pagel, MD PhD

Blood (2014) 124 (21): 3749.

https://doi.org/10.1182/blood.V124.21.3749.3749

Published: 2014

Journal Articles

211 At-Anti-CD45 Radioimmunotherapy Can Replace TBI Prior to Haploidentical Bone Marrow Transplantation and Yield Long-Term Hematopoietic Engraftment

Johnnie J. Orozco, MD PhD, Aimee L. Kenoyer, BS, Ethan R. Balkin, PhD, Donald K. Hamlin, BS, D Scott Wilbur, PhD, Sofia H.L. Frost, PhD, Mark D. Hylarides, PhD, Damian J. Green, MD, Ajay K. Gopal, MD, Brenda M. Sandmaier, MD, Oliver W. Press, MD PhD, Paul V. O'Donnell, MD PhD, John M. Pagel, MD PhD

Blood (2014) 124 (21): 2417.

https://doi.org/10.1182/blood.V124.21.2417.2417

Published: 2014

Journal Articles

Astatine-211 Conjugated To Anti-CD20 Monoclonal Antibody Eliminates B-Cell Lymphoma In a Mouse Model

Damian J. Green, MD, Mazyar Shadman, MD, MPH, Shani L. Frayo, BS, Jon C. Jones, Mark D. Hylarides, PhD, Aimee L. Kenoyer, BS, D. Scott Wilbur, PhD, Donald K. Hamlin, BS, Yukang Lin, PhD, Ajay K. Gopal, MD, Sofia H.L. Frost, PhD, Johnnie J. Orozco, MD, PhD, John M. Pagel, MD, PhD, Oliver W. Press, MD, PhD

Blood (2013) 122 (21): 4415.

https://doi.org/10.1182/blood.V122.21.4415.4415

Published: 2013

Journal Articles

Anti-CD38 Pretargeted Radioimmunotherapy Eradicates Multiple Myeloma Xenografts In a Murine Model

Damian J. Green, MD, Jon C. Jones, Mark D. Hylarides, PhD, Donald K. Hamlin, BS, D Scott Wilbur, PhD, Yukang Lin, PhD, Aimee L. Kenoyer, BS, Shani L. Frayo, BS, William I. Bensinger, MD, Ajay K. Gopal, MD, Johnnie J. Orozco, MD, PhD, Theodore A. Gooley, PhD, Brent L. Wood, MD, PhD, John M. Pagel, MD, PhD, Oliver W. Press, MD, PhD

Blood (2013) 122 (21): 882.

https://doi.org/10.1182/blood.V122.21.882.882

Published: 2013

Journal Articles

Anti-CD45 Monoclonal Antibody (MAb) Dose Optimization For Astatine-211 ( 211 At)-Radioimmunotherapy (RIT) Of Relapsed Non-Hodgkin Lymphoma (NHL) In a Canine Model

Sofia H.L. Frost, PhD, Erlinda B. Santos, BS, Brian W. Miller, PhD, Tom A. Bäck, PhD, Donald K. Hamlin, BS, D. Scott Wilbur, PhD, Aimee L. Kenoyer, BS, Shani L. Frayo, BS, Oliver W. Press, MD, PhD, Rainer Storb, MD, Brenda M. Sandmaier, MD, John M. Pagel, MD, PhD

Blood (2013) 122 (21): 5139.

https://doi.org/10.1182/blood.V122.21.5139.5139

Published: 2013

Journal Articles

Anti-CD45 radioimmunotherapy using 211 At with bone marrow transplantation prolongs survival in a disseminated murine leukemia model

Johnnie J. Orozco, Tom Bäck, Aimee Kenoyer, Ethan R. Balkin, Donald K. Hamlin, D. Scott Wilbur, Darrell R. Fisher, Shani L. Frayo, Mark D. Hylarides, Damian J. Green, Ajay K. Gopal, Oliver W. Press, John M. Pagel

Blood (2013) 121 (18): 3759–3767.

https://doi.org/10.1182/blood-2012-11-467035

Published: 2013

Journal Articles

Anti-CD45 Radioimmunotherapy Using the Alpha-Emitting Radionuclide 211 At Combined with Bone Marrow Transplantation Prolongs Survival in a Disseminated Murine Leukemia Model

Johnnie J. Orozco, MD, PhD, Aimee Kenoyer, BS, Tom Bäck, PhD, Ethan R. Balkin, PhD, Donald K. Hamlin, BS, D Scott Wilbur, PhD, Darrell R. Fisher, PhD, Shani L. Frayo, BS, Mark D. Hylarides, PhD, Damian J. Green, MD, Ajay K. Gopal, MD, Oliver W. Press, MD, PhD, John M. Pagel, MD, PhD

Blood (2012) 120 (21): 4096.

https://doi.org/10.1182/blood.V120.21.4096.4096

Published: 2012

Journal Articles

Anti-CD45 Radioimmunotherapy Facilitates Donor Engraftment and Prolongs Survival in the Absence of TBI Prior to Haploidentical Bone Marrow Transplantation in a Disseminated Murine Leukemia Model

Johnnie J. Orozco, MD, PhD, Aimee Kenoyer, BS, Ethan R. Balkin, PhD, Donald K. Hamlin, BS, D Scott Wilbur, PhD, Darrell R. Fisher, PhD, Shani L. Frayo, BS, Mark D. Hylarides, PhD, Damian J. Green, MD, Ajay K. Gopal, MD, Paul O'Donnell, MD, PhD, Oliver W. Press, MD, PhD, John M. Pagel, MD, PhD

Blood (2012) 120 (21): 4101.

https://doi.org/10.1182/blood.V120.21.4101.4101

Published: 2012

Journal Articles

Durable donor engraftment after radioimmunotherapy using α-emitter astatine-211–labeled anti-CD45 antibody for conditioning in allogeneic hematopoietic cell transplantation

Yun Chen, Brian Kornblit, Donald K. Hamlin, George E. Sale, Erlinda B. Santos, D. Scott Wilbur, Barry E. Storer, Rainer Storb, Brenda M. Sandmaier

Blood (2012) 119 (5): 1130–1138.

https://doi.org/10.1182/blood-2011-09-380436

Published: 2012

NARROW

Humanization of Clinically Used Murine CD45 Antibody for Optimized CD45-Targeted Radioimmunotherapy

CD45-Directed Radioimmunotherapy with the Alpha-Emitter Astatine-211 As Conditioning for Autologous Hematopoietic Stem/Progenitor Cell Gene Therapy: Results from a Nonhuman Primate Model

BCMA-Directed Low Dose Alpha-Emitter Therapy Eliminates Minimal Residual Disease in a Multiple Myeloma Mouse Xenograft Model

Development of Astatine-211 ( 211 At)-Based Anti-CD123 Radioimmunotherapy for Acute Leukemias and Other CD123+ Hematologic Malignancies

The α-emitter astatine-211 targeted to CD38 can eradicate multiple myeloma in a disseminated disease model

The Alpha Emitter Astatine-211 Targeted to CD38 Can Eradicate Multiple Myeloma in Minimal Residual Disease Models

CD38-bispecific antibody pretargeted radioimmunotherapy for multiple myeloma and other B-cell malignancies

Novel Bispecific Antibody Targeting CD45 and 90 Y-DOTA Is Effective Therapy for Acute Myeloid Leukemia in Preclinical Murine Models

Addition of Astatine-211-Labeled Anti-CD45 Antibody to Total Body Irradiation (TBI) As Conditioning for DLA-Identical Marrow Transplantation: A Novel Strategy to Overcome Graft Rejection in a Canine Presensitization Model

Anti-CD45 radioimmunotherapy without TBI before transplantation facilitates persistent haploidentical donor engraftment

Astatine-211 conjugated to an anti-CD20 monoclonal antibody eradicates disseminated B-cell lymphoma in a mouse model

Pre-Targeted Radioimmunotherapy Employing a Recombinant Bispecific Antibody Using a Murine Xenograft Model of Human Leukemia

211 At-Anti-CD45 Radioimmunotherapy Can Replace TBI Prior to Haploidentical Bone Marrow Transplantation and Yield Long-Term Hematopoietic Engraftment

Astatine-211 Conjugated To Anti-CD20 Monoclonal Antibody Eliminates B-Cell Lymphoma In a Mouse Model

Anti-CD38 Pretargeted Radioimmunotherapy Eradicates Multiple Myeloma Xenografts In a Murine Model

Anti-CD45 Monoclonal Antibody (MAb) Dose Optimization For Astatine-211 ( 211 At)-Radioimmunotherapy (RIT) Of Relapsed Non-Hodgkin Lymphoma (NHL) In a Canine Model

Anti-CD45 radioimmunotherapy using 211 At with bone marrow transplantation prolongs survival in a disseminated murine leukemia model

Anti-CD45 Radioimmunotherapy Using the Alpha-Emitting Radionuclide 211 At Combined with Bone Marrow Transplantation Prolongs Survival in a Disseminated Murine Leukemia Model

Anti-CD45 Radioimmunotherapy Facilitates Donor Engraftment and Prolongs Survival in the Absence of TBI Prior to Haploidentical Bone Marrow Transplantation in a Disseminated Murine Leukemia Model

Durable donor engraftment after radioimmunotherapy using α-emitter astatine-211–labeled anti-CD45 antibody for conditioning in allogeneic hematopoietic cell transplantation

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American Society of Hematology

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American Society of Hematology

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