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Francesca Alvarez-Calderon
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Journal Articles

B-cell–directed CAR T-cell therapy activates CD8 + cytotoxic CAR neg bystander T cells in patients and nonhuman primates

James Kaminski, Ryan A. Fleming, Francesca Alvarez-Calderon, Marlana B. Winschel, Connor McGuckin, Emily E. Ho, Fay Eng, Xianliang Rui, Paula Keskula, Lorenzo Cagnin, Joanne Charles, Jillian Zavistaski, Steven P. Margossian, Malika A. Kapadia, James B. Rottman, Jennifer Lane, Susanne H. C. Baumeister, Victor Tkachev, Alex K. Shalek, Leslie S. Kean, Ulrike Gerdemann
Journal: Blood
Blood (2024) 144 (1): 46–60.
https://doi.org/10.1182/blood.2023022717
Published: 2024
Includes: Supplemental data
Journal Articles

Alloengraftment without significant toxicity or GVHD in CD45 antibody-drug conjugate–conditioned Fanconi anemia mice

Asim Saha, Rahul Palchaudhuri, Leanne Lanieri, Sharon Hyzy, Megan J. Riddle, Jamie Panthera, Cindy R. Eide, Jakub Tolar, Angela Panoskaltsis-Mortari, Lev Gorfinkel, Victor Tkachev, Ulrike Gerdemann, Francesca Alvarez-Calderon, Elisa Rojas Palato, Margaret L. MacMillan, John E. Wagner, Leslie S. Kean, Mark J. Osborn, Hans-Peter Kiem, David T. Scadden, Lisa M. Olson, Bruce R. Blazar
Journal: Blood
Blood (2024) 143 (21): 2201–2216.
https://doi.org/10.1182/blood.2023023549
Published: 2024
Includes: Supplemental data
Journal Articles

Targeting of the CD161 inhibitory receptor enhances T-cell–mediated immunity against hematological malignancies

Francesca Alvarez Calderon, Byong H. Kang, Oleksandr Kyrysyuk, Shiwei Zheng, Hao Wang, Nathan D. Mathewson, Adrienne M. Luoma, Xiaohan Ning, Jason Pyrdol, Xuan Cao, Mario L. Suvà, Guo-Cheng Yuan, K. Dane Wittrup, Kai W. Wucherpfennig
Journal: Blood
Blood (2024) 143 (12): 1124–1138.
https://doi.org/10.1182/blood.2023022882
Published: 2024
Includes: Supplemental data
Journal Articles

Cyclosporine and Voclosporin Resistant Immune Effector Cells to Improve Outcomes after Stem Cell Transplantation

Holly Wobma, Jiayi Dong, Francesca Alvarez Calderon, Xianliang Rui, Katherine Michaelis, Bruce R Blazar, Victor Tkachev, Ulrike Gerdemann, Leslie Kean
Journal: Blood
Blood (2023) 142 (Supplement 1): 3447.
https://doi.org/10.1182/blood-2023-180218
Published: 2023
Journal Articles

Enhanced T Cell Function of PTPN2 Deleted CAR-T Cells Comes at a Cost: PTPN2 Knockout CAR-Ts Secrete More Cytokines and Demonstrate Increased Cytotoxicity, but Exhibit More Severe CRS and Icans in a Non-Human Primate Model

Francesca Alvarez Calderon, Ryan A Fleming, Lev Gorfinkel, Katherine Michaelis, Xianliang Rui, James Kaminski, Dana Bonin, Anick Mallette, Katherine Brodeur, Heber Domingues, Jennifer Lane, Victor Tkachev, Leslie Kean, Ulrike Gerdemann
Journal: Blood
Blood (2023) 142 (Supplement 1): 2087.
https://doi.org/10.1182/blood-2023-187499
Published: 2023
Journal Articles

In Vivo Delivery of RNA By Lipid Nanoparticles (LNP) to Hematopoietic Stem Cells and T Cells in Humanized Mice and Non-Human Primates

Michael T. Monte, Han Gu, Laura Saunders, Mohit Gupta, Lei Liu, Apiwat Wangweerawong, Thomas V. Colace, Aaron Zannini, Lorenzo Tozzi, Yu Cao, Giulia Schiroli, William E. Salomon, James B. Rottman, Rahul Palchaudhuri, Ulrike Gerdemann, Lev Gorfinkel, Francesca Alvarez Calderon, Leslie Kean, Hari Pujar, Z. Jane Wang
Journal: Blood
Blood (2023) 142 (Supplement 1): 4818.
https://doi.org/10.1182/blood-2023-187271
Published: 2023
Journal Articles

CAR-T Cell Infusion Results in Activation of CD160+/NKG2D+/CCL5+ Non-CAR CD8+ Cytotoxic 'Bystander' T Cells in Both Non-Human Primates (NHP) and Patients Receiving B-Cell-Directed CAR-Ts

Ulrike Gerdemann, James Kaminski, Ryan A Fleming, Victor Tkachev, Francesca Alvarez Calderon, Connor McGuckin, Xianliang Rui, Jennifer Lane, Alex K. Shalek, Leslie Kean
Journal: Blood
Blood (2022) 140 (Supplement 1): 1167–1168.
https://doi.org/10.1182/blood-2022-169435
Published: 2022
Journal Articles

A Novel Human OX40L-CAR-Treg Specifically Targets Activated Antigen-Presenting Cells and Effectively Controls T Cell Alloreactivity and Xeno-GvHD

Xianliang Rui, Francesca Alvarez Calderon, Ulrike Gerdemann, Connor McGuckin, Lorenzo Cagnin, Bruce R. Blazar, Victor Tkachev, Leslie S. Kean
Journal: Blood
Blood (2022) 140 (Supplement 1): 871–872.
https://doi.org/10.1182/blood-2022-165745
Published: 2022
Journal Articles

Uncovering CD4 + T-cell exhaustion in B-ALL

Ulrike Gerdemann, Francesca Alvarez-Calderon
Journal: Blood
Blood (2022) 140 (4): 294–296.
https://doi.org/10.1182/blood.2022016597
Published: 2022
Journal Articles

Low Rates of Venoocclusive Disease and Non-Relapse Mortality in Pediatric Patients Undergoing Allogeneic Hematopoietic Cell Transplantation Following Inotuzumab Ozogamicin Reinduction for Relapsed or Refractory B Cell Acute Lymphoblastic Leukemia

Jonathan D. Paolino, Jiemin Yang, Andrew E. Place, Christine N. Duncan, Steven P. Margossian, Leslie E. Lehmann, John T. Horan, Malika Kapadia, Jennifer S. Whangbo, Francesca Alvarez Calderon, Melissa A. Burns, Leslie S. Kean, Lewis B. Silverman, Donna S. Neuberg, Susanne H.C. Baumeister
Journal: Blood
Blood (2021) 138 (Supplement 1): 2853.
https://doi.org/10.1182/blood-2021-152857
Published: 2021