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Steven P. Margossian
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Journal Articles

B-cell–directed CAR T-cell therapy activates CD8 + cytotoxic CAR neg bystander T cells in patients and nonhuman primates

James Kaminski, Ryan A. Fleming, Francesca Alvarez-Calderon, Marlana B. Winschel, Connor McGuckin, Emily E. Ho, Fay Eng, Xianliang Rui, Paula Keskula, Lorenzo Cagnin, Joanne Charles, Jillian Zavistaski, Steven P. Margossian, Malika A. Kapadia, James B. Rottman, Jennifer Lane, Susanne H. C. Baumeister, Victor Tkachev, Alex K. Shalek, Leslie S. Kean, Ulrike Gerdemann
Journal: Blood
Blood (2024) 144 (1): 46–60.
https://doi.org/10.1182/blood.2023022717
Published: 2024
Includes: Supplemental data
Journal Articles

Out-of-specification tisagenlecleucel does not compromise safety or efficacy in pediatric acute lymphoblastic leukemia

Clinical Trials & Observations
Jenna Rossoff, Christina Baggott, Snehit Prabhu, Holly Pacenta, Christine L. Phillips, Heather Stefanski, Julie-An Talano, Amy Moskop, Steven P. Margossian, Michael R. Verneris, Gary Douglas Myers, Nicole Karras, Patrick A. Brown, Muna Qayed, Michelle Hermiston, Prakash Satwani, Christa Krupski, Amy K. Keating, Rachel Wilcox, Cara A. Rabik, Vanessa A. Fabrizio, Michael Kunicki, Vasant Chinnabhandar, A. Yasemin Goksenin, Kevin J. Curran, Crystal L. Mackall, Theodore W. Laetsch, Liora M. Schultz
Journal: Blood
Blood (2021) 138 (21): 2138–2142.
https://doi.org/10.1182/blood.2021012392
Published: 2021
Journal Articles

Real-World Outcomes for Pediatric and Young Adult Patients with Relapsed or Refractory (R/R) B-Cell Acute Lymphoblastic Leukemia (ALL) Treated with Tisagenlecleucel: Update from the Center for International Blood and Marrow Transplant Research (CIBMTR) Registry

Samuel John, Michael A. Pulsipher, Amy Moskop, Zhen-Huan Hu, Christine L. Phillips, Erin Marie Hall, Steven P. Margossian, Sarah Nikiforow, Paul L. Martin, Benjamin Oshrine, Amy K. Keating, Rayne H. Rouce, Ranjan Tiwari, Santiago Redondo, Jennifer Willert, Abhijit Agarwal, Marcelo C Pasquini, Stephan A. Grupp
Journal: Blood
Blood (2021) 138 (Supplement 1): 428.
https://doi.org/10.1182/blood-2021-146393
Published: 2021
Journal Articles

Low Rates of Venoocclusive Disease and Non-Relapse Mortality in Pediatric Patients Undergoing Allogeneic Hematopoietic Cell Transplantation Following Inotuzumab Ozogamicin Reinduction for Relapsed or Refractory B Cell Acute Lymphoblastic Leukemia

Jonathan D. Paolino, Jiemin Yang, Andrew E. Place, Christine N. Duncan, Steven P. Margossian, Leslie E. Lehmann, John T. Horan, Malika Kapadia, Jennifer S. Whangbo, Francesca Alvarez Calderon, Melissa A. Burns, Leslie S. Kean, Lewis B. Silverman, Donna S. Neuberg, Susanne H.C. Baumeister
Journal: Blood
Blood (2021) 138 (Supplement 1): 2853.
https://doi.org/10.1182/blood-2021-152857
Published: 2021
Journal Articles

Disease Burden Impacts Outcomes in Pediatric and Young Adult B-Cell Acute Lymphoblastic Leukemia after Commercial Tisagenlecleucel: Results from the Pediatric Real World CAR Consortium (PRWCC)

Liora M. Schultz, MD, Christina Baggott, RN, PhD, Snehit Prabhu, PhD, Holly Pacenta, MD, Christine L Phillips, MD, Jenna Rossoff, MD, Heather Stefanski, MDPhD, Julie-An Talano, MD, Amy Moskop, MD, Steven P. Margossian, MD PhD, Michael R Verneris, MD, Gary Douglas Myers, MD, Nicole Karras, MD, Patrick A. Brown, MD, Muna Qayed, MDMSc, Michelle Hermiston, MD PhD, Prakash Satwani, MD, Christa Krupski, DO, MPH, Amy Keating, MD, Rachel Wilcox, Cara A Rabik, MDPhD, Vanessa Fabrizio, MD, Michael Kunicki, Vasant Chinnabhandar, MD, A. Yasemin Goksenin, MD PhD MA, MPH, Kevin J. Curran, MD, Crystal L. Mackall, MD, Theodore W. Laetsch, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 14–15.
https://doi.org/10.1182/blood-2020-134472
Published: 2020
Journal Articles

Real-World Treatment of Pediatric Patients with Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia Using Tisagenlecleucel That Is out of Specification for Commercial Release

Jenna Rossoff, MD, Christina Baggott, RN, PhD, Snehit Prabhu, PhD, Holly Pacenta, MD, Christine L Phillips, MD, Heather Stefanski, MDPhD, Julie-An Talano, MD, Amy Moskop, MD, Steven P. Margossian, MD PhD, Michael R Verneris, MD, Gary Douglas Myers, MD, Nicole Karras, MD, Patrick A. Brown, MD, Muna Qayed, MDMSc, Michelle Hermiston, MD PhD, Prakash Satwani, MD, Christa Krupski, DO, MPH, Amy Keating, MD, Rachel Wilcox, Cara A Rabik, MDPhD, Vanessa Fabrizio, MD, Michael Kunicki, Vasant Chinnabhandar, MD, A. Yasemin Goksenin, MD PhD MA, MPH, Kevin J. Curran, MD, Crystal L. Mackall, MD, Theodore W. Laetsch, MD, Liora M. Schultz, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 42–44.
https://doi.org/10.1182/blood-2020-136674
Published: 2020
Journal Articles

Toxicity and response after CD19-specific CAR T-cell therapy in pediatric/young adult relapsed/refractory B-ALL

Clinical Trials & Observations
Kevin J. Curran, Steven P. Margossian, Nancy A. Kernan, Lewis B. Silverman, David A. Williams, Neerav Shukla, Rachel Kobos, Christopher J. Forlenza, Peter Steinherz, Susan Prockop, Farid Boulad, Barbara Spitzer, Maria I. Cancio, Jaap Jan Boelens, Andrew L. Kung, Yasmin Khakoo, Victoria Szenes, Jae H. Park, Craig S. Sauter, Glenn Heller, Xiuyan Wang, Brigitte Senechal, Richard J. O’Reilly, Isabelle Riviere, Michel Sadelain, Renier J. Brentjens
Journal: Blood
Blood (2019) 134 (26): 2361–2368.
https://doi.org/10.1182/blood.2019001641
Published: 2019
Includes: Supplemental data
Journal Articles

Allogeneic CD34-Selected HSCT Following CAR T-Cells Is Associated with Low TRM and Favorable OS in Pediatric/Young Adult Patients with Relapsed/Refractory B-ALL

Vanessa Fabrizio, MD, Farid Boulad, MD, Maria I. Cancio, MD, Meghan A. Higman, MD PhD, Steven P. Margossian, MD PhD, Audrey Mauguen, PhD, Susan Prockop, MD, Andromachi Scaradavou, MD, Niketa C. Shah, MD, Barbara Spitzer, MD, Nick Yeager, Nancy A. Kernan, Richard O'Reilly, MD, Jaap Jan Boelens, MD PhD, Kevin J. Curran, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4582.
https://doi.org/10.1182/blood-2019-121767
Published: 2019
Journal Articles

Tisagenlecleucel Chimeric Antigen Receptor (CAR) T-Cell Therapy for Relapsed/Refractory Children and Young Adults with Acute Lymphoblastic Leukemia (ALL): Real World Experience from the Center for International Blood and Marrow Transplant Research (CIBMTR) and Cellular Therapy (CT) Registry

Stephan Grupp, MD PhD, Zhen-Huan Hu, MPH, Yiyun Zhang, PhD, Amy Keating, MD, Michael A. Pulsipher, MD, Christine Philips, Steven P. Margossian, MD PhD, Joseph Rosenthal, MD MS, Dana Salzberg, MD, Deborah E. Schiff, MD, Gregory Yanik, MD, Kevin J. Curran, MD, Andrew C. Harris, MD, Peiman Hematti, MD, Sarah Nikiforow, MD PhD, Patricia Steinert, PhD, Lan Yi, PhD, Raghav Chawla, MD PhD, Mary M. Horowitz, Eric Bleickardt, MD, Marcelo C. Pasquini, MDMS
Journal: Blood
Blood (2019) 134 (Supplement_1): 2619.
https://doi.org/10.1182/blood-2019-129279
Published: 2019
Journal Articles

Ruxolitinib and Steroid Refractory/Dependent Bronchiolitis Obliterans after Hematopoietic Cell Transplantation: A Steroid Sparing Agent That Also Resulted in Improved Lung Function in Children

Michelle Schoettler, MD, Meera Subramaniam, MD, Steven P. Margossian, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3407.
https://doi.org/10.1182/blood-2018-99-114971
Published: 2018
Journal Articles

Individual Patient Dose-Escalated Low-Dose Interleukin-2 for Steroid-Refractory Chronic Graft-Vs.-Host Disease in Children and Adults: Safety, Efficacy and Immune Correlates

Jennifer Whangbo, MD PhD, Haesook T Kim, PhD, Jeremy Stewart, BA, Lauren Leonard, BSc, Soomin Kim, BA, Carol Reynolds, PhD, Marie Chammas, BSc, Kelly Verrill, BSN, Michelle A. Lee, MD PhD, Steven P. Margossian, MD PhD, Christine Duncan, MD MSc, Leslie E. Lehmann, MD, Sarah Nikiforow, MD PhD, Edwin Alyea, MD, Philippe Armand, MD PhD, Corey Cutler, MD MPH, FRCPC, Vincent T Ho, MD, Bruce Blazar, MD, Joseph H. Antin, MD, Jerome Ritz, MD, Robert J. Soiffer, MD, John Koreth, MBBS, DPhil
Journal: Blood
Blood (2017) 130 (Supplement 1): 3248.
https://doi.org/10.1182/blood.V130.Suppl_1.3248.3248
Published: 2017
Journal Articles

High Dose Cyclophosphamide and Pre-Treatment Disease Burden Dictate Response and Survival in a Multicenter Clinical Trial Using CD19-Specific CAR T Cells for Relapsed/Refractory B-ALL

Kevin J. Curran, MD, Steven P. Margossian, MD PhD, Nancy A. Kernan, MD, Lewis B. Silverman, MD, Jae H. Park, MD, Craig S. Sauter, MD, Eric L Smith, MDPhD, Farid Boulad, MD, Maria I. Cancio, MD, Christopher Forlenza, Carolyn Jackson, Neerav Shukla, MD, Barbara Spitzer, Susan Prockop, MD, Peter G. Steinherz, MD, Andrew L. Kung, MD PhD, Richard J. O'Reilly, MD, Isabelle Riviere, PhD, Michel Sadelain, MD PhD, Renier J. Brentjens, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1326.
https://doi.org/10.1182/blood.V130.Suppl_1.1326.1326
Published: 2017
Journal Articles

Functional Imaging in Children and Adolescents with Relapsed or Refractory Hodgkin Lymphoma and Outcome after Autologous Transplantation

Nmazuo Ozuah, MBBS, Hisham Dahmoush, MD, Frederick Grant, MD, Leslie Lehmann, MD, Amy Billett, MD, Steven P. Margossian, MD PhD
Journal: Blood
Blood (2016) 128 (22): 2264.
https://doi.org/10.1182/blood.V128.22.2264.2264
Published: 2016
Journal Articles

Multi-Center Clinical Trial of CAR T Cells in Pediatric/Young Adult Patients with Relapsed B-Cell ALL

Kevin J. Curran, MD, Isabelle Riviere, PhD, Lewis B. Silverman, MD, Rachel Kobos, MD, Neerav Shukla, MD, Peter G Steinherz, MD, Farid Boulad, MD, Susan Prockop, MD, Andromachi Scaradavou, MD, Steven P. Margossian, MD PhD, Xiuyan Wang, PhD, Yongzeng Wang, PhD, Victoria Szenes, NP, Colleen H Dansereau, MSN, RN, Brenda MacKinnon, RN, Craig S. Sauter, MD, Jae H. Park, MD, Nancy A. Kernan, MD, Richard J O'Reilly, MD, Michel Sadelain, MD PhD, Renier J. Brentjens, MD PhD
Journal: Blood
Blood (2015) 126 (23): 2533.
https://doi.org/10.1182/blood.V126.23.2533.2533
Published: 2015
Journal Articles

25-OH Vitamin D Deficiency Following Pediatric Hematopoietic Stem Cell Transplant.

Christine Duncan, MD, MMSc, Erin Apfelbaum, RN, Katherine Whitley, Steven P. Margossian, MD, PhD, Leslie E. Lehmann, MD
Journal: Blood
Blood (2010) 116 (21): 1310.
https://doi.org/10.1182/blood.V116.21.1310.1310
Published: 2010
Journal Articles

Functional Interaction between FANCD2 and ATM in the DNA Damage Response.

Steven P. Margossian, MD, PhD, Gary Ho, Richard Kennedy, MD, PhD, Alan D. D’Andrea, MD
Journal: Blood
Blood (2005) 106 (11): 181.
https://doi.org/10.1182/blood.V106.11.181.181
Published: 2005
Journal Articles

Regulated interaction of the Fanconi anemia protein, FANCD2, with chromatin

Rocio Montes de Oca, Paul R. Andreassen, Steven P. Margossian, Richard C. Gregory, Toshiyasu Taniguchi, XiaoZhe Wang, Scott Houghtaling, Markus Grompe, Alan D. D'Andrea
Journal: Blood
Blood (2005) 105 (3): 1003–1009.
https://doi.org/10.1182/blood-2003-11-3997
Published: 2005