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Theodore W. Laetsch
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Journal Articles

Role of B Cell Recovery in Relapse Risk and CD19 Phenotype Following Real-World Use of Tisagenlecleucel for Pediatric B-Acute Lymphoblastic Leukemia: A Multi-Institutional Retrospective Study

Xiaopei Lily Zeng, Soyang Kwon, Anant Vatsayan, Christina Baggott, Snehit Prabhu, Samuel John, Holly L. Pacenta, Christine L. Phillips, Jenna Rossoff, Julie-An Talano, Amy Moskop, Michael R Verneris, Douglas D. Myers, Erin Marie Hall, Nicole A Karras, Challice L. Bonifant, Muna Qayed, Michelle L. Hermiston, Prakash Satwani, Christa Krupski, Amy K Keating, Susanne H.C. Baumeister, Vanessa A. Fabrizio, Vasant Chinnabhandar, Emily Egeler, Sharon Mavroukakis, Khanh Nguyen, Kevin J. Curran, Crystal L. Mackall, Theodore W. Laetsch, Liora Michal Schultz, Kevin O. McNerney
Journal: Blood
Blood (2024) 144 (Supplement 1): 2817.
https://doi.org/10.1182/blood-2024-211231
Published: 2024
Journal Articles

The Role of Gut Microbiota in Modulating Efficacy and Adverse Effects of CAR T-Cell Therapy in the Pediatric Population

Zoe O'Connor, Ashley Bui, Laura Coughlin, Shuheng Gan, Samuel John, Nicole Poulides, Parastoo Sabaeifard, Xiaowei Zhan, Stephen Lim, Angelica Sanjuan, Theodore W. Laetsch, Andrew Y. Koh
Journal: Blood
Blood (2024) 144 (Supplement 1): 3429.
https://doi.org/10.1182/blood-2024-211415
Published: 2024
Journal Articles

Risk Factors and Outcomes for Hematotoxicity Following Tisagenlecleucel for Pediatric B-Acute Lymphoblastic Leukemia

Kevin O. McNerney, Vanessa A. Fabrizio, Aimee C. Talleur, Stephanie Si Lim, Alexandra Dreyzin, Christina Baggott, Anant Vatsayan, Jenna Rossoff, Snehit Prabhu, Holly L. Pacenta, Christine L Phillips, Julie-An Talano, Amy Moskop, Michael R Verneris, Douglas Myers, Nicole Karras, Challice L. Bonifant, Muna Qayed, Michelle L. Hermiston, Prakash Satwani, Christa Krupski, Amy Keating, Susanne H.C. Baumeister, Vasant Chinnabhandar, Emily Egeler, Kevin J Curran, Crystal L. Mackall, Theodore W. Laetsch, Liora Michal Schultz, Swati Naik
Journal: Blood
Blood (2023) 142 (Supplement 1): 2133.
https://doi.org/10.1182/blood-2023-189921
Published: 2023
Journal Articles

Establishing Costs for Commercial Chimeric Antigen Receptor T-Cell (Tisagenlecleucel; Kymriah) in Children and Young Adult B-Cell Acute Lymphoblastic Leukemia; A Merged Analysis from the Prwcc and PHIS

Prakash Satwani, Karen Chao, Maria Lopez-Garcia, Matt Hall, Zhezhen Jin, Lena E Winestone, Danielle Novetsky Friedman, Rachel Phelan, Christina Baggott, Samuel John, Holly L. Pacenta, Theodore W. Laetsch, Christine L Phillips, Michael R Verneris, Vanessa A. Fabrizio, Amy Keating, Julie-An Talano, Amy Moskop, Susanne H.C. Baumeister, Muna Qayed, Doug Douglas Myers, Erin Marie Hall, Snehit Prabhu, Khanh Nguyen, Casey A Carr, Crystal L. Mackall, John K Lin, Jeremy Goldhaber-Fiebert, Liora Michal Schultz
Journal: Blood
Blood (2023) 142 (Supplement 1): 6912.
https://doi.org/10.1182/blood-2023-187462
Published: 2023
Journal Articles

Differences in Absolute Neutrophil Count Eligibility Criteria of Pediatric Phase I and Phase I/II Oncology Clinical Trials According to Sponsorship

Rebecca Kelly, Jenny Ruiz, Richard Aplenc, Theodore W. Laetsch, Alix E. Seif
Journal: Blood
Blood (2023) 142 (Supplement 1): 7327.
https://doi.org/10.1182/blood-2023-186392
Published: 2023
Journal Articles

Peripheral Blast Count at Apheresis Acts Independent of Disease Burden As a Risk Factor for Survival Following Tisagenlecleucel in Children and Young Adults

Vanessa A. Fabrizio, Kristen Miller, Christina Baggott, Snehit Prabhu, Holly Pacenta, Christine L. Phillips, Jenna Rossoff, Heather E. Stefanski, Julie Talano, Amy Moskop, Susanne H.C. Baumeister, Gary Douglas Myers, Nicole Karras, Patrick A. Brown, Muna Qayed, Michelle L. Hermiston, Prakash Satwani, Christa Krupski, Rachel Wilcox, Vasant Chinnabhandar, Kevin J. Curran, Crystal L. Mackall, Theodore W. Laetsch, Amy K. Keating, Michael R. Verneris, Liora M. Schultz
Journal: Blood
Blood (2022) 140 (Supplement 1): 4661–4663.
https://doi.org/10.1182/blood-2022-169603
Published: 2022
Journal Articles

Obesity Associates with Inferior Outcomes and Toxicity in Pediatric and Young Adult Patient with Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia Treated with Commercially Manufactured Tisagenlecleucel

Anthony J Ross, Christina Baggott, Snehit Prabhu, Holly Pacenta, Christine Philips, Jenna Rossoff, Heather E Stefanski, Julie Talano, Amy Moskop, Susanne H.C. Baumeister, Michael R Verneris, Gary Douglas Myers, Nicole Karras, Muna Qayed, Michelle L. Hermiston, Prakash Satwani, Christa Krupski, Amy K. Keating, Rachel Wilcox, Vanessa A Fabrizio, Vasant Chinnabhandar, Kevin J. Curran, Crystal L. Mackall, Theodore W. Laetsch, Sandra K Althouse, Shannon L. Maude, Curtis J Henry, Liora M. Schultz, Jodi L. Skiles
Journal: Blood
Blood (2022) 140 (Supplement 1): 10419–10421.
https://doi.org/10.1182/blood-2022-163336
Published: 2022
Journal Articles

Standard Cytogenetic Risk Stratification Is Not Predictive of CD19 CAR Outcomes and Impact of Disease Burden Varies between Cytogenetic Risk Groups

John C. Molina, Vasant Chinnabhandar, Vanessa A Fabrizio, Michael Kunicki, Holly Pacenta, Jenna Rossoff, Heather E Stefanski, Julie Talano, Amy Moskop, Michael R Verneris, Gary Douglas Myers, Nicole Karras, Christina Baggott, Muna Qayed, Michelle L. Hermiston, Prakash Satwani, Christa Krupski, Amy K. Keating, Susanne H.C. Baumeister, Kevin J. Curran, Crystal L. Mackall, Theodore W. Laetsch, Liora M. Schultz, Stephanie M. Smith
Journal: Blood
Blood (2022) 140 (Supplement 1): 10386–10388.
https://doi.org/10.1182/blood-2022-165951
Published: 2022
Journal Articles

Out-of-specification tisagenlecleucel does not compromise safety or efficacy in pediatric acute lymphoblastic leukemia

Clinical Trials & Observations
Jenna Rossoff, Christina Baggott, Snehit Prabhu, Holly Pacenta, Christine L. Phillips, Heather Stefanski, Julie-An Talano, Amy Moskop, Steven P. Margossian, Michael R. Verneris, Gary Douglas Myers, Nicole Karras, Patrick A. Brown, Muna Qayed, Michelle Hermiston, Prakash Satwani, Christa Krupski, Amy K. Keating, Rachel Wilcox, Cara A. Rabik, Vanessa A. Fabrizio, Michael Kunicki, Vasant Chinnabhandar, A. Yasemin Goksenin, Kevin J. Curran, Crystal L. Mackall, Theodore W. Laetsch, Liora M. Schultz
Journal: Blood
Blood (2021) 138 (21): 2138–2142.
https://doi.org/10.1182/blood.2021012392
Published: 2021
Journal Articles

KMT2A Rearrangements Are Associated with Lineage Switch Following CD19 Targeting CAR T-Cell Therapy

Adam J. Lamble, Regina M. Myers, Agne Taraseviciute, Samuel John, Bonnie Yates, Seth M. Steinberg, Jennifer Sheppard, Alexandra E. Kovach, Brent L. Wood, Michael Borowitz, Maryalice Stetler-Stevenson, Constance M. Yuan, Vinodh Pillai, Toni Foley, Perry Chung, Lee Chen, Daniel W. Lee, Colleen Annesley, Amanda M. DiNofia, Stephan A. Grupp, Michael R Verneris, Lia Gore, Theodore W. Laetsch, Deepa Bhojwani, Patrick A. Brown, Michael A. Pulsipher, Susan R. Rheingold, Rebecca A Gardner, Nirali N. Shah
Journal: Blood
Blood (2021) 138 (Supplement 1): 256.
https://doi.org/10.1182/blood-2021-153336
Published: 2021
Journal Articles

Real-World Treatment of Pediatric Patients with Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia Using Tisagenlecleucel That Is out of Specification for Commercial Release

Jenna Rossoff, MD, Christina Baggott, RN, PhD, Snehit Prabhu, PhD, Holly Pacenta, MD, Christine L Phillips, MD, Heather Stefanski, MDPhD, Julie-An Talano, MD, Amy Moskop, MD, Steven P. Margossian, MD PhD, Michael R Verneris, MD, Gary Douglas Myers, MD, Nicole Karras, MD, Patrick A. Brown, MD, Muna Qayed, MDMSc, Michelle Hermiston, MD PhD, Prakash Satwani, MD, Christa Krupski, DO, MPH, Amy Keating, MD, Rachel Wilcox, Cara A Rabik, MDPhD, Vanessa Fabrizio, MD, Michael Kunicki, Vasant Chinnabhandar, MD, A. Yasemin Goksenin, MD PhD MA, MPH, Kevin J. Curran, MD, Crystal L. Mackall, MD, Theodore W. Laetsch, MD, Liora M. Schultz, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 42–44.
https://doi.org/10.1182/blood-2020-136674
Published: 2020
Journal Articles

Pre-CAR Blinatumomab Is Associated with Increased Post-CD19 CAR Relapse and Decreased Event Free Survival

Agne Taraseviciute, MD, Seth M. Steinberg, PhD, Regina M. Myers, MD, Lia Gore, MD, Adam J. Lamble, MD, Patrick A. Brown, MD, Jennifer Sheppard, Bonnie Yates, NP, Perry Chung, MD, Lee Chen, Colleen Annesley, MD, Deepa Bhojwani, MD, Theodore W. Laetsch, MD, Rebecca A Gardner, MD, Susan R. Rheingold, MD, Michael A Pulsipher, MD, Nirali N. Shah, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 13–14.
https://doi.org/10.1182/blood-2020-139260
Published: 2020
Journal Articles

Disease Burden Impacts Outcomes in Pediatric and Young Adult B-Cell Acute Lymphoblastic Leukemia after Commercial Tisagenlecleucel: Results from the Pediatric Real World CAR Consortium (PRWCC)

Liora M. Schultz, MD, Christina Baggott, RN, PhD, Snehit Prabhu, PhD, Holly Pacenta, MD, Christine L Phillips, MD, Jenna Rossoff, MD, Heather Stefanski, MDPhD, Julie-An Talano, MD, Amy Moskop, MD, Steven P. Margossian, MD PhD, Michael R Verneris, MD, Gary Douglas Myers, MD, Nicole Karras, MD, Patrick A. Brown, MD, Muna Qayed, MDMSc, Michelle Hermiston, MD PhD, Prakash Satwani, MD, Christa Krupski, DO, MPH, Amy Keating, MD, Rachel Wilcox, Cara A Rabik, MDPhD, Vanessa Fabrizio, MD, Michael Kunicki, Vasant Chinnabhandar, MD, A. Yasemin Goksenin, MD PhD MA, MPH, Kevin J. Curran, MD, Crystal L. Mackall, MD, Theodore W. Laetsch, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 14–15.
https://doi.org/10.1182/blood-2020-134472
Published: 2020
Journal Articles

Venetoclax and Navitoclax in Pediatric Patients with Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma

Jeffrey E. Rubnitz, MD, Thomas B. Alexander, MDMPH, Theodore W. Laetsch, MD, Seong Lin Khaw, MD, Vinod A. Pullarkat, MD, Joseph T. Opferman, PhD, Kathryn G Roberts, PhD, Lindsey Rosenwinkel, Bo Tong, PhD, John C. Pesko, PhD, Mohamed Badawi, Deeksha Vishwamitra, PhD, Su Young Kim, Charles G Mullighan, MBBS, MD, Norman J. Lacayo, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 12–13.
https://doi.org/10.1182/blood-2020-134582
Published: 2020
Journal Articles

Updated Analysis of the Efficacy and Safety of Tisagenlecleucel in Pediatric and Young Adult Patients with Relapsed/Refractory (r/r) Acute Lymphoblastic Leukemia

Stephan A. Grupp, MD PhD, Shannon L. Maude, MD PhD, Susana Rives, MD PhD, Andre Baruchel, MD, Michael W. Boyer, MD, Henrique Bittencourt, MD PhD, Peter Bader, MD PhD, Jochen Büchner, MDPhD, Theodore W. Laetsch, MD, Heather Stefanski, MDPhD, Gary Douglas Myers, MD, Muna Qayed, MD MSc, Michael A. Pulsipher, MD, Barbara De Moerloose, MD PhD, Gregory A. Yanik, MD, Kara L. Davis, DO, Paul L. Martin, MD PhD, Eneida R. Nemecek, MD, Christina Peters, MD, Joerg Krueger, MD, Adriana Balduzzi, MD, Nicolas Boissel, MD PhD, Francoise Marie Mechinaud, MD FRACP, Mimi Leung, Lamis K. Eldjerou, MD, Lan Yi, PhD, Karen Thudium Mueller, PharmD,MSc, Eric Bleickardt, MD, Hidefumi Hiramatsu, MD, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 895.
https://doi.org/10.1182/blood-2018-99-112599
Published: 2018
Journal Articles

Molecular Detection of Minimal Residual Disease Precedes Morphological Relapse and Could be Used to Identify Relapse in Pediatric and Young Adult B-Cell Acute Lymphoblastic Leukemia Patients Treated with Tisagenlecleucel

Michael A. Pulsipher, MD, Xia Han, M.S., Máire Quigley, PhD, Gabor Kari, MD, Susana Rives, MD PhD, Theodore W. Laetsch, MD, Gary Douglas Myers, MD, Hidefumi Hiramatsu, MD, PhD, Gregory A. Yanik, MD, Muna Qayed, MD MSc, Timothy Driscoll, MD, Michael W. Boyer, MD, Heather Stefanski, MDPhD, Jochen Büchner, MDPhD, Andre Baruchel, MD, Peter Bader, MD PhD, Lan Yi, PhD, Creton Kalfoglou, Harlan Robins, PhD, Erik Yusko, PhD, Güllü Görgün, PhD, Eric Bleickardt, MD, Stephane Wong, PhD MBA, Stephan A. Grupp, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1551.
https://doi.org/10.1182/blood-2018-99-115460
Published: 2018
Journal Articles

False-positive results with select HIV-1 NAT methods following lentivirus-based tisagenlecleucel therapy

Clinical Trials & Observations
Theodore W. Laetsch, Shannon L. Maude, Michael C. Milone, Kara L. Davis, Joerg Krueger, Ana Maria Cardenas, Lamis K. Eldjerou, Christopher H. Keir, Patricia A. Wood, Stephan A. Grupp
Journal: Blood
Blood (2018) 131 (23): 2596–2598.
https://doi.org/10.1182/blood-2017-12-822940
Published: 2018
Journal Articles

CTL019 Model-Based Cellular Kinetic Analysis of Chimeric Antigen Receptor (CAR) T Cells to Characterize the Impact of Tocilizumab on Expansion and to Identify Correlates of Cytokine Release Syndrome Severity

Andrew M Stein, Stephan A Grupp, MD PhD, John E Levine, MD, Theodore W Laetsch, MD, Michael A Pulsipher, MD, Michael W Boyer, MD, Keith J August, MD MS, Bruce L Levine, PhD, Carl H June, MD, Lori Tomassian, MS, Sweta Shah, PharmD, Mimi Leung, MPH, Pai-Hsi Huang, Sebastien Jolivet, Rakesh Awasthi, PhD, Karen Thudium Mueller, PharmD,MSc, Patricia A Wood, MD PhD, Shannon L Maude, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2561.
https://doi.org/10.1182/blood.V130.Suppl_1.2561.2561
Published: 2017
Journal Articles

CTL019 Therapy Appears Safe and Effective in Pediatric Patients with Down Syndrome with Relapsed/ Refractory (r/r) Acute Lymphoblastic Leukemia

Theodore W Laetsch, MD, Shannon L Maude, MD PhD, Stephan A Grupp, MD PhD, Michael W Boyer, MD, Andrew C Harris, MD, Muna Qayed, MDMSc, Christine L Phillips, MD, Michael A Pulsipher, MD, Henrique Bittencourt, MD PhD, Patricia A Wood, MD PhD, Karen Thudium Mueller, PharmD,MSc, Yanqui Weng, PhD, Carl H June, MD, Bruce L Levine, PhD, Hidefumi Hiramatsu, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1280.
https://doi.org/10.1182/blood.V130.Suppl_1.1280.1280
Published: 2017
Journal Articles

Impact of Humoral Immunogenicity (Anti-mCAR19 Antibodies) on CTL019 Cellular Kinetics, Efficacy, and Safety

Karen Thudium Mueller, PharmD,MSc, Edward Waldron, PhD, Denise Sickert, PhD, Stephan A Grupp, MD PhD, Shannon L Maude, MD PhD, John E Levine, MD, Theodore W Laetsch, MD, Michael A Pulsipher, MD, Michael W Boyer, MD, Keith J August, MD MS, Rakesh Awasthi, PhD, Bruce L Levine, PhD, Carl H June, MD, Tetiana Taran, MD, Patricia A Wood, MD PhD, Gary Douglas Myers, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1281.
https://doi.org/10.1182/blood.V130.Suppl_1.1281.1281
Published: 2017