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Journal Articles

WU-CART-007 (WT-7) Is an Effective Treatment for Adolescent Patients with Relapsed or Refractory (R/R) T-Cell Acute Lymphoblastic Leukemia/ Lymphoblastic Lymphoma (T-ALL/LBL) - Subgroup Analysis of WU-CART-007 1001

Shannon L. Maude, Deepa Bhojwani, Alan S. Wayne, Friso G. J. Calkoen, André Baruchel, Christian Michel Zwaan, Michael P. Rettig, Ouiam Bakkacha, Justo L. Gonzalez, Deborah Masters, Maria del Rosario, Laura Simpson, Preeta Dasgupta, Tony Wu, Stephen Moran, Michael Munroe, Haley Irons, Eileen McNulty, Matthew L. Cooper, Alexander Hamil, John Muth, Brett Ramsey, Jan K Davidson-Moncada, John F. DiPersio
Journal: Blood
Blood (2024) 144 (Supplement 1): 3461.
https://doi.org/10.1182/blood-2024-201998
Published: 2024
Journal Articles

WU-CART-007 (WT-7), an Allogeneic CAR T-Cell Targeting CD7 in Relapsed/Refractory (R/R) T-Cell Acute Lymphoblastic Leukemia/Lymphoma (T-ALL/LBL): Phase 2 Results

Armin Ghobadi, Ibrahim Aldoss, Shannon L. Maude, Deepa Bhojwani, Rawan Faramand, Ashish Bajel, Friso G. J. Calkoen, Alan S. Wayne, Bhagirathbhai Dholaria, Ryan J Mattison, Anita W. Rijneveld, Christian Michel Zwaan, André Baruchel, Nicolas Boissel, Michael P. Rettig, Maria del Rosario, Stephen Moran, Alexander Hamil, Ouiam Bakkacha, Deborah Masters, Justo L. Gonzalez, Michael Munroe, Laura Simpson, Preeta Dasgupta, Tony Wu, John Muth, Haley Irons, Brett Ramsey, Eileen McNulty, Matthew L. Cooper, Jan K Davidson-Moncada, John F. DiPersio
Journal: Blood
Blood (2024) 144 (Supplement 1): 3450.
https://doi.org/10.1182/blood-2024-202005
Published: 2024
Journal Articles

WUC007-03: A Phase 2 Study of Anti-CD7 Allogenic CAR-T Cells (WT-7) in Patients with Relapsed/Refractory (R/R) T-Cell Acute Lymphoblastic Leukemia (T-ALL)/Lymphoblastic Lymphoma (LBL)

Armin Ghobadi, Shannon L. Maude, Ibrahim Aldoss, Ashish Bajel, Ryan J Mattison, Deepa Bhojwani, Alan S. Wayne, Rawan Faramand, Bhagirathbhai Dholaria, Seong Lin Khaw, Anita W. Rijneveld, Friso G. J. Calkoen, Christian Michel Zwaan, André Baruchel, Nicolas Boissel, Andrej Lissat, Stefan Schwartz, Peter Bader, Fabian Lang, Michael P. Rettig, Haley Irons, Brett Ramsey, John Muth, Laura Simpson, Preeta Dasgupta, Stephen Moran, Michael Munroe, Maria del Rosario, Tony Wu, Ouiam Bakkacha, Justo L. Gonzalez, Deborah Masters, Alexander Hamil, Eileen McNulty, Matthew L. Cooper, Jan K Davidson-Moncada, John F. DiPersio
Journal: Blood
Blood (2024) 144 (Supplement 1): 7225.
https://doi.org/10.1182/blood-2024-201825
Published: 2024
Journal Articles

Trial in Progress: Update on the TACL T2020-003 Randomized Phase 2 Trial to Improve Diet and Exercise in Acute Lymphoblastic Leukemia (IDEAL-2)

Etan Orgel, Sarah K. Tasian, Yueh-Yun Chi, Jemily Malvar, Christina M. Dieli-Conwright, Rubi Buxton, Mackenzie Frederick, Hannah Williams, Karen R Rabin, Susan R Rheingold, Robin Norris, Tamara P. Miller, Brent L. Wood, Ellynore Florendo, Ellen Chang, Lisa Hartman, Mallorie M. Heneghan, Michelle L. Hermiston, Joel Kaplan, Tamra Slone, Deepa Bhojwani, Alan S. Wayne, Steven D. Mittelman
Journal: Blood
Blood (2024) 144 (Supplement 1): 2828.1.
https://doi.org/10.1182/blood-2024-201871
Published: 2024
Journal Articles

TCL1A Is Associated with Blinatumomab Response and Immune Activation in Pediatric B-ALL

Andrew Hughes, Rawan Shraim, Lahari Uppuluri, Haley Newman, Gongping Shi, Julie Asare, Theresa Ryan, Elizabeth A. Raetz, James A. Whitlock, Maureen M. O'Brien, Deepa Bhojwani, Rachel E. Rau, Kara L. Davis, Stacy Cooper, Patrick Brown, Stephen P. Hunger, Mignon L. Loh, Laura E. Hogan, Stephan A. Grupp, Jun J. Yang, David T. Teachey, Caroline Diorio
Journal: Blood
Blood (2024) 144 (Supplement 1): 634.
https://doi.org/10.1182/blood-2024-203756
Published: 2024
Journal Articles

A Retrospective Study of Inotuzumab Ozogamicin in Individuals with Down Syndrome and B-Cell Acute Lymphoblastic Leukemia

Amanda M Li, Catherine Aftandilian, Susan Colace, Sarah Fanizzi, Kelly Elizabeth Faulk, Erin M. Guest, Ammar Hayani, Richard Ho, Anjali Khanna, Kasey Leger, David McCall, Tamara P. Miller, Holly Pacenta, Troy Quigg, Jeremy D. Rubinstein, Deepa Bhojwani, Susan R Rheingold, Maureen M. O'Brien, Karen R Rabin
Journal: Blood
Blood (2024) 144 (Supplement 1): 4204.
https://doi.org/10.1182/blood-2024-209455
Published: 2024
Journal Articles

Metabolomic Profiling of Asparaginase-Induced Hepatotoxicity in Pediatric Acute Lymphoblastic Leukemia

Amani Alqahatni, Deepa Bhojwani, Houda Alachkar
Journal: Blood
Blood (2024) 144 (Supplement 1): 2845.
https://doi.org/10.1182/blood-2024-211306
Published: 2024
Journal Articles

Clinical Factors Associated with Prolonged Cytopenias after CD19 Chimeric Antigen Receptor T-Cell Therapy for Pediatric B-Cell Acute Lymphoblastic Leukemia

Regina M. Myers, Yimei Li, Adam Lamble, Emily M. Hsieh, Samuel John, Gregory Dolan, Hongyan Liu, Lee Chen, Jennifer Sheppard, Amanda M. DiNofia, Colleen Annesley, Stephan A. Grupp, Deepa Bhojwani, Rebecca A. Gardner, Lia Gore, Susan R Rheingold, Nirali N. Shah, Michael A. Pulsipher
Journal: Blood
Blood (2024) 144 (Supplement 1): 4827.
https://doi.org/10.1182/blood-2024-202027
Published: 2024
Journal Articles

Monocytic Differentiation in B-Lymphoblastic Leukemia with CRLF2 rearrangement at Diagnosis: Implications for Pathogenesis and Post-Therapeutic Lineage Switch

Alexandra E. Kovach, Sara K. Silbert, Annie Luong, Gerald Lu, Michael Lu, Hao-Wei Wang, Karen M Chisholm, Andrew Doan, Deepa Bhojwani, Adam Lamble, Nirali N. Shah, Chintan Parekh, Gordana Raca, Brent L. Wood
Journal: Blood
Blood (2024) 144 (Supplement 1): 2799.
https://doi.org/10.1182/blood-2024-198961
Published: 2024
Journal Articles

Examining Disparities By Race, Ethnicity, and Socioeconomic Factors in Children and Young Adults with Relapsed Acute Lymphoblastic Leukemia: A Report from the Children's Oncology Group

John A Ligon, Deepa Bhojwani, Alice Dang, Lingyun Ji, Susan R Rheingold, Xinxin Xu, Meenakshi Devidas, John A. Kairalla, Mary Shago, Nyla A. Heerema, Andrew J. Carroll, Michael J. Borowitz, Brent L. Wood, Naomi J. Winick, William L. Carroll, Stephen P. Hunger, Elizabeth A. Raetz, Mignon L. Loh, Sumit Gupta, Lena E Winestone
Journal: Blood
Blood (2024) 144 (Supplement 1): 2797.
https://doi.org/10.1182/blood-2024-193893
Published: 2024
Journal Articles

TBL1 Inhibition Eradicates Drug Resistant Leukemia Initiating Cells in T-ALL

Samantha Hurwitz, Tatiana Fourfouris, Rachel Friedmann, Ki Jun Lee, Zesheng Wan, Sarah Richmann, Babak Moghimi, Fariba Navid, Justine Delgado, Chintan Parekh, Deepa Bhojwani, Yong-Mi Kim
Journal: Blood
Blood (2024) 144 (Supplement 1): 1418.
https://doi.org/10.1182/blood-2024-208681
Published: 2024
Journal Articles

Optical Genome Mapping Allows Detection and Characterization of Cytogenetically Cryptic Oncogenic Fusions in Pediatric Acute Myeloid Leukemia

Gordana Raca, Alexandra E. Kovach, Karin Miller, Jennifer Han, Katherine Ma, Cindy Fong, Jianling Ji, Ryan Schmidt, Andrew Doan, Deepa Bhojwani
Journal: Blood
Blood (2023) 142 (Supplement 1): 5038.
https://doi.org/10.1182/blood-2023-188356
Published: 2023
Journal Articles

Phase 1/2 Dose-Escalation/Dose-Expansion Study of Anti-CD7 Allogeneic CAR-T Cells (WU-CART-007) in Relapsed or Refractory (R/R) T-Cell Acute Lymphoblastic Leukemia/ Lymphoblastic Lymphoma (T-ALL/LBL)

Armin Ghobadi, Ibrahim Aldoss, Shannon L. Maude, Deepa Bhojwani, Alan S. Wayne, Ashish Bajel, Rawan Faramand, Ryan J Mattison, Bhagirathbhai Dholaria, Michael P. Rettig, Ken Jacobs, Ouiam Bakkacha, John Muth, Angela Pannunzio, Brett Ramsey, Eileen McNulty, Matt L. Cooper, Jan Davidson-Moncada, John F. DiPersio
Journal: Blood
Blood (2023) 142 (Supplement 1): 770.
https://doi.org/10.1182/blood-2023-178723
Published: 2023
Journal Articles

Risk Stratified Treatment for Patients with Newly Diagnosed Juvenile Myelomonocytic Leukemia: A Phase 1/2 Non-Randomized Study of Trametinib and Azacitidine with or without Chemotherapy

Elliot Stieglitz, Yueh-Yun Chi, Bill H. Chang, Sarah K. Tasian, Marielle Yohe, Christopher C Dvorak, Erica Southworth, Janel R. Long-Boyle, Jessica Van Ziffle, Zied Abdullaev, Roy Leong, Alan S. Wayne, Deepa Bhojwani, Mignon L. Loh
Journal: Blood
Blood (2023) 142 (Supplement 1): 3210.
https://doi.org/10.1182/blood-2023-177838
Published: 2023
Journal Articles

Impact of Central Nervous System (CNS) Leukemia Status-Based Therapeutic Protocol Change on the Incidence of CNS2 Diagnosis in Pediatric B-Lymphoblastic Acute Leukemia

Alyssa Rodriguez, Maximilian Wengyn, My H. Vu, Andrew Doan, Gordana Raca, Deepa Bhojwani, Paul S. Gaynon, Alexandra E. Kovach
Journal: Blood
Blood (2023) 142 (Supplement 1): 1457.
https://doi.org/10.1182/blood-2023-190743
Published: 2023
Journal Articles

Impact of Treatment with Inotuzumab Ozogamicin before or after Chimeric Antigen Receptor T-Cell Therapy in Children with Relapsed/Refractory Acute Lymphoblastic Leukemia

Susan R Rheingold, Lingyun Ji, Lia Gore, Xinxin Xu, Deepa Bhojwani, Nirali N. Shah, Elizabeth A. Raetz, Mignon L. Loh, Maureen M. O'Brien
Journal: Blood
Blood (2023) 142 (Supplement 1): 2876.
https://doi.org/10.1182/blood-2023-183103
Published: 2023
Journal Articles

Results from the Phase 1 Portion of a Trial of Oral Ixazomib Combined with Chemotherapy in Relapsed/Refractory Acute Lymphoblastic Leukemia or Lymphoma in Children, Adolescents and Young Adults: A Report from the Therapeutic Advances in Childhood Leukemia and Lymphoma (TACL) Consortium

Eric S. Schafer, Yueh-Yun Chi, Jemily Malvar, Teresa Rushing, Andrew Doan, Holly L. Pacenta, Reuven J. Schore, Richard Sposto, Roy Leong, Paul S. Gaynon, Jeffrey E. Rubnitz, Julio C. Barredo, Tamra Slone, Melinda Pauly, Alan S. Wayne, Deepa Bhojwani, Terzah M. Horton
Journal: Blood
Blood (2023) 142 (Supplement 1): 2872.
https://doi.org/10.1182/blood-2023-180414
Published: 2023
Journal Articles

Anti-Leukemic Activity of Luveltamab Tazevibulin (LT, STRO-002), a Novel Folate Receptor-α (FR-α)-Targeting Antibody Drug Conjugate (ADC) in Relapsed/Refractory CBF2AT3::GLIS2 AML

Robin Williams, Lane Miller, Stephanie Massaro, Elizabeth Krieger, Melinda Pauly, Catherine Nelson, Rebecca Johnson, Jennifer J.G. Welch, Deepa Bhojwani, Babak Moghimi, Philip Neff, Terzah M. Horton, Hamayun Imran, Raul C. Ribeiro, Terri L. Guinipero, Matthew A. Kutny, Felipe Bautista, Amy Johnson, Karen Lewing, Alan S Gamis, Julienne Brackett, David McCall, Teena Bhatla, Maria Luisa Sulis, Amy Tellinghuisen, Jill C. Beck, Soheil Meshinchi
Journal: Blood
Blood (2023) 142 (Supplement 1): 4295.
https://doi.org/10.1182/blood-2023-180141
Published: 2023
Journal Articles

The Role of Integrin Beta-1 in the Chemoresistance of Acute Myeloid Leukemia

Heather Ogana, Samantha Hurwitz, Zesheng Wan, Hye Na Kim, Samy Jambon, Hisham Abdel-Azim, Miller Huang, Moghimi Babak, Nora Heisterkamp, Anne-Marie Carbonell, Chintan Parekh, Marina Konopleva, Deepa Bhojwani, Yong-Mi Kim
Journal: Blood
Blood (2022) 140 (Supplement 1): 8799–8800.
https://doi.org/10.1182/blood-2022-167902
Published: 2022
Journal Articles

TBL1 Inhibitor, Tegavivint, Supresses Cell Survival and Promotes Sensitivity to Chemotherapy in ALL and AML

Samantha Hurwitz, Heather Ogana, Zesheng Wan, Fariba Navid, Deepa Bhojwani, Yong-Mi Kim
Journal: Blood
Blood (2022) 140 (Supplement 1): 5995.
https://doi.org/10.1182/blood-2022-167445
Published: 2022