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Journal Articles

Obesity is associated with poor prognosis in ph-like acute lymphoblastic leukemia

Free
Maiah Zarrabi, Yueh-Yun Chi, Steven Mittelman, Yong-Mi Kim, Etan Orgel
Journal: Blood
Blood (2025) 146 (Supplement 1): 1542.
https://doi.org/10.1182/blood-2025-1542
Published: 2025
Journal Articles

Direct measurement is required for accurate assessment of body composition during therapy for acute lymphoblastic leukemia: A report from the T2020-003 IDEAL2 trial

Free
Etan Orgel, Yueh-Yun Chi, Jemily Malvar, Rubi Buxton, Mackenzie Frederick, Hannah Williams, Tamara Miller, Brent Wood, Christina Dieli-Conwright, Karen Rabin, Susan Rheingold, Robin Norris, Elllynore Florendo, Lisa Hartman, Mallorie Heneghan, Tamra Slone, Joel Kaplan, Ellen Chang, Bill Chang, Deepa Bhojwani, Alan Wayne, Sarah Tasian, Steven Mittelman
Journal: Blood
Blood (2025) 146 (Supplement 1): 6831.
https://doi.org/10.1182/blood-2025-6831
Published: 2025
Journal Articles

Trial in Progress: Update on the TACL T2020-003 Randomized Phase 2 Trial to Improve Diet and Exercise in Acute Lymphoblastic Leukemia (IDEAL-2)

Free
Etan Orgel, Sarah K. Tasian, Yueh-Yun Chi, Jemily Malvar, Christina M. Dieli-Conwright, Rubi Buxton, Mackenzie Frederick, Hannah Williams, Karen R Rabin, Susan R Rheingold, Robin Norris, Tamara P. Miller, Brent L. Wood, Ellynore Florendo, Ellen Chang, Lisa Hartman, Mallorie M. Heneghan, Michelle L. Hermiston, Joel Kaplan, Tamra Slone, Deepa Bhojwani, Alan S. Wayne, Steven D. Mittelman
Journal: Blood
Blood (2024) 144 (Supplement 1): 2828.1.
https://doi.org/10.1182/blood-2024-201871
Published: 2024
Journal Articles

Managing Hypersensitivity Reactions after Asparaginase Treatment: A Systematic Literature Review

Free
Luke Maese, Etan Orgel, Lei Bai, Amy Nguyen, Alison Martin, Holly Gould, Melisa Stricherz
Journal: Blood
Blood (2024) 144 (Supplement 1): 7611.
https://doi.org/10.1182/blood-2024-199760
Published: 2024
Journal Articles

Neurofilament Light Chain: A Potential Biomarker for Chemotherapy Induced Peripheral Neuropathy in Pediatric Adolescent Young Adults

Free
Jennifer Belsky, Etan Orgel, Allie Carter, Maryam Lustberg, Michael E. Roth, Steven D. Rhodes, Jeff Dage, Bryan P Schneider
Journal: Blood
Blood (2024) 144 (Supplement 1): 7739.
https://doi.org/10.1182/blood-2024-211208
Published: 2024
Journal Articles

Utility of a Second Interim Maintenance Phase to Improve Outcomes for Pediatric Acute Lymphoblastic Leukemia: A Report from the Children's Oncology Group

Free
Etan Orgel, Michael J. Burke, John A. Kairalla, Emily Hibbitts, Meenakshi Devidas, Michael J. Borowitz, Brent L. Wood, Nyla A. Heerema, Andrew J. Carroll, Kelly Maloney, Leonard A. Mattano, Anne Angiolillo, Eric C. Larsen, Wanda L. Salzer, David T. Teachey, Naomi J. Winick, William L. Carroll, Stephen P. Hunger, Elizabeth A. Raetz, Mignon L. Loh
Journal: Blood
Blood (2024) 144 (Supplement 1): 2813.
https://doi.org/10.1182/blood-2024-194872
Published: 2024
Journal Articles

Apixaban Is Effective and Safe in Reducing Venous Thromboembolism (VTE) in Obese Patients with Newly Diagnosed Pediatric Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma (ALL/LL) a Sub-Study Analysis of the Prevapix-ALL/Children's Oncology Group ACCL1333 Trial

Free
Vilmarie Rodriguez, Sarah O'Brien, Glen Lew, Etan Orgel, Kimberly Derr, Mark A. Ranalli, Corinna L. Schultz, Adam J. Esbenshade, Arteid Memaj, Joshua Dyme, Nicholas Favatella, Lesley Mitchell
Journal: Blood
Blood (2023) 142 (Supplement 1): 810.
https://doi.org/10.1182/blood-2023-180037
Published: 2023
Journal Articles

Real-World Performance of 2022 Revised World Health Organization (WHO) Criteria for Mixed Phenotype Acute Leukemia (MPAL) B/Myeloid Defined Only By Isolated MPO Expression (isoMPO)

Free
Alexandra E. Kovach, Sunil S. Raikar, Jemily Malvar, Matthew J. Oberley, Gerald Wertheim, Karen R. Rabin, Jyotinder N. Punia, Alix Seif, Reuven J. Schore, Dragos C. Luca, Terri L. Guinipero, William G. Woods, Viviane Cahen, Yueh-Yun Chi, Maurice R.G. O'Gorman, Brent L. Wood, Etan Orgel
Journal: Blood
Blood (2023) 142 (Supplement 1): 1467.
https://doi.org/10.1182/blood-2023-174110
Published: 2023
Journal Articles

The International Consensus Classification of acute leukemias of ambiguous lineage

Free
Olga K. Weinberg, Daniel A. Arber, Hartmut Döhner, Charles G. Mullighan, Etan Orgel, Anna Porwit, Richard M. Stone, Michael J. Borowitz
Journal: Blood
Blood (2023) 141 (18): 2275–2277.
https://doi.org/10.1182/blood.2022019493
Published: 2023
Journal Articles

Efficacy and Safety of FLAG-Ida As Frontline Therapy in a Pediatric AML Population: A Single Institution Experience

Free
Andrew Doan, Holly K.T. Huang, Ari J. Hadar, Jemily Malvar, Teresa Rushing, Gordana Raca, Alexandra E. Kovach, Paul Gaynon, Etan Orgel
Journal: Blood
Blood (2021) 138 (Supplement 1): 2342.
https://doi.org/10.1182/blood-2021-148965
Published: 2021
Journal Articles

Standardization in the Diagnosis of Mixed Phenotype Acute Leukemia (MPAL): Semiquantitative, Universally Applicable Flow Cytometric Criteria for Immunophenotypic Lineage Assignment and Isolated MPO

Free
Alexandra E. Kovach, Sunil S. Raikar, Matthew J. Oberley, Gerald Wertheim, Karen R Rabin, Jyotinder N. Punia, Alix E. Seif, Reuven J Schore, Dragos C. Luca, Terri Guinipero, William G Woods, Viviane Cahen, Maurice R.G. O'Gorman, Etan Orgel, Brent L. Wood
Journal: Blood
Blood (2021) 138 (Supplement 1): 4475.
https://doi.org/10.1182/blood-2021-154295
Published: 2021
Journal Articles

Increased prevalence of CRLF2 rearrangements in obesity-associated acute lymphoblastic leukemia

Free
Clinical Trials & Observations
Steven D. Mittelman, Jiyoon Kim, Gordana Raca, Gang Li, Matthew J. Oberley, Etan Orgel
Journal: Blood
Blood (2021) 138 (2): 199–202.
https://doi.org/10.1182/blood.2021011106
Published: 2021
Includes: Supplemental data
Journal Articles

Preexisting or therapy-induced mutations in relapsed acute lymphoblastic leukemia?

Free
Paul S. Gaynon, Etan Orgel, Lingyun Ji
Journal: Blood
Blood (2020) 136 (19): 2233–2235.
https://doi.org/10.1182/blood.2020005258
Published: 2020
Journal Articles

Integrin α6 mediates the drug resistance of acute lymphoblastic B-cell leukemia

Free
Eun Ji Gang, Hye Na Kim, Yao-Te Hsieh, Yongsheng Ruan, Heather A. Ogana, Solomon Lee, Jennifer Pham, Huimin Geng, Eugene Park, Lars Klemm, Cheryl L. Willman, William L. Carroll, Steven D. Mittelman, Etan Orgel, Matthew J. Oberley, Chintan Parekh, Hisham Abdel-Azim, Deepa Bhojwani, Alan S. Wayne, Adèle De Arcangelis, Elisabeth Georges-Labouesse, Elizabeth Wayner, Halvard Bonig, Aspram Minasyan, Johanna ten Hoeve, Thomas G. Graeber, Markus Müschen, Nora Heisterkamp, Yong-Mi Kim
Journal: Blood
Blood (2020) 136 (2): 210–223.
https://doi.org/10.1182/blood.2019001417
Published: 2020
Includes: Supplemental data
Journal Articles

Clinical Outcomes in Pediatric Mixed Phenotype Acute Leukemia (MPAL) Differ Depending on Disease Classification Criteria; A Multi-Center Cohort Study

Free
Matthew J. Oberley, MD PhD, Gerald Wertheim, MD, PhD, Sunil S. Raikar, MD, Jemily Malvar, Richard Sposto, PhD, Jyotinder N. Punia, MD, Karen R. Rabin, MD PhD, Alix E. Seif, MD, Reuven J. Schore, MD, Dragos C. Luca, MD, Terri Guinipero, MD, William G. Woods, MD, Maurice R.G. O'Gorman, MD PhD, Etan Orgel, MD MS
Journal: Blood
Blood (2018) 132 (Supplement 1): 4080.
https://doi.org/10.1182/blood-2018-99-117377
Published: 2018
Journal Articles

L-Carnitine Does Not Reduce Cytotoxicity from Induction Chemotherapy for Acute Lymphoblastic Leukemia

Free
Jessica Sea, PhD, Etan Orgel, MD MS, Steven D. Mittelman, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5156.
https://doi.org/10.1182/blood-2018-99-117921
Published: 2018
Journal Articles

Age but Not Adiposity Predicts Asparaginase-Induced Hepatotoxicity during Induction Therapy for Adolescent and Young Adults with Acute Lymphoblastic Leukemia

Free
Etan Orgel, MD MS, Celia Framson, MPH, RD, Rubi Vazquez, PT DPT, David R. Freyer, DO MS, Steven D. Mittelman, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2662.
https://doi.org/10.1182/blood-2018-99-110268
Published: 2018
Journal Articles

Minimal Residual Disease Risk-Stratification in Pediatric Mixed Phenotype Acute Leukemia: Results of a Multi-Center Cohort Study

Free
Matthew J. Oberley, MD PhD, Sunil S. Raikar, MD, Jemily Malvar, Gerald Wertheim, MD, PhD, Alix E. Seif, MD, Terri Guinipero, MD, Richard Sposto, PhD, Karen R. Rabin, MD PhD, Jyotinder N. Punia, MD, Reuven J. Schore, MD, Dragos C. Luca, MD, William G. Woods, MD, Maurice R.G. O'Gorman, MD PhD, Etan Orgel, MD MS
Journal: Blood
Blood (2018) 132 (Supplement 1): 558.
https://doi.org/10.1182/blood-2018-99-113606
Published: 2018
Journal Articles

Efficacy of ALL Therapy for WHO2016-Defined Mixed Phenotype Acute Leukemia: A Report from the Children's Oncology Group

Free
Etan Orgel, MD MS, Thomas B. Alexander, MDMPH, Brent Wood, MDPhD, Samir Kahwash, MD, Meenakshi Devidas, Yunfeng Dai, PhD, Todd A Alonzo, PhD, Charles G. Mullighan, MBBS, MD, Hiroto Inaba, MD, Stephen P. Hunger, MD, Alan S Gamis, MD MPH, Andrew J. Carroll, III, PhD, Nyla A. Heerema, PhD, Jason Berman, MD, William G Woods, MD, Mignon L. Loh, MD, Patrick A. Zweidler-McKay, MDPhD, John T Horan, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 883.
https://doi.org/10.1182/blood.V130.Suppl_1.883.883
Published: 2017
Journal Articles

Integrin alpha6-Deletion Induces Apoptosis and Src Signaling Changes in Acute Lymphoblastic Leukemia Cells

Free
Eun Ji Gang, MD PhD, Hye Na Kim, Johanna Scott, PhD, Matthew J Oberley, MDPhD, Etan Orgel, MD MS, Steven D. Mittelman, MDPhD, Yao-Te Hsieh, PhD, Markus Muschen, MD, Deepa Bhojwani, MD, Daniel Braas, PhD, Thomas Graeber, PhD, Nora Heisterkamp, PhD, Yong-Mi Kim, MD MPH, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3878.
https://doi.org/10.1182/blood.V130.Suppl_1.3878.3878
Published: 2017