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Journal Articles

Optimized treatment for pediatric patients with low-risk Acute Myeloid Leukemia: A report from the Children's oncology group study AAML1831

Free
Reena Pabari, Chana Glasser, Todd Alonzo, Jim Wang, Richard Aplenc, Alan Gamis, Betsy Hirsch, Gordana Raca, Soheil Meshinchi, Kasey Leger, Kelly Getz, Anders Kolb, Jessica Pollard, Sarah Tasian, Matthew Kutny, Todd Cooper
Journal: Blood
Blood (2025) 146 (Supplement 1): 878.
https://doi.org/10.1182/blood-2025-878
Published: 2025
Journal Articles

Feasibility and utility of unmatched whole-genome sequencing (uWGS)  for pediatric acute leukemias: An analysis of leukemia precision-based therapy (LEAP) study samples

Free
Jesús Gutiérrez-Abril, Dylan Domenico, Gunes Gundem, Juan Arango Ossa, Anu Amallraja, Konstantinos Liosis, Sarah Tasian, Todd Cooper, Melinda Pauly, Kelly Maloney, Michael Burke, Stacy Cooper, Nathan Gossai, Jennifer McNeer, Justine Kahn, Nobuko Hijiya, Matthew Barth, Jeffrey Magee, Mignon Loh, Kimberly Stegmaier, Marian Harris, Emily Stockfisch, Francesco Maura, Andrew Kung, Elli Papaemmanuil, Maria Luisa Sulis, Yana Pikman, Neerav Shukla
Journal: Blood
Blood (2025) 146 (Supplement 1): 2561.
https://doi.org/10.1182/blood-2025-2561
Published: 2025
Journal Articles

CD19 CAR T cell therapy is an effective strategy for first CNS relapse in pediatric b ALL

Free
Amanda DiNofia, Regina Myers, Yimei Li, Hongyan Liu, Richard Aplenc, Diane Baniewicz, Allison Barz Leahy, Lucy Cain, Colleen Callahan, Caroline Diorio, Joseph Fraietta, Elizabeth Hexner, Caitlin Hopkins, Stephen Hunger, Vanessa Gonzalez, Julie Jadlowsky, Mariam Kerolos, Raabia Khan, Susan McClory, Shannon Maude, Gabriela Plesa, Susan Rheingold, Mackenzie Stewart, Sarah Tasian, Melissa Varghese, Lisa Wray, Stephan Grupp
Journal: Blood
Blood (2025) 146 (Supplement 1): 648.
https://doi.org/10.1182/blood-2025-648
Published: 2025
Journal Articles

Etoposide can be safely removed from induction chemotherapy without impacting survival for pediatric acute myeloid leukemia – a report from the Children's oncology group study AAML1831

Free
Jenna Rossoff, Jing Chen, Todd Alonzo, Jim Wang, Richard Aplenc, Alan Gamis, Betsy Hirsch, Gordana Raca, Soheil Meshinchi, Anders Kolb, Sarah Tasian, Jessica Pollard, Matthew Kutny, Todd Cooper
Journal: Blood
Blood (2025) 146 (Supplement 1): 877.
https://doi.org/10.1182/blood-2025-877
Published: 2025
Journal Articles

Direct measurement is required for accurate assessment of body composition during therapy for acute lymphoblastic leukemia: A report from the T2020-003 IDEAL2 trial

Free
Etan Orgel, Yueh-Yun Chi, Jemily Malvar, Rubi Buxton, Mackenzie Frederick, Hannah Williams, Tamara Miller, Brent Wood, Christina Dieli-Conwright, Karen Rabin, Susan Rheingold, Robin Norris, Elllynore Florendo, Lisa Hartman, Mallorie Heneghan, Tamra Slone, Joel Kaplan, Ellen Chang, Bill Chang, Deepa Bhojwani, Alan Wayne, Sarah Tasian, Steven Mittelman
Journal: Blood
Blood (2025) 146 (Supplement 1): 6831.
https://doi.org/10.1182/blood-2025-6831
Published: 2025
Journal Articles

A novel intercontinental external quality assessment program for flow cytometric measurable residual disease assessment in pediatric AML

Free
Margarita Maurer-Granofszky, Flavia Battistutta, Boutheina Bouslama, Lisa Brodersen, Chad Hudson, Christel Katerkamp, Pamela Scarparo, Anastasia Soboli, Jeroen te Marvelde, Barbara Buldini, Linda Fogelstrand, David Gillis, Hélène Lapillonne, Michael Loken, Vincent van der Velden, Nils Von Neuhoff, Lucy Wheeler, Todd Cooper, Sarah Tasian, Dirk Reinhardt, Gwen Nichols, C. Zwaan, Michael Dworzak
Journal: Blood
Blood (2025) 146 (Supplement 1): 3514.
https://doi.org/10.1182/blood-2025-3514
Published: 2025
Journal Articles

CD123-directed chimeric antigen receptor T-cell (CART123) therapy for relapsed/refractory pediatric acute myeloid leukemia

Free
Lucy Cain, Yimei Li, Anand Bhagwat, Diane Baniewicz, Allison Barz Leahy, Colleen Callahan, Shannon Christensen, Angela Cosey, Amanda DiNofia, Caroline Diorio, Joseph Fraietta, Vanessa Gonzalez, Elizabeth Hexner, Stephen Hunger, Amy Marshall, Shannon Maude, Susan McClory, Regina Myers, Gabriela Plesa, Susan Rheingold, Aakruti Sharma, Mackenzie Stewart, Lisa Wray, Earline Young-Robinson, Stephan Grupp, Saar Gill, Sarah Tasian, Richard Aplenc
Journal: Blood
Blood (2025) 146 (Supplement 1): 1643.
https://doi.org/10.1182/blood-2025-1643
Published: 2025
Journal Articles

From bench to IND: Validation of TSLPR CAR T-cells reveal discrepancies in detection modalities and inform dose selection for a Phase 1 clinical trial in relapsed/refractory CRLF2-rearranged B-ALL patients.

Free
Christopher Chien, Marie Pouzolles, Angela Su, Hannah Song, Brynn Duncan, Dina Schneider, Rimas Orentas, Haneen Shalabi, Sarah Tasian, Terry Fry, Steven Highfill, Nirali Shah, Naomi Taylor
Journal: Blood
Blood (2025) 146 (Supplement 1): 4101.
https://doi.org/10.1182/blood-2025-4101
Published: 2025
Journal Articles

Tumor-induced dendritic cell dysfunction impairs T-cell proliferation and confers poor prognosis in high-risk acute lymphoblastic leukemia

Free
Anil Kumar, Kory Hamane, Caroline Duault, Joao Rodrigues Lima-Junior, Da Hae Jung, Hanjun Qin, Sheyla Salcido, Min Huang, Xinying Guo, Adeleh Taghi Khani, Ashly Sanchez Ortiz, Lucy Ghoda, Guido Marcucci, Norman Lacayo, Kathleen Sakamoto, Christian Hurtz, Martin Carroll, Sarah Tasian, Huimin Geng, Lingyun Ji, Saro Armenian, Shai Izraeli, Holden Maecker, Xiwei Wu, Srividya Swaminathan
Journal: Blood
Blood (2025) 146 (Supplement 1): 5138.
https://doi.org/10.1182/blood-2025-5138
Published: 2025
Journal Articles

Identifying and overcoming mechanisms of resistance to a VpreB1-directed antibody-drug conjugate in the treatment of B-cell acute lymphoblastic leukemia

Free
Robin Williams, Xiaohong Wang, Jason Ostergaard, Joseph Muretta, Sarah Tasian, Stuart Winter, Peter Gordon
Journal: Blood
Blood (2025) 146 (Supplement 1): 5115.
https://doi.org/10.1182/blood-2025-5115
Published: 2025
Journal Articles

HEM-ismart: An international proof-of-concept therapeutic stratification trial of molecular anomalies in relapsed or refractory hematological malignancies in children

Free
Andrej Lissat, Francisco Bautista, Olli Lohi, Uri Ilan, Judith Boer, Monique Den Boer, Cornelia Eckert, Anne Elsinghorst, Ellis van Liempt, Britta Vormoor, Birgit Burkhardt, Jean Pierre Bourquin, Marie-Emilie Dourthe, Martha Grootenhuis, Frederick van Delft, Alwin Huitema, Shai Izraeli, Franco Locatelli, Marion Mateos, Denis Schewe, Arend von Stackelberg, Sarah Tasian, David Teachey, Harm Van Tinteren, C. Zwaan
Journal: Blood
Blood (2025) 146 (Supplement 1): 1582.
https://doi.org/10.1182/blood-2025-1582
Published: 2025
Journal Articles

ITCC-101/APAL2020D: A randomized Phase 3 trial of fludarabine/cytarabine/gemtuzumab ozogamycin with or without venetoclax in children with relapsed Acute Myeloid Leukemia

Free
Sae Ishimaru, Gwenaëlle Gueguen, Seth Karol, Francisco Bautista, Marjolein Mijnders-Remers, Jurren Sluijs, Jesse Anderson, Jennifer Lukin, Ann Collins, Harm Van Tinteren, Faith Galderisi, Mazaher Dhalla, Maika Onishi, Frank Scherer, Kristina Unnebrink, Daisuke Tomizawa, Dirk Reinhardt, Franco Locatelli, Alba Rubio-San-Simón, Gwen Nichols, Todd Cooper, Sarah Tasian, C. Zwaan
Journal: Blood
Blood (2025) 146 (Supplement 1): 1656.
https://doi.org/10.1182/blood-2025-1656
Published: 2025
Journal Articles

Clinical, cytogenetic and molecular characteriszation of Mecom- rearranged pediatric de novo Acute Myeloid Leukemia (AML): A retrospective cohort study of the international-berlin-frankfurt-Münster (I-BFM) AML-study group

Free
Anna Cvrtak, Karin Nebral, Heidrun Boztug, Oussama Abla, Evangelia Antoniou, Barbara Buldini, Malgorzata Czogala, Valerie de Haas, Amber Gibson, Mane Gizhlaryan, Bianca Goemans, Irén Haltrich, Hiroto Inaba, Nkemdirim Jacob, Kristian Juul-Dam, Charikleia Kelaidi, Jeffery Klco, Nora Mühlegger, Tasleema Patel, Martina Pigazzi, Nastassja Scheidegger, Marketa Zaliova, Jonas Abrahamsson, Todd Cooper, Branko Cuglievan, Barbara De Moerloose, Brenda Gibson, Henrik Hasle, Gertjan Kaspers, Franco Locatelli, Arnaud Petit, Sophia Polychronopoulou, Dirk Reinhardt, Patricia Rubio, Jan Stary, Sarah Tasian, Daisuke Tomizawa, Michael Dworzak
Journal: Blood
Blood (2025) 146 (Supplement 1): 1608.
https://doi.org/10.1182/blood-2025-1608
Published: 2025