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Steven Highfill
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Journal Articles

E valuating the S afety of HCAR19 (Now Actalycabtagene Autoleucel- Actaly-Cel™), a Novel H umanized CD19-Directed Chimeric Antigen Receptor T-Cells in Pediatric, Adolescents, and Young Adults with Relapsed/ Refractory B- Acute Lymphoblastic Leukemia (ESHA) - Report of Phase-1B

Gaurav Narula, Swaminathan Keerthivasagam, Hasmukh Jain, Chetan Dhamne, Prashant Tembhare, Papagudi Ganesan Subramanian, Nikhil Patkar, Minal Poojary, Albeena Nisar, Deepali Pandit, Khushali Pandit, Atharva Karulkar, Ankesh Kumar Jaiswal, Aalia Khan, Shreshtha Shah, Afrin Firfiray, Juber Pendhari, Sweety Asija, Ambalika Chowdury, Ankit Banik, Nirmalya Roy Moulik, Shyam Srinivasan, Shilpushp Bhosle, Sumathi Hiregoudar, Shashank Ojha, Lingaraj Nayak, Jayshree Thorat, Bhausaheb Bagal, Manju Sengar, Nishant Jindal, Akanksha Chichra, Sumeet Mirgh, Anant Gokarn, Sachin Punatar, Sunil Rajadhyaksha, Navin Khattry, Shripad Banavali, Steven Highfill, Nirali N. Shah, Rahul Purwar
Journal: Blood
Blood (2023) 142 (Supplement 1): 6878.
https://doi.org/10.1182/blood-2023-180867
Published: 2023
Journal Articles

Making Anti-CD19 CAR-T Cell Therapy Accessible and Affordable: First-in-Human Phase I Clinical Trial Experience from India

Atharva Karulkar, Hasmukh Jain, Shreshtha Shah, Aalia Khan, Ankesh Jaiswal, Afrin Firfiray, Prashant Suvasia, Priyanshi Suvasia, Juber Pendhari, Sweety Asija, Ambalika Chowdury, Ankit Banik, Smrithi Ravikumar, Neha Sharma, Minal Poojary, Sumathi Hiregoudar, Preeti Desai, Anisha Navkudkar, Sunil Rajadhyaksha, Jayashree Thorat, Prashant R. Tembhare, Albeena Nisar, Manju Sengar, David F. Stroncek, Steven Highfill, Nirali N. Shah, Gaurav Narula, Rahul Purwar
Journal: Blood
Blood (2022) 140 (Supplement 1): 4610–4611.
https://doi.org/10.1182/blood-2022-168928
Published: 2022
Journal Articles

Transient Responses and Significant Toxicities Due to Cytopenias and Rashes with Anti-CD30 CAR T Cells for CD30-Expressing Lymphomas: Results of a Phase I Clinical Trial

Jennifer N. Brudno, Jeremiah Karrs, Danielle Natrakul, Nisha Patel, Lekha Mikkilineni, Jennifer Mann, David F. Stroncek, Steven Highfill, Norris Lam, Genevieve C. Fromm, Rashmika Patel, Stefania Pittaluga, James N. Kochenderfer
Journal: Blood
Blood (2022) 140 (Supplement 1): 12731–12732.
https://doi.org/10.1182/blood-2022-157149
Published: 2022
Journal Articles

Allogeneic Peripheral Blood Stem Cell Transplantation for Bone Marrow Failure Syndromes Using CD34 + -Selected Progenitor Cells Co-Infused with a Reduced Number of Non-Mobilized T-Cells

Georg Aue, Yazan Migdady, Yimo Wang, Jennifer Wilder, Brian Wells, Rosa Nadal Rios, Joseph A. Clara, Robert Reger, Kristen Gunn, Melissa Spencer, Jennifer Farren, Patricia Prince, Reem A Shalabi, Steven Highfill, David F. Stroncek, Xin Tian, Richard W. Childs
Journal: Blood
Blood (2022) 140 (Supplement 1): 7576–7577.
https://doi.org/10.1182/blood-2022-169922
Published: 2022
Journal Articles

Extended Detection in Peripheral Blood Following Infusion of Chronic Granulomatous Disease Patient Autologous Granulocytes Corrected By mRNA Transfection in Patients with Chronic Granulomatous Disease

Vera Bzhilyanskaya, Ronald J. Meis, Narda Theobald, Tyra Estwick, Hong Lei, Steven Highfill, David F. Stroncek, Leonard Chen, Kamille West-Mitchell, Gary A. Dahl, Harry L Malech, Suk See De Ravin, Julie Brault
Journal: Blood
Blood (2022) 140 (Supplement 1): 5475–5476.
https://doi.org/10.1182/blood-2022-170390
Published: 2022
Journal Articles

T Cells Expressing a Fully-Human Anti-BCMA Chimeric Antigen Receptor with a Heavy-Chain-Only Antigen-Recognition Domain Exhibit Rapid and Durable Activity Against Multiple Myeloma

Lekha Mikkilineni, Elisabet E. Manasanch, Danielle Natrakul, Katherine Weissler, Jennifer N. Brudno, Jennifer Mann, Stephanie L Goff, James C Yang, Norris Lam, Irina Maric, Hao-Wei Wang, Constance M. Yuan, David F. Stroncek, Steven Highfill, Micaela Ganadan, Rashmika Patel, Steven A Rosenberg, James N. Kochenderfer
Journal: Blood
Blood (2022) 140 (Supplement 1): 7433–7434.
https://doi.org/10.1182/blood-2022-159156
Published: 2022
Journal Articles

Treatment of Patients with T Cells Expressing a Fully-Human Anti-BCMA CAR with a Heavy-Chain Antigen-Recognition Domain Caused High Rates of Sustained Complete Responses and Relatively Mild Toxicity

Lekha Mikkilineni, Elisabet E. Manasanch, Danielle Natrakul, Jennifer N. Brudno, Jennifer Mann, Stephanie L Goff, James C Yang, Norris Lam, Irina Maric, Maryalice Stetler-Stevenson, Hao-Wei Wang, Constance M. Yuan, Tyler Lowe, David F. Stroncek, Steven Highfill, Rashmika Patel, Micaela Ganadan, Steven A Rosenberg, James N. Kochenderfer
Journal: Blood
Blood (2021) 138 (Supplement 1): 3837.
https://doi.org/10.1182/blood-2021-152688
Published: 2021
Journal Articles

Single Chain Variable Fragment Linker Length Regulates CAR Biology and T Cell Efficacy

Nathan Singh, MD, Noelle V. Frey, MD, Boris Engels, PhD, David M. Barrett, Olga Shestova, PhD, Pranali Ravikumar, MS, Amy Shyu, Steven Highfill, PhD, Linlin Zhao, Liaomin Peng, Brian Granda, Melissa Ramones, Xeuqing Maggie Lu, David A Christian, PhD, Jessica Perazzelli, Simon F Lacey, PhD, Nathan Roy, Janis K Burkhardt, PhD, Florent Colomb, Mohamed Abdel-Mohsen, Regina M Young, PhD, Jennifer Brogdon, PhD, Stephan Grupp, MD PhD, Carl H June, MD, Shannon L. Maude, MD PhD, Saar I. Gill, MD PhD, Marco Ruella, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 247.
https://doi.org/10.1182/blood-2019-131024
Published: 2019
Journal Articles

A Pilot Study of Adoptive Cellular Immunotherapy for Progressive Multifocal Leukoencephalopathy with Ex Vivo Generated Polyomavirus-Specific T-Cells

Irene Cortese, Austin John Barrett, David F. Stroncek, Steven Highfill, PhD, Erin Beck, Frances Andrada, Joan Ohayon, Jennifer Dwyer, Matthew Schindler, Georg Aue, Daniel Reich, Avindra Nath, Pawel Muranski, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4535.
https://doi.org/10.1182/blood-2018-99-119832
Published: 2018
Journal Articles

Regression of Epithelial Cancers Following T Cell Receptor Gene Therapy Targeting Human Papillomavirus-16 E7

Scott Michael Norberg, DO, Nisha Nagarsheth, PhD, Stacey Doran, MD, Jennifer A Kanakry, MD, Sabina Adhikary, PhD, Colleen Schweitzer, PhD, Stephanie H Astrow, PhD, William Faquin, MD, Nikolaos Gkitsas, Steven Highfill, PhD, Christian S Hinrichs
Journal: Blood
Blood (2018) 132 (Supplement 1): 492.
https://doi.org/10.1182/blood-2018-99-117017
Published: 2018