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James C Yang
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Journal Articles

T Cells Expressing a Fully-Human Anti-BCMA Chimeric Antigen Receptor with a Heavy-Chain-Only Antigen-Recognition Domain Exhibit Rapid and Durable Activity Against Multiple Myeloma

Lekha Mikkilineni, Elisabet E. Manasanch, Danielle Natrakul, Katherine Weissler, Jennifer N. Brudno, Jennifer Mann, Stephanie L Goff, James C Yang, Norris Lam, Irina Maric, Hao-Wei Wang, Constance M. Yuan, David F. Stroncek, Steven Highfill, Micaela Ganadan, Rashmika Patel, Steven A Rosenberg, James N. Kochenderfer
Journal: Blood
Blood (2022) 140 (Supplement 1): 7433–7434.
https://doi.org/10.1182/blood-2022-159156
Published: 2022
Journal Articles

Treatment of Patients with T Cells Expressing a Fully-Human Anti-BCMA CAR with a Heavy-Chain Antigen-Recognition Domain Caused High Rates of Sustained Complete Responses and Relatively Mild Toxicity

Lekha Mikkilineni, Elisabet E. Manasanch, Danielle Natrakul, Jennifer N. Brudno, Jennifer Mann, Stephanie L Goff, James C Yang, Norris Lam, Irina Maric, Maryalice Stetler-Stevenson, Hao-Wei Wang, Constance M. Yuan, Tyler Lowe, David F. Stroncek, Steven Highfill, Rashmika Patel, Micaela Ganadan, Steven A Rosenberg, James N. Kochenderfer
Journal: Blood
Blood (2021) 138 (Supplement 1): 3837.
https://doi.org/10.1182/blood-2021-152688
Published: 2021
Journal Articles

Deep and Durable Remissions of Relapsed Multiple Myeloma on a First-in-Humans Clinical Trial of T Cells Expressing an Anti-B-Cell Maturation Antigen (BCMA) Chimeric Antigen Receptor (CAR) with a Fully-Human Heavy-Chain-Only Antigen Recognition Domain

Lekha Mikkilineni, MD, Elisabet E. Manasanch, MD, Danielle Vanasse, BS, Jennifer N. Brudno, MD, Jennifer Mann, CRNP, Richard Sherry, MD, Stephanie L Goff, MD, James C Yang, MD, Norris Lam, BS, Irina Maric, MD MSci, Maryalice Stetler-Stevenson, MD PhD, Hao-Wei Wang, MD PhD, Constance M. Yuan, MD PhD, David F. Stroncek, MD, Steven L Highfill, PhD, Vicki Fellowes, Micaela Ganadan, BSN, RN, Rashmika Patel, Steven A Rosenberg, MD PhD, James N. Kochenderfer, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 50–51.
https://doi.org/10.1182/blood-2020-138839
Published: 2020
Journal Articles

Anti-CD19 CAR T Cells Administered after Low-Dose Chemotherapy Can Induce Remissions of Chemotherapy-Refractory Diffuse Large B-Cell Lymphoma

James N Kochenderfer, MD, Robert Somerville, PhD, Lily Lu, PhD, Alex Iwamoto, B.S., James C Yang, MD, Christopher Klebanoff, MD, Udai Kammula, MD, Richard M Sherry, MD, Shi Victoria, M.S., Constance Yuan, MD PhD, Steven Feldman, PhD, Tatyana Feldman, MD, Andre Goy, MD MS, Kathleen E Morton, RN, Mary Ann Toomey, RN, Steven A. Rosenberg, MD PhD
Journal: Blood
Blood (2014) 124 (21): 550.
https://doi.org/10.1182/blood.V124.21.550.550
Published: 2014
Journal Articles

Effective Treatment Of Chemotherapy-Refractory Diffuse Large B-Cell Lymphoma With Autologous T Cells Genetically-Engineered To Express An Anti-CD19 Chimeric Antigen Receptor

James N. Kochenderfer, M.D., Mark E. Dudley, Ph.D., Sadik H. Kassim, Ph.D., Robert O. Carpenter, James C. Yang, MD, Giao Q. Phan, MD, Marybeth S. Hughes, MD, Richard M. Sherry, MD, Steven Feldman, Ph.D., David Spaner, MD, PhD, Debbie-Ann N. Nathan, RN, Kathleen E. Morton, RN, Mary Ann Toomey, RN, Steven A. Rosenberg, M.D., Ph.D.
Journal: Blood
Blood (2013) 122 (21): 168.
https://doi.org/10.1182/blood.V122.21.168.168
Published: 2013
Journal Articles

Expression profiling of TCR-engineered T cells demonstrates overexpression of multiple inhibitory receptors in persisting lymphocytes

Daniel Abate-Daga, Ken-ichi Hanada, Jeremy L. Davis, James C. Yang, Steven A. Rosenberg, Richard A. Morgan
Journal: Blood
Blood (2013) 122 (8): 1399–1410.
https://doi.org/10.1182/blood-2013-04-495531
Published: 2013
Includes: Supplemental data
Journal Articles

B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor–transduced T cells

Clinical Trials & Observations
James N. Kochenderfer, Mark E. Dudley, Steven A. Feldman, Wyndham H. Wilson, David E. Spaner, Irina Maric, Maryalice Stetler-Stevenson, Giao Q. Phan, Marybeth S. Hughes, Richard M. Sherry, James C. Yang, Udai S. Kammula, Laura Devillier, Robert Carpenter, Debbie-Ann N. Nathan, Richard A. Morgan, Carolyn Laurencot, Steven A. Rosenberg
Journal: Blood
Blood (2012) 119 (12): 2709–2720.
https://doi.org/10.1182/blood-2011-10-384388
Published: 2012
Includes: Supplemental data
Journal Articles

Molecular identification of an MHC-independent ligand recognized by a human α/β T-cell receptor

Ken-ichi Hanada, Qiong J. Wang, Takashi Inozume, James C. Yang
Journal: Blood
Blood (2011) 117 (18): 4816–4825.
https://doi.org/10.1182/blood-2010-11-317743
Published: 2011
Journal Articles

Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen

Laura A. Johnson, Richard A. Morgan, Mark E. Dudley, Lydie Cassard, James C. Yang, Marybeth S. Hughes, Udai S. Kammula, Richard E. Royal, Richard M. Sherry, John R. Wunderlich, Chyi-Chia R. Lee, Nicholas P. Restifo, Susan L. Schwarz, Alexandria P. Cogdill, Rachel J. Bishop, Hung Kim, Carmen C. Brewer, Susan F. Rudy, Carter VanWaes, Jeremy L. Davis, Aarti Mathur, Robert T. Ripley, Debbie A. Nathan, Carolyn M. Laurencot, Steven A. Rosenberg
Journal: Blood
Blood (2009) 114 (3): 535–546.
https://doi.org/10.1182/blood-2009-03-211714
Published: 2009