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Journal Articles

Adoptive Transfer of T Cells Genetically Engineered to Express T-Cell Receptors Targeting Neoantigens Arising from p53 and Ras Hotspot Mutations in Hematologic Malignancies

Kathryn M Cappell, Sanghyun P Kim, Noam Levin, Norris Lam, Christina Amatya, Lauren C Cutmore, Rachel Beyer, Steven A Rosenberg, James N Kochenderfer
Journal: Blood
Blood (2023) 142 (Supplement 1): 888.
https://doi.org/10.1182/blood-2023-189459
Published: 2023
Journal Articles

Transient Responses and Significant Toxicities Due to Cytopenias and Rashes with Anti-CD30 CAR T Cells for CD30-Expressing Lymphomas: Results of a Phase I Clinical Trial

Jennifer N. Brudno, Jeremiah Karrs, Danielle Natrakul, Nisha Patel, Lekha Mikkilineni, Jennifer Mann, David F. Stroncek, Steven Highfill, Norris Lam, Genevieve C. Fromm, Rashmika Patel, Stefania Pittaluga, James N. Kochenderfer
Journal: Blood
Blood (2022) 140 (Supplement 1): 12731–12732.
https://doi.org/10.1182/blood-2022-157149
Published: 2022
Journal Articles

T Cells Expressing a Fully-Human Anti-BCMA Chimeric Antigen Receptor with a Heavy-Chain-Only Antigen-Recognition Domain Exhibit Rapid and Durable Activity Against Multiple Myeloma

Lekha Mikkilineni, Elisabet E. Manasanch, Danielle Natrakul, Katherine Weissler, Jennifer N. Brudno, Jennifer Mann, Stephanie L Goff, James C Yang, Norris Lam, Irina Maric, Hao-Wei Wang, Constance M. Yuan, David F. Stroncek, Steven Highfill, Micaela Ganadan, Rashmika Patel, Steven A Rosenberg, James N. Kochenderfer
Journal: Blood
Blood (2022) 140 (Supplement 1): 7433–7434.
https://doi.org/10.1182/blood-2022-159156
Published: 2022
Journal Articles

Treatment of Patients with T Cells Expressing a Fully-Human Anti-BCMA CAR with a Heavy-Chain Antigen-Recognition Domain Caused High Rates of Sustained Complete Responses and Relatively Mild Toxicity

Lekha Mikkilineni, Elisabet E. Manasanch, Danielle Natrakul, Jennifer N. Brudno, Jennifer Mann, Stephanie L Goff, James C Yang, Norris Lam, Irina Maric, Maryalice Stetler-Stevenson, Hao-Wei Wang, Constance M. Yuan, Tyler Lowe, David F. Stroncek, Steven Highfill, Rashmika Patel, Micaela Ganadan, Steven A Rosenberg, James N. Kochenderfer
Journal: Blood
Blood (2021) 138 (Supplement 1): 3837.
https://doi.org/10.1182/blood-2021-152688
Published: 2021
Journal Articles

Development of a Bicistronic Anti-CD19/CD20 CAR Construct Including Optimization to Abrogate Retroviral Recombination Events

Norris Lam, Stephanie Choi, Shicheng Yang, Richard Finney, Margaret Cam, Xiaolin Wu, James N. Kochenderfer
Journal: Blood
Blood (2021) 138 (Supplement 1): 4808.
https://doi.org/10.1182/blood-2021-150865
Published: 2021
Journal Articles

Deep and Durable Remissions of Relapsed Multiple Myeloma on a First-in-Humans Clinical Trial of T Cells Expressing an Anti-B-Cell Maturation Antigen (BCMA) Chimeric Antigen Receptor (CAR) with a Fully-Human Heavy-Chain-Only Antigen Recognition Domain

Lekha Mikkilineni, MD, Elisabet E. Manasanch, MD, Danielle Vanasse, BS, Jennifer N. Brudno, MD, Jennifer Mann, CRNP, Richard Sherry, MD, Stephanie L Goff, MD, James C Yang, MD, Norris Lam, BS, Irina Maric, MD MSci, Maryalice Stetler-Stevenson, MD PhD, Hao-Wei Wang, MD PhD, Constance M. Yuan, MD PhD, David F. Stroncek, MD, Steven L Highfill, PhD, Vicki Fellowes, Micaela Ganadan, BSN, RN, Rashmika Patel, Steven A Rosenberg, MD PhD, James N. Kochenderfer, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 50–51.
https://doi.org/10.1182/blood-2020-138839
Published: 2020
Journal Articles

T Cells Expressing an Anti-B-Cell Maturation Antigen (BCMA) Chimeric Antigen Receptor with a Fully-Human Heavy-Chain-Only Antigen Recognition Domain Induce Remissions in Patients with Relapsed Multiple Myeloma

Lekha Mikkilineni, MD, Elisabet E. Manasanch, MD, Norris Lam, BS, Danielle Vanasse, BS, Jennifer N. Brudno, MD, Irina Maric, MD MSci, Jeremy J. Rose, MS, Maryalice Stetler-Stevenson, MD PhD, Hao-Wei Wang, MD PhD, Constance M. Yuan, MD PhD, David F. Stroncek, MD, Jennifer Mann, CRNP, Micaela Ganadan, BSN, RN, Rashmika Patel, Nathan Trinklein, PhD, Ben Buelow, MD PhD, Ronald E. Gress, MD, James N. Kochenderfer, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3230.
https://doi.org/10.1182/blood-2019-129088
Published: 2019
Journal Articles

Low Levels of Neurologic Toxicity with Retained Anti-Lymphoma Activity in a Phase I Clinical Trial of T Cells Expressing a Novel Anti-CD19 CAR

Jennifer Brudno, MD, Steven Hartman, Norris Lam, BS, David F. Stroncek, John M. Rossi, MS, Yueh-wei Shen, Allen Xue, PhD, Adrian Bot, MD PhD, Jennifer A Kanakry, MD, Steven Z. Pavletic, MD, Lekha Mikkilineni, MD, Mark Roschewski, MD, Robert M. Dean, MD, Jeremy J. Rose, MS, Rashmika Patel, Brenna Hansen, Steve A. Rosenberg, Ronald E. Gress, MD, James N. Kochenderfer, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 697.
https://doi.org/10.1182/blood-2018-99-113731
Published: 2018
Journal Articles

T Cells Expressing Anti-B-Cell Maturation Antigen (BCMA) Chimeric Antigen Receptors with Antigen Recognition Domains Made up of Only Single Human Heavy Chain Variable Domains Specifically Recognize Bcma and Eradicate Tumors in Mice

Norris Lam, BS, Leah Alabanza, PhD, Nathan Trinklein, PhD, Ben Buelow, MD PhD, James N. Kochenderfer, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 504.
https://doi.org/10.1182/blood.V130.Suppl_1.504.504
Published: 2017
Journal Articles

T Cells Genetically Modified to Express an Anti-B-Cell Maturation Antigen Chimeric Antigen Receptor with a CD28 Costimulatory Moiety Cause Remissions of Poor-Prognosis Relapsed Multiple Myeloma

Jennifer Brudno, MD, Norris Lam, BS, Michael Wang, MD, David Stroncek, MD, Irina Maric, Maryalice Stetler-Stevenson, Constance Yuan, Steven Hartman, Jennifer A. Kanakry, MD, Steven Z. Pavletic, MD, Steven A. Feldman, Judith Lawrence, Rashmika Patel, Brenna Hansen, Ronald E. Gress, MD, James N. Kochenderfer, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 524.
https://doi.org/10.1182/blood.V130.Suppl_1.524.524
Published: 2017