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Steven A. Feldman
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Journal Articles

Safe and Effective Combination of Donor-Derived, Allogeneic CD19/CD22-CAR T Cells with Myeloablative Graft-Engineered Allo-HCT for High-Risk B-ALL

Lori Muffly, Snegha Ananth, Lindsay Danley, Caroline Wagner, Diana Kordek, Kimi DeNoble, Ayesha Fraser, Emily Egeler, Alfonso Molina, Zachary Ehlinger, Moksha Desai, Hossein Daghagh, Ramya Tunuguntla, Annie K. Brown, Raquel Ibañez, Anne Marijn Kramer, Zinaida Good, Sally Arai, Laura Johnston, Robert Lowsky, Andrew R. Rezvani, Judith Shizuru, Lekha Mikkilineni, Parveen Shiraz, Surbhi Sidana, Wen-Kai Weng, Vanessa E. Kennedy, Sushma Bharadwaj, Saurabh Dahiya, Matthew J. Frank, Everett H. Meyer, Robert S. Negrin, Steven A. Feldman, Crystal L. Mackall, Bita Sahaf, David B. Miklos, Melody Smith
Journal: Blood
Blood (2024) 144 (Supplement 1): 679.
https://doi.org/10.1182/blood-2024-211959
Published: 2024
Journal Articles

CD22-Directed CAR T-Cell Therapy for Large B-Cell Lymphomas Progressing after CD19-Directed CAR T-Cell Therapy: Continued Durable Remissions at 3-Year Follow-up

Anne Marijn Kramer, John H. Baird, Hrishikesh Srinagesh, Emily Egeler, Kendall Levine, Annie K. Brown, Sharon Mavroukakis, Kristen Cunanan, Yi-Jiun Su, Neha Agarwal, Mark P. Hamilton, Sushma Bharadwaj, Sally Arai, Laura Johnston, Robert Lowsky, Everett H. Meyer, Robert S. Negrin, Andrew R. Rezvani, Judith Shizuru, Lekha Mikkilineni, Hitomi Hosoya, Parveen Shiraz, Surbhi Sidana, Wen-Kai Weng, Vanessa E. Kennedy, Melody Smith, Saurabh Dahiya, Kara L. Davis, Sneha Ramakrishna, Liora Michal Schultz, Ramya Tunuguntla, Steven A. Feldman, Lori Muffly, Crystal L. Mackall, David B. Miklos, Matthew J. Frank
Journal: Blood
Blood (2024) 144 (Supplement 1): 69.
https://doi.org/10.1182/blood-2024-198544
Published: 2024
Journal Articles

CD22-Directed CAR T-Cell Therapy Achieves Complete Remission in CD19-Directed CAR T-Cell Refractory Follicular and Mantle Cell Lymphoma

Anne Marijn Kramer, Hrishikesh Srinagesh, Yi-Jiun Su, Mark P. Hamilton, Kendall Levine, Eleonora Migliore, Kimi DeNoble, Annie K. Brown, Kristen Cunanan, Neha Agarwal, Claire Lohman, Sharon Mavroukakis, Sushma Bharadwaj, Sally Arai, Laura Johnston, Robert Lowsky, Everett H. Meyer, Robert S. Negrin, Andrew R. Rezvani, Judith Shizuru, Lekha Mikkilineni, Hitomi Hosoya, Parveen Shiraz, Surbhi Sidana, Wen-Kai Weng, Vanessa E. Kennedy, Melody Smith, Saurabh Dahiya, Kara L. Davis, Sneha Ramakrishna, Liora Michal Schultz, Ramya Tunuguntla, Steven A. Feldman, Lori Muffly, Crystal L. Mackall, David B. Miklos, Matthew J. Frank
Journal: Blood
Blood (2024) 144 (Supplement 1): 2064.
https://doi.org/10.1182/blood-2024-198489
Published: 2024
Journal Articles

CD22 CAR T Cells Demonstrate Favorable Safety Profile and High Response Rates in Pediatric and Adult B-ALL: Results of a Phase 1b Study

Nikeshan Jeyakumar, Sneha Ramakrishna, Matthew J Frank, Bita Sahaf, Steven A. Feldman, David B. Miklos, Crystal L. Mackall, Kara L. Davis, Lori Muffly, Liora M. Schultz
Journal: Blood
Blood (2022) 140 (Supplement 1): 2374–2375.
https://doi.org/10.1182/blood-2022-164456
Published: 2022
Journal Articles

Long-Term Follow-up of CD19/22 CAR Therapy in Children and Young Adults with B-ALL Reveals Efficacy, Tolerability and High Survival Rates When Coupled with Hematopoietic Stem Cell Transplantation

Liora M. Schultz, Sneha Ramakrishna, Reema Baskar, Rebecca M Richards, Jennifer Moon, Christina Baggott, Michelle Fujimoto, Michael Kunicki, Amy Li, Sneha Jariwala, Courtney Erickson, Ashley Jacobs, Karen Yamabe, Valentin Barsan, Robbie G. Majzner, Emily L. Egeler, Sharon Mavroukakis, Zachary Ehlinger, Warren D. Reynolds, Bita Sahaf, Lori Muffly, Matthew J Frank, Anne-Louise Gramstrup, Harshini Chinnasamy, Shabnum Patel, David B. Miklos, Steven A. Feldman, Crystal L. Mackall, Kara L. Davis
Journal: Blood
Blood (2022) 140 (Supplement 1): 10300–10302.
https://doi.org/10.1182/blood-2022-167789
Published: 2022
Journal Articles

CD22-CAR T-Cell Therapy Mediates High Durable Remission Rates in Adults with Large B-Cell Lymphoma Who Have Relapsed after CD19-CAR T-Cell Therapy

Matthew J. Frank, John H. Baird, Shabnum Patel, Juliana Craig, Jay Y. Spiegel, Zachary Ehlinger, Harshini Chinnasamy, Sheren F. Younes, Jean S. Oak, Yasodha Natkunam, Warren D. Reynolds, Maria Iglesias, Emma Crawford, Hrishikesh K. Srinagesh, Emily L. Egeler, Sally Arai, Laura J. Johnston, Robert Lowsky, Robert S. Negrin, Andrew R. Rezvani, Parveen Shiraz, Surbhi Sidana, Wen-Kai Weng, Liora M. Schultz, Sneha Ramakrishna, Kara L. Davis, Bita Sahaf, Steven A. Feldman, Crystal L. Mackall, David B. Miklos, Lori Muffly
Journal: Blood
Blood (2021) 138 (Supplement 1): 741.
https://doi.org/10.1182/blood-2021-152145
Published: 2021
Journal Articles

CD22-directed CAR T-cell therapy induces complete remissions in CD19-directed CAR–refractory large B-cell lymphoma

Clinical Trials & Observations Brief Report
John H. Baird, Matthew J. Frank, Juliana Craig, Shabnum Patel, Jay Y. Spiegel, Bita Sahaf, Jean S. Oak, Sheren F. Younes, Michael G. Ozawa, Eric Yang, Yasodha Natkunam, John Tamaresis, Zachary Ehlinger, Warren D. Reynolds, Sally Arai, Laura Johnston, Robert Lowsky, Everett Meyer, Robert S. Negrin, Andrew R. Rezvani, Parveen Shiraz, Surbhi Sidana, Wen-Kai Weng, Kara L. Davis, Sneha Ramakrishna, Liora Schultz, Chelsea Mullins, Allison Jacob, Ilan Kirsch, Steven A. Feldman, Crystal L. Mackall, David B. Miklos, Lori Muffly
Journal: Blood
Blood (2021) 137 (17): 2321–2325.
https://doi.org/10.1182/blood.2020009432
Published: 2021
Includes: Supplemental data
Journal Articles

CD22-Directed CAR T-Cell Therapy Mediates Durable Complete Responses in Adults with Relapsed or Refractory Large B-Cell Lymphoma after Failure of CD19-Directed CAR T-Cell Therapy and High Response Rates in Adults with Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia

John H. Baird, MD, Matthew J. Frank, MD PhD, Juliana Craig, BA, Shabnum Patel, PhD, Jay Y. Spiegel, MDFRCPC, Bita Sahaf, PhD, Sheren F. Younes, MD PhD, Jean S. Oak, MD PhD, Yasodha Natkunam, MD PhD, Zachary Ehlinger, MS, Warren D. Reynolds, BS, Sally Arai, MD MS, Laura J. Johnston, MD, Robert Lowsky, MD FRCP, Robert S. Negrin, MD, Andrew R. Rezvani, MD, Parveen Shiraz, MD, Surbhi Sidana, MD, Wen-Kai Weng, MD PhD, Liora M. Schultz, MD, Sneha Ramakrishna, MD, Kara L Davis, DO, Steven A. Feldman, PhD, Crystal L. Mackall, MD, David B. Miklos, MD PhD, Lori S. Muffly, MD MS
Journal: Blood
Blood (2020) 136 (Supplement 1): 28–29.
https://doi.org/10.1182/blood-2020-139087
Published: 2020
Journal Articles

Identification of Dual Positive CD19+/CD3+ T Cells in an Apheresis Product Undergoing Chimeric Antigen Receptor (CAR) Transduction

Liora M Schultz, MD, Shabnum Patel, PhD, Sneha Ramakrishna, MD, Alice Bertaina, MD PhD, Neehar Bhatia, Jean Oak, MD PhD, Robbie G. Majzner, MD, Christina Baggott, RN, PhD, Kara L. Davis, DO, Crystal L. Mackall, MD, Steven A Feldman, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4471.
https://doi.org/10.1182/blood-2019-129436
Published: 2019
Journal Articles

Phase I Trial Using CD19/CD22 Bispecific CAR T Cells in Pediatric and Adult Acute Lymphoblastic Leukemia (ALL)

Liora M Schultz, MD, Lori S Muffly, MD, Jay Y. Spiegel, MDFRCPC, Sneha Ramakrishna, MD, Nasheed Hossain, MD, Christina Baggott, RN, PhD, Bita Sahaf, PhD, Shabnum Patel, PhD, Juliana Craig, BA, Jenny Yoon, Meena Kadapakkam, MD, Robbie G. Majzner, MD, Matthew J. Frank, MD PhD, Courtney Erickson, Anne Cunniffe Marcy, MSBH, Michelle Fujimoto, Neehar Bhatia, Everett H Meyer, MD PhD, Katherine A. Kong, Emily Egeler, Sharon Mavroukakis, Haiying Qin, MS, Terry J. Fry, MD, Steven A Feldman, PhD, David B Miklos, MD PhD, Crystal L. Mackall, MD, Kara L. Davis, DO
Journal: Blood
Blood (2019) 134 (Supplement_1): 744.
https://doi.org/10.1182/blood-2019-129411
Published: 2019
Journal Articles

Phase I Experience with a Bi-Specific CAR Targeting CD19 and CD22 in Adults with B-Cell Malignancies

Nasheed Hossain, MD, Bita Sahaf, PhD, Matthew Abramian, PhD, Jay Y. Spiegel, MD, Katie Kong, Stephen Kim, Sharon Mavroukakis, Jean Oak, MD PhD, Yasodha Natkunam, MD PhD, Everett H Meyer, MD PhD, Matthew J. Frank, MD PhD, Steven A Feldman, PhD, Steven R. Long, MD, Haiying Qin, MS, Terry J. Fry, MD, Lori S Muffly, MD, Crystal L. Mackall, MD, David B. Miklos, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 490.
https://doi.org/10.1182/blood-2018-99-110142
Published: 2018
Journal Articles

Enhanced Expression of CXCR4 Facilitates the Trafficking of Anti-c-Kit Chimeric Antigen Receptor (CAR) T Cells to Bone Marrow and Achieves Effective Donor Stem Cell Engraftment

Yasuyuki Arai, MDPhD, Cristina I. Corsino, Sherry M. Koontz, Masaki Tajima, Mary A. Black, Colin L. Sweeney, Uimook Choi, Steven A. Feldman, Mary C. Dinauer, Harry L Malech, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4446.
https://doi.org/10.1182/blood.V130.Suppl_1.4446.4446
Published: 2017
Journal Articles

T Cells Genetically Modified to Express an Anti-B-Cell Maturation Antigen Chimeric Antigen Receptor with a CD28 Costimulatory Moiety Cause Remissions of Poor-Prognosis Relapsed Multiple Myeloma

Jennifer Brudno, MD, Norris Lam, BS, Michael Wang, MD, David Stroncek, MD, Irina Maric, Maryalice Stetler-Stevenson, Constance Yuan, Steven Hartman, Jennifer A. Kanakry, MD, Steven Z. Pavletic, MD, Steven A. Feldman, Judith Lawrence, Rashmika Patel, Brenna Hansen, Ronald E. Gress, MD, James N. Kochenderfer, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 524.
https://doi.org/10.1182/blood.V130.Suppl_1.524.524
Published: 2017
Journal Articles

T cells expressing an anti–B-cell maturation antigen chimeric antigen receptor cause remissions of multiple myeloma

Clinical Trials & Observations
Syed Abbas Ali, Victoria Shi, Irina Maric, Michael Wang, David F. Stroncek, Jeremy J. Rose, Jennifer N. Brudno, Maryalice Stetler-Stevenson, Steven A. Feldman, Brenna G. Hansen, Vicki S. Fellowes, Frances T. Hakim, Ronald E. Gress, James N. Kochenderfer
Journal: Blood
Blood (2016) 128 (13): 1688–1700.
https://doi.org/10.1182/blood-2016-04-711903
Published: 2016
Includes: Supplemental data
Journal Articles

Donor-derived CD19-targeted T cells cause regression of malignancy persisting after allogeneic hematopoietic stem cell transplantation

James N. Kochenderfer, Mark E. Dudley, Robert O. Carpenter, Sadik H. Kassim, Jeremy J. Rose, William G. Telford, Frances T. Hakim, David C. Halverson, Daniel H. Fowler, Nancy M. Hardy, Anthony R. Mato, Dennis D. Hickstein, Juan C. Gea-Banacloche, Steven Z. Pavletic, Claude Sportes, Irina Maric, Steven A. Feldman, Brenna G. Hansen, Jennifer S. Wilder, Bazetta Blacklock-Schuver, Bipulendu Jena, Michael R. Bishop, Ronald E. Gress, Steven A. Rosenberg
Journal: Blood
Blood (2013) 122 (25): 4129–4139.
https://doi.org/10.1182/blood-2013-08-519413
Published: 2013
Includes: Supplemental data
Journal Articles

B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor–transduced T cells

Clinical Trials & Observations
James N. Kochenderfer, Mark E. Dudley, Steven A. Feldman, Wyndham H. Wilson, David E. Spaner, Irina Maric, Maryalice Stetler-Stevenson, Giao Q. Phan, Marybeth S. Hughes, Richard M. Sherry, James C. Yang, Udai S. Kammula, Laura Devillier, Robert Carpenter, Debbie-Ann N. Nathan, Richard A. Morgan, Carolyn Laurencot, Steven A. Rosenberg
Journal: Blood
Blood (2012) 119 (12): 2709–2720.
https://doi.org/10.1182/blood-2011-10-384388
Published: 2012
Includes: Supplemental data
Journal Articles

A Phase I Clinical Trial of Treatment of B-Cell Malignancies with Autologous Anti-CD19-CAR-Transduced T Cells

James N. Kochenderfer, Mark E. Dudley, Maryalice Stetler-Stevenson, Wyndham H. Wilson, John E. Janik, Debbie-Ann N. Nathan, Irina Maric, Mark Raffeld, Steven A. Feldman, Richard A. Morgan, Steven A. Rosenberg
Journal: Blood
Blood (2010) 116 (21): 2865.
https://doi.org/10.1182/blood.V116.21.2865.2865
Published: 2010
Journal Articles

Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19

Brief Report
James N. Kochenderfer, Wyndham H. Wilson, John E. Janik, Mark E. Dudley, Maryalice Stetler-Stevenson, Steven A. Feldman, Irina Maric, Mark Raffeld, Debbie-Ann N. Nathan, Brock J. Lanier, Richard A. Morgan, Steven A. Rosenberg
Journal: Blood
Blood (2010) 116 (20): 4099–4102.
https://doi.org/10.1182/blood-2010-04-281931
Published: 2010
Includes: Supplemental data