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David B. Miklos
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Journal Articles

Donor Regulatory T-Cell Therapy to Prevent Graft-Versus-Host Disease

Clinical Trials & Observations
Everett Meyer, Anna Pavlova, Alejandro Villar-Prados, Cameron S Bader, Bryan Xie, Lori Muffly, Paige Kim, Katherine C. Sutherland, Sushma Bharadwaj, Saurabh Dahiya, Matthew J Frank, Sally Arai, Laura Johnston, David B Miklos, Andrew R. Rezvani, Parveen Shiraz, Surbhi Sidana, Judith A. Shizuru, Wen-Kai Weng, Vaibhav Agrawal, Amy Putnam, Nathanial B Fernhoff, John Tamaresis, Ying Lu, Rahul D Pawar, J Scott McClellan, Robert Lowsky, Robert S. Negrin
Journal: Blood
Blood blood.2024026446.
https://doi.org/10.1182/blood.2024026446
Published: 2025
Includes: Supplemental data
Journal Articles

Safe and Effective Combination of Donor-Derived, Allogeneic CD19/CD22-CAR T Cells with Myeloablative Graft-Engineered Allo-HCT for High-Risk B-ALL

Lori Muffly, Snegha Ananth, Lindsay Danley, Caroline Wagner, Diana Kordek, Kimi DeNoble, Ayesha Fraser, Emily Egeler, Alfonso Molina, Zachary Ehlinger, Moksha Desai, Hossein Daghagh, Ramya Tunuguntla, Annie K. Brown, Raquel Ibañez, Anne Marijn Kramer, Zinaida Good, Sally Arai, Laura Johnston, Robert Lowsky, Andrew R. Rezvani, Judith Shizuru, Lekha Mikkilineni, Parveen Shiraz, Surbhi Sidana, Wen-Kai Weng, Vanessa E. Kennedy, Sushma Bharadwaj, Saurabh Dahiya, Matthew J. Frank, Everett H. Meyer, Robert S. Negrin, Steven A. Feldman, Crystal L. Mackall, Bita Sahaf, David B. Miklos, Melody Smith
Journal: Blood
Blood (2024) 144 (Supplement 1): 679.
https://doi.org/10.1182/blood-2024-211959
Published: 2024
Journal Articles

CD22-Directed CAR T-Cell Therapy for Large B-Cell Lymphomas Progressing after CD19-Directed CAR T-Cell Therapy: Continued Durable Remissions at 3-Year Follow-up

Anne Marijn Kramer, John H. Baird, Hrishikesh Srinagesh, Emily Egeler, Kendall Levine, Annie K. Brown, Sharon Mavroukakis, Kristen Cunanan, Yi-Jiun Su, Neha Agarwal, Mark P. Hamilton, Sushma Bharadwaj, Sally Arai, Laura Johnston, Robert Lowsky, Everett H. Meyer, Robert S. Negrin, Andrew R. Rezvani, Judith Shizuru, Lekha Mikkilineni, Hitomi Hosoya, Parveen Shiraz, Surbhi Sidana, Wen-Kai Weng, Vanessa E. Kennedy, Melody Smith, Saurabh Dahiya, Kara L. Davis, Sneha Ramakrishna, Liora Michal Schultz, Ramya Tunuguntla, Steven A. Feldman, Lori Muffly, Crystal L. Mackall, David B. Miklos, Matthew J. Frank
Journal: Blood
Blood (2024) 144 (Supplement 1): 69.
https://doi.org/10.1182/blood-2024-198544
Published: 2024
Journal Articles

Interim Results from a Phase 2 Pivotal Study (DALY II USA) of Tandem CD20-CD19-Directed Non-Cryopreserved CAR-T Cells - Zamtocabtagene Autoleucel (Zamto-Cel) in Patients with Relapsed/Refractory Diffuse Large B Cell Lymphoma

Nirav N. Shah, Richard T. Maziarz, Caron A. Jacobson, Patrick B. Johnston, Sunil Abhyankar, Iris Isufi, Miguel Angel Perales, Monalisa Ghosh, Matthew Ulrickson, Allison C. Rosenthal, Javier L. Munoz, Nancy M. Hardy, Aaron P. Rapoport, Reem Karmali, Farrukh T. Awan, Matthew Stuart McKinney, Mitchell Horwitz, Matthew Lunning, Nathan Denlinger, Marek Ancukiewicz, Madhavi Nallewar, Kimberly C Coleman, Esther Eromosele, Remigiusz Kaleta, Johanna Theruvath, Anna Wijatyk, David B. Miklos
Journal: Blood
Blood (2024) 144 (Supplement 1): 68.
https://doi.org/10.1182/blood-2024-208539
Published: 2024
Journal Articles

Single Institution Analysis of Lymphoma Treatment Related Post-CAR Myeloid Neoplasms

Mark Hamilton, Nick Phillips, Dasom Lee, Zachary Ehlinger, Anne Marijn Kramer, Hrishikesh Srinagesh, Zinaida Good, Xiaoman Kang, Mari Olsen, Chih Long Liu, Feng Tian, Brian J. Sworder, Hitomi Hosoya, Joseph G. Schroers-Martin, Sushma Bharadwaj, Sally Arai, Laura Johnston, Robert Lowsky, Everett H. Meyer, Robert S. Negrin, Andrew R. Rezvani, Judith Shizuru, Lekha Mikkilineni, Parveen Shiraz, Surbhi Sidana, Wen-Kai Weng, Vanessa E. Kennedy, Melody Smith, Lori Muffly, David Kurtz, Saurabh Dahiya, Matthew J. Frank, Crystal L. Mackall, Bita Sahaf, David B. Miklos, Ash A. Alizadeh
Journal: Blood
Blood (2024) 144 (Supplement 1): 96.
https://doi.org/10.1182/blood-2024-205378
Published: 2024
Journal Articles

CCL8/CCL13-Producing Tumor-Associated Macrophages Linked to Poor Outcomes after CAR T Cell Therapy for LBCL

Kelvin C. Mo, Christine Y. Yeh, Mark P. Hamilton, Jay Spiegel, Moksha Desai, Zachary Ehlinger, Warren D. Reynolds, Eric Yang, Michael G. Ozawa, Yiyun Chen, Snehit Prabhu, Matthew J. Frank, Lori Muffly, Gursharan K. Claire, Sushma Bharadwaj, Saurabh Dahiya, Katherine A. Kong, Elena Sotillo, Bita Sahaf, Sylvia Plevritis, David B. Miklos, Crystal L. Mackall, Zinaida Good
Journal: Blood
Blood (2024) 144 (Supplement 1): 368.
https://doi.org/10.1182/blood-2024-198942
Published: 2024
Journal Articles

Direct Method for Estimating the Fraction of T and B/Plasma Cell-Derived DNA

Takeshi Sugio, Mohammad Shahrokh Esfahani, Soyeong Jun, Brian J. Sworder, Mark P. Hamilton, Hitomi Hosoya, Mari Olsen, Xiaoman Kang, Chih Long Liu, Feng Tian, David B. Miklos, David Kurtz, Maximilian Diehn, Ash A. Alizadeh
Journal: Blood
Blood (2024) 144 (Supplement 1): 2223.
https://doi.org/10.1182/blood-2024-193441
Published: 2024
Journal Articles

Indolent CD8+ CAR T-Cell Lymphoma of the Gastrointestinal Tract after Ciltacabtagene Autoleucel Therapy for Relapsed/Refractory Multiple Myeloma

Hitomi Hosoya, Sebastian Fernandez-Pol, John Gubatan, Zachary Ehlinger, Claire Lohman, Armando N Bastidas Torres, Safa Najidh, Alexa Kwang, George Duran, Charles Wright III, Vanessa E. Kennedy, Sushma Bharadwaj, Melody Smith, Saurabh Dahiya, Matthew J. Frank, Lori Muffly, Wen-Kai Weng, Bita Sahaf, David Kurtz, Crystal L. Mackall, Michael S. Khodadoust, David B. Miklos, Surbhi Sidana, Lekha Mikkilineni
Journal: Blood
Blood (2024) 144 (Supplement 1): 4846.
https://doi.org/10.1182/blood-2024-207885
Published: 2024
Journal Articles

Resolving the Microarchitecture of Classic and Transformed Follicular Lymphoma By Single Cell Alignment to Spatial Transcriptomes

Troy Noordenbos, Joseph G. Schroers-Martin, Mark P. Hamilton, Soyeong Jun, Takeshi Sugio, Brian J. Sworder, Chloé Beate Steen, Mari Olsen, Chih Long Liu, Aaron Newman, Brooke Howitt, Yasodha Natkunam, David B. Miklos, Maximilian Diehn, Matthew J. Frank, Ash A. Alizadeh
Journal: Blood
Blood (2024) 144 (Supplement 1): 2993.
https://doi.org/10.1182/blood-2024-199300
Published: 2024
Journal Articles

Anti-BCMA CAR T-Cell Expansion and Its Association with Response and Toxicity in Multiple Myeloma

Hitomi Hosoya, Alexandria Jensen, Vanna Hovanky, Sylvester Homsy, Juancarlos E Cancilla, Sunita Patil, Vanessa E. Kennedy, Sushma Bharadwaj, Melody Smith, Parveen Shiraz, Matthew J. Frank, Saurabh Dahiya, Sally Arai, Wen-Kai Weng, Lori Muffly, Bita Sahaf, Crystal L. Mackall, David B. Miklos, Lekha Mikkilineni, Surbhi Sidana
Journal: Blood
Blood (2024) 144 (Supplement 1): 2006.
https://doi.org/10.1182/blood-2024-211128
Published: 2024
Journal Articles

Five-Year Outcomes of Patients (Pts) with Relapsed/Refractory Mantle Cell Lymphoma (R/R MCL) Treated with Brexucabtagene Autoleucel (Brexu-cel) in ZUMA-2 Cohorts 1 and 2

Michael Wang, Andre Goy, Javier Munoz, Frederick L. Locke, Caron A. Jacobson, Brian T. Hill, John Timmerman, Ian W. Flinn, David B. Miklos, John M. Pagel, Marie José Kersten, Edouard Forcade, Max S. Topp, Roch Houot, Amer Beitinjaneh, Dan Zheng, Mengru Chang, Rhine Shen, Wangshu Zhang, Rita Damico Khalid, Ioana Kloos, Patrick M. Reagan
Journal: Blood
Blood (2024) 144 (Supplement 1): 4388.
https://doi.org/10.1182/blood-2024-198018
Published: 2024
Journal Articles

Improvements in Axicabtagene Ciloleucel Manufacturing Result in High Delivery Success and More Predictable Turnaround Time for Patients with Relapsed/Refractory Large B-Cell Lymphoma

David B. Miklos, Wike Tong, Eric Kim, Brandon Kerr, Morgan Neuwirth, Laura Alquist, Clare Spooner
Journal: Blood
Blood (2024) 144 (Supplement 1): 3477.
https://doi.org/10.1182/blood-2024-198267
Published: 2024
Journal Articles

Investigating Treatment Kinetics and Local Response during and after Bridging Radiotherapy Prior to CAR-T Cell Therapy for Lymphomas

Daniella Klebaner, Natalie Park, Mallika Marar, Matthew J. Frank, Susan Hiniker, Richard T. Hoppe, Joseph G. Schroers-Martin, Ranjana H. Advani, Ash A. Alizadeh, Sushma Bharadwaj, David B. Miklos, Saurabh Dahiya, Michael S. Binkley
Journal: Blood
Blood (2024) 144 (Supplement 1): 7130.
https://doi.org/10.1182/blood-2024-200930
Published: 2024
Journal Articles

Point-of-Care Bispectral Electroencephalogram (BSEEG) As a New Tool in Detecting Immune Effector Cell Associated Neurotoxicity (ICANS) in Patients Treated with Chimeric Antigen Receptor T-Cell (CAR-T)

Sylvester Homsy, Tomoteru Seki, Hieu Dinh Nguyen, Akiyoshi Shimura, Nipun Gorantla, Nathan James Phuong, Nima Ghalehsari, Arash Velayati, Nikeshan Jeyakumar, Mark P. Hamilton, Vanessa E. Kennedy, Lekha Mikkilineni, Sushma Bharadwaj, Melody Smith, Saurabh Dahiya, Matthew J. Frank, Lori Muffly, Surbhi Sidana, Wen-Kai Weng, David B. Miklos, Hitomi Hosoya, Gen Shinozaki
Journal: Blood
Blood (2024) 144 (Supplement 1): 7134.
https://doi.org/10.1182/blood-2024-202728
Published: 2024
Journal Articles

CD22-Directed CAR T-Cell Therapy Achieves Complete Remission in CD19-Directed CAR T-Cell Refractory Follicular and Mantle Cell Lymphoma

Anne Marijn Kramer, Hrishikesh Srinagesh, Yi-Jiun Su, Mark P. Hamilton, Kendall Levine, Eleonora Migliore, Kimi DeNoble, Annie K. Brown, Kristen Cunanan, Neha Agarwal, Claire Lohman, Sharon Mavroukakis, Sushma Bharadwaj, Sally Arai, Laura Johnston, Robert Lowsky, Everett H. Meyer, Robert S. Negrin, Andrew R. Rezvani, Judith Shizuru, Lekha Mikkilineni, Hitomi Hosoya, Parveen Shiraz, Surbhi Sidana, Wen-Kai Weng, Vanessa E. Kennedy, Melody Smith, Saurabh Dahiya, Kara L. Davis, Sneha Ramakrishna, Liora Michal Schultz, Ramya Tunuguntla, Steven A. Feldman, Lori Muffly, Crystal L. Mackall, David B. Miklos, Matthew J. Frank
Journal: Blood
Blood (2024) 144 (Supplement 1): 2064.
https://doi.org/10.1182/blood-2024-198489
Published: 2024
Journal Articles

NKTR-255 Vs Placebo to Enhance Complete Responses and Durability Following CD19-Directed CAR-T Therapy in Patients with Relapsed/ Refractory (R/R) Large B-Cell Lymphoma (LBCL)

Sairah Ahmed, John F. DiPersio, James H Essell, Catherine S. Diefenbach, Miguel Angel Perales, Cristina Castilla-Llorente, Saurabh Dahiya, Sohail Chaudhry, Heng Xu, Yi Liu, Christie Fanton, Zachary Lee, Mario Q. Marcondes, Mary Tagliaferri, Jonathan Zalevsky, David B. Miklos, Cameron J. Turtle, Joseph P. McGuirk
Journal: Blood
Blood (2024) 144 (Supplement 1): 2068.
https://doi.org/10.1182/blood-2024-203576
Published: 2024
Journal Articles

Safety and Efficacy of Chimeric Antigen Receptor T-Cell Therapy in Octogenarian Patients (Aged ≥ 80) with Relapsed or Refractory (R/R) Large B-Cell Lymphoma (LBCL)

Dasom Lee, Sushma Bharadwaj, Masooma S Rana, Alexandria Jensen, William Wang, Nima Ghalehsari, Bita Sahaf, Jayasindhu Mallampet, Sarah Elkordy, Theresa Latchford, Sally Arai, Laura Johnston, Hitomi Hosoya, Robert Lowsky, Robert S. Negrin, Andrew R. Rezvani, Judith Shizuru, Everett H. Meyer, Parveen Shiraz, Lekha Mikkilineni, Wen-Kai Weng, Lauren S. Maeda, Melody Smith, Surbhi Sidana, Lori Muffly, Matthew J. Frank, David B. Miklos, Saurabh Dahiya
Journal: Blood
Blood (2024) 144 (Supplement 1): 386.
https://doi.org/10.1182/blood-2024-201822
Published: 2024
Journal Articles

CD22-Directed CAR T Cell Single Cell Multiomic Features Associated with Immune Effector Cell-Associated Hemophagocytic Lymphohistiocytosis-like Syndrome (IEC-HS)

Anne Marijn Kramer, Tara Murty, Yiyun Chen, Hrishikesh Srinagesh, Mark P. Hamilton, Kelvin C. Mo, Snehit Prabhu, Moksha Desai, Adam Kuo, Zachary Ehlinger, Warren D. Reynolds, John H. Baird, Yi-Jiun Su, Neha Agarwal, Bita Sahaf, Lori Muffly, Crystal L. Mackall, David B. Miklos, Matthew J. Frank, Zinaida Good
Journal: Blood
Blood (2024) 144 (Supplement 1): 911.
https://doi.org/10.1182/blood-2024-198688
Published: 2024
Journal Articles

Real-world and clinical trial outcomes in large B-cell lymphoma with axicabtagene ciloleucel across race and ethnicity

Clinical Trials & Observations
Frederick L. Locke, Tanya Siddiqi, Caron A. Jacobson, Armin Ghobadi, Sairah Ahmed, David B. Miklos, Miguel-Angel Perales, Javier Munoz, Warren B. Fingrut, Martina Pennisi, Jordan Gauthier, Mazyar Shadman, Lohith Gowda, Abu-Sayeef Mirza, Muhammad Bilal Abid, Sanghee Hong, Navneet S. Majhail, Mohamed A. Kharfan-Dabaja, Arushi Khurana, Talha Badar, Yi Lin, N. Nora Bennani, Megan M. Herr, Zhen-Huan Hu, Hai-Lin Wang, Anjani Baer, Elande Baro, Harry Miao, Clare Spooner, Hairong Xu, Marcelo C. Pasquini
Journal: Blood
Blood (2024) 143 (26): 2722–2734.
https://doi.org/10.1182/blood.2023023447
Published: 2024
Includes: Supplemental data
Journal Articles

CAR19 Therapy Drives Expansion of Clonal Hematopoiesis and Associated Cytopenias

Mark P. Hamilton, Brian J. Sworder, Stefan K. Alig, Zinaida Good, Jan Boegeholz, Joseph Schroers-Martin, John Tamaresis, Mohammad Shahrokh Esfahani, Ying Lu, Mari Olsen, Chih Long Liu, Zachary Ehlinger, Moksha Desai, Felicia Liu-Fei, Lori S. Muffly, Robert S. Negrin, Sally Arai, Laura Johnston, Robert Lowsky, Everett H. Meyer, Andrew R. Rezvani, Judith Shizuru, Wen-Kai Weng, Parveen Shiraz, Surbhi Sidana, Sushma Bharadwaj, Melody Smith, Saurabh Dahiya, Bita Sahaf, Maximilian Diehn, Matthew J. Frank, Crystal L. Mackall, David M. Kurtz, David B. Miklos, Ash A. Alizadeh
Journal: Blood
Blood (2023) 142 (Supplement 1): 360.
https://doi.org/10.1182/blood-2023-182522
Published: 2023