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Judith Shizuru
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Journal Articles

Double-dose axicabtagene ciloleucel (Axi-Cel-2) as second-line therapy for high-risk relapsed or refractory large B-cell lymphoma (r/rLBCL): Interim results from a Phase 1b study

Free
Dasom (Caroline) Lee, Kameron Rodrigues, Masooma Rana, Kendall Kozy, Sunny Salazar, Alexandria Jensen, Moksha Desai, Jayasindhu Mallampet, Claire Lohman, Ying-Wen Huang, Xiaoman Kang, Feng Tian, Jurik Mutter, Nick Phillips, Colleen Schweitzer, Faisal Cheema, Lekha Mikkilineni, Andrew Rezvani, Laura Johnston, Judith Shizuru, Everett Meyer, Robert Lowsky, Wen-Kai Weng, Melody Smith, Sushma Bharadwaj, Robert Negrin, Surbhi Sidana, Lori Muffly, Bita Sahaf, Yasodha Natkunam, Rhine Shen, Matthew Frank, Crystal Mackall, Zinaida Good, Ash Alizadeh, David Miklos, Saurabh Dahiya
Journal: Blood
Blood (2025) 146 (Supplement 1): 671.
https://doi.org/10.1182/blood-2025-671
Published: 2025
Journal Articles

Evaluating thymic stromal lymphopoietin (TSLP) as a biomarker in acute graft versus host disease

Free
Parveen Shiraz, Ioannis Louloudis, Joanna Liliental, Shailja Patel, Alexandria Jensen, Sonia Fonseca, Kathy Le, Binta Diallo, Anna Pavlova, Sally Arai, Robert Negrin, Andrew Rezvani, Laura Johnston, Wen-Kai Weng, Robert Lowsky, Lori Muffly, David Miklos, Vanessa Kennedy, Everett Meyer, John Levine, James Ferrara, Judith Shizuru
Journal: Blood
Blood (2025) 146 (Supplement 1): 586.
https://doi.org/10.1182/blood-2025-586
Published: 2025
Journal Articles

Hematopoietic stem cell transplantation using briquilimab (Anti-CD117 Antibody-Conditioning), immunosuppression and TCRαβ+ T-cell/CD19+ B-cell depleted haploidentical grafts in patients with fanconi anemia: An approach without irradiation, busulfan and calcineurin inhibitors.

Free
Rajni Agarwal, Alice Bertaina, Charmaine Soco, Janel Long-Boyle, Gopin Saini, Nivedita Kunte, Lyndsie Hiroshima, Yan Yi Chan, Hana Willner, Mark Krampf, Maite Van Hentenryck, Rhonda Perriman, Elena Istomina, Giulia Barbarito, Amelia Scheck, Hena Din, Edna Klinger, Jerry Cheng, Marcin Wlodarski, Jaap Jan Boelens, Judith Shizuru, Wendy Pang, Kenneth Weinberg, Robertson Parkman, Maria-Grazia Roncarolo, Matthew Porteus, Agnieszka Czechowicz
Journal: Blood
Blood (2025) 146 (Supplement 1): 2432.
https://doi.org/10.1182/blood-2025-2432
Published: 2025
Journal Articles

Allogeneic HSC and regulatory T cell  (Orca-T) engineered cell therapy following reduced intensity conditioning: Results of a single center Phase 1 study

Free
Alejandro Villar-Prados, Paige Kim, Katherine Sutherland, Robert Negrin, Sally Arai, Matthew Frank, Laura Johnston, Robert Lowsky, David Miklos, Lori Muffly, Saurabh Dahiya, Andrew Rezvani, Surbhi Sidana, Parveen Shiraz, Judith Shizuru, Wen-Kai Weng, Melody Smith, Sushma Bharadwaj, John Tamaresis, Anna Pavlova, J. Scott McClellan, Everett Meyer
Journal: Blood
Blood (2025) 146 (Supplement 1): 111.
https://doi.org/10.1182/blood-2025-111
Published: 2025
Journal Articles

Patients with TP53-mutated AML/MDS without complex or monosomal karyotype can achieve durable survival benefits with allogeneic HCT

Free
Nikeshan Jeyakumar, Nancy Torres, Suneeta Godbole, Fiona Yamamoto, Bing Zhang, Sally Arai, Sushma Bharadwaj, Saurabh Dahiya, Hany Elmariah, Matthew Frank, Hitomi Hosoya, Laura Johnston, Everett Meyer, Lekha Mikkilineni, Robert Lowsky, Robert Negrin, Andrew Rezvani, Judith Shizuru, Surbhi Sidana, Melody Smith, Wen-Kai Weng, David Miklos, Matthew Schwede, Gabriel Mannis, Tian Zhang, Lori Muffly, Vanessa Kennedy
Journal: Blood
Blood (2025) 146 (Supplement 1): 2525.
https://doi.org/10.1182/blood-2025-2525
Published: 2025
Journal Articles

Superior efficacy and persistence of Orca-T-allogeneic CAR19/22 versus autologous CAR19/22 in high-risk adult B-ALL

Free
Alfonso Molina, Parveen Shiraz, Alyssa Kanegai, Ayesha Fraser, Diana Kordek, Caroline Wagner, Hrishikesh Srinagesh, Lindsay Danley, Arvind Ramakrishnan, Hossein Daghagh, Ying-Wen Huang, Gaurav Dhapola, Aman Siddiqui, Sally Arai, Sushma Bharadwaj, Saurabh Dahiya, Hany Elmariah, Matthew Frank, Hitomi Hosoya, Vanessa Kennedy, Laura Johnston, Everett Meyer, Lekha Mikkilineni, Robert Lowsky, Robert Negrin, Andrew Rezvani, Judith Shizuru, Surbhi Sidana, Wen-Kai Weng, Catherine McIntyre, Steven Feldman, Bita Sahaf, Crystal Mackall, David Miklos, Lori Muffly, Melody Smith
Journal: Blood
Blood (2025) 146 (Supplement 1): 514.
https://doi.org/10.1182/blood-2025-514
Published: 2025
Journal Articles

Post-transplant cyclophosphamide vs tacrolimus/methotrexate: Improved GRFS, reduced NRM, and less severe GVHD in myeloablative HLA-matched allogeneic transplantation

Free
Alfonso Molina, Quenton Bubb, Ryan Yee, Sally Arai, Sushma Bharadwaj, Saurabh Dahiya, Hany Elmariah, Matthew Frank, Hitomi Hosoya, Laura Johnston, Everett Meyer, Lekha Mikkilineni, Robert Lowsky, Robert Negrin, Andrew Rezvani, Judith Shizuru, Surbhi Sidana, Melody Smith, Wen-Kai Weng, David Miklos, Lori Muffly, Vanessa Kennedy
Journal: Blood
Blood (2025) 146 (Supplement 1): 2494.
https://doi.org/10.1182/blood-2025-2494
Published: 2025
Journal Articles

CD22-directed CAR-T cells induce complete remissions in high-risk follicular and Mantle Cell Lymphoma with limited neurotoxicity

Free
Hrishikesh Srinagesh, Anne Marijn Kramer, Mark Hamilton, Yi-Jiun Su, Kendall Kozy, LaTesha Jackson, Annie Brown, Kimi DeNoble, Sharon Mavroukakis, Claire Lohman, Kristen Cunanan, Neha Agarwal, Sushma Bharadwaj, Warren Reynolds, Sally Arai, Laura Johnston, Robert Lowsky, Everett Meyer, Robert Negrin, Andrew Rezvani, Judith Shizuru, Lekha Mikkilineni, Hitomi Hosoya, Parveen Shiraz, Surbhi Sidana, Wen-Kai Weng, Vanessa Kennedy, Melody Smith, Saurabh Dahiya, Kara Davis, Sneha Ramakrishna, Liora Schultz, Ramya Tunuguntla, Lori Muffly, Crystal Mackall, David Miklos, Matthew Frank
Journal: Blood
Blood (2025) 146 (Supplement 1): 4159.
https://doi.org/10.1182/blood-2025-4159
Published: 2025
Journal Articles

Spatial Characterization of Molecular Pathways Suggests the Dysregulation of LGR5 Expressing Fibroblasts in Patients with sclerodermatous Chronic Graft-Vs-Host Disease

Free
Marjia Afrin, Sahar Nasr, Cristabelle De Souza, Brooke Howitt, Antonia Maria Mueller, Sally Arai, Judith Shizuru, Gerlinde Wernig
Journal: Blood
Blood (2024) 144 (Supplement 1): 3536.
https://doi.org/10.1182/blood-2024-211863
Published: 2024
Journal Articles

Safety and Efficacy of Chimeric Antigen Receptor T-Cell Therapy in Octogenarian Patients (Aged ≥ 80) with Relapsed or Refractory (R/R) Large B-Cell Lymphoma (LBCL)

Free
Dasom Lee, Sushma Bharadwaj, Masooma S Rana, Alexandria Jensen, William Wang, Nima Ghalehsari, Bita Sahaf, Jayasindhu Mallampet, Sarah Elkordy, Theresa Latchford, Sally Arai, Laura Johnston, Hitomi Hosoya, Robert Lowsky, Robert S. Negrin, Andrew R. Rezvani, Judith Shizuru, Everett H. Meyer, Parveen Shiraz, Lekha Mikkilineni, Wen-Kai Weng, Lauren S. Maeda, Melody Smith, Surbhi Sidana, Lori Muffly, Matthew J. Frank, David B. Miklos, Saurabh Dahiya
Journal: Blood
Blood (2024) 144 (Supplement 1): 386.
https://doi.org/10.1182/blood-2024-201822
Published: 2024
Journal Articles

CD22-Directed CAR T-Cell Therapy Achieves Complete Remission in CD19-Directed CAR T-Cell Refractory Follicular and Mantle Cell Lymphoma

Free
Anne Marijn Kramer, Hrishikesh Srinagesh, Yi-Jiun Su, Mark P. Hamilton, Kendall Levine, Eleonora Migliore, Kimi DeNoble, Annie K. Brown, Kristen Cunanan, Neha Agarwal, Claire Lohman, Sharon Mavroukakis, Sushma Bharadwaj, Sally Arai, Laura Johnston, Robert Lowsky, Everett H. Meyer, Robert S. Negrin, Andrew R. Rezvani, Judith Shizuru, Lekha Mikkilineni, Hitomi Hosoya, Parveen Shiraz, Surbhi Sidana, Wen-Kai Weng, Vanessa E. Kennedy, Melody Smith, Saurabh Dahiya, Kara L. Davis, Sneha Ramakrishna, Liora Michal Schultz, Ramya Tunuguntla, Steven A. Feldman, Lori Muffly, Crystal L. Mackall, David B. Miklos, Matthew J. Frank
Journal: Blood
Blood (2024) 144 (Supplement 1): 2064.
https://doi.org/10.1182/blood-2024-198489
Published: 2024
Journal Articles

Safe and Effective Combination of Donor-Derived, Allogeneic CD19/CD22-CAR T Cells with Myeloablative Graft-Engineered Allo-HCT for High-Risk B-ALL

Free
Lori Muffly, Snegha Ananth, Lindsay Danley, Caroline Wagner, Diana Kordek, Kimi DeNoble, Ayesha Fraser, Emily Egeler, Alfonso Molina, Zachary Ehlinger, Moksha Desai, Hossein Daghagh, Ramya Tunuguntla, Annie K. Brown, Raquel Ibañez, Anne Marijn Kramer, Zinaida Good, Sally Arai, Laura Johnston, Robert Lowsky, Andrew R. Rezvani, Judith Shizuru, Lekha Mikkilineni, Parveen Shiraz, Surbhi Sidana, Wen-Kai Weng, Vanessa E. Kennedy, Sushma Bharadwaj, Saurabh Dahiya, Matthew J. Frank, Everett H. Meyer, Robert S. Negrin, Steven A. Feldman, Crystal L. Mackall, Bita Sahaf, David B. Miklos, Melody Smith
Journal: Blood
Blood (2024) 144 (Supplement 1): 679.
https://doi.org/10.1182/blood-2024-211959
Published: 2024
Journal Articles

CD22-Directed CAR T-Cell Therapy for Large B-Cell Lymphomas Progressing after CD19-Directed CAR T-Cell Therapy: Continued Durable Remissions at 3-Year Follow-up

Free
Anne Marijn Kramer, John H. Baird, Hrishikesh Srinagesh, Emily Egeler, Kendall Levine, Annie K. Brown, Sharon Mavroukakis, Kristen Cunanan, Yi-Jiun Su, Neha Agarwal, Mark P. Hamilton, Sushma Bharadwaj, Sally Arai, Laura Johnston, Robert Lowsky, Everett H. Meyer, Robert S. Negrin, Andrew R. Rezvani, Judith Shizuru, Lekha Mikkilineni, Hitomi Hosoya, Parveen Shiraz, Surbhi Sidana, Wen-Kai Weng, Vanessa E. Kennedy, Melody Smith, Saurabh Dahiya, Kara L. Davis, Sneha Ramakrishna, Liora Michal Schultz, Ramya Tunuguntla, Steven A. Feldman, Lori Muffly, Crystal L. Mackall, David B. Miklos, Matthew J. Frank
Journal: Blood
Blood (2024) 144 (Supplement 1): 69.
https://doi.org/10.1182/blood-2024-198544
Published: 2024
Journal Articles

Single Institution Analysis of Lymphoma Treatment Related Post-CAR Myeloid Neoplasms

Free
Mark Hamilton, Nick Phillips, Dasom Lee, Zachary Ehlinger, Anne Marijn Kramer, Hrishikesh Srinagesh, Zinaida Good, Xiaoman Kang, Mari Olsen, Chih Long Liu, Feng Tian, Brian J. Sworder, Hitomi Hosoya, Joseph G. Schroers-Martin, Sushma Bharadwaj, Sally Arai, Laura Johnston, Robert Lowsky, Everett H. Meyer, Robert S. Negrin, Andrew R. Rezvani, Judith Shizuru, Lekha Mikkilineni, Parveen Shiraz, Surbhi Sidana, Wen-Kai Weng, Vanessa E. Kennedy, Melody Smith, Lori Muffly, David Kurtz, Saurabh Dahiya, Matthew J. Frank, Crystal L. Mackall, Bita Sahaf, David B. Miklos, Ash A. Alizadeh
Journal: Blood
Blood (2024) 144 (Supplement 1): 96.
https://doi.org/10.1182/blood-2024-205378
Published: 2024
Journal Articles

A phase 1 clinical trial of NKTR-255 with CD19-22 CAR T-cell therapy for refractory B-cell acute lymphoblastic leukemia

Free
Clinical Trials & Observations
Hrishikesh Srinagesh, Clayton Jackson, Parveen Shiraz, Nikeshan Jeyakumar, Mark Hamilton, Emily Egeler, Sharon Mavroukakis, Adam Kuo, Juancarlos Cancilla, Bita Sahaf, Neha Agarwal, Alyssa Kanegai, Anne Marijn Kramer, Sally Arai, Sushma Bharadwaj, Saurabh Dahiya, Hitomi Hosoya, Laura Johnston, Vanessa Kennedy, Michaela Liedtke, Robert Lowsky, Lekha Mikkilineni, Robert Negrin, Andrew Rezvani, Surbhi Sidana, Judith Shizuru, Melody Smith, Wen-Kai Weng, Steven Feldman, Matthew J. Frank, Zachary Lee, Mary Tagliaferri, A. Mario Marcondes, David Miklos, Crystal Mackall, Lori Muffly
Journal: Blood
Blood (2024) 144 (16): 1689–1698.
https://doi.org/10.1182/blood.2024024952
Published: 2024
Includes: Supplemental data
Journal Articles

Phase 1 Trial Results for Patients with Advanced Hematologic Malignancies Undergoing Reduced Intensity Allogeneic HCT with Orca-T Donor Cell Therapy Product and Single Agent Tacrolimus

Free
Alejandro Villar-Prados, Everett H. Meyer, Katherine Sutherland, Robert S. Negrin, Sally Arai, Matthew J. Frank, Laura Johnston, Robert Lowsky, David B. Miklos, Lori S. Muffly, Saurabh Dahiya, Andrew R. Rezvani, Surbhi Sidana, Parveen Shiraz, Judith Shizuru, Wen-Kai Weng, Melody Smith, Sushma Bharadwaj, John Tamaresis, Anna Pavlova, Scott McClellan
Journal: Blood
Blood (2023) 142 (Supplement 1): 3560.
https://doi.org/10.1182/blood-2023-188162
Published: 2023
Journal Articles

Radiation and Busulfan-Free Hematopoietic Stem Cell Transplantation Using Briquilimab (JSP191) Anti-CD117 Antibody-Conditioning, Transient Immunosuppression and TCRαβ + T-Cell/CD19 + B-Cell Depleted Haploidentical Grafts in Patients with Fanconi Anemia

Free
Rajni Agarwal, Alice Bertaina, Charmaine Fay Soco, Gopin Saini, Nivedita Kunte, Lyndsie Hiroshima, Yan Yi Chan, Hana Willner, Mark L. Krampf, Rofida Nofal, Giulia Barbarito, Sushmita Sen, Matthias Felber, Maite Van Hentenryck, Emily Walck, Amelia Scheck, Supawat Thongthip, Aaron C. Logan, Kirstin Dougall, Ali Bouge, Jaap Jan Boelens, Janel R. Long-Boyle, Irving L. Weissman, Judith Shizuru, Wendy W Pang, Kenneth I. Weinberg, Robertson Parkman, Maria-Grazia Roncarolo, Matthew Porteus, Agnieszka Czechowicz
Journal: Blood
Blood (2023) 142 (Supplement 1): 229.
https://doi.org/10.1182/blood-2023-178400
Published: 2023
Journal Articles

Targeting of CD25+ Activated T Cells in Gvhd-Associated Marrow Suppression and Cytopenias

Free
Tami D. John, Laura Valine, Giulia Barbarito, Hye-Sook Kwon, Sally Arai, Beth Martin-Kool, Radhika Kumari, Judith Shizuru, Jean S. Oak, Robertson Parkman, Alice Bertaina, Kenneth I. Weinberg
Journal: Blood
Blood (2023) 142 (Supplement 1): 7033.
https://doi.org/10.1182/blood-2023-190968
Published: 2023
Journal Articles

CAR19 Therapy Drives Expansion of Clonal Hematopoiesis and Associated Cytopenias

Free
Mark P. Hamilton, Brian J. Sworder, Stefan K. Alig, Zinaida Good, Jan Boegeholz, Joseph Schroers-Martin, John Tamaresis, Mohammad Shahrokh Esfahani, Ying Lu, Mari Olsen, Chih Long Liu, Zachary Ehlinger, Moksha Desai, Felicia Liu-Fei, Lori S. Muffly, Robert S. Negrin, Sally Arai, Laura Johnston, Robert Lowsky, Everett H. Meyer, Andrew R. Rezvani, Judith Shizuru, Wen-Kai Weng, Parveen Shiraz, Surbhi Sidana, Sushma Bharadwaj, Melody Smith, Saurabh Dahiya, Bita Sahaf, Maximilian Diehn, Matthew J. Frank, Crystal L. Mackall, David M. Kurtz, David B. Miklos, Ash A. Alizadeh
Journal: Blood
Blood (2023) 142 (Supplement 1): 360.
https://doi.org/10.1182/blood-2023-182522
Published: 2023
Journal Articles

Final Results from Phase 1 Study of Briquilimab, an Anti-CD117 Monoclonal Antibody, in Combination with Low Dose Irradiation and Fludarabine Conditioning, Shows Durable Remissions in Older Adults with Acute Myeloid Leukemia in Complete Remission and Myelodysplastic Syndrome Undergoing Allogeneic Hematopoietic Cell Transplantation

Free
Arpita Gandhi, Andrew Artz, Catherine J. Lee, Ankur Varma, Bart L. Scott, Hye-Sook Kwon, Minyoung Youn, Chikako Yanagiba, Jeyakavitha Arulprakasam, Anne Le, Judith Shizuru, Wendy W Pang, Lori S. Muffly
Journal: Blood
Blood (2023) 142 (Supplement 1): 470.
https://doi.org/10.1182/blood-2023-185533
Published: 2023