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Excellent Safety Profile of a Low-Cost Novel Humanized CD19 CAR T-Cell Therapy, Actalycabtagene Autoleucel : Potential Impact on Access and Feasibility

Atharva Karulkar, Ankesh Kumar Jaiswal, Aalia Khan, Devanshi Kalra, Smrithi Ravikumar, Netra Ghandade, Ruchira Patil, Shreshtha Shah, Afrin Firfiray, Juber Pendhari, Rushikesh Patil, Manivasagam S, Jayshree Thorat, Neha Sharma, Alok Shetty, Thomas Eipe, Lingaraj Nayak, Bhausaheb Bagal, Manju Sengar, Gaurav Narula, Nirali N. Shah, Sattva S. Neelapu, Hasmukh Jain, Rahul Purwar
Journal: Blood
Blood (2023) 142 (Supplement 1): 257.
https://doi.org/10.1182/blood-2023-177594
Published: 2023
Journal Articles

High Efficacy and Excellent Safety Profile of Actalycabtagene Autoleucel, a Humanized CD19 CAR-T Product in r/r B-Cell Malignancies: A Phase II Pivotal Trial

Hasmukh Jain, Atharva Karulkar, Devanshi Kalra, Smrithi Ravikumar, Netra Ghandade, Ruchira Patil, Shreshtha Shah, Afrin Firfiray, Juber Pendhari, Rushikesh Patil, Manivasagam S, Neha Sharma, Alok Shetty, Lingaraj Nayak, Bhausaheb Bagal, Shripad Banavali, Gaurav Narula, Preeti Desai, Anisha Navkudkar, Prashant Tembhare, Navin Khattry, Epari Sridhar, Nikhil Patkar, Sumeet Gujral, Tanuja Shet, Uma Sakhadeo, Papagudi Ganesan Subramanian, Jayshree Thorat, Anamika Prashant, Sachin Punatar, Anant Gokarn, Kinjalka Ghosh, Archi Agrawal, Yash Jain, Venkatesh Rangarajan, Shashank Ojha, Shilpushp Bhosle, Siddhartha Laskar, Sangeeta Kakoti, Sumeet Mirgh, Sumathi Hiregoudar, Minal Poojary, Nitin Shetty, Vasundhara Patil, Akshay Baheti, Sanjay Biswas, Gaurav Salunkhe, Kunal Gala, Manju Sengar, Nirali N. Shah, Sattva S. Neelapu, Rahul Purwar
Journal: Blood
Blood (2023) 142 (Supplement 1): 4838.
https://doi.org/10.1182/blood-2023-185507
Published: 2023
Journal Articles

E valuating the S afety of HCAR19 (Now Actalycabtagene Autoleucel- Actaly-Cel™), a Novel H umanized CD19-Directed Chimeric Antigen Receptor T-Cells in Pediatric, Adolescents, and Young Adults with Relapsed/ Refractory B- Acute Lymphoblastic Leukemia (ESHA) - Report of Phase-1B

Gaurav Narula, Swaminathan Keerthivasagam, Hasmukh Jain, Chetan Dhamne, Prashant Tembhare, Papagudi Ganesan Subramanian, Nikhil Patkar, Minal Poojary, Albeena Nisar, Deepali Pandit, Khushali Pandit, Atharva Karulkar, Ankesh Kumar Jaiswal, Aalia Khan, Shreshtha Shah, Afrin Firfiray, Juber Pendhari, Sweety Asija, Ambalika Chowdury, Ankit Banik, Nirmalya Roy Moulik, Shyam Srinivasan, Shilpushp Bhosle, Sumathi Hiregoudar, Shashank Ojha, Lingaraj Nayak, Jayshree Thorat, Bhausaheb Bagal, Manju Sengar, Nishant Jindal, Akanksha Chichra, Sumeet Mirgh, Anant Gokarn, Sachin Punatar, Sunil Rajadhyaksha, Navin Khattry, Shripad Banavali, Steven Highfill, Nirali N. Shah, Rahul Purwar
Journal: Blood
Blood (2023) 142 (Supplement 1): 6878.
https://doi.org/10.1182/blood-2023-180867
Published: 2023
Journal Articles

Making Anti-CD19 CAR-T Cell Therapy Accessible and Affordable: First-in-Human Phase I Clinical Trial Experience from India

Atharva Karulkar, Hasmukh Jain, Shreshtha Shah, Aalia Khan, Ankesh Jaiswal, Afrin Firfiray, Prashant Suvasia, Priyanshi Suvasia, Juber Pendhari, Sweety Asija, Ambalika Chowdury, Ankit Banik, Smrithi Ravikumar, Neha Sharma, Minal Poojary, Sumathi Hiregoudar, Preeti Desai, Anisha Navkudkar, Sunil Rajadhyaksha, Jayashree Thorat, Prashant R. Tembhare, Albeena Nisar, Manju Sengar, David F. Stroncek, Steven Highfill, Nirali N. Shah, Gaurav Narula, Rahul Purwar
Journal: Blood
Blood (2022) 140 (Supplement 1): 4610–4611.
https://doi.org/10.1182/blood-2022-168928
Published: 2022
Journal Articles

Phase I Trial of Humanized CD19 CART-Cell Therapy Developed in India: Safe, Active and Feasible for Outpatient Therapy

Hasmukh Jain, Atharva Karulkar, Neha Sharma, Manju Sengar, Ankesh Jaiswal, Shreshtha Shah, Aalia Khan, Afrin Firfiray, Sweety Asija, Prashant Suvasia, Priyanshi Suvasia, Juber Pendhari, Devanshi Kalra, Smrithi Ravikumar, Gaurav Narula, Shripad Banavali, Minal Poojary, Sumathi Hiregoudar, Lingaraj Nayak, Bhausaheb Bagal, Prashant R. Tembhare, Sridhar Epari, Navin Khattry, Nikhil Patkar, Sumeet Gujral, Tanuja Shet, Papagudi Ganesan Subramanian, Jayashree Thorat, Sachin Punatar, Anant Gokarn, Kinjalka Ghosh, Archi Agarwal, Preeti Desai, Shashank Ojha, Subhash Yadav, Shil Pushp Bhosale, Sunil Rajadhyaksha, Anisha Navkudkar, Siddharth Laskar, Sumeet Prakash Mirgh, Albeena Nisar, Deepali Pandit, Ruchira Patil, Rahul Purwar, Sattva S. Neelapu, Nirali N. Shah
Journal: Blood
Blood (2022) 140 (Supplement 1): 10332–10334.
https://doi.org/10.1182/blood-2022-166082
Published: 2022
Journal Articles

Genomic Landscape of Juvenile Myelomonocytic Leukemia: A Real World Context

Gaurav Chatterjee, MD, Gaurav Narula, MD, Shrinidhi Nathany, MD, Prashant Tembhare, MD, Papagudi Ganesan Subramanian, MD, Sumeet Gujral, MD, Maya Prasad, Nirmalya Roy Moulik, MD, Vasudev Bhat, Chetan A. Dhamne, MD, Shripad Banavali, MD, Nikhil Patkar, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1728.
https://doi.org/10.1182/blood-2019-129750
Published: 2019
Journal Articles

Flow-Cytometry Based Detection of Any Minimal Residual Disease (FC-MRD) in Children with T-Acute Lymphoblastic Leukemias (T-ALL) Is a Powerful Indicator of Outcome

Prashant Tembhare, MD, Gaurav Narula, MD, Gaurav Chatterjee, MD, Twinkle Khanka, Mahima Sanyal, Sitaram Ghogale, Nikhil Patkar, MD, Nilesh Deshpande, Yajamanam Badrinath, Sumeet Gujral, MD, Shripad Banavali, MD, Papagudi Ganesan Subramanian, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2585.
https://doi.org/10.1182/blood-2019-128347
Published: 2019
Journal Articles

An Integrated Genomic Classification That Includes Copy Number Alterations Is Highly Predictive of Post Induction Minimal Residual Disease (MRD) Status in Childhood Precursor B Lineage Acute Lymphoblastic Leukemia

Nikhil Patkar, MD, Papagudi Ganesan Subramanian, MD, Prashant Tembhare, MD, Pratibha Amare Kadam, PhD, Asma Bibi, MD, Karishma Chopra, MSc, Satish Mirgal, MSc, Sagar Rambhiya, MSc, Swapnali Joshi, MSc, Shruti Chaudhary, PhD, Russel Mascrenhas, MSc, Sona Dusseja, MSc, Gaurav Narula, MD, Brijesh Arora, DM, Shripad Banavali, MD, Sumeet Gujral, MD
Journal: Blood
Blood (2015) 126 (23): 2615.
https://doi.org/10.1182/blood.V126.23.2615.2615
Published: 2015
Journal Articles

Bendamustine Monotherapy Is Effective As Salvage Therapy in Patients with Refractory / Relapsed Pediatric Hodgkin Lymphoma (HL): A Retrospective Analysis

Sneha Tandon, MD, Shripad Banavali, MD, Brijesh Arora, DM, Gaurav Narula, MD, Maya Prasad, MD, Tanuja Shet, MD, Sumeet Gujral, MD
Journal: Blood
Blood (2015) 126 (23): 5099.
https://doi.org/10.1182/blood.V126.23.5099.5099
Published: 2015
Journal Articles

Sorafenib Combined with Non-Conventional Chemotherapy Produces Deep Remissions in FMS-like Tyrosine Kinase-3 Gene / Internal Tandem Duplication Positive (FLT-3 / ITD+) Acute Myeloid Leukemia (AML) Patients

Shripad Banavali, MD, Nirav Thacker, DM, Brijesh Arora, DM, Gaurav Narula, MD, Maya Prasad, MD, Nirmalya Pradhan, MD, Saroj Panda, DM, Nikhil Patkar, MD, Prashant Tembhare, MD, Papagudi Ganesan Subramanian, MD
Journal: Blood
Blood (2015) 126 (23): 4939.
https://doi.org/10.1182/blood.V126.23.4939.4939
Published: 2015