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Journal Articles

Granulocyte Transfusions As an Adjunctive Therapy in Severe Aplastic Anemia

Roma V. Rajput, Vaani Shah, Ruba Shalhoub, Kamille West-Mitchell, Cathy Conry-Cantilena, David J. Young, Cynthia E. Dunbar, Bhavisha A. Patel, Richard W. Childs, Neal S. Young, Colin O. Wu, Emma M. Groarke, Shelley S. Kalsi

Blood (2022) 140 (Supplement 1): 8556–8557.

https://doi.org/10.1182/blood-2022-162595

Published: 2022

Journal Articles

Allogeneic Peripheral Blood Stem Cell Transplantation for Bone Marrow Failure Syndromes Using CD34 + -Selected Progenitor Cells Co-Infused with a Reduced Number of Non-Mobilized T-Cells

Georg Aue, Yazan Migdady, Yimo Wang, Jennifer Wilder, Brian Wells, Rosa Nadal Rios, Joseph A. Clara, Robert Reger, Kristen Gunn, Melissa Spencer, Jennifer Farren, Patricia Prince, Reem A Shalabi, Steven Highfill, David F. Stroncek, Xin Tian, Richard W. Childs

Blood (2022) 140 (Supplement 1): 7576–7577.

https://doi.org/10.1182/blood-2022-169922

Published: 2022

Journal Articles

Promising Preliminary Activity of Optimized Affinity, CD38 CAR NK Cells Generated Using a Non-Viral Engineering Approach in Gene Edited Cord Blood Derived NK Cells for the Treatment of Multiple Myeloma

Rohit Duggal, Sumit Sen Santara, Myra Gordon, Aoife Kilgallon, David Hermanson, Richard W. Childs, Michael E. O'Dwyer

Blood (2021) 138 (Supplement 1): 4793.

https://doi.org/10.1182/blood-2021-151379

Published: 2021

Journal Articles

Tc Buster Transposon Engineered CLL-1 CAR-NK Cells Efficiently Target Acute Myeloid Leukemia

Mark Gurney, Eimear O'Reilly, Sarah Corcoran, Sarah Brophy, David Hardwicke, Janusz Krawczyk, David Hermanson, Richard W. Childs, Eva Szegezdi, Michael E. O'Dwyer

Blood (2021) 138 (Supplement 1): 1725.

https://doi.org/10.1182/blood-2021-147244

Published: 2021

Journal Articles

Strong Predictors of Chromosomal Aberrations and Myeloid Neoplasia Following Immunosuppression Therapy for Severe Aplastic Anemia: A Retrospective Cohort Study

Emma M. Groarke, Bhavisha A. Patel, Ruba Shalhoub, Fernanda Gutierrez-Rodrigues, Parth Desai, Harshraj Leuva, Casey Paton, Nina Spitofsky, Jennifer Lotter, Olga Rios, Richard W. Childs, David J. Young, Alina Dulau-Florea, Cynthia E. Dunbar, Katherine R. Calvo, Colin O. Wu, Neal S. Young

Blood (2021) 138 (Supplement 1): 601.

https://doi.org/10.1182/blood-2021-146070

Published: 2021

Journal Articles

CRISPR Gene-Editing of Chemokine Receptors As a Novel Strategy to Redirect NK Cell Trafficking In Vivo

Emily R. Levy, PhD, Joseph Clara, MD, David Allan, PhD, Robert Reger, MS, Richard W. Childs, MD

Blood (2020) 136 (Supplement 1): 3.

https://doi.org/10.1182/blood-2020-141408

Published: 2020

Journal Articles

Cell Density of NK Cells during Ex Vivo Expansion Impacts NK Cell Surface TRAIL Expression

Joseph A. Clara, MD, Robert Reger, MS, Mala Chakraborty, PhD, Steven L Highfill, PhD, Jianjian Jin, PhD, David F. Stroncek, MD, Richard W. Childs, MD

Blood (2020) 136 (Supplement 1): 5–6.

https://doi.org/10.1182/blood-2020-141487

Published: 2020

Journal Articles

Rapid Engraftment, Immune Recovery, and Resolution of Transfusion Dependence in Treatment-Refractory Severe Aplastic Anemia Following Transplantation with Ex Vivo Expanded Umbilical Cord Blood (Omidubicel)

Mohamed Samour, MD, Georg Aue, MD PhD, Joseph Clara, Jennifer Wilder, Robert Reger, MS, Rosa Nadal Rios, MD, Kate Stringaris, MD PhD, Brian Wells, Lisa Cook, Kristen Gunn, Reem A Shalabi, PharmD, Josef Rivero, Patricia Prince, David F. Stroncek, MD, Willy A. Flegel, MD, Xin Tian, PhD, Richard W. Childs, MD

Blood (2020) 136 (Supplement 1): 37–38.

https://doi.org/10.1182/blood-2020-137771

Published: 2020

Journal Articles

Outcome of Repeated Vaccination to Hepatitis B Virus in Patients Failing to Respond to Vaccination Following Allogeneic Hematopoietic Stem Cell Transplantation (HSCT): If at First You Don't Succeed, Try Try Again

Reem A Shalabi, PharmD, Michelle A Borg, PharmD, Thomas E Hughes, PharmD, Tracey Walsh-Chocolaad, PharmD, Rodica Ciurea, Lisa Cook, Tatyana Worthy, MSN, Kristen Gunn, Brian Wells, Georg Aue, Xin Tian, Richard W. Childs, MD

Blood (2019) 134 (Supplement_1): 2012.

https://doi.org/10.1182/blood-2019-127336

Published: 2019

Journal Articles

Effect of Cyclosporine Inhalation Solution (CIS) on Lung Function and Inflammatory Biomarkers in Patients with Hematopoietic Stem Cell Transplant (HSCT) Associated Bronchiolitis Obliterans Syndrome (BOS)

Janhavi Athale, MD, Nicole J Gormley, MD, Robert Reger, MS, Sara Alsaaty, MS, Debra Reda, BSN, Tatyana Worthy, MSN, Ankit Saxena, Ph. D, Xin Tian, Ph. D, Richard W. Childs, MD, Anthony F Suffredini, MD

Blood (2019) 134 (Supplement_1): 4552.

https://doi.org/10.1182/blood-2019-122966

Published: 2019

Journal Articles

Robust Cell Selections and Depletions across Various Hematopoietic Cell Fractions on the Clinimacs Plus Instrument

Thejaswi Bikkani, MBBS, Katherine Li, Anusha Rao, Angela Pickett, Xiaobai Li, PhD, Minoo Battiwalla, MD, Richard W. Childs, MD, John Barrett, MD, Andre Larochelle, MD PhD, Elizabeth Kang, MD, David F. Stroncek, Sandhya R. Panch, MD MPH

Blood (2018) 132 (Supplement 1): 3818.

https://doi.org/10.1182/blood-2018-99-118582

Published: 2018

Journal Articles

Intrabone Delivery of CD34+ Cells Using an Optimized Delivery System Does Not Enhance Engraftment in a Rhesus Macaque Model of Hematopoietic Stem Cell Transplantation

Blood (2018) 132 (Supplement 1): 5677.

https://doi.org/10.1182/blood-2018-99-114730

Published: 2018

Journal Articles

Rapid Engraftment and Immune Recovery in Treatment Refractory Severe Aplastic Anemia Patients Undergoing Ex Vivo Nicotinamide-Expanded (NAM-Expanded) Unrelated Cord Blood Transplantation

Richard W. Childs, MD, Phuong T. Vo, MD, Georg Aue, Jennifer Wilder, Brian Wells, Joseph Clara, MD, Reem Shalabi, Patricia Prince, David F. Stroncek, Robert Reger, MS, Willy A. Flegel, MD, Sharon Adams, MT, CHS (ABHI), Kristen Gunn, Tatyana Worthy, Lisa Cook, Xin Tian

Blood (2018) 132 (Supplement 1): 5789.

https://doi.org/10.1182/blood-2018-99-119546

Published: 2018

Journal Articles

Clonal Expansion and Long-Term Persistence of Rhesus Macaque NK Cells with an Adaptive Phenotype

Chuanfeng Wu, MDPhD, Diego A Espinoza, Samson J. Koelle, BA, Di Yang, MD, Heinrich Schlums, Jan K. Davidson-Moncada, MD PhD, Rong Lu, Amitinder Kaur, Hammer Quirin, Brian Li, Sandhya R. Panch, MD MPH, Robert E Donahue, Richard W. Childs, Chiara Romagnani, Yenan Bryceson, Cynthia E. Dunbar, MD

Blood (2016) 128 (22): 549.

https://doi.org/10.1182/blood.V128.22.549.549

Published: 2016

Journal Articles

Complement Inhibition Using Eculizumab Overcomes Platelet Transfusion Refractoriness in Allo-Immunized Patients Receiving HLA Mismatched Platelets

Phuong T. Vo, MD, Enkhtsetseg Purev, Kamille A West, MD, Michael Hochman, Emily C. McDuffee, PhD DO, Tatyana Worthy, Lisa Cook, Catalina Ramos, Brian Wells, Willy A. Flegel, Sharon Adams, Robert N. Reger, Georg Aue, Richard W. Childs

Blood (2016) 128 (22): 3840.

https://doi.org/10.1182/blood.V128.22.3840.3840

Published: 2016

Journal Articles

A Naive NK Cell Repertoire in the Circulation of Haploidentical Stem Cell Donors Pre Mobilization Predicts Rejection of Cord Myeloid Cells in Patients Undergoing Combined Haploidentical and Unrelated Cord Blood HSCT

Mattias Carlsten, MD, PhD, Robert N. Reger, Ritesh Kotecha, Enkhtsetseg Purev, Xin Tian, Roger Kurlander, Georg Aue, Richard W. Childs

Blood (2016) 128 (22): 2199.

https://doi.org/10.1182/blood.V128.22.2199.2199

Published: 2016

Journal Articles

Excellent Outcomes of Combined Haploidentical and Cord-Blood (Haplo-Cord) Transplantation and HLA-Matched Sibling (Matched-Sib) Donor Transplantation for High-Risk Patients with Severe Aplastic Anemia (SAA) Refractory to Immunosuppressive Therapy

Blood (2016) 128 (22): 4689.

https://doi.org/10.1182/blood.V128.22.4689.4689

Published: 2016

Journal Articles

Identification and Ex Vivo Expansion of a Circulating NK Cell Progenitor Population That Leads to Sustained Production of CD56+ NK Cells

Jan K. Davidson-Moncada, MD PhD, Taylor Harrison Wand, BA, Robert N. Reger, B.S., Chuanfeng Wu, PhD, Cynthia E. Dunbar, MD, Richard W. Childs, MD

Blood (2015) 126 (23): 850.

https://doi.org/10.1182/blood.V126.23.850.850

Published: 2015

Journal Articles

mRNA Transfection of NK Cells with Gain-of-Function CXCR4 As a Novel Method to Enhance the Homing of Adoptively Transferred NK Cells to the Bone Marrow for the Treatment of Hematological Malignancies

Emily R. Levy, Robert N. Reger, B.S., Mattias Carlsten, MD, PhD, Richard W. Childs, MD

Blood (2015) 126 (23): 3089.

https://doi.org/10.1182/blood.V126.23.3089.3089

Published: 2015

Journal Articles

ER-Stress-Induced Suppression of HLA-E on Bortezomib-Evading Malignant Plasma Cells Dramatically Enhances Their Susceptibility to NK Cell Killing: Identification of an Achilles Heel in Myeloma Cells That Can be Utilized to Prevent Disease Relapse Following Bortezomib Treatment

Mattias Carlsten, MD, PhD, Ali Namazi, MD, Robert N. Reger, B.S., Maria Berg, Richard W. Childs, MD

Blood (2015) 126 (23): 4296.

https://doi.org/10.1182/blood.V126.23.4296.4296

Published: 2015

NARROW

Granulocyte Transfusions As an Adjunctive Therapy in Severe Aplastic Anemia

Allogeneic Peripheral Blood Stem Cell Transplantation for Bone Marrow Failure Syndromes Using CD34 + -Selected Progenitor Cells Co-Infused with a Reduced Number of Non-Mobilized T-Cells

Promising Preliminary Activity of Optimized Affinity, CD38 CAR NK Cells Generated Using a Non-Viral Engineering Approach in Gene Edited Cord Blood Derived NK Cells for the Treatment of Multiple Myeloma

Tc Buster Transposon Engineered CLL-1 CAR-NK Cells Efficiently Target Acute Myeloid Leukemia

Strong Predictors of Chromosomal Aberrations and Myeloid Neoplasia Following Immunosuppression Therapy for Severe Aplastic Anemia: A Retrospective Cohort Study

CRISPR Gene-Editing of Chemokine Receptors As a Novel Strategy to Redirect NK Cell Trafficking In Vivo

Cell Density of NK Cells during Ex Vivo Expansion Impacts NK Cell Surface TRAIL Expression

Rapid Engraftment, Immune Recovery, and Resolution of Transfusion Dependence in Treatment-Refractory Severe Aplastic Anemia Following Transplantation with Ex Vivo Expanded Umbilical Cord Blood (Omidubicel)

Outcome of Repeated Vaccination to Hepatitis B Virus in Patients Failing to Respond to Vaccination Following Allogeneic Hematopoietic Stem Cell Transplantation (HSCT): If at First You Don't Succeed, Try Try Again

Effect of Cyclosporine Inhalation Solution (CIS) on Lung Function and Inflammatory Biomarkers in Patients with Hematopoietic Stem Cell Transplant (HSCT) Associated Bronchiolitis Obliterans Syndrome (BOS)

Robust Cell Selections and Depletions across Various Hematopoietic Cell Fractions on the Clinimacs Plus Instrument

Intrabone Delivery of CD34+ Cells Using an Optimized Delivery System Does Not Enhance Engraftment in a Rhesus Macaque Model of Hematopoietic Stem Cell Transplantation

Rapid Engraftment and Immune Recovery in Treatment Refractory Severe Aplastic Anemia Patients Undergoing Ex Vivo Nicotinamide-Expanded (NAM-Expanded) Unrelated Cord Blood Transplantation

Clonal Expansion and Long-Term Persistence of Rhesus Macaque NK Cells with an Adaptive Phenotype

Complement Inhibition Using Eculizumab Overcomes Platelet Transfusion Refractoriness in Allo-Immunized Patients Receiving HLA Mismatched Platelets

A Naive NK Cell Repertoire in the Circulation of Haploidentical Stem Cell Donors Pre Mobilization Predicts Rejection of Cord Myeloid Cells in Patients Undergoing Combined Haploidentical and Unrelated Cord Blood HSCT

Excellent Outcomes of Combined Haploidentical and Cord-Blood (Haplo-Cord) Transplantation and HLA-Matched Sibling (Matched-Sib) Donor Transplantation for High-Risk Patients with Severe Aplastic Anemia (SAA) Refractory to Immunosuppressive Therapy

Identification and Ex Vivo Expansion of a Circulating NK Cell Progenitor Population That Leads to Sustained Production of CD56+ NK Cells

mRNA Transfection of NK Cells with Gain-of-Function CXCR4 As a Novel Method to Enhance the Homing of Adoptively Transferred NK Cells to the Bone Marrow for the Treatment of Hematological Malignancies

ER-Stress-Induced Suppression of HLA-E on Bortezomib-Evading Malignant Plasma Cells Dramatically Enhances Their Susceptibility to NK Cell Killing: Identification of an Achilles Heel in Myeloma Cells That Can be Utilized to Prevent Disease Relapse Following Bortezomib Treatment

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American Society of Hematology

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American Society of Hematology

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