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Ruba Shalhoub
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Journal Articles

Clonal landscape and clinical outcomes of telomere biology disorders: somatic rescue and cancer mutations

Fernanda Gutierrez-Rodrigues, Emma M. Groarke, Natthakan Thongon, Juan Jose Rodriguez-Sevilla, Luiz Fernando B. Catto, Marena R. Niewisch, Ruba Shalhoub, Lisa J. McReynolds, Diego V. Clé, Bhavisha A. Patel, Xiaoyang Ma, Dalton Hironaka, Flávia S. Donaires, Nina Spitofsky, Barbara A. Santana, Tsung-Po Lai, Lemlem Alemu, Sachiko Kajigaya, Ivana Darden, Weiyin Zhou, Paul V. Browne, Subrata Paul, Justin Lack, David J. Young, Courtney D. DiNardo, Abraham Aviv, Feiyang Ma, Michel Michels De Oliveira, Ana Paula de Azambuja, Cynthia E. Dunbar, Malgorzata Olszewska, Emmanuel Olivier, Eirini P. Papapetrou, Neelam Giri, Blanche P. Alter, Carmem Bonfim, Colin O. Wu, Guillermo Garcia-Manero, Sharon A. Savage, Neal S. Young, Simona Colla, Rodrigo T. Calado
Journal: Blood
Blood (2024) 144 (23): 2402–2416.
https://doi.org/10.1182/blood.2024025023
Published: 2024
Includes: Supplemental data
Journal Articles

T Lymphopenia and Aged Immune System Characterize Immunodeficiency in Adult Patients with Telomere Biology Disorders

Luiz Fernando Bazzo Catto, Nidhi Aggarwal, Ruba Shalhoub, Natthakan Thongon, Tania Rene Machado, Ivana Darden, Jennifer Lotter, Bhavisha A. Patel, Geraldine Aubert, Colin O. Wu, Simona Colla, Cynthia E. Dunbar, Fernanda Rodrigues, Emma M. Groarke
Journal: Blood
Blood (2024) 144 (Supplement 1): 4094.
https://doi.org/10.1182/blood-2024-207500
Published: 2024
Journal Articles

Danazol Treatment for Telomere Biology Disorders: Long-Term Results of a Phase I/II Study

Nicholas C. Lee, Fernanda Gutierrez-Rodrigues, Ruba Shalhoub, Tania Rene Machado, Jennifer Lotter, Lemlem Alemu, Diego Quinones Raffo, Geraldine Aubert, Colin O. Wu, Bhavisha A. Patel, Neal S. Young, Emma M. Groarke
Journal: Blood
Blood (2024) 144 (Supplement 1): 439.
https://doi.org/10.1182/blood-2024-194335
Published: 2024
Journal Articles

Patient Reported Outcomes in Vexas Syndrome

Bhavisha A. Patel, Emma M. Groarke, Ruba Shalhoub, Fernanda Rodrigues, Alice Fike, Kaitlin Quinn, Ivana Darden, Shanni Liu, Wendy Goodspeed, Rui Miao, Colin O. Wu, Neal S. Young, Peter C Grayson
Journal: Blood
Blood (2024) 144 (Supplement 1): 3711.
https://doi.org/10.1182/blood-2024-205755
Published: 2024
Journal Articles

Venous and arterial thrombosis in patients with VEXAS syndrome

Clinical Trials & Observations
Yael Kusne, Atefeh Ghorbanzadeh, Alina Dulau-Florea, Ruba Shalhoub, Pedro E. Alcedo, Khanh Nghiem, Marcela A. Ferrada, Alexander Hines, Kaitlin A. Quinn, Sumith R. Panicker, Amanda K. Ombrello, Kaaren Reichard, Ivana Darden, Wendy Goodspeed, Jibran Durrani, Lorena Wilson, Horatiu Olteanu, Terra Lasho, Daniel L. Kastner, Kenneth J. Warrington, Abhishek Mangaonkar, Ronald S. Go, Raul C. Braylan, David B. Beck, Mrinal M. Patnaik, Neal S. Young, Katherine R. Calvo, Ana I. Casanegra, Peter C. Grayson, Matthew J. Koster, Colin O. Wu, Yogendra Kanthi, Bhavisha A. Patel, Damon E. Houghton, Emma M. Groarke
Journal: Blood
Blood (2024) 143 (21): 2190–2200.
https://doi.org/10.1182/blood.2023022329
Published: 2024
Includes: Supplemental data
Journal Articles

Distinct Immune and Molecular Profiles of Hepatitis-Associated Aplastic Anemia

Roma V. Rajput, Dalton Hironaka, Ruba Shalhoub, Lemlem Alemu, Emma M. Groarke, Jennifer Lotter, Olga Rios, Ivana Darden, Colin O. Wu, Fernanda Gutierrez-Rodrigues, Xingmin Feng, Neal S. Young, Bhavisha A. Patel
Journal: Blood
Blood (2023) 142 (Supplement 1): 1340.
https://doi.org/10.1182/blood-2023-180902
Published: 2023
Journal Articles

Spectrum of clonal hematopoiesis in VEXAS syndrome

CME
Fernanda Gutierrez-Rodrigues, Yael Kusne, Jenna Fernandez, Terra Lasho, Ruba Shalhoub, Xiaoyang Ma, Hugh Alessi, Christy Finke, Matthew J. Koster, Abhishek Mangaonkar, Kenneth J. Warrington, Kebede Begna, Zhuoer Xie, Amanda K. Ombrello, David Viswanatha, Marcela Ferrada, Lorena Wilson, Ronald Go, Taxiarchis Kourelis, Kaaren Reichard, Horatiu Olteanu, Ivana Darden, Dalton Hironaka, Lemlem Alemu, Sachiko Kajigaya, Sofia Rosenzweig, Rodrigo T. Calado, Emma M. Groarke, Daniel L. Kastner, Katherine R. Calvo, Colin O. Wu, Peter C. Grayson, Neal S. Young, David B. Beck, Bhavisha A. Patel, Mrinal M. Patnaik
Journal: Blood
Blood (2023) 142 (3): 244–259.
https://doi.org/10.1182/blood.2022018774
Published: 2023
Includes: Supplemental data
Journal Articles

Differential diagnosis of bone marrow failure syndromes guided by machine learning

Fernanda Gutierrez-Rodrigues, Eric Munger, Xiaoyang Ma, Emma M. Groarke, Youbao Tang, Bhavisha A. Patel, Luiz Fernando B. Catto, Diego V. Clé, Marena R. Niewisch, Raquel M. Alves-Paiva, Flávia S. Donaires, André Luiz Pinto, Gustavo Borges, Barbara A. Santana, Lisa J. McReynolds, Neelam Giri, Burak Altintas, Xing Fan, Ruba Shalhoub, Christopher M. Siwy, Carrie Diamond, Diego Quinones Raffo, Kathleen Craft, Sachiko Kajigaya, Ronald M. Summers, Paul Liu, Lea Cunningham, Dennis D. Hickstein, Cynthia E. Dunbar, Ricardo Pasquini, Michel Michels De Oliveira, Elvira D. R. P. Velloso, Blanche P. Alter, Sharon A. Savage, Carmem Bonfim, Colin O. Wu, Rodrigo T. Calado, Neal S. Young
Journal: Blood
Blood (2023) 141 (17): 2100–2113.
https://doi.org/10.1182/blood.2022017518
Published: 2023
Includes: Supplemental data
Journal Articles

Clonal Hematopoiesis in Vexas Syndrome

Bhavisha A. Patel, Fernanda Gutierrez-Rodrigues, Yael Kusne, Jenna A. Fernandez, Terra Lasho, Ruba Shalhoub, Xiaoyang Ma, Hugh Alessi, Christy Finke, Matthew Koster, Abhishek A. Mangaonkar, Kenneth Warrington, Kebede H. Begna, Zhuoer Xie, Amanda Ombrello, David S. Viswanatha, Marcela Ferrada, Lorena Wilson, Ronald Go, Taxiarchis Kourelis, Kaaren K. Reichard, Horatiu Olteanu, Emma M. Groarke, Ivana Darden, Dalton Hironaka, Sofia Rosenzweig, Daniel L. Kastner, Katherine R. Calvo, Colin O. Wu, Peter C. Grayson, David B. Beck, Mrinal M.M. Patnaik, Neal S. Young
Journal: Blood
Blood (2022) 140 (Supplement 1): 5745–5746.
https://doi.org/10.1182/blood-2022-160263
Published: 2022
Journal Articles

Pulmonary Function before and after Hematopoietic Cell Transplant in People Living with Sickle Cell Disease

Amy Parker Ruhl, Ruba Shalhoub, Neal Jeffries, Alexis Leonard, Emily Limerick, Amisha Barochia, Matthew M. Hsieh, Courtney D. Fitzhugh
Journal: Blood
Blood (2022) 140 (Supplement 1): 8294–8295.
https://doi.org/10.1182/blood-2022-157235
Published: 2022
Journal Articles

Granulocyte Transfusions As an Adjunctive Therapy in Severe Aplastic Anemia

Roma V. Rajput, Vaani Shah, Ruba Shalhoub, Kamille West-Mitchell, Cathy Conry-Cantilena, David J. Young, Cynthia E. Dunbar, Bhavisha A. Patel, Richard W. Childs, Neal S. Young, Colin O. Wu, Emma M. Groarke, Shelley S. Kalsi
Journal: Blood
Blood (2022) 140 (Supplement 1): 8556–8557.
https://doi.org/10.1182/blood-2022-162595
Published: 2022
Journal Articles

Thrombotic Manifestations in Patients with Vexas Syndrome

Pedro E. Alcedo Andrade, Ruba Shalhoub, Alina Dulau-Florea, Khanh Nghiem, Marcela Ferrada, Lorena Wilson, Ivana Darden, Wendy Goodspeed, Katherine R. Calvo, David B. Beck, Daniel L. Kastner, Peter C. Grayson, Neal S. Young, Colin O. Wu, Yogendra Kanthi, Bhavisha A. Patel, Emma M. Groarke
Journal: Blood
Blood (2022) 140 (Supplement 1): 2788–2789.
https://doi.org/10.1182/blood-2022-163608
Published: 2022
Journal Articles

Predictors, Risk Factors and Outcomes of Patients with SAA with Anti-HLA Class I Antibodies Treated with Immunosuppressive Therapy

Jibran Durrani, Leonard Chen, Ruba Shalhoub, Nu Ri Cha, Xiaoyang Ma, Jennifer Lotter, Olga Rios, Colin O. Wu, Willy A. Flegel, Neal S. Young, Bhavisha A. Patel, Emma M. Groarke
Journal: Blood
Blood (2022) 140 (Supplement 1): 77–78.
https://doi.org/10.1182/blood-2022-163442
Published: 2022
Journal Articles

Characterizing Immunodeficiency in Patients with Telomere Biology Disorders

Nidhi Aggarwal, Xiaoyang Ma, Fernanda Gutierrez-Rodrigues, Ruba Shalhoub, Ivana Darden, Bhavisha A. Patel, Colin O. Wu, Neal S. Young, Emma M. Groarke
Journal: Blood
Blood (2022) 140 (Supplement 1): 5826–5827.
https://doi.org/10.1182/blood-2022-163264
Published: 2022
Journal Articles

Clonal hematopoiesis is not significantly associated with COVID-19 disease severity

Clinical Trials & Observations
Yifan Zhou, Ruba Shalhoub, Stephanie N. Rogers, Shiqin Yu, Muxin Gu, Margarete A. Fabre, Pedro M. Quiros, Tae-Hoon Shin, Arch Diangson, Wenhan Deng, Shubha Anand, Wenhua Lu, Matthew Cullen, Anna L. Godfrey, Jacobus Preller, Jerome Hadjadj, Emmanuelle Jouanguy, Aurélie Cobat, Laurent Abel, Frederic Rieux-Laucat, Benjamin Terrier, Alain Fischer, Lara Novik, Ingelise J. Gordon, Larisa Strom, Martin R. Gaudinski, Andrea Lisco, Irini Sereti, Thomas J. Gniadek, Andrea Biondi, Paolo Bonfanti, Luisa Imberti, Clifton L. Dalgard, Yu Zhang, Kerry Dobbs, Helen C. Su, Luigi D. Notarangelo, Colin O. Wu, Peter J. M. Openshaw, Malcolm G. Semple, Ziad Mallat, Kenneth Baillie, Cynthia E. Dunbar, George S. Vassiliou
Journal: Blood
Blood (2022) 140 (14): 1650–1655.
https://doi.org/10.1182/blood.2022015721
Published: 2022
Includes: Supplemental data
Journal Articles

Long-term outcomes in patients with severe aplastic anemia treated with immunosuppression and eltrombopag: a phase 2 study

Clinical Trials & Observations
Bhavisha A. Patel, Emma M. Groarke, Jennifer Lotter, Ruba Shalhoub, Fernanda Gutierrez-Rodrigues, Olga Rios, Diego Quinones Raffo, Colin O. Wu, Neal S. Young
Journal: Blood
Blood (2022) 139 (1): 34–43.
https://doi.org/10.1182/blood.2021012130
Published: 2022
Includes: Supplemental data
Journal Articles

HLA associations, somatic loss of HLA expression, and clinical outcomes in immune aplastic anemia

CME Clinical Trials & Observations
Yoshitaka Zaimoku, Bhavisha A. Patel, Sharon D. Adams, Ruba Shalhoub, Emma M. Groarke, Audrey Ai Chin Lee, Sachiko Kajigaya, Xingmin Feng, Olga Julia Rios, Holly Eager, Lemlem Alemu, Diego Quinones Raffo, Colin O. Wu, Willy A. Flegel, Neal S. Young
Journal: Blood
Blood (2021) 138 (26): 2799–2809.
https://doi.org/10.1182/blood.2021012895
Published: 2021
Includes: Supplemental data
Journal Articles

Strong Predictors of Chromosomal Aberrations and Myeloid Neoplasia Following Immunosuppression Therapy for Severe Aplastic Anemia: A Retrospective Cohort Study

Emma M. Groarke, Bhavisha A. Patel, Ruba Shalhoub, Fernanda Gutierrez-Rodrigues, Parth Desai, Harshraj Leuva, Casey Paton, Nina Spitofsky, Jennifer Lotter, Olga Rios, Richard W. Childs, David J. Young, Alina Dulau-Florea, Cynthia E. Dunbar, Katherine R. Calvo, Colin O. Wu, Neal S. Young
Journal: Blood
Blood (2021) 138 (Supplement 1): 601.
https://doi.org/10.1182/blood-2021-146070
Published: 2021
Journal Articles

Outcomes in Pediatric Patients with Severe Aplastic Anemia Treated with Standard Immunosuppression and Eltrombopag

Emma M. Groarke, MD, Bhavisha A Patel, MD, Carrie Diamond, MD, Fernanda Gutierrez-Rodrigues, PhD, Alana Vicente, MD, Olga Rios, RN, Jennifer Lotter, PA-C, Daniela Baldoni, Ruba Shalhoub, Colin Wu, PhD, Neal S. Young, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 454.
https://doi.org/10.1182/blood-2019-124811
Published: 2019
Journal Articles

Towards Improved Decision-Making Based on Genomics in Bone Marrow Failure

Fernanda Gutierrez-Rodrigues, PhD, Carrie Diamond, MD, Ruba Shalhoub, André Pinto, Flávia S Donaires, PhD, Diego V Clé, MD PhD, Luiz Guilherme Darrigo, PhD, Luiz Fernando Catto, MD, Xing Fan, MD, Maria del Pilar Fernandez Ibanez, Sachiko Kajigaya, PhD, Cynthia E. Dunbar, MD, Carmem M. S. Bonfim, MD, Danielle M. Townsley, MD MSc, Rodrigo T. Calado, MD PhD, Neal S. Young, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2587.
https://doi.org/10.1182/blood-2018-99-115026
Published: 2018