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Ivana Darden
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Journal Articles

Clonal landscape and clinical outcomes of telomere biology disorders: somatic rescue and cancer mutations

Fernanda Gutierrez-Rodrigues, Emma M. Groarke, Natthakan Thongon, Juan Jose Rodriguez-Sevilla, Luiz Fernando B. Catto, Marena R. Niewisch, Ruba Shalhoub, Lisa J. McReynolds, Diego V. Clé, Bhavisha A. Patel, Xiaoyang Ma, Dalton Hironaka, Flávia S. Donaires, Nina Spitofsky, Barbara A. Santana, Tsung-Po Lai, Lemlem Alemu, Sachiko Kajigaya, Ivana Darden, Weiyin Zhou, Paul V. Browne, Subrata Paul, Justin Lack, David J. Young, Courtney D. DiNardo, Abraham Aviv, Feiyang Ma, Michel Michels De Oliveira, Ana Paula de Azambuja, Cynthia E. Dunbar, Malgorzata Olszewska, Emmanuel Olivier, Eirini P. Papapetrou, Neelam Giri, Blanche P. Alter, Carmem Bonfim, Colin O. Wu, Guillermo Garcia-Manero, Sharon A. Savage, Neal S. Young, Simona Colla, Rodrigo T. Calado
Journal: Blood
Blood (2024) 144 (23): 2402–2416.
https://doi.org/10.1182/blood.2024025023
Published: 2024
Includes: Supplemental data
Journal Articles

Patient Reported Outcomes in Vexas Syndrome

Bhavisha A. Patel, Emma M. Groarke, Ruba Shalhoub, Fernanda Rodrigues, Alice Fike, Kaitlin Quinn, Ivana Darden, Shanni Liu, Wendy Goodspeed, Rui Miao, Colin O. Wu, Neal S. Young, Peter C Grayson
Journal: Blood
Blood (2024) 144 (Supplement 1): 3711.
https://doi.org/10.1182/blood-2024-205755
Published: 2024
Journal Articles

T Lymphopenia and Aged Immune System Characterize Immunodeficiency in Adult Patients with Telomere Biology Disorders

Luiz Fernando Bazzo Catto, Nidhi Aggarwal, Ruba Shalhoub, Natthakan Thongon, Tania Rene Machado, Ivana Darden, Jennifer Lotter, Bhavisha A. Patel, Geraldine Aubert, Colin O. Wu, Simona Colla, Cynthia E. Dunbar, Fernanda Rodrigues, Emma M. Groarke
Journal: Blood
Blood (2024) 144 (Supplement 1): 4094.
https://doi.org/10.1182/blood-2024-207500
Published: 2024
Journal Articles

Trial in Progress: A Phase I/II Study of the JAK1/2 Inhibitor Ruxolitinib for Relapsed/Refractory Immune Bone Marrow Failure

Emma M. Groarke, Jennifer Lotter, Ivana Darden, Alfiya Bikineyeva, Uzoamaka Okeke, Rachel Blair, Julie Erb-Alvarez, Jichun Chen, Xingmin Feng, Jibran Durrani, Neal S. Young, Bhavisha A. Patel
Journal: Blood
Blood (2024) 144 (Supplement 1): 1323.1.
https://doi.org/10.1182/blood-2024-199789
Published: 2024
Journal Articles

Single-Cell Multi-Omics Analysis Reveals Dysfunctional Features of the Immune Responses in Vexas Syndrome

Hiroki Mizumaki, Shouguo Gao, Zhijie Wu, Xingmin Feng, Fernanda Gutierrez-Rodrigues, Lemlem Alemu, Diego Quinones Raffo, Ivana Darden, Sachiko Kajigaya, Emma M. Groarke, Neal S. Young, Bhavisha A. Patel
Journal: Blood
Blood (2024) 144 (Supplement 1): 4056.
https://doi.org/10.1182/blood-2024-198166
Published: 2024
Journal Articles

Venous and arterial thrombosis in patients with VEXAS syndrome

Clinical Trials & Observations
Yael Kusne, Atefeh Ghorbanzadeh, Alina Dulau-Florea, Ruba Shalhoub, Pedro E. Alcedo, Khanh Nghiem, Marcela A. Ferrada, Alexander Hines, Kaitlin A. Quinn, Sumith R. Panicker, Amanda K. Ombrello, Kaaren Reichard, Ivana Darden, Wendy Goodspeed, Jibran Durrani, Lorena Wilson, Horatiu Olteanu, Terra Lasho, Daniel L. Kastner, Kenneth J. Warrington, Abhishek Mangaonkar, Ronald S. Go, Raul C. Braylan, David B. Beck, Mrinal M. Patnaik, Neal S. Young, Katherine R. Calvo, Ana I. Casanegra, Peter C. Grayson, Matthew J. Koster, Colin O. Wu, Yogendra Kanthi, Bhavisha A. Patel, Damon E. Houghton, Emma M. Groarke
Journal: Blood
Blood (2024) 143 (21): 2190–2200.
https://doi.org/10.1182/blood.2023022329
Published: 2024
Includes: Supplemental data
Journal Articles

Distinct Immune and Molecular Profiles of Hepatitis-Associated Aplastic Anemia

Roma V. Rajput, Dalton Hironaka, Ruba Shalhoub, Lemlem Alemu, Emma M. Groarke, Jennifer Lotter, Olga Rios, Ivana Darden, Colin O. Wu, Fernanda Gutierrez-Rodrigues, Xingmin Feng, Neal S. Young, Bhavisha A. Patel
Journal: Blood
Blood (2023) 142 (Supplement 1): 1340.
https://doi.org/10.1182/blood-2023-180902
Published: 2023
Journal Articles

Clinical Manifestations Are Evolving and Progressive in Patients with Vexas Syndrome

Bhavisha A. Patel, Marcela Ferrada, Kaitlin Quinn, Kristy Freeman, Ivana Darden, Wendy Goodspeed, Lisa Duncan, Roxanne Merkel, Alice Fike, Peter C Grayson, Neal S. Young, Emma M. Groarke
Journal: Blood
Blood (2023) 142 (Supplement 1): 703.
https://doi.org/10.1182/blood-2023-187454
Published: 2023
Journal Articles

Spectrum of clonal hematopoiesis in VEXAS syndrome

CME
Fernanda Gutierrez-Rodrigues, Yael Kusne, Jenna Fernandez, Terra Lasho, Ruba Shalhoub, Xiaoyang Ma, Hugh Alessi, Christy Finke, Matthew J. Koster, Abhishek Mangaonkar, Kenneth J. Warrington, Kebede Begna, Zhuoer Xie, Amanda K. Ombrello, David Viswanatha, Marcela Ferrada, Lorena Wilson, Ronald Go, Taxiarchis Kourelis, Kaaren Reichard, Horatiu Olteanu, Ivana Darden, Dalton Hironaka, Lemlem Alemu, Sachiko Kajigaya, Sofia Rosenzweig, Rodrigo T. Calado, Emma M. Groarke, Daniel L. Kastner, Katherine R. Calvo, Colin O. Wu, Peter C. Grayson, Neal S. Young, David B. Beck, Bhavisha A. Patel, Mrinal M. Patnaik
Journal: Blood
Blood (2023) 142 (3): 244–259.
https://doi.org/10.1182/blood.2022018774
Published: 2023
Includes: Supplemental data
Journal Articles

Characterizing Immunodeficiency in Patients with Telomere Biology Disorders

Nidhi Aggarwal, Xiaoyang Ma, Fernanda Gutierrez-Rodrigues, Ruba Shalhoub, Ivana Darden, Bhavisha A. Patel, Colin O. Wu, Neal S. Young, Emma M. Groarke
Journal: Blood
Blood (2022) 140 (Supplement 1): 5826–5827.
https://doi.org/10.1182/blood-2022-163264
Published: 2022
Journal Articles

Treatment of Refractory Diamond-Blackfan Anemia with Eltrombopag

Brynn B Duncan, Jennifer Lotter, Jeanine Superata, Ma Evette Barranta, Ivana Darden, Sanjay Venugopal, Colin O. Wu, Cynthia E. Dunbar, David J. Young
Journal: Blood
Blood (2022) 140 (Supplement 1): 5824–5825.
https://doi.org/10.1182/blood-2022-160297
Published: 2022
Journal Articles

Clonal Hematopoiesis in Vexas Syndrome

Bhavisha A. Patel, Fernanda Gutierrez-Rodrigues, Yael Kusne, Jenna A. Fernandez, Terra Lasho, Ruba Shalhoub, Xiaoyang Ma, Hugh Alessi, Christy Finke, Matthew Koster, Abhishek A. Mangaonkar, Kenneth Warrington, Kebede H. Begna, Zhuoer Xie, Amanda Ombrello, David S. Viswanatha, Marcela Ferrada, Lorena Wilson, Ronald Go, Taxiarchis Kourelis, Kaaren K. Reichard, Horatiu Olteanu, Emma M. Groarke, Ivana Darden, Dalton Hironaka, Sofia Rosenzweig, Daniel L. Kastner, Katherine R. Calvo, Colin O. Wu, Peter C. Grayson, David B. Beck, Mrinal M.M. Patnaik, Neal S. Young
Journal: Blood
Blood (2022) 140 (Supplement 1): 5745–5746.
https://doi.org/10.1182/blood-2022-160263
Published: 2022
Journal Articles

Eosinophilia in Vexas Syndrome: Expanding Hematologic Phenotype

Ashvind Anand Prabahran, Fernanda Gutierrez-Rodrigues, Serene Ahmad, Edward W Cowen, Ivana Darden, Emma M. Groarke, Marcela Ferrada, Peter C. Grayson, Amy D Klion, Katherine R. Calvo, Irina Maric, Neal S. Young, Bhavisha A. Patel
Journal: Blood
Blood (2022) 140 (Supplement 1): 2607–2608.
https://doi.org/10.1182/blood-2022-160287
Published: 2022
Journal Articles

Thrombotic Manifestations in Patients with Vexas Syndrome

Pedro E. Alcedo Andrade, Ruba Shalhoub, Alina Dulau-Florea, Khanh Nghiem, Marcela Ferrada, Lorena Wilson, Ivana Darden, Wendy Goodspeed, Katherine R. Calvo, David B. Beck, Daniel L. Kastner, Peter C. Grayson, Neal S. Young, Colin O. Wu, Yogendra Kanthi, Bhavisha A. Patel, Emma M. Groarke
Journal: Blood
Blood (2022) 140 (Supplement 1): 2788–2789.
https://doi.org/10.1182/blood-2022-163608
Published: 2022