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Juan Jose Rodriguez-Sevilla
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Journal Articles

Clonal landscape and clinical outcomes of telomere biology disorders: somatic rescue and cancer mutations

Fernanda Gutierrez-Rodrigues, Emma M. Groarke, Natthakan Thongon, Juan Jose Rodriguez-Sevilla, Luiz Fernando B. Catto, Marena R. Niewisch, Ruba Shalhoub, Lisa J. McReynolds, Diego V. Clé, Bhavisha A. Patel, Xiaoyang Ma, Dalton Hironaka, Flávia S. Donaires, Nina Spitofsky, Barbara A. Santana, Tsung-Po Lai, Lemlem Alemu, Sachiko Kajigaya, Ivana Darden, Weiyin Zhou, Paul V. Browne, Subrata Paul, Justin Lack, David J. Young, Courtney D. DiNardo, Abraham Aviv, Feiyang Ma, Michel Michels De Oliveira, Ana Paula de Azambuja, Cynthia E. Dunbar, Malgorzata Olszewska, Emmanuel Olivier, Eirini P. Papapetrou, Neelam Giri, Blanche P. Alter, Carmem Bonfim, Colin O. Wu, Guillermo Garcia-Manero, Sharon A. Savage, Neal S. Young, Simona Colla, Rodrigo T. Calado
Journal: Blood
Blood (2024) 144 (23): 2402–2416.
https://doi.org/10.1182/blood.2024025023
Published: 2024
Includes: Supplemental data
Journal Articles

Pharmacological Targeting of the Heme-Regulated Inhibitor Kinase Overcomes Ineffective Erythropoiesis in Patients with Myelodysplastic Syndromes with Ringed Sideroblasts and Sickle Cell Disease

Vera Adema, Giulia Faccincani, Amy Cooper, Juan Jose Rodriguez-Sevilla, Jieqing Chen, Natthakan Thongon, Teresa Perry, Jennifer Tran, Fernando Alvarez, Zhijun Kang, Vijayan Ramaswamy, Roopa Thapar, Troy Johnson, Guillermo Garcia-Manero, Faika Mseeh, David Kummer, Philip Jones, Timothy Heffernan, Simona Colla
Journal: Blood
Blood (2024) 144 (Supplement 1): 153.
https://doi.org/10.1182/blood-2024-205770
Published: 2024
Journal Articles

Characteristics and Survival Outcome of Patients with Isolated 11q Deletion Myelodysplastic Syndromes

Jeannot Kekedjian, Rami S. Komrokji, Najla H. Al Ali, Kensuke Takaoka, David Sallman, Zhuoer Xie, Eric Padron, Kelly S. Chien, Guillermo Montalban-Bravo, Julie Braish, Samuel Urrutia, Alex Bataller, Alexandre Bazinet, Rashmi Kanagal-Shamanna, Guilin Tang, Yue Wei, Hui Yang, Juan Jose Rodriguez Sevilla, Guillermo Garcia-Manero, Koji Sasaki
Journal: Blood
Blood (2024) 144 (Supplement 1): 6746.
https://doi.org/10.1182/blood-2024-208444
Published: 2024
Journal Articles

A Single-Cell T-Cell Reference Map Delineates the Biological Landscape of CD4 + T Cells in Myelodysplastic Syndromes Under Venetoclax Therapy

Juan Jose Rodriguez Sevilla, Yang Liu, Irene Ganan-Gomez, Vera Adema, Kelly S. Chien, Guillermo Montalban-Bravo, Natthakan Thongon, Guillermo Garcia-Manero, Rashmi Kanagal-Shamanna, Sanam Loghavi, Hui Yang, Linghua Wang, Simona Colla
Journal: Blood
Blood (2024) 144 (Supplement 1): 50.
https://doi.org/10.1182/blood-2024-202641
Published: 2024
Journal Articles

CDC2-like Kinases (CLKs) Inhibition As a Novel Targeted Therapeutic Strategy in Myelodysplastic Syndromes (MDS)

Hui Yang, Zhihong Fang, Yue Wei, Juan Jose Rodriguez Sevilla, Marcos Estecio, Guillermo Montalban-Bravo, Kelly S. Chien, Guillermo Garcia-Manero
Journal: Blood
Blood (2024) 144 (Supplement 1): 6691.
https://doi.org/10.1182/blood-2024-207573
Published: 2024
Journal Articles

Application of Next-Generation Cytogenetics in a Clinical Laboratory for Diagnostic Work-up of Myelodysplastic Syndromes/Neoplasms (MDS)

Anindita Ghosh, Guilin Tang, Hui Yang, Koji Sasaki, Gokce A. Toruner, Juan Jose Rodriguez-Sevilla, Raja Luthra, Danielle Hammond, L. Jeffrey Medeiros, Carlos E. Bueso-Ramos, Guillermo Montalban-Bravo, Kelly S. Chien, Guillermo Garcia-Manero, Rashmi Kanagal-Shamanna
Journal: Blood
Blood (2024) 144 (Supplement 1): 7519.
https://doi.org/10.1182/blood-2024-211967
Published: 2024
Journal Articles

T-cell dysfunctions in myelodysplastic syndromes

Juan Jose Rodriguez-Sevilla, Simona Colla
Journal: Blood
Blood (2024) 143 (14): 1329–1343.
https://doi.org/10.1182/blood.2023023166
Published: 2024
Includes: Supplemental data
Journal Articles

A road map of relapse in MDS after allo-HSCT

Juan Jose Rodriguez-Sevilla, Simona Colla
Journal: Blood
Blood (2024) 143 (11): 941–943.
https://doi.org/10.1182/blood.2023023533
Published: 2024
Journal Articles

Myelodysplastic Syndrome Hematopoietic Stem Cells Can Undergo Differentiation Trajectory Rewiring to Escape Venetoclax Vulnerability

Juan Jose Rodriguez Sevilla, Irene Ganan-Gomez, Feiyang Ma, Kelly S. Chien, Guillermo Montalban-Bravo, Rashmi Kanagal-Shamanna, Sanam Loghavi, Vera Adema, Natthakan Thongon, Alexandre Bazinet, Guillermo Garcia-Manero, Simona Colla
Journal: Blood
Blood (2023) 142 (Supplement 1): 584.
https://doi.org/10.1182/blood-2023-180447
Published: 2023
Journal Articles

Influence of Co-Mutational Patterns in Disease Phenotype and Clinical Outcomes of Chronic Myelomonocytic Leukemia

Guillermo Montalban-Bravo, David Swanson, Rashmi Kanagal-Shamanna, Juan Jose Rodriguez-Sevilla, Danielle E. Hammond, Kelly S. Chien, Koji Sasaki, Elias Jabbour, Courtney D. DiNardo, Koichi Takahashi, Nicholas J. Short, Ghayas C. Issa, Naveen Pemmaraju, Tapan M. Kadia, Farhad Ravandi, Naval Daver, Gautam Borthakur, Sanam Loghavi, Sherry Pierce, Carlos E. Bueso-Ramos, Hagop M. Kantarjian, Guillermo Garcia-Manero
Journal: Blood
Blood (2023) 142 (Supplement 1): 4601.
https://doi.org/10.1182/blood-2023-178061
Published: 2023
Journal Articles

Mutant Natural Killer Cell Dysfunction Enables the Immune Escape of Premalignant MDS Cell Clones

Irene Ganan-Gomez, Bijender Kumar, Juan Jose Rodriguez Sevilla, Feiyang Ma, Yi June Kim, Kelly S. Chien, Kate Nelson, Hui Yang, Roselyn Tan, Zongrui Li, Tomoyuki Tanaka, Hidetaka Uryu, Rashmi Kanagal-Shamanna, Sanam Loghavi, Gheath Alatrash, Rafael Bejar, Katayoun Rezvani, Koichi Takahashi, Guillermo Garcia-Manero, May Daher, MD, Simona Colla
Journal: Blood
Blood (2023) 142 (Supplement 1): 514.
https://doi.org/10.1182/blood-2023-184349
Published: 2023
Journal Articles

A Phase 2 Study of Canakinumab in Patients with Lower-Risk Myelodysplastic Syndromes or Chronic Myelomonocytic Leukemia

Juan Jose Rodriguez Sevilla, Vera Adema, Kelly S. Chien, Irene Ganan-Gomez, Guillermo Montalban-Bravo, Samuel Urrutia, Joby Joseph, Hui Yang, Gautam Borthakur, Nicholas J. Short, Ghayas C. Issa, Tapan M. Kadia, Koichi Takahashi, Danielle E. Hammond, Guillermo Garcia-Manero
Journal: Blood
Blood (2023) 142 (Supplement 1): 1866.
https://doi.org/10.1182/blood-2023-185259
Published: 2023
Journal Articles

Early Immune Profile Assessment By Flow Cytometry Predicts Severe COVID-19 Pneumonia

Abora Rial-Villavecchia, Maria Teresa Asensi, Carme Giménez-Argente, Joan Gómez-Junyent, Juan Jose Rodriguez-Sevilla, Leonor Arenillas, Ana Ferrer, Eloi García-Vives, Jaime Rodriguez-Morera, Jade Soldado-Folgado, Xavier Calvo
Journal: Blood
Blood (2021) 138 (Supplement 1): 4197.
https://doi.org/10.1182/blood-2021-151282
Published: 2021
Journal Articles

Multiple TET2 Mutations As a New Biological Clue for Differentiating Oligomonocytic Chronic Myelomonocytic Leukemia from Myelodysplastic Syndromes

Nieves Garcia-Gisbert, Leonor Arenillas, David Roman-Bravo, Juan José Rodríguez-Sevilla, Brayan Merchan, Sara Garcia-Avila, Concepción Fernández-Rodríguez, Joan Gibert, Antonio Salar, Beatriz Bellosillo, Ana Ferrer, Xavier Calvo
Journal: Blood
Blood (2021) 138 (Supplement 1): 1530.
https://doi.org/10.1182/blood-2021-152674
Published: 2021
Journal Articles

Clinical Outcomes of Oligomonocytic Chronic Myelomonocytic Leukemia (OM-CMML) and Predictive Factors of Evolution of OM-CMML into Overt Chronic Myelomonocytic Leukemia (CMML)

David Roman-Bravo, Leonor Arenillas, Maria Teresa Asensi, Nieves Garcia-Gisbert, Juan Jose Rodriguez-Sevilla, Brayan Merchan, Sara García Ávila, Beatriz Bellosillo, Concepción Fernández-Rodríguez, Lourdes Florensa, Ana Ferrer, Xavier Calvo
Journal: Blood
Blood (2021) 138 (Supplement 1): 1533.
https://doi.org/10.1182/blood-2021-146447
Published: 2021