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Journal Articles

Clonal landscape and clinical outcomes of telomere biology disorders: somatic rescue and cancer mutations

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Fernanda Gutierrez-Rodrigues, Emma M. Groarke, Natthakan Thongon, Juan Jose Rodriguez-Sevilla, Luiz Fernando B. Catto, Marena R. Niewisch, Ruba Shalhoub, Lisa J. McReynolds, Diego V. Clé, Bhavisha A. Patel, Xiaoyang Ma, Dalton Hironaka, Flávia S. Donaires, Nina Spitofsky, Barbara A. Santana, Tsung-Po Lai, Lemlem Alemu, Sachiko Kajigaya, Ivana Darden, Weiyin Zhou, Paul V. Browne, Subrata Paul, Justin Lack, David J. Young, Courtney D. DiNardo, Abraham Aviv, Feiyang Ma, Michel Michels De Oliveira, Ana Paula de Azambuja, Cynthia E. Dunbar, Malgorzata Olszewska, Emmanuel Olivier, Eirini P. Papapetrou, Neelam Giri, Blanche P. Alter, Carmem Bonfim, Colin O. Wu, Guillermo Garcia-Manero, Sharon A. Savage, Neal S. Young, Simona Colla, Rodrigo T. Calado
Journal: Blood
Blood (2024) 144 (23): 2402–2416.
https://doi.org/10.1182/blood.2024025023
Published: 2024
Includes: Supplemental data
Journal Articles

Danazol Treatment for Telomere Biology Disorders: Long-Term Results of a Phase I/II Study

Free
Nicholas C. Lee, Fernanda Gutierrez-Rodrigues, Ruba Shalhoub, Tania Rene Machado, Jennifer Lotter, Lemlem Alemu, Diego Quinones Raffo, Geraldine Aubert, Colin O. Wu, Bhavisha A. Patel, Neal S. Young, Emma M. Groarke
Journal: Blood
Blood (2024) 144 (Supplement 1): 439.
https://doi.org/10.1182/blood-2024-194335
Published: 2024
Journal Articles

T Cell Receptor Clonal Dynamics and Hematopoietic Recovery after Immunotherapy in Severe Aplastic Anemia

Free
Zhijie Wu, Shouguo Gao, Xingmin Feng, Haoran Li, Nicolas Sompairac, Shirin Jamshidi, Desmond Choy, Rita Antunes Dos Reis, Qingyan Gao, Sachiko Kajigaya, Lemlem Alemu, Diego Quinones Raffo, Emma M. Groarke, Shahram Kordasti, Bhavisha A. Patel, Neal S. Young
Journal: Blood
Blood (2024) 144 (Supplement 1): 34.
https://doi.org/10.1182/blood-2024-203468
Published: 2024
Journal Articles

Single-Cell Multi-Omics Analysis Reveals Dysfunctional Features of the Immune Responses in Vexas Syndrome

Free
Hiroki Mizumaki, Shouguo Gao, Zhijie Wu, Xingmin Feng, Fernanda Gutierrez-Rodrigues, Lemlem Alemu, Diego Quinones Raffo, Ivana Darden, Sachiko Kajigaya, Emma M. Groarke, Neal S. Young, Bhavisha A. Patel
Journal: Blood
Blood (2024) 144 (Supplement 1): 4056.
https://doi.org/10.1182/blood-2024-198166
Published: 2024
Journal Articles

Longitudinal Contribution of Distinct Hematopoietic Clones during Marrow Recovery in Immune Aplastic Anemia

Free
Fernanda Gutierrez-Rodrigues, Emma M. Groarke, Lemlem Alemu, Olga Rios, Diego Quinones Raffo, Jennifer Lotter, Neal S. Young, Bhavisha A. Patel
Journal: Blood
Blood (2024) 144 (Supplement 1): 32.
https://doi.org/10.1182/blood-2024-206215
Published: 2024
Journal Articles

Distinct Immune and Molecular Profiles of Hepatitis-Associated Aplastic Anemia

Free
Roma V. Rajput, Dalton Hironaka, Ruba Shalhoub, Lemlem Alemu, Emma M. Groarke, Jennifer Lotter, Olga Rios, Ivana Darden, Colin O. Wu, Fernanda Gutierrez-Rodrigues, Xingmin Feng, Neal S. Young, Bhavisha A. Patel
Journal: Blood
Blood (2023) 142 (Supplement 1): 1340.
https://doi.org/10.1182/blood-2023-180902
Published: 2023
Journal Articles

Characterization of Hematopoietic Stem and Progenitor Cells of PNH Patients Using Single-Cell RNA Sequencing Analysis

Free
Hiroki Mizumaki, Shouguo Gao, Zhijie Wu, Emma M. Groarke, Lemlem Alemu, Diego Quinones Raffo, Olga Rios, Sachiko Kajigaya, Bhavisha A. Patel, Neal S. Young
Journal: Blood
Blood (2023) 142 (Supplement 1): 4085.
https://doi.org/10.1182/blood-2023-181078
Published: 2023
Journal Articles

Spectrum of clonal hematopoiesis in VEXAS syndrome

Free
CME
Fernanda Gutierrez-Rodrigues, Yael Kusne, Jenna Fernandez, Terra Lasho, Ruba Shalhoub, Xiaoyang Ma, Hugh Alessi, Christy Finke, Matthew J. Koster, Abhishek Mangaonkar, Kenneth J. Warrington, Kebede Begna, Zhuoer Xie, Amanda K. Ombrello, David Viswanatha, Marcela Ferrada, Lorena Wilson, Ronald Go, Taxiarchis Kourelis, Kaaren Reichard, Horatiu Olteanu, Ivana Darden, Dalton Hironaka, Lemlem Alemu, Sachiko Kajigaya, Sofia Rosenzweig, Rodrigo T. Calado, Emma M. Groarke, Daniel L. Kastner, Katherine R. Calvo, Colin O. Wu, Peter C. Grayson, Neal S. Young, David B. Beck, Bhavisha A. Patel, Mrinal M. Patnaik
Journal: Blood
Blood (2023) 142 (3): 244–259.
https://doi.org/10.1182/blood.2022018774
Published: 2023
Includes: Supplemental data
Journal Articles

CBFB-MYH11 Is Required for the Maintenance of Inv(16) AML

Free
Sipra Panda, Yiqian Wang, Lisa Richter, Michelle Becker, Lisa J Garrett, Cecilia Rivas, Lemlem Alemu, Ling Zhao, Paul P. Liu, R. Katherine Hyde
Journal: Blood
Blood (2022) 140 (Supplement 1): 2995–2996.
https://doi.org/10.1182/blood-2022-169475
Published: 2022
Journal Articles

HLA associations, somatic loss of HLA expression, and clinical outcomes in immune aplastic anemia

Free
CME Clinical Trials & Observations
Yoshitaka Zaimoku, Bhavisha A. Patel, Sharon D. Adams, Ruba Shalhoub, Emma M. Groarke, Audrey Ai Chin Lee, Sachiko Kajigaya, Xingmin Feng, Olga Julia Rios, Holly Eager, Lemlem Alemu, Diego Quinones Raffo, Colin O. Wu, Willy A. Flegel, Neal S. Young
Journal: Blood
Blood (2021) 138 (26): 2799–2809.
https://doi.org/10.1182/blood.2021012895
Published: 2021
Includes: Supplemental data
Journal Articles

Clonal Hematopoiesis in Telomere Biology Disorders Associates with the Underlying Germline Defect and Somatic Mutations in POT1 , PPM1D, and TERT promoter

Free
Fernanda Gutierrez-Rodrigues, Emma M Groarke, Diego V Clé, Bhavisha A. Patel, Flávia S Donaires, Nina Spitofsky, Lemlem Alemu, Bárbara A Santana, Sachiko Kajigaya, Simona Colla, Michel Michels De Oliveira, Carmem M. S. Bonfim, Rodrigo T. Calado, Neal S. Young
Journal: Blood
Blood (2021) 138 (Supplement 1): 1111.
https://doi.org/10.1182/blood-2021-151199
Published: 2021
Journal Articles

RUNX1 and CBFβ-SMMHC transactivate target genes together in abnormal myeloid progenitors for leukemia development

Free
Tao Zhen, Yaqiang Cao, Gang Ren, Ling Zhao, R. Katherine Hyde, Guadalupe Lopez, Dechun Feng, Lemlem Alemu, Keji Zhao, P. Paul Liu
Journal: Blood
Blood (2020) 136 (21): 2373–2385.
https://doi.org/10.1182/blood.2020007747
Published: 2020
Includes: Supplemental data
Journal Articles

Analysis of Deficiency of Adenosine Deaminase 2 Pathogenesis Based on Single Cell RNA Sequencing of Monocytes

Free
Naoki Watanabe, Shouguo Gao, PhD, Sachiko Kajigaya, Carrie Diamond, MD, Lemlem Alemu, BS, Amanda Ombrello, MD, Neal S. Young, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2317.
https://doi.org/10.1182/blood-2019-123859
Published: 2019
Journal Articles

Spectrum and Clinical Significance of HLA Class I Alleles and Their Somatic Mutations in Immune Aplastic Anemia

Free
Yoshitaka Zaimoku, MD PhD, Sharon D. Adams, MT, CHS (ABHI), Bhavisha A Patel, MD, Audrey Ai Chin Lee, MS, CHT (ABHI), Sachiko Kajigaya, PhD, Xingmin Feng, PhD, Olga Rios, RN, Holly DiFebo, RN, Lemlem Alemu, BS, Diego Quinones Raffo, MSc, Emma M. Groarke, MD, Willy A. Flegel, MD, Neal S. Young, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3738.
https://doi.org/10.1182/blood-2019-127359
Published: 2019
Journal Articles

Deficit of Circulating CD19 + CD24 hi CD38 hi Regulatory B Cells in Severe Aplastic Anemia

Free
Yoshitaka Zaimoku, MD PhD, Bhavisha A Patel, MD, Sachiko Kajigaya, PhD, Xingmin Feng, PhD, Lemlem Alemu, BS, Diego Quinones Raffo, MSc, Emma M. Groarke, MD, Neal S. Young, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1219.
https://doi.org/10.1182/blood-2019-127053
Published: 2019
Journal Articles

Single Cell RNA Sequencing and V(D)J Profiling of T-Cell Large Granular Lymphocytosis

Free
Shouguo Gao, PhD, Zhijie Wu, MD PhD, Carrie Diamond, MD, Bradley Arnold, BS, Valentina Giudice, MD, Lemlem Alemu, BS, John Barrett, MD, Sawa Ito, MD, Sachiko Kajigaya, PhD, Neal S. Young, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2404.
https://doi.org/10.1182/blood-2018-99-115166
Published: 2018
Journal Articles

Title: Runx1 Is Indispensable for Leukemia Development Induced By Cbfb-MYH11

Free
Tao Zhen, PhD, Erika Mijin Kwon, PhD, R. Katherine Hyde, PhD, Ling Zhao, MD PhD, Guadalupe Lopez, Lemlem Alemu, BS, Paul P Liu, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1337.
https://doi.org/10.1182/blood-2018-99-116930
Published: 2018
Journal Articles

Chd7 deficiency delays leukemogenesis in mice induced by Cbfb-MYH11

Free
Tao Zhen, Erika M. Kwon, Ling Zhao, Jingmei Hsu, R. Katherine Hyde, Ying Lu, Lemlem Alemu, Nancy A. Speck, P. Paul Liu
Journal: Blood
Blood (2017) 130 (22): 2431–2442.
https://doi.org/10.1182/blood-2017-04-780106
Published: 2017
Includes: Supplemental data
Journal Articles

Runx1 Is Strictly Required for Cbfb-MYH11 Induced Leukemia Development

Free
Tao Zhen, PhD, Erika Mijin Kwon, PhD, R. Katherine Hyde, PhD, Ling Zhao, MD PhD, Guadalupe Lopez, Lemlem Alemu, Pu Paul Liu, MD PhD
Journal: Blood
Blood (2016) 128 (22): 2722.
https://doi.org/10.1182/blood.V128.22.2722.2722
Published: 2016
Journal Articles

RUNX1 and CBFB-MYH11 Are Required for the Maintenance of Inv(16) AML

Free
Yiqian Wang, Kira Hannon, Lisa Richter, Michelle Becker, Lisa Garett, Cecilia Rivas, Lemlem Alemu, Ling Zhao, MD PhD, Pu Paul Liu, MD PhD, R. Katherine Hyde, PhD
Journal: Blood
Blood (2016) 128 (22): 2715.
https://doi.org/10.1182/blood.V128.22.2715.2715
Published: 2016