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Horatiu Olteanu
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Journal Articles

Interplay between mutant DNMT3A and UBA1 worsens survival through altered inflammatory and metabolic pathways

Free
Jenna Fernandez, Jerome Hadjadj, Yael Kusne, Pankaj Pradeep, Fernanda Gutierrez-Rodrigues, Bhavisha Patel, Aubrey Pinteric, Christy Finke, Maria Sirenko, Emma Groarke, Matthew J Koster, Abhishek Mangaonkar, Naseema Gangat, Kenneth Warrington, Kaaren Reichard, Horatiu Olteanu, David Viswanatha, Rong He, Megan Sullivan, Kambiz Kalantari, Neal Young, Terra Lasho, David Beck, Mrinal Patnaik
Journal: Blood
Blood (2025) 146 (Supplement 1): 3191.
https://doi.org/10.1182/blood-2025-3191
Published: 2025
Journal Articles

Upfront therapy with allogeneic hematopoietic stem cell transplantation versus DNA methyltransferase inhibitors in patients with vexas syndrome: A comparative matched cohort efficacy analysis of 39 patients

Free
Saubia Fathima, Ali Alsugair, Kimberly Langer, Terra Lasho, Christy Finke, Mark Litzow, Aasiya Matin, Urshila Durani, Mehrdad Hefazi Torghabeh, William Hogan, Mithun Shah, Ronald Go, Gabriel Bartoo, Jade Kutzke, Kristen McCullough, Matthew J Koster, Kenneth Warrington, Kaaren Reichard, Horatiu Olteanu, Yael Kusne, Jeanne Palmer, Saurabh Chhabra, Mary Riwes, Joseph McGuirk, Elizabeth Krakow, Amelia Langston, Taxiarchis Kourelis, David Dingli, Mrinal Patnaik, Hassan Alkhateeb, Abhishek Mangaonkar
Journal: Blood
Blood (2025) 146 (Supplement 1): 981.
https://doi.org/10.1182/blood-2025-981
Published: 2025
Journal Articles

Artificial intelligence accelerates the identification of measurable residual multiple myeloma by flow cytometry

Free
Clarissa Jordan, Matthew Weybright, Dragan Jevremovic, Min Shi, April Chiu, Michael Timm, Gregory Otteson, Horatiu Olteanu, Jansen Seheult, Pedro Horna
Journal: Blood
Blood (2025) 146 (Supplement 1): 2224.
https://doi.org/10.1182/blood-2025-2224
Published: 2025
Journal Articles

Artificial Intelligence-Enhancement of Flow Cytometry Data Accelerates the Identification of Minimal Residual Chronic Lymphocytic Leukemia

Free
April Chiu, Jansen N Seheult, Min Shi, Dragan Jevremovic, Matthew J Weybright, Michael M Timm, Gregory E Otteson, Horatiu Olteanu, Pedro Horna
Journal: Blood
Blood (2024) 144 (Supplement 1): 1858.
https://doi.org/10.1182/blood-2024-199901
Published: 2024
Journal Articles

A Comparative Study of Plasma Cell Detection By Peripheral Smear and Peripheral Blood Flow Cytometry

Free
Arwa Bohra, Rafla Hassan, Saurabh Zanwar, Dragan Jevremovic, Horatiu Olteanu, Wilson I. Gonsalves, Gregory Otteson, Pedro Horna, S. Vincent Rajkumar, Shaji Kumar
Journal: Blood
Blood (2024) 144 (Supplement 1): 3319.
https://doi.org/10.1182/blood-2024-211626
Published: 2024
Journal Articles

Flow Cytometry-Based Assessment of the Proportion of Monoclonal Plasma Cells in Synthetic Phase (S-phase) Is an Independent Marker of Adverse Prognosis in Patients with Newly Diagnosed Multiple Myeloma

Free
Saurabh Zanwar, Dragan Jevremovic, Prashant Kapoor, Horatiu Olteanu, Francis Buadi, Pedro Horna, Wilson I. Gonsalves, Gregory Otteson, Suzanne R Hayman, Nadine Abdallah, Moritz Binder, Joselle Cook, Angela Dispenzieri, David Dingli, Morie A. Gertz, Taxiarchis Kourelis, Nelson Leung, Yi Lin, Eli Muchtar, Rahma M Warsame, Amie Fonder, Miriam Hobbs, Yi Lisa Hwa, Michelle G. Rogers, Robert A. Kyle, Vincent Rajkumar, Shaji Kumar
Journal: Blood
Blood (2024) 144 (Supplement 1): 4704.
https://doi.org/10.1182/blood-2024-201052
Published: 2024
Journal Articles

DNMT3A Mutant Clonal Hematopoiesis in Vexas Syndrome Epigenetically Potentiates IL-13 and IL-15 Inflammatory Pathways and Is Associated with Increased Mortality

Free
Jenna A. Fernandez, Yael Kusne, Fernanda Gutierrez-Rodrigues, Bhavisha A. Patel, Christy Finke, Emma M. Groarke, Matthew J Koster, Abhishek A. Mangaonkar, Naseema Gangat, Kenneth Warrington, Kaaren K. Reichard, Horatiu Olteanu, David Viswanatha, Rong He, Megan Sullivan, Kambiz Kalantari, Alexander Hines, Daniel Montes, Neal S. Young, David B Beck, Wazim Ismail Mohammed, Alexandre Gaspar-Maia, Terra L. Lasho, Mrinal M. Patnaik
Journal: Blood
Blood (2024) 144 (Supplement 1): 2686.
https://doi.org/10.1182/blood-2024-204334
Published: 2024
Journal Articles

Presence of Circulating Tumor Cells on Peripheral Blood Flow Cytometry at Best Response Predicts Overall Survival in Multiple Myeloma

Free
Arwa Bohra, Saurabh Zanwar, Dragan Jevremovic, Horatiu Olteanu, Wilson I. Gonsalves, Gregory Otteson, Pedro Horna, Vincent Rajkumar, Shaji Kumar
Journal: Blood
Blood (2024) 144 (Supplement 1): 3340.
https://doi.org/10.1182/blood-2024-212089
Published: 2024
Journal Articles

Artificial Intelligence-Enhancement of Flow Cytometry Data Accelerates the Identification of Minimal Residual B Lymphoblastic Leukemia

Free
Jansen N Seheult, Matthew J Weybright, Min Shi, Dragan Jevremovic, April Chiu, Michael M Timm, Gregory E Otteson, Horatiu Olteanu, Pedro Horna
Journal: Blood
Blood (2024) 144 (Supplement 1): 4226.
https://doi.org/10.1182/blood-2024-199894
Published: 2024
Journal Articles

Venous and arterial thrombosis in patients with VEXAS syndrome

Free
Clinical Trials & Observations
Yael Kusne, Atefeh Ghorbanzadeh, Alina Dulau-Florea, Ruba Shalhoub, Pedro E. Alcedo, Khanh Nghiem, Marcela A. Ferrada, Alexander Hines, Kaitlin A. Quinn, Sumith R. Panicker, Amanda K. Ombrello, Kaaren Reichard, Ivana Darden, Wendy Goodspeed, Jibran Durrani, Lorena Wilson, Horatiu Olteanu, Terra Lasho, Daniel L. Kastner, Kenneth J. Warrington, Abhishek Mangaonkar, Ronald S. Go, Raul C. Braylan, David B. Beck, Mrinal M. Patnaik, Neal S. Young, Katherine R. Calvo, Ana I. Casanegra, Peter C. Grayson, Matthew J. Koster, Colin O. Wu, Yogendra Kanthi, Bhavisha A. Patel, Damon E. Houghton, Emma M. Groarke
Journal: Blood
Blood (2024) 143 (21): 2190–2200.
https://doi.org/10.1182/blood.2023022329
Published: 2024
Includes: Supplemental data
Journal Articles

Machine Learning Enhancement of Flow Cytometry Data Accelerates the Identification of Minimal Residual Acute Myeloid Leukemia

Free
Jansen N Seheult, Min Shi, Horatiu Olteanu, Gregory E Otteson, Michael M Timm, Matthew J Weybright, Pedro Horna
Journal: Blood
Blood (2023) 142 (Supplement 1): 4339.
https://doi.org/10.1182/blood-2023-190275
Published: 2023
Journal Articles

Spectrum of clonal hematopoiesis in VEXAS syndrome

Free
CME
Fernanda Gutierrez-Rodrigues, Yael Kusne, Jenna Fernandez, Terra Lasho, Ruba Shalhoub, Xiaoyang Ma, Hugh Alessi, Christy Finke, Matthew J. Koster, Abhishek Mangaonkar, Kenneth J. Warrington, Kebede Begna, Zhuoer Xie, Amanda K. Ombrello, David Viswanatha, Marcela Ferrada, Lorena Wilson, Ronald Go, Taxiarchis Kourelis, Kaaren Reichard, Horatiu Olteanu, Ivana Darden, Dalton Hironaka, Lemlem Alemu, Sachiko Kajigaya, Sofia Rosenzweig, Rodrigo T. Calado, Emma M. Groarke, Daniel L. Kastner, Katherine R. Calvo, Colin O. Wu, Peter C. Grayson, Neal S. Young, David B. Beck, Bhavisha A. Patel, Mrinal M. Patnaik
Journal: Blood
Blood (2023) 142 (3): 244–259.
https://doi.org/10.1182/blood.2022018774
Published: 2023
Includes: Supplemental data
Journal Articles

Improved semiautomated detection of TRBC-restricted Sézary cells unveils a spectrum of clonal cluster immunophenotypes

Free
Pedro Horna, Gregory Otteson, Min Shi, Jansen N. Seheult, Dragan Jevremovic, Horatiu Olteanu
Journal: Blood
Blood (2022) 140 (26): 2852–2856.
https://doi.org/10.1182/blood.2022017548
Published: 2022
Includes: Supplemental data
Journal Articles

DNMT3A/TET2 Mutant Clonal Hematopoiesis in Vexas Syndrome Results in DNA Hypomethylation and Transcriptional Activation of WT1 and MPL Oncogenic Pathways

Free
Jenna A. Fernandez, Bhavisha A. Patel, Fernanda Gutierrez-Rodrigues, Yael Kusne, Terra Lasho, Christy Finke, Matthew Koster, Abhishek A. Mangaonkar, Naseema Gangat, Kenneth Warrington, Kaaren K. Reichard, Horatiu Olteanu, Peter C. Grayson, Neal S. Young, David B. Beck, Mrinal M. Patnaik
Journal: Blood
Blood (2022) 140 (Supplement 1): 11410–11411.
https://doi.org/10.1182/blood-2022-167359
Published: 2022
Journal Articles

Monocytopenia As an Adverse Prognosticator in Vexas Syndrome

Free
Yael Kusne, Matthew Koster, Kenneth Warrington, Ronald Go, Terra Lasho, Christy Finke, Jenna A. Fernandez, Kebede Begna, Allison M. Bock, Kaaren K. Reichard, Horatiu Olteanu, Jennifer Herrick, Mrinal M.M. Patnaik
Journal: Blood
Blood (2022) 140 (Supplement 1): 11406–11407.
https://doi.org/10.1182/blood-2022-165706
Published: 2022
Journal Articles

Clonal Hematopoiesis in Vexas Syndrome

Free
Bhavisha A. Patel, Fernanda Gutierrez-Rodrigues, Yael Kusne, Jenna A. Fernandez, Terra Lasho, Ruba Shalhoub, Xiaoyang Ma, Hugh Alessi, Christy Finke, Matthew Koster, Abhishek A. Mangaonkar, Kenneth Warrington, Kebede H. Begna, Zhuoer Xie, Amanda Ombrello, David S. Viswanatha, Marcela Ferrada, Lorena Wilson, Ronald Go, Taxiarchis Kourelis, Kaaren K. Reichard, Horatiu Olteanu, Emma M. Groarke, Ivana Darden, Dalton Hironaka, Sofia Rosenzweig, Daniel L. Kastner, Katherine R. Calvo, Colin O. Wu, Peter C. Grayson, David B. Beck, Mrinal M.M. Patnaik, Neal S. Young
Journal: Blood
Blood (2022) 140 (Supplement 1): 5745–5746.
https://doi.org/10.1182/blood-2022-160263
Published: 2022
Journal Articles

Disease-Modifying Potential of BET Inhibitor Pelabresib (CPI-0610) As Demonstrated By Improvements in Bone Marrow Function and Clinical Activity in Patients with Myelofibrosis - Preliminary Data

Free
Srdan Verstovsek, Mohamed E Salama, John Mascarenhas, Moshe Talpaz, Ruben A. Mesa, Alessandro Vannucchi, Raajit Rampal, Stephen T. Oh, Horatiu Olteanu, April Chiu, Dong Chen, Curtis A. Hanson, Natalia Curto-Garcia, Pietro Taverna, Jike Cui, Oksana Zavidij, Zehua Chen, Gozde Colak, Sergey Efuni, Patricia J Keller, Patrick Trojer, Claire N. Harrison
Journal: Blood
Blood (2021) 138 (Supplement 1): 2568.
https://doi.org/10.1182/blood-2021-152267
Published: 2021
Journal Articles

Histopathologic Characterization of Vexas Syndrome

Free
Mohammad I. Barouqa, Aishwarya Ravindran, Dong Chen, Jennifer L Oliveira, Horatiu Olteanu, Matthew T Howard, Gang Zheng, Mrinal M. Patnaik, Kebede H. Begna, Allison M. Bock, Ronald Go, Matthew Koster, Taxiarchis Kourelis, Abhishek A. Mangaonkar, Jay Ryu, Matthew Samec, Julio C. Sartori Valinotti, Kenneth Warrington, Kaaren K. Reichard
Journal: Blood
Blood (2021) 138 (Supplement 1): 4656.
https://doi.org/10.1182/blood-2021-152739
Published: 2021
Journal Articles

Clinical, Molecular, and Prognostic Comparisons between Clonal Cytopenias of Undetermined Significance and Lower-Risk Myelodysplastic Syndromes - a Study of 184 Molecularly Annotated Patients

Free
Marissa Li, MD, Terra Lasho, PhD, Alejandro Ferrer, PhD, Naseema Gangat, MBBS, Aref Al-Kali, MD, Abhishek A. Mangaonkar, MBBS, Michelle Elliot, MD, Mark Litzow, MD, William J Hogan, MB, BCh, Animesh Pardanani, MBBS, PhD, Alexandra Wolanskyj-Spinner, MD, Kaaren K. Reichard, MD, Matthew T Howard, MD, Rebecca L. King, MD, Mithun Vinod Shah, MD PhD, Hassan B. Alkhateeb, MD, Kebede H. Begna, MD, Ayalew Tefferi, MD, Christy Finke, BS, Moritz Binder, MDMPH, Horatiu Olteanu, MD PhD, Mrinal M. Patnaik, MDMBBS
Journal: Blood
Blood (2020) 136 (Supplement 1): 35–36.
https://doi.org/10.1182/blood-2020-134963
Published: 2020
Journal Articles

Spectrum of Hematological Malignancies in 130 Patients with Germline Predisposition Syndromes - Mayo Clinic Germline Predisposition Study

Free
Emma Catherine Difilippo, BS, Alejandro Ferrer, PhD, Laura Schultz-Rogers, PhD, Naseema Gangat, MBBS, Shakila P Khan, MD, Aref Al-Kali, MD, Abhishek A. Mangaonkar, MBBS, Animesh Pardanani, MBBS, PhD, Michelle Elliot, MD, Mark Litzow, MD, William J Hogan, MB, BCh, Alexandra P. Wolanskyj, MD, Phuong L. Nguyen, MD, Kaaren K. Reichard, MD, Matthew T Howard, MD, Rebecca L. King, MD, Dong Chen, MD, PhD, Rong He, MD, David S. Viswanatha, MD, Terra Lasho, PhD, Rajiv K. Pruthi, M.B.B.S, Pavel Pichurin, Teresa Kruisselbrink, MS, Brendan Lanpher, MD, Mark E Wylam, MD, Jennifer L. Oliveira, MD, Dusica Babovic-Vuksanovic, MD, Horatiu Olteanu, MD PhD, Mrinal M. Patnaik, MDMBBS
Journal: Blood
Blood (2020) 136 (Supplement 1): 34–35.
https://doi.org/10.1182/blood-2020-139050
Published: 2020