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Journal Articles

High-dose IV ascorbic acid therapy for patients with CCUS with TET2 mutations

Zhuoer Xie, Jenna Fernandez, Terra Lasho, Christy Finke, Michelle Amundson, Kristen B. McCullough, Betsy R. LaPlant, Abhishek A. Mangaonkar, Naseema Gangat, Kaaren K. Reichard, Michelle Elliott, Thomas E. Witzig, Mrinal M. Patnaik
Journal: Blood
Blood (2024) 144 (23): 2456–2461.
https://doi.org/10.1182/blood.2024024962
Published: 2024
Includes: Supplemental data
Journal Articles

Venous and arterial thrombosis in patients with VEXAS syndrome

Clinical Trials & Observations
Yael Kusne, Atefeh Ghorbanzadeh, Alina Dulau-Florea, Ruba Shalhoub, Pedro E. Alcedo, Khanh Nghiem, Marcela A. Ferrada, Alexander Hines, Kaitlin A. Quinn, Sumith R. Panicker, Amanda K. Ombrello, Kaaren Reichard, Ivana Darden, Wendy Goodspeed, Jibran Durrani, Lorena Wilson, Horatiu Olteanu, Terra Lasho, Daniel L. Kastner, Kenneth J. Warrington, Abhishek Mangaonkar, Ronald S. Go, Raul C. Braylan, David B. Beck, Mrinal M. Patnaik, Neal S. Young, Katherine R. Calvo, Ana I. Casanegra, Peter C. Grayson, Matthew J. Koster, Colin O. Wu, Yogendra Kanthi, Bhavisha A. Patel, Damon E. Houghton, Emma M. Groarke
Journal: Blood
Blood (2024) 143 (21): 2190–2200.
https://doi.org/10.1182/blood.2023022329
Published: 2024
Includes: Supplemental data
Journal Articles

Spectrum of clonal hematopoiesis in VEXAS syndrome

CME
Fernanda Gutierrez-Rodrigues, Yael Kusne, Jenna Fernandez, Terra Lasho, Ruba Shalhoub, Xiaoyang Ma, Hugh Alessi, Christy Finke, Matthew J. Koster, Abhishek Mangaonkar, Kenneth J. Warrington, Kebede Begna, Zhuoer Xie, Amanda K. Ombrello, David Viswanatha, Marcela Ferrada, Lorena Wilson, Ronald Go, Taxiarchis Kourelis, Kaaren Reichard, Horatiu Olteanu, Ivana Darden, Dalton Hironaka, Lemlem Alemu, Sachiko Kajigaya, Sofia Rosenzweig, Rodrigo T. Calado, Emma M. Groarke, Daniel L. Kastner, Katherine R. Calvo, Colin O. Wu, Peter C. Grayson, Neal S. Young, David B. Beck, Bhavisha A. Patel, Mrinal M. Patnaik
Journal: Blood
Blood (2023) 142 (3): 244–259.
https://doi.org/10.1182/blood.2022018774
Published: 2023
Includes: Supplemental data
Journal Articles

Genomic and Transcriptional Profiling Stratifies Vq Myeloma Lines into Two Clusters with Distinct Risk Signatures and Drug Responses

Evan Flietner, Mei Yu, Adhithi Rajagopalan, Yun Zhou, Yubin Feng, Anthony Veltri, Terra Lasho, Zhi Wen, Yuqian Sun, Robert Burns, Mrinal M. Patnaik, Natalie Callander, Fotis Asimakopoulos, Demin Wang, Jing Zhang
Journal: Blood
Blood (2022) 140 (Supplement 1): 9935–9936.
https://doi.org/10.1182/blood-2022-162827
Published: 2022
Journal Articles

Phase II Study Assessing Safety and Preliminary Efficacy of High Dose Intravenous Ascorbic Acid in Patients with TET2 Mutant Clonal Cytopenias of Undetermined Significance

Zhuoer Xie, Kristen McCullough, Terra Lasho, Jenna A. Fernandez, Christy Finke, Michelle Renee Amundson, Betsy Laplant, Abhishek A. Mangaonkar, Naseema Gangat, Kaaren K. Reichard, Michelle A Elliott, Thomas E. Witzig, Mrinal M.M. Patnaik
Journal: Blood
Blood (2022) 140 (Supplement 1): 2893–2894.
https://doi.org/10.1182/blood-2022-165163
Published: 2022
Journal Articles

DNMT3A/TET2 Mutant Clonal Hematopoiesis in Vexas Syndrome Results in DNA Hypomethylation and Transcriptional Activation of WT1 and MPL Oncogenic Pathways

Jenna A. Fernandez, Bhavisha A. Patel, Fernanda Gutierrez-Rodrigues, Yael Kusne, Terra Lasho, Christy Finke, Matthew Koster, Abhishek A. Mangaonkar, Naseema Gangat, Kenneth Warrington, Kaaren K. Reichard, Horatiu Olteanu, Peter C. Grayson, Neal S. Young, David B. Beck, Mrinal M. Patnaik
Journal: Blood
Blood (2022) 140 (Supplement 1): 11410–11411.
https://doi.org/10.1182/blood-2022-167359
Published: 2022
Journal Articles

U2AF1 Mutant Clonal Hematopoiesis Is Infrequent, Context Dependent, and Commonly Co-Occurs with BCOR Mutations

Stephanie L. Pritzl, Talha Badar, Alejandro Ferrer, Terra Lasho, Christy Finke, Abhishek A. Mangaonkar, Kristen McCullough, Naseema Gangat, Jenna A. Fernandez, Aref Al-Kali, David S. Viswanatha, Rong He, James M. Foran, Mrinal M. Patnaik
Journal: Blood
Blood (2022) 140 (Supplement 1): 11408–11409.
https://doi.org/10.1182/blood-2022-166794
Published: 2022
Journal Articles

Monocytopenia As an Adverse Prognosticator in Vexas Syndrome

Yael Kusne, Matthew Koster, Kenneth Warrington, Ronald Go, Terra Lasho, Christy Finke, Jenna A. Fernandez, Kebede Begna, Allison M. Bock, Kaaren K. Reichard, Horatiu Olteanu, Jennifer Herrick, Mrinal M.M. Patnaik
Journal: Blood
Blood (2022) 140 (Supplement 1): 11406–11407.
https://doi.org/10.1182/blood-2022-165706
Published: 2022
Journal Articles

Prevalence and Impact of Clonal Hematopoiesis in Therapy Related Myeloid Neoplasms Occurring in the Context of Low-Grade Follicular Lymphoma Treated with Radioisotope Therapy

Zhuoer Xie, Terra Lasho, Arushi Khurana, Alejandro Ferrer, Christy Finke, Abhishek A. Mangaonkar, Stephen M. Ansell, Jenna A. Fernandez, Mithun V. Shah, Aref Al-Kali, Naseema Gangat, Jithma P. Abeykoon, Thomas E. Witzig, Mrinal M.M. Patnaik
Journal: Blood
Blood (2022) 140 (Supplement 1): 11403–11405.
https://doi.org/10.1182/blood-2022-165124
Published: 2022
Journal Articles

Longitudinal Single Cell Multiomic Analysis of a Patient with GATA2 Haploinsufficiency with ASXL1 Mutant Clonal Hematopoiesis

Alejandro Ferrer, Rekha Mudappathi, Terra Lasho, Ryan M. Carr, Jenna A. Fernandez, Christy Finke, Naseema Gangat, Roshini S. Abraham, Moritz Binder, Abhishek A. Mangaonkar, Junwen Wang, Mrinal M. Patnaik
Journal: Blood
Blood (2022) 140 (Supplement 1): 8672–8673.
https://doi.org/10.1182/blood-2022-167808
Published: 2022
Journal Articles

Clonal Hematopoiesis in Vexas Syndrome

Bhavisha A. Patel, Fernanda Gutierrez-Rodrigues, Yael Kusne, Jenna A. Fernandez, Terra Lasho, Ruba Shalhoub, Xiaoyang Ma, Hugh Alessi, Christy Finke, Matthew Koster, Abhishek A. Mangaonkar, Kenneth Warrington, Kebede H. Begna, Zhuoer Xie, Amanda Ombrello, David S. Viswanatha, Marcela Ferrada, Lorena Wilson, Ronald Go, Taxiarchis Kourelis, Kaaren K. Reichard, Horatiu Olteanu, Emma M. Groarke, Ivana Darden, Dalton Hironaka, Sofia Rosenzweig, Daniel L. Kastner, Katherine R. Calvo, Colin O. Wu, Peter C. Grayson, David B. Beck, Mrinal M.M. Patnaik, Neal S. Young
Journal: Blood
Blood (2022) 140 (Supplement 1): 5745–5746.
https://doi.org/10.1182/blood-2022-160263
Published: 2022
Journal Articles

Asxl1 loss cooperates with oncogenic Nras in mice to reprogram the immune microenvironment and drive leukemic transformation

Xiaona You, Fabao Liu, Moritz Binder, Alexis Vedder, Terra Lasho, Zhi Wen, Xin Gao, Evan Flietner, Adhithi Rajagopalan, Yun Zhou, Christy Finke, Abhishek Mangaonkar, Ruiqi Liao, Guangyao Kong, Erik A. Ranheim, Nathalie Droin, Anthony M. Hunter, Sergey Nikolaev, Maria Balasis, Omar Abdel-Wahab, Ross L. Levine, Britta Will, Kalyan Vara Ganesh Nadiminti, David Yang, Klaus Geissler, Eric Solary, Wei Xu, Eric Padron, Mrinal M. Patnaik, Jing Zhang
Journal: Blood
Blood (2022) 139 (7): 1066–1079.
https://doi.org/10.1182/blood.2021012519
Published: 2022
Includes: Supplemental data
Journal Articles

Clonal Hematopoiesis of Indeterminate Potential Is Associated with Increased Age-Independent Morbidity and Mortality in Patients with COVID-19- the Beyond DNA COVID-19 Project

Marissa Li, Terra Lasho, Moritz Binder, Wazim Mohammed Ismail, Susan M. Geyer, Jenna Fernandez, Yael Kusne, Abhishek A. Mangaonkar, Minsuk Kim, Alexandre Gaspar Maia, Nicholas Chia, Mrinal M. Patnaik
Journal: Blood
Blood (2021) 138 (Supplement 1): 2164.
https://doi.org/10.1182/blood-2021-151548
Published: 2021
Journal Articles

Clonal Compositions Involving Epigenetic Regulator Gene Mutations in Clonal Hematopoiesis, Clonal Cytopenias of Undetermined Significance and Chronic Myelomonocytic Leukemia

Zhuoer Xie, Gina Campestri, Terra Lasho, Christy Finke, Marissa Li, Moritz Binder, Keith Robertson, Jenna Fernandez, Meredith C. Hyun, Rami S. Komrokji, Amer M. Zeidan, Jan Philipp Bewersdorf, Joshua F. Zeidner, Catherine C. Coombs, Yazan F. Madanat, Elizabeth A. Griffiths, Catherine Lai, Michael R. Savona, Mithun V. Shah, Mark R. Litzow, Ayalew Tefferi, Abhishek A. Mangaonkar, Naseema Gangat, Aref Al-Kali, Mrinal M. Patnaik
Journal: Blood
Blood (2021) 138 (Supplement 1): 2592.
https://doi.org/10.1182/blood-2021-146849
Published: 2021
Journal Articles

Tumor Mutational Burden in Histiocytic Neoplasms

Aldo A. Acosta-Medina, Jithma P. Abeykoon, Surendra Dasari, Antonious Z. Hazim, N. Nora Bennani, Terra Lasho, Aishwarya Ravindran, Karen Rech, Mithun V. Shah, Gaurav Goyal, Ronald Go
Journal: Blood
Blood (2021) 138 (Supplement 1): 3634.
https://doi.org/10.1182/blood-2021-153128
Published: 2021
Journal Articles

Differential Prognostic Impact of IDH1 and IDH2 Mutations in Chronic Myelomonocytic Leukemia

Connor M. Walsh, Anthony Hunter, Terra Lasho, Christy Finke, Rami S. Komrokji, Mithun V. Shah, Ayalew Tefferi, Abhishek A. Mangaonkar, Matthew T Howard, Naseema Gangat, Aref Al-Kali, Najla Al Ali, Eric Padron, Mrinal M. Patnaik
Journal: Blood
Blood (2021) 138 (Supplement 1): 3684.
https://doi.org/10.1182/blood-2021-150786
Published: 2021
Journal Articles

Cell-Type and Allele Specific Distribution of Multiple TET2 Mutations in Two Patients with Chronic Myelomonocytic Leukemia (CMML)

Terra Lasho, Christy Finke, Michael M. Timm, Robert Durruthy-Durruthy, Marc Arribas-Layton, Mrinal M. Patnaik, Ayalew Tefferi, Naseema Gangat, Abhishek A. Mangaonkar, Moritz Binder, Alexandre Gaspar Maia, Wazim Mohammed Ismail, Matthew T Howard, Nicholas Chia
Journal: Blood
Blood (2021) 138 (Supplement 1): 1470.
https://doi.org/10.1182/blood-2021-153802
Published: 2021
Journal Articles

Loss of LKB1/ STK11 Facilitates Leukemic Progression of the Myeloproliferative Neoplasms

Christian Marinaccio, MSc, Praveen K Suraneni, PhD, Hamza Celik, PhD, Andrew Volk, PhD, Jeremy Q. Wen, MD PhD, Te Ling, PhD, Terra Lasho, PhD, Richard P. Koche, PhD, Christopher Famulare, MS, Brady L. Stein, MD, Sandeep Gurbuxani, MBBS, PhD, Ronald Hoffman, MD, Naseema Gangat, MBBS, Navdeep Chandel, Ross L. Levine, MD, Raajit K. Rampal, MD PhD, Grant Challen, Ayalew Tefferi, MD, John D. Crispino, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 1.
https://doi.org/10.1182/blood-2020-140557
Published: 2020
Journal Articles

Gene Body Methylation and Transcriptional Activity in ASXL1-Mutant Chronic Myelomonocytic Leukemia

Moritz Binder, MDMPH, Ryan M. Carr, MD PhD, Terra Lasho, PhD, Christy Finke, BS, Abhishek A. Mangaonkar, MBBS, Christopher Pin, PhD, Kurt Berger, Tamas Ordog, MD, Bonnie Alver, PhD, Keith Robertson, PhD, David Marks, PhD, Martin Fernandez-Zapico, MD, Alexandre Gaspar Maia, PhD, Mrinal M. Patnaik, MDMBBS
Journal: Blood
Blood (2020) 136 (Supplement 1): 31–32.
https://doi.org/10.1182/blood-2020-134964
Published: 2020
Journal Articles

Clinical, Molecular, and Prognostic Comparisons between Clonal Cytopenias of Undetermined Significance and Lower-Risk Myelodysplastic Syndromes - a Study of 184 Molecularly Annotated Patients

Marissa Li, MD, Terra Lasho, PhD, Alejandro Ferrer, PhD, Naseema Gangat, MBBS, Aref Al-Kali, MD, Abhishek A. Mangaonkar, MBBS, Michelle Elliot, MD, Mark Litzow, MD, William J Hogan, MB, BCh, Animesh Pardanani, MBBS, PhD, Alexandra Wolanskyj-Spinner, MD, Kaaren K. Reichard, MD, Matthew T Howard, MD, Rebecca L. King, MD, Mithun Vinod Shah, MD PhD, Hassan B. Alkhateeb, MD, Kebede H. Begna, MD, Ayalew Tefferi, MD, Christy Finke, BS, Moritz Binder, MDMPH, Horatiu Olteanu, MD PhD, Mrinal M. Patnaik, MDMBBS
Journal: Blood
Blood (2020) 136 (Supplement 1): 35–36.
https://doi.org/10.1182/blood-2020-134963
Published: 2020