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Christophe Marzac
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Journal Articles

Progressive chromatin rewiring by ETO2::GLIS2 revealed in a human iPSC model of pediatric leukemia initiation

Fabien Boudia, Marie Baille, Loelia Babin, Zakia Aid, Elie Robert, Julie Riviere, Klaudia Galant, Verónica Alonso-Pérez, Laura Anselmi, Brahim Arkoun, Nassera Abermil, Christophe Marzac, Salvatore Nicola Bertuccio, Alexia Regnault de Premesnil, Cecile K. Lopez, Alexandre Eeckhoutte, Audrey Naimo, Betty Leite, Cyril Catelain, Christophe Metereau, Patrick Gonin, Nathalie Gaspar, Juerg Schwaller, Olivier A Bernard, Hana Raslova, Murielle Gaudry, Antonin Marchais, Hélène Lapillonne, Arnaud Petit, Francoise Pflumio, Marie-Laure Arcangeli, Erika Brunet, Thomas Mercher
Journal: Blood
Blood blood.2024024505.
https://doi.org/10.1182/blood.2024024505
Published: 2024
Includes: Supplemental data
Journal Articles

AUTX703, a Novel and Potent KAT2A and KAT2B Protein Degrader, Induces Differentiation and Offers Survival Advantage in a Primary Human AML Xenograft Model

Hélène Duparc, James Neef, Janany Kandiah, Maulasri Bhatta, Agathe Chédeville, Joe DeBartolo, Sara Sinicropi-Yao, Betty Chan, Alex Constan, Christophe Marzac, Jean-Baptiste Micol, Laura Antipov, Stephane De Botton, Katharine E Yen, David S Millan, Iléana Antony-Debré, Kimberly S Straley
Journal: Blood
Blood (2024) 144 (Supplement 1): 3585.
https://doi.org/10.1182/blood-2024-208179
Published: 2024
Journal Articles

Emergence of DNA Damage Repair Clonal Hematopoiesis after Peptide Receptor Radionuclide Therapy for Neuroendocrine Tumors

Romain Loyaux, Julien Hadoux, Sandrine Oziel, Alice Durand, Karine Bouhier-Leporrier, Lavinia Vija, Magalie Haissaguerre, Aurelie Ferru, Livia Lamartina, Desiree Déandreis, Laura Gerard, Arnaud Pages, Rachel El-Ferkh, Amira Habza, Galina Jepiral, Michel Ducreux, Christophe Marzac, Thomas Walter, Nathalie Charrier, Noémie Simon-Tillaux, Eric Baudin, Jean-Baptiste Micol
Journal: Blood
Blood (2024) 144 (Supplement 1): 1289.
https://doi.org/10.1182/blood-2024-204958
Published: 2024
Journal Articles

An Atypical Somatic Calr Variant Acquired in Cis to a Germline Calr variant Induces Constitutive Signaling of the Thrombopoietin Receptor and Results in Essential Thrombocythemia

Laetitia Borderon, Jihyun Song, Soo Jin Kim, Christophe Marzac, Christine Bellanné-Chantelot, Nicolas Papadopoulos, Stefan N. Constantinescu, William Vainchenker, Isabelle Plo, Josef T. Prchal, Caroline Marty
Journal: Blood
Blood (2023) 142 (Supplement 1): 3161.
https://doi.org/10.1182/blood-2023-179381
Published: 2023
Journal Articles

Mutational Profile and Dynamics of PPM1D -Mutant Clones in the Spectrum of Myeloid Disorders

Jean Pegliasco, David Fandrei, Florence Pasquier, Nathalie Ibrahim, Maria Kfoury, Guillemette Imbert-De-Tremiolles, Nourhan Lizziek, Céline Berthon, Mael Heiblig, Delphine Lebon, Ambroise Marcais, Mathieu Meunier, Ahmad Aljijakli, Emilie Lemasle, Sylvain Chantepie, Cécile Pautas, Pierre-Yves Dumas, Stephanie Haiat, Cyril Quivoron, Ileana antony-Debre, Sophie Cotteret, Raphael Itzykson, Hervé Dombret, Nicolas Duployez, Nathalie Droin, Christophe Marzac, Elsa Bernard, Jean-Baptiste Micol
Journal: Blood
Blood (2023) 142 (Supplement 1): 4064.
https://doi.org/10.1182/blood-2023-189428
Published: 2023
Journal Articles

1-Year Data Analysis from a Cancer Center Molecular Tumor Board Dedicated to Clonal Hematopoiesis

Jean-Baptiste Micol, Ahmadreza Arbab, Damien Vasseur, Arnaud Bayle, Mihaela Aldea, Romain Loyaux, Veronique Verge, Veronique Saada, Alice Fievet, Nathalie Auger, Sophie Cotteret, Florence Pasquier, Christophe Willekens, Camille Bigenwald, Cristina Castilla-Llorente, Stephane De Botton, Eric Solary, Elsa Bernard, Etienne Rouleau, Antoine Italiano, Christophe Marzac, Aline Renneville
Journal: Blood
Blood (2023) 142 (Supplement 1): 1322.
https://doi.org/10.1182/blood-2023-186721
Published: 2023
Journal Articles

Therapy Related Myeloid Neoplasms Following PARP Inhibitors : Real-Life Experience

Vincent Marmouset, Justine Decroocq, Sylvain Garciaz, Gabriel Etienne, Amine Belhabri, Sarah Bertoli, Lauris Gastaud, Celestine Simand, Sylvain Chantepie, Madalina Uzunov, Alexis Genthon, Celine Berthon, Edmond Chiche, Pierre-Yves Dumas, Jacques Vargaftig, Géraldine Salmeron, Emilie Lemasle, Emmanuelle Tavernier, Jeremy Delage, Marion Loirat, Nadine Morineau, Felix Blanc-Durand, Patricia Pautier, Veronique Vergé, Nathalie Auger, Myrtille Thomas, Laetitia Stefani, Marion Lepelley, Thomas Boyer, Sylvain Thepot, Marie-Pierre Gourin, Pascal Bourquard, Matthieu Duchmann, Pierre Morice, Mauricette Michallet, Lionel Ades, Pierre Fenaux, Christian Recher, Hervé Dombret, Arnaud Pages, Christophe Marzac, Alexandra Leary, Jean-Baptiste Micol
Journal: Blood
Blood (2022) 140 (Supplement 1): 12335–12338.
https://doi.org/10.1182/blood-2022-163478
Published: 2022
Journal Articles

Reduced Venetoclax Exposition to Seven Days of Azacitidine Is Efficient in Treatment-Naïve Patients with Acute Myeloid Leukemia

Christophe Willekens, Samy Chraibi, Justine Decroocq, Benjamin Carpentier, Delphine Lebon, Sarah Bonnet, Nicolas Gauthier, Arnaud Pagès, Matteo Dragani, Sabine Khalife-Hachem, Jean-Baptiste Micol, Florence Pasquier, Stefan Wickenhauser, Véronique Saada, Véronique Vergé, Ahmadreza Arbab, Christophe Marzac, Laurent Pascal, Damien Roos-Weil, Eric Jourdan, Didier Bouscary, Stéphane de Botton
Journal: Blood
Blood (2022) 140 (Supplement 1): 537–538.
https://doi.org/10.1182/blood-2022-165464
Published: 2022
Journal Articles

Inferring the dynamics of mutated hematopoietic stem and progenitor cells induced by IFNα in myeloproliferative neoplasms

Matthieu Mosca, Gurvan Hermange, Amandine Tisserand, Robert Noble, Christophe Marzac, Caroline Marty, Cécile Le Sueur, Hugo Campario, Gaëlle Vertenoeil, Mira El-Khoury, Cyril Catelain, Philippe Rameau, Cyril Gella, Julien Lenglet, Nicole Casadevall, Rémi Favier, Eric Solary, Bruno Cassinat, Jean-Jacques Kiladjian, Stefan N. Constantinescu, Florence Pasquier, Michael E. Hochberg, Hana Raslova, Jean-Luc Villeval, François Girodon, William Vainchenker, Paul-Henry Cournède, Isabelle Plo
Journal: Blood
Blood (2021) 138 (22): 2231–2243.
https://doi.org/10.1182/blood.2021010986
Published: 2021
Includes: Supplemental data
Journal Articles

Single-Cell Multi-Omics Reveals the Genetic, Cellular and Molecular Landscape of TP53 Mutated Leukemic Transformation in MPN

Alba Rodriguez-Meira, Haseeb Rahman, Ruggiero Norfo, Wei Wen, Agathe Chédeville, Jennifer O'Sullivan, Guanlin Wang, Aimee Paterson, Eleni Louka, Charlotte K Brierley, Warren W Kretzschmar, Francois Girodon, Zemin Ren, Matthew Bashton, Amir Enshaei, Mark W. Drummond, Florence Pasquier, Christophe Marzac, Claire N. Harrison, Isabelle Plo, Sten Eirik W Jacobsen, Supat Thongjuea, Bethan Psaila, Ileana Antony-Debre, Adam J. Mead
Journal: Blood
Blood (2021) 138 (Supplement 1): 3.
https://doi.org/10.1182/blood-2021-150191
Published: 2021
Journal Articles

Molecular Characteristics of Response to Olutasidenib (FT-2102) in Patients with Relapsed/Refractory mIDH1 Acute Myeloid Leukemia

Stephane De Botton, Karen Yee, Christian Recher, Andrew H. Wei, Pau Montesinos, David Taussig, Arnaud Pigneux, Thorsten Braun, Antonio Curti, Jordi Esteve, Carolyn Grove, Brian A. Jonas, Asim Khwaja, Olivier Legrand, Pierre Peterlin, Montserrat Arnan Sangerman, William G. Blum, Daniela Cilloni, Devendra Hiwase, Joseph G. Jurcic, Jürgen Krauter, Xavier Thomas, Justin Watts, Jay Yang, Zihao Xin, Alex Sedkov, Sylvie Guichard, Jennifer Sweeney, Christophe Marzac, Jorge E. Cortes, Pierre Fenaux
Journal: Blood
Blood (2021) 138 (Supplement 1): 2351.
https://doi.org/10.1182/blood-2021-144912
Published: 2021
Journal Articles

Therapy Related Myeloid Neoplasm Post PARP Inhibitors: Potential Clonal Selection.

Jean-Edouard Martin, Sabine Khalife-Hachem, Thomas Grinda, Maria Kfoury, Sylvain Garciaz, Florence Pasquier, MD PhD, Jacques Vargaftig, Madalina Uzunov, MD, Amine Belhabri, MD, Sarah Bertoli, MD PhD, Nathalie Auger, Veronique Saada, Christel Guillouf, Iléana Antony-Debre, PhD, Etienne Rouleau, Flore Salviat, Olivier Caron, Patricia Pautier, Gabriel Etienne, MD PhD, Norbert Vey, MD, Filippo Rosselli, Stephane De Botton, Alexandra Leary, Christophe Marzac, MD, Jean-Baptiste Micol, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 14–15.
https://doi.org/10.1182/blood-2020-139971
Published: 2020
Journal Articles

Clonal Hematopoiesis in the Molecular Landscape of Therapy-Related Myeloid Neoplasms in Patients Previously Treated for Gynecologic and Breast Cancers

Sabine Khalife-Hachem, Khalil Saleh, MD, Florence Pasquier, MD PhD, Anthony Tarabay, Cyril Quivoron, Sophie Cotteret, Christophe Willekens, MD, Veronique Saada, Ines-Maria Vaz-Luis, Suzette Delaloge, Alexandra Leary, Hana Raslova, PhD, Filippo Rosselli, Olivier Caron, Iléana Antony-Debre, PhD, Eric Solary, MD PhD, Stephane de Botton, MD PhD, Christophe Marzac, MD, Jean-Baptiste Micol, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3722.
https://doi.org/10.1182/blood-2019-126872
Published: 2019
Journal Articles

Predicting the Long-Term Efficacy of Ifnα in JAK2 V617F and Calr -Mutated MPN Patients

Amandine Tisserand, Robert Noble, PhD, Matthieu Mosca, PhD, Christophe Marzac, MD, Gaelle Vertenoeil, MD, Hugo Campario, PharmD, Mira El-Khoury, PhD, Caroline Marty, PhD, Philippe Rameau, Nicole Casadevall, MD, Eric Solary, MD PhD, Florence Pasquier, MD PhD, Hana Raslova, PhD, Bruno Cassinat, PharmD, PhD, Stefan N Constantinescu, MD PhD, Jean-Jacques Kiladjian, MD PhD, Francois Girodon, MD PhD, Michael Hochberg, PhD, Villeval Jean-Luc, PhD, William Vainchenker, MD PhD, Isabelle Plo
Journal: Blood
Blood (2019) 134 (Supplement_1): 4196.
https://doi.org/10.1182/blood-2019-127903
Published: 2019
Journal Articles

Differential Impact of Interferon Alpha on JAK2 V617F and Calr Mutated Hematopoietic Stem and Progenitor Cells in Classical MPN

Matthieu Mosca, PhDstudent, Lamia Lamrani, PhD, Christophe Marzac, MD, Amandine Tisserand, Valérie Edmond, PhD, Tracy Dagher, PhDstudent, Mira El-Khoury, PhD, Caroline Marty, PhD, Hugo Campario, PharmD, Nicole Casadevall, MD, Eric Solary, MD PhD, Hana Raslova, PhD, Bruno Cassinat, PharmD, PhD, Stefan N Constantinescu, MD, Jean-Jacques Kiladjian, MD PhD, Francois Girodon, MD PhD, Jean-Luc Villeval, PhD, William Vainchenker, MD PhD, Isabelle Plo, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4333.
https://doi.org/10.1182/blood-2018-99-114744
Published: 2018
Journal Articles

ATG2B/Gskip in De Novo Acute Myeloid Leukemia (AML): High Prevalence of Germline Predisposition in French West Indies and Potential Role of Overexpression in Acquired AML

Jean Pegliasco, Barbara Panneau-Schmaltz, PhD, Jean-Edouard Martin, Samy Chraibi, Clemence Legoupil, Florence Pasquier, MD PhD, Christophe Willekens, MD, Odile Bera, Olivier Caron, Jean-Henri Bourhis, Roseline Tang, Adel Ben-Ali, Maureen Lopez, Sophie Cotteret, Veronique Saada, Nathalie Auger, Jacques Delaunay, MD, Pascale Cornillet-Lefebvre, Christian Recher, MD PhD, Stephane de Botton, MD PhD, William Vainchenker, MD PhD, Pascal Fuseau, Raouf Benabelali, Philippe Helias, Christophe Marzac, MD, Isabelle Plo, PhD, Jean-Come Meniane, MD, Christine Bellanné-Chantelot, PharmD, PhD, Jean-Baptiste Micol, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1482.
https://doi.org/10.1182/blood-2018-99-110366
Published: 2018
Journal Articles

Efficacy of 5-Azacitidine on IDH1/2 Acute Myeloid Leukemia/Myelodysplastic Syndromes and Correlation with 2-Hydroxyglutarate Production

Christophe Willekens, MD, Veronique Saada, Sophie Broutin, Julia Delahousse, Aline Renneville, MDPhD, Cynthia Petrovanu, Christophe Marzac, Jean-Baptiste Micol, MD PhD, Éric Solary, MD PhD, Florence Pasquier, MD PhD, Julien Lazarovici, MD, Vincent Ribrag, Claude Preudhomme, PharmD, PhD, Cyril Quivoron, Virginie Penard-Lacronique, PhD, Angelo Paci, Stephane de Botton, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1313.
https://doi.org/10.1182/blood.V130.Suppl_1.1313.1313
Published: 2017
Journal Articles

Calreticulin Mutants Induce an Early Clonal Dominance and a Megakaryocytic Phenotype through the Activation of MPL/JAK2 Pathway in Human Primary Cells

Mira EL Khoury, Gaelle Vertenoeil, Caroline Marty, Christophe Marzac, Matthieu Mosca, Christian Pecquet, PhD, Fabrizia Favale, Robert Kralovics, Najet Debili, Nicole Casadevall, MD, Hana Raslova, PhD, Stefan N. Constantinescu, MD PhD, Isabelle Plo, William Vainchenker, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1959.
https://doi.org/10.1182/blood.V128.22.1959.1959
Published: 2016
Journal Articles

Presence of atypical thrombopoietin receptor (MPL) mutations in triple-negative essential thrombocythemia patients

Xénia Cabagnols, Fabrizia Favale, Florence Pasquier, Kahia Messaoudi, Jean Philippe Defour, Jean Christophe Ianotto, Christophe Marzac, Jean Pierre Le Couédic, Nathalie Droin, Ilyas Chachoua, Remi Favier, M’boyba Khadija Diop, Valérie Ugo, Nicole Casadevall, Najet Debili, Hana Raslova, Christine Bellanné-Chantelot, Stefan N. Constantinescu, Olivier Bluteau, Isabelle Plo, William Vainchenker
Journal: Blood
Blood (2016) 127 (3): 333–342.
https://doi.org/10.1182/blood-2015-07-661983
Published: 2016
Includes: Supplemental data
Journal Articles

Differential Association of Calreticulin Type 1 and Type 2 Mutations with Myelofibrosis and Essential Thrombocytemia: Relevance for Disease Evolution

Xenia Cabagnols, undegraduate, Jean-Philippe Defour, BPharm,, Valérie Ugo, MD PhD, Jean Christophe Ianotto, Pascal Mossuz, Julie Mondet, Francois Girodon, MD PhD, Alexandre Ji-Hye, MD, Olivier Mansier, MD, Jean François Viallard, MD, Eric Lippert, Anne Murati, MD, MJ Mozziconacci, Ollivier Legrand, MD PhD, Pascale Saussoy, Marie-Christianne Vekemans, MD, Laurent Knoops, Florence Pasquier, Vincent Ribrag, Eric Solary, Isabelle Plo, Stefan N. Constantinescu, MD PhD, Nicole Casadevall, MD, William Vainchenker, MD, PhD, Christophe Marzac, MD, Olivier Bluteau, PhD
Journal: Blood
Blood (2014) 124 (21): 1823.
https://doi.org/10.1182/blood.V124.21.1823.1823
Published: 2014