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Journal Articles

Secreted mutant calreticulins as rogue cytokines in myeloproliferative neoplasms

Christian Pecquet, Nicolas Papadopoulos, Thomas Balligand, Ilyas Chachoua, Amandine Tisserand, Gaëlle Vertenoeil, Audrey Nédélec, Didier Vertommen, Anita Roy, Caroline Marty, Harini Nivarthi, Jean-Philippe Defour, Mira El-Khoury, Eva Hug, Andrea Majoros, Erica Xu, Oleh Zagrijtschuk, Tudor E. Fertig, Daciana S. Marta, Heinz Gisslinger, Bettina Gisslinger, Martin Schalling, Ilaria Casetti, Elisa Rumi, Daniela Pietra, Chiara Cavalloni, Luca Arcaini, Mario Cazzola, Norio Komatsu, Yoshihiko Kihara, Yoshitaka Sunami, Yoko Edahiro, Marito Araki, Roman Lesyk, Veronika Buxhofer-Ausch, Sonja Heibl, Florence Pasquier, Violaine Havelange, Isabelle Plo, William Vainchenker, Robert Kralovics, Stefan N. Constantinescu
Journal: Blood
Blood (2023) 141 (8): 917–929.
https://doi.org/10.1182/blood.2022016846
Published: 2023
Includes: Supplemental data
Journal Articles

Inferring the dynamics of mutated hematopoietic stem and progenitor cells induced by IFNα in myeloproliferative neoplasms

Matthieu Mosca, Gurvan Hermange, Amandine Tisserand, Robert Noble, Christophe Marzac, Caroline Marty, Cécile Le Sueur, Hugo Campario, Gaëlle Vertenoeil, Mira El-Khoury, Cyril Catelain, Philippe Rameau, Cyril Gella, Julien Lenglet, Nicole Casadevall, Rémi Favier, Eric Solary, Bruno Cassinat, Jean-Jacques Kiladjian, Stefan N. Constantinescu, Florence Pasquier, Michael E. Hochberg, Hana Raslova, Jean-Luc Villeval, François Girodon, William Vainchenker, Paul-Henry Cournède, Isabelle Plo
Journal: Blood
Blood (2021) 138 (22): 2231–2243.
https://doi.org/10.1182/blood.2021010986
Published: 2021
Includes: Supplemental data
Journal Articles

Predicting the Long-Term Efficacy of Ifnα in JAK2 V617F and Calr -Mutated MPN Patients

Amandine Tisserand, Robert Noble, PhD, Matthieu Mosca, PhD, Christophe Marzac, MD, Gaelle Vertenoeil, MD, Hugo Campario, PharmD, Mira El-Khoury, PhD, Caroline Marty, PhD, Philippe Rameau, Nicole Casadevall, MD, Eric Solary, MD PhD, Florence Pasquier, MD PhD, Hana Raslova, PhD, Bruno Cassinat, PharmD, PhD, Stefan N Constantinescu, MD PhD, Jean-Jacques Kiladjian, MD PhD, Francois Girodon, MD PhD, Michael Hochberg, PhD, Villeval Jean-Luc, PhD, William Vainchenker, MD PhD, Isabelle Plo
Journal: Blood
Blood (2019) 134 (Supplement_1): 4196.
https://doi.org/10.1182/blood-2019-127903
Published: 2019
Journal Articles

Calreticulin mutants as oncogenic rogue chaperones for TpoR and traffic-defective pathogenic TpoR mutants

Christian Pecquet, Ilyas Chachoua, Anita Roy, Thomas Balligand, Gaëlle Vertenoeil, Emilie Leroy, Roxana-Irina Albu, Jean-Philippe Defour, Harini Nivarthi, Eva Hug, Erica Xu, Yasmine Ould-Amer, Céline Mouton, Didier Colau, Didier Vertommen, Myat Marlar Shwe, Caroline Marty, Isabelle Plo, William Vainchenker, Robert Kralovics, Stefan N. Constantinescu
Journal: Blood
Blood (2019) 133 (25): 2669–2681.
https://doi.org/10.1182/blood-2018-09-874578
Published: 2019
Includes: Supplemental data
Journal Articles

Secreted Mutant Calreticulins As Rogue Cytokines Trigger Thrombopoietin Receptor Activation Specifically in CALR Mutated Cells: Perspectives for MPN Therapy

Christian Pecquet, PhD, Thomas Balligand, MD, Ilyas Chachoua, PhD, Anita Roy, PhD, Gaelle Vertenoeil, MD, Didier Colau, PhD, Emanuel Fertig, MD, Caroline Marty, PhD, Harini Nivarthi, PhD, Jean-Philippe Defour, BPharm, PhD, Erica Xu, Eva Hug, PhD, Heinz Gisslinger, Bettina Gisslinger, Martin Schalling, MSc, Ilaria Carola Casetti, MD, Elisa Rumi, MD, Daniela Pietra, PhD, Chiara Cavalloni, MD, Luca Arcaini, MD, Mario Cazzola, Norio Komatsu, MD PhD, Yoshihiko Kihara, PhD, Yoshitaka Sunami, MD PhD, Yoko Edahiro, MD PhD, Marito Araki, PhD, Isabelle Plo, PhD, William Vainchenker, MD PhD, Robert Kralovics, PhD, Stefan N Constantinescu, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4.
https://doi.org/10.1182/blood-2018-99-118348
Published: 2018
Journal Articles

Calreticulin Mutants Induce an Early Clonal Dominance and a Megakaryocytic Phenotype through the Activation of MPL/JAK2 Pathway in Human Primary Cells

Mira EL Khoury, Gaelle Vertenoeil, Caroline Marty, Christophe Marzac, Matthieu Mosca, Christian Pecquet, PhD, Fabrizia Favale, Robert Kralovics, Najet Debili, Nicole Casadevall, MD, Hana Raslova, PhD, Stefan N. Constantinescu, MD PhD, Isabelle Plo, William Vainchenker, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1959.
https://doi.org/10.1182/blood.V128.22.1959.1959
Published: 2016
Journal Articles

Thrombopoietin receptor activation by myeloproliferative neoplasm associated calreticulin mutants

Ilyas Chachoua, Christian Pecquet, Mira El-Khoury, Harini Nivarthi, Roxana-Irina Albu, Caroline Marty, Vitalina Gryshkova, Jean-Philippe Defour, Gaëlle Vertenoeil, Anna Ngo, Ann Koay, Hana Raslova, Pierre J. Courtoy, Meng Ling Choong, Isabelle Plo, William Vainchenker, Robert Kralovics, Stefan N. Constantinescu
Journal: Blood
Blood (2016) 127 (10): 1325–1335.
https://doi.org/10.1182/blood-2015-11-681932
Published: 2016
Includes: Supplemental data