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Journal Articles

Performance and Interlaboratory Reproducibility of Droplet Digital Polymerase Chain Reaction (ddPCR) and Real Time PCR for KIT D816V Mutation Detection: A Nationwide Pilot Study By the RIMA (Rete Italiana Mastocitosi) Association

Cecilia Monaldi, Sara De Santis, Manuela Mancini, Daniela Pietra, Giovanna De Matteis, Sonia Fabris, Niccolò Bolli, Santa Errichiello, Barbara Izzo, Francesca Gesullo, Paola Guglielmelli, Gessica Minnella, Patrizia Chiusolo, Cristina Papayannidis, Chiara Sartor, Chiara Elena, Ilaria Tanasi, Massimiliano Bonifacio, Federica Grifoni, Mariarita Sciumè, Massimo Triggiani, Francesco Mannelli, Livio Pagano, Alessandro Maria Vannucchi, Nicholas C. P. Cross, Michele Cavo, Roberta Zanotti, Simona Soverini
Journal: Blood
Blood (2023) 142 (Supplement 1): 6393.
https://doi.org/10.1182/blood-2023-181521
Published: 2023
Journal Articles

BCL-Xl Represents a Novel Therapeutic Target in Type 2 Mutant Calr-Driven Myeloproliferative Neoplasms

Mirielle Nauman, Daniele Vanni, Nicole Arellano, Thao Trang Nguyen, James LaBelle, Caner Saygin, Silvia Catricalà, Ilaria Carola Casetti, Oscar Borsani, Elisa Rumi, Daniela Pietra, Shannon Elf
Journal: Blood
Blood (2023) 142 (Supplement 1): 3148.
https://doi.org/10.1182/blood-2023-190295
Published: 2023
Journal Articles

Germline MPL Mutations May be a Rare Cause of “Triple-Negative” Thrombocytosis

Oscar Borsani, Daniela Pietra, Ilaria Carola Casetti, Daniele Vanni, Giacomo Riccaboni, Silvia Catricalà, Grazia Bossi, Luca Arcaini, Elisa Rumi
Journal: Blood
Blood (2023) 142 (Supplement 1): 4560.
https://doi.org/10.1182/blood-2023-173958
Published: 2023
Journal Articles

Glutamine Metabolism Is Altered in Myeloproliferative Neoplasms and Represents a Potential Novel Therapeutic Target

Chad Coen, Jizhi Yan, Caner Saygin, Nicole Arellano, Mirielle Nauman, Katarzyna Zawieracz, Daniele Vanni, Silvia Catricalà, Ilaria Carola Casetti, Oscar Borsani, Elisa Rumi, Daniela Pietra, Shannon Elf, Hunter Blaylock
Journal: Blood
Blood (2023) 142 (Supplement 1): 6350.
https://doi.org/10.1182/blood-2023-189731
Published: 2023
Journal Articles

Secreted mutant calreticulins as rogue cytokines in myeloproliferative neoplasms

Christian Pecquet, Nicolas Papadopoulos, Thomas Balligand, Ilyas Chachoua, Amandine Tisserand, Gaëlle Vertenoeil, Audrey Nédélec, Didier Vertommen, Anita Roy, Caroline Marty, Harini Nivarthi, Jean-Philippe Defour, Mira El-Khoury, Eva Hug, Andrea Majoros, Erica Xu, Oleh Zagrijtschuk, Tudor E. Fertig, Daciana S. Marta, Heinz Gisslinger, Bettina Gisslinger, Martin Schalling, Ilaria Casetti, Elisa Rumi, Daniela Pietra, Chiara Cavalloni, Luca Arcaini, Mario Cazzola, Norio Komatsu, Yoshihiko Kihara, Yoshitaka Sunami, Yoko Edahiro, Marito Araki, Roman Lesyk, Veronika Buxhofer-Ausch, Sonja Heibl, Florence Pasquier, Violaine Havelange, Isabelle Plo, William Vainchenker, Robert Kralovics, Stefan N. Constantinescu
Journal: Blood
Blood (2023) 141 (8): 917–929.
https://doi.org/10.1182/blood.2022016846
Published: 2023
Includes: Supplemental data
Journal Articles

Risk of Thrombosis in Myeloproliferative Neoplasms after Sars-Cov-2 Vaccination

Oscar Borsani, Virginia Valeria Ferretti, Ilaria Carola Casetti, Daniele Vanni, Chiara Trotti, Martina Boldini, Daniela Pietra, Annalisa De Silvestri, Luca Arcaini, Elisa Rumi
Journal: Blood
Blood (2022) 140 (Supplement 1): 6830–6831.
https://doi.org/10.1182/blood-2022-157967
Published: 2022
Journal Articles

Autoantibodies against type I IFNs in patients with Ph-negative myeloproliferative neoplasms

Oscar Borsani, Paul Bastard, Jérémie Rosain, Adrian Gervais, Emanuela Sant’Antonio, Daniele Vanni, Ilaria Carola Casetti, Daniela Pietra, Chiara Trotti, Silvia Catricalà, Virginia Valeria Ferretti, Luca Malcovati, Luca Arcaini, Jean-Laurent Casanova, Alessandro Borghesi, Elisa Rumi
Journal: Blood
Blood (2022) 139 (17): 2716–2720.
https://doi.org/10.1182/blood.2021014890
Published: 2022
Includes: Supplemental data
Journal Articles

Autoantibodies Against Type I IFNs in Patients with Ph-Negative Myeloproliferative Neoplasms

Oscar Borsani, Paul Bastard, Jérémie Rosain, Adrian Gervais, Emanuela Sant'Antonio, Daniele Vanni, Ilaria Carola Casetti, Daniela Pietra, Chiara Trotti, Virginia Valeria Ferretti, Luca Malcovati, Luca Arcaini, Alessandro Borghesi, Jean-Laurent Casanova, Elisa Rumi
Journal: Blood
Blood (2021) 138 (Supplement 1): 3587.
https://doi.org/10.1182/blood-2021-150660
Published: 2021
Journal Articles

Type 1 Calreticulin Mutations Differentially Activate the IRE1α-XBP1 Pathway of the Unfolded Protein Response to Drive Myeloproliferative Neoplasms

Juan Ibarra, Yassmin Elbanna, Katarzyna Kurylowicz, Harrison S Greenbaum, Maria Evers, Nicole S Arellano, Dongbo Yang, Althea Bock-Hughes, Chenyu Liu, Quinn Smith, Julian Lutze, Julian Baumeister, Milena Kalmer, Kathrin Olschok, Benjamin Nicholson, Diane Silva, Luke Maxwell, Jonathan Dowgielewicz, Michele Ciboddo, Elisa Rumi, Daniela Pietra, Steffen Koschmieder, Sandeep Gurbuxani, Rebekka K. Schneider, Scott Oakes, Shannon Elf
Journal: Blood
Blood (2021) 138 (Supplement 1): 628.
https://doi.org/10.1182/blood-2021-147859
Published: 2021
Journal Articles

Novel drivers and modifiers of MPL-dependent oncogenic transformation identified by deep mutational scanning

Brief Report
Jessica L. Bridgford, Su Min Lee, Christine M. M. Lee, Paola Guglielmelli, Elisa Rumi, Daniela Pietra, Stephen Wilcox, Yash Chhabra, Alan F. Rubin, Mario Cazzola, Alessandro M. Vannucchi, Andrew J. Brooks, Matthew E. Call, Melissa J. Call
Journal: Blood
Blood (2020) 135 (4): 287–292.
https://doi.org/10.1182/blood.2019002561
Published: 2020
Includes: Supplemental data
Journal Articles

Defective interaction of mutant calreticulin and SOCE in megakaryocytes from patients with myeloproliferative neoplasms

Christian A. Di Buduo, Vittorio Abbonante, Caroline Marty, Francesco Moccia, Elisa Rumi, Daniela Pietra, Paolo M. Soprano, Dmitry Lim, Daniele Cattaneo, Alessandra Iurlo, Umberto Gianelli, Giovanni Barosi, Vittorio Rosti, Isabelle Plo, Mario Cazzola, Alessandra Balduini
Journal: Blood
Blood (2020) 135 (2): 133–144.
https://doi.org/10.1182/blood.2019001103
Published: 2020
Includes: Supplemental data
Journal Articles

Evaluation of Virus-Specific T Cell Responses in Patients Affected with Myeloproliferative Neoplasms Treated with Ruxolitinib

Elisa Rumi, MD, Chiara Cavalloni, MD, Giuditta Comolli, Virginia Valeria Ferretti, Irene Cassaniti, Daniela Pietra, PhD, Chiara Trotti, MD, Michele Ciboddo, MD, Melania Degli Antoni, Milena Furione, Fausto Baldanti, MD, Luca Arcaini, Mario Cazzola, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1660.
https://doi.org/10.1182/blood-2019-127994
Published: 2019
Journal Articles

Mutational landscape of the transcriptome offers putative targets for immunotherapy of myeloproliferative neoplasms

Fiorella Schischlik, Roland Jäger, Felix Rosebrock, Eva Hug, Michael Schuster, Raimund Holly, Elisabeth Fuchs, Jelena D. Milosevic Feenstra, Edith Bogner, Bettina Gisslinger, Martin Schalling, Elisa Rumi, Daniela Pietra, Gottfried Fischer, Ingrid Faé, Loan Vulliard, Jörg Menche, Torsten Haferlach, Manja Meggendorfer, Anna Stengel, Christoph Bock, Mario Cazzola, Heinz Gisslinger, Robert Kralovics
Journal: Blood
Blood (2019) 134 (2): 199–210.
https://doi.org/10.1182/blood.2019000519
Published: 2019
Includes: Supplemental data
Journal Articles

Abnormal Regulation of Intracellular Calcium in Human Megakaryocytes Contributes to the Pathophysiology of Calr-Mutant Myeloproliferative Neoplasms

Christian Andrea Di Buduo, PhD, Vittorio Abbonante, PhD, Elisa Rumi, MD, Daniela Pietra, PhD, Francesco Moccia, PhD, Giovanni Barosi, MD, Vittorio Rosti, MD, Mario Cazzola, Alessandra Balduini, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1782.
https://doi.org/10.1182/blood-2018-99-116166
Published: 2018
Journal Articles

Secreted Mutant Calreticulins As Rogue Cytokines Trigger Thrombopoietin Receptor Activation Specifically in CALR Mutated Cells: Perspectives for MPN Therapy

Christian Pecquet, PhD, Thomas Balligand, MD, Ilyas Chachoua, PhD, Anita Roy, PhD, Gaelle Vertenoeil, MD, Didier Colau, PhD, Emanuel Fertig, MD, Caroline Marty, PhD, Harini Nivarthi, PhD, Jean-Philippe Defour, BPharm, PhD, Erica Xu, Eva Hug, PhD, Heinz Gisslinger, Bettina Gisslinger, Martin Schalling, MSc, Ilaria Carola Casetti, MD, Elisa Rumi, MD, Daniela Pietra, PhD, Chiara Cavalloni, MD, Luca Arcaini, MD, Mario Cazzola, Norio Komatsu, MD PhD, Yoshihiko Kihara, PhD, Yoshitaka Sunami, MD PhD, Yoko Edahiro, MD PhD, Marito Araki, PhD, Isabelle Plo, PhD, William Vainchenker, MD PhD, Robert Kralovics, PhD, Stefan N Constantinescu, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4.
https://doi.org/10.1182/blood-2018-99-118348
Published: 2018
Journal Articles

Mutational Landscape of the Transcriptome Offers a Rich Neoantigen Resource for Immunotherapy of Myeloproliferative Neoplasms

Fiorella Schischlik, MSc, Roland Jäger, PhD, Felix Rosebrock, Eva Hug, PhD, Michael Schuster, PhD, Raimund Holly, Elisabeth Fuchs, Jelena D. Milosevic Feenstra, PhD, Edith Bogner, Bettina Gisslinger, Martin Schalling, MSc, Elisa Rumi, MD, Daniela Pietra, PhD, Gottfried Fischer, MD, Ingrid Faé, Vulliard Loan, Jörg Menche, PhD, Torsten Haferlach, MD, Manja Meggendorfer, PhD, Anna Stengel, PhD, Christoph Bock, PhD, Mario Cazzola, Heinz Gisslinger, Robert Kralovics, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3058.
https://doi.org/10.1182/blood-2018-99-118049
Published: 2018
Journal Articles

Solid Tumors in Post-Polycythemia Vera and Post-Essential Thrombocythemia Myelofibrosis: A Study on 2220 Patients

Barbara Mora, Elisa Rumi, MD, Paola Guglielmelli, MD PhD, Daniela Barraco, MD, Margherita Maffioli, MD, Alessandro Rambaldi, MD, Marianna Caramella, MD, Rami S. Komrokji, MD, Jason R. Gotlib, MDMS, Jean-Jacques Kiladjian, MD PhD, Francisco Cervantes, MD PhD, Timothy Devos, Francesca Palandri, PhD MD, Valerio De Stefano, MD, Marco Ruggeri, MD, Richard T. Silver, MD, Giulia Benevolo, MD, Francesco Albano, MD, Chiara Cavalloni, MD, Daniela Pietra, PhD, Tiziano Barbui, MD, Giada Rotunno, PhD, Mario Cazzola, Alessandro M. Vannucchi, MD, Toni Giorgino, PhD, Francesco Passamonti, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3039.
https://doi.org/10.1182/blood-2018-99-115318
Published: 2018
Journal Articles

Allogeneic Hematopoietic Stem Cell Transplantation for Patients with Polycythemia Vera or Essential Thrombocythemia Transformed to Myelofibrosis or Acute Myeloid Leukemia: a Single Center Experience

Paolo Bernasconi, Anna Amelia Colombo, MD, Daniela Caldera, MD, Virginia Valeria Ferretti, Silvia Mangiacavalli, MD, Marta Ubezio, MD, Daniela Pietra, PhD, Elisa Rumi, MD, Ilaria Carola Casetti, MD, Matteo Davià, Marina Boni, Irene Dambruoso, Rita Zappatore
Journal: Blood
Blood (2017) 130 (Supplement 1): 5497.
https://doi.org/10.1182/blood.V130.Suppl_1.5497.5497
Published: 2017
Journal Articles

Genomic Profiling of Blast Phase in Philadelphia-Negative Myeloproliferative Neoplasms

Elisa Roncoroni, Jelena D. Milosevic Feenstra, PhD, Elisa Rumi, MD, Daniela Pietra, PhD, Virginia Valeria Ferretti, Marta Bellini, MD, Chiara Cavalloni, MD, Ilaria Carola Casetti, MD, Roland Jäger, PhD, Edith Bogner, Michele Ciboddo, MD, Patrizia Zappasodi, MD, Cristina Picone, Laura Vanelli, Cesare Astori, MD, Robert Kralovics, PhD, Mario Cazzola, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1652.
https://doi.org/10.1182/blood.V130.Suppl_1.1652.1652
Published: 2017
Journal Articles

Clinical significance of somatic mutation in unexplained blood cytopenia

Clinical Trials & Observations
Luca Malcovati, Anna Gallì, Erica Travaglino, Ilaria Ambaglio, Ettore Rizzo, Elisabetta Molteni, Chiara Elena, Virginia Valeria Ferretti, Silvia Catricalà, Elisa Bono, Gabriele Todisco, Antonio Bianchessi, Elisa Rumi, Silvia Zibellini, Daniela Pietra, Emanuela Boveri, Clara Camaschella, Daniela Toniolo, Elli Papaemmanuil, Seishi Ogawa, Mario Cazzola
Journal: Blood
Blood (2017) 129 (25): 3371–3378.
https://doi.org/10.1182/blood-2017-01-763425
Published: 2017
Includes: Supplemental data