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Sara De Santis
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Journal Articles

ASXL1 Mutations at Diagnosis Did Not Impact on the Depth of Molecular Response (MR) and on Treatment-Free Remission (TFR) Eligibility in Chronic Phase (CP) Chronic Myeloid Leukemia (CML) Patients (pts) Receiving either Nilotinib (NIL) First-Line or Imatinib (IM) with Early Switch to NIL in Case of No Optimal Response in the SUSTRENIM Clinical Trial

Simona Soverini, Sara De Santis, Cecilia Monaldi, Manuela Mancini, Valentina Giai, Marco Cerrano, Isabella Capodanno, Massimiliano Bonifacio, Elisabetta Abruzzese, Alessandra Iurlo, Fausto Castagnetti, Rosaria Sancetta, Luciano Levato, Carmen Fava, Mario Tiribelli, Francesco Cavazzini, Maria Cristina Miggiano, Niccolò Bolli, Agostino Tafuri, Alessandro Lucchesi, Daniele Vallisa, Monia Lunghi, Caterina Musolino, Samantha Bruno, Cristina Mosca, Mauro Ciriello, Giovanni Marsili, Alfonso Piciocchi, Paola Fazi, Michele Cavo, Jeroen J.W.M. Janssen, Peter E. Westerweel, Fabrizio Pane
Journal: Blood
Blood (2024) 144 (Supplement 1): 3158.
https://doi.org/10.1182/blood-2024-205465
Published: 2024
Journal Articles

Optimizing Molecular Diagnosis of Systemic Mastocytosis in the Era of KIT Tyrosine Kinase Inhibitors: Results of a Survey and of a Nationwide Proficiency Control Round of KIT D816V Mutation Testing Promoted By the RIMA (Rete Italiana MAstocitosi) Association

Simona Soverini, Cecilia Monaldi, Sara De Santis, Manuela Mancini, Francesco Albano, Luisa Anelli, Loredana Bruno, Ignazio Brusca, Grazia Fazio, Lilia Maria Corral Abascal, Francesca Guerrini, Clara Bono, Giovanni Iaquinta, Paola Grammatico, Elisabetta Novella, Omar Perbellini, Orietta Spinelli, Silvia Salmoiraghi, Stefano Baldoni, Alessia Persico, Giuseppa De Luca, Calogero Lauricella, Giovanna Piras, Angelo D. Palmas, Samantha Bruno, Cristina Mosca, Chiara Sartor, Cristina Papayannidis, Paola Guglielmelli, Alessandro M. Vannucchi, Patrizia Bonadonna, Francesco Mannelli, Nicholas C. P. Cross, Michele Cavo, Roberta Zanotti, Chiara Elena
Journal: Blood
Blood (2024) 144 (Supplement 1): 7640.
https://doi.org/10.1182/blood-2024-202485
Published: 2024
Journal Articles

Loss of Function of SETD2 Tumor Suppressor in Chronic Myeloid Leukemia (CML) Progenitors Fosters Genomic Instability and Enhances Clonogenic Potential

Sara De Santis, Manuela Mancini, Cecilia Monaldi, Gabriele Gugliotta, Samantha Bruno, Fausto Castagnetti, Miriam Iezza, Marco Cerrano, Alessandra Iurlo, Sara Galimberti, Serena Balducci, Fabio Stagno, Michele Cavo, Simona Soverini
Journal: Blood
Blood (2023) 142 (Supplement 1): 1785.
https://doi.org/10.1182/blood-2023-185677
Published: 2023
Journal Articles

Performance and Interlaboratory Reproducibility of Droplet Digital Polymerase Chain Reaction (ddPCR) and Real Time PCR for KIT D816V Mutation Detection: A Nationwide Pilot Study By the RIMA (Rete Italiana Mastocitosi) Association

Cecilia Monaldi, Sara De Santis, Manuela Mancini, Daniela Pietra, Giovanna De Matteis, Sonia Fabris, Niccolò Bolli, Santa Errichiello, Barbara Izzo, Francesca Gesullo, Paola Guglielmelli, Gessica Minnella, Patrizia Chiusolo, Cristina Papayannidis, Chiara Sartor, Chiara Elena, Ilaria Tanasi, Massimiliano Bonifacio, Federica Grifoni, Mariarita Sciumè, Massimo Triggiani, Francesco Mannelli, Livio Pagano, Alessandro Maria Vannucchi, Nicholas C. P. Cross, Michele Cavo, Roberta Zanotti, Simona Soverini
Journal: Blood
Blood (2023) 142 (Supplement 1): 6393.
https://doi.org/10.1182/blood-2023-181521
Published: 2023
Journal Articles

Aurora Kinase a/MDM2-Mediated SETD2 Loss of Function in Chronic Myeloid Leukemia Patients in Blast Crisis Can be Therapeutically Targeted Inducing Apoptotic Cell Death in a Caspase-Dependent Way

Manuela Mancini, PhD, Sara De Santis, Dr, Cecilia Monaldi, Dr, Luana Bavaro, Dr, Margherita Martelli, Dr, Gabriele Gugliotta, MD PhD, Fausto Castagnetti, MD PhD, Gianantonio Rosti, MD, Maria Chiara Fontana, PhD, Samantha Bruno, Dr, Elisa Dan, PhD, Barbara Sinigaglia, Dr, Alessandra Iurlo, MD PhD, Nicola Orofino, MD, Elisabetta Abruzzese, MD, Marzia Salvucci, MD, Patrizia Pregno, Antonella Gozzini, MD, Monica Crugnola, MD, Francesco Albano, MD, Massimiliano Bonifacio, MD, Elisabetta Calistri, MD, Mario Tiribelli, Gianni Binotto, MD, Annalisa Imovilli, Elena Trabacchi, MD, Sara Galimberti, MD PhD, Claudia Baratè, Elena Tenti, Michele Baccarani, MD, Giovanni Martinelli, MD, Michele Cavo, Simona Soverini, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4142.
https://doi.org/10.1182/blood-2019-126500
Published: 2019
Journal Articles

In Systemic Masocytosis, Midostaurin Targets Both Kit and Aurora Kinase a Reverting H3K36Me3 Deficiency and Synergizes with Second-Generation Tyrosine Kinase Inhibitors

Manuela Mancini, PhD, Cecilia Monaldi, Dr, Sara De Santis, Dr, Cristina Papayannidis, Michela Rondoni, MD, Luana Bavaro, Dr, Margherita Martelli, Dr, Antonio Curti, MD PhD, Maria Chiara Fontana, PhD, Samantha Bruno, Dr, Roberta Zanotti, MD, Massimiliano Bonifacio, MD, Luigi Scaffidi, MD, Livio Pagano, MD, Marianna Criscuolo, MD, Francesco Albano, MD, Fabio Ciceri, MD, Chiara Elena, MD, Patrizia Tosi, Massimo Delledonne, Carla Avanzato, Luciano Xumerle, Peter Valent, MD, Giovanni Martinelli, Michele Cavo, Simona Soverini, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4204.
https://doi.org/10.1182/blood-2019-126538
Published: 2019
Journal Articles

Aurora Kinase a/MDM2-Mediated SETD2 Loss of Function in Chronic Myeloid Leukemia Patients in Blast Crisis Induces Genetic Instability and Can be Therapeutically Targeted

Manuela Mancini, PhD, Sara De Santis, Cecilia Monaldi, Luana Bavaro, Margherita Martelli, Fausto Castagnetti, Gabriele Gugliotta, MD PhD, Gianantonio Rosti, Maria Chiara Fontana, MSc, Elisa Dan, Barbara Sinigaglia, Alessandra Iurlo, Nicola Orofino, Elisabetta Abruzzese, Marzia Salvucci, Patrizia Pregno, Antonella Gozzini, Monica Crugnola, MD, Francesco Albano, MD, Massimiliano Bonifacio, Elisabetta Calistri, MD, Mario Tiribelli, Gianni Binotto, MD, Annalisa Imovilli, Elena Trabacchi, MD, Sara Galimberti, Claudia Baratè, Elena Tenti, Michele Baccarani, MD, Giovanni Martinelli, Michele Cavo, MD, Simona Soverini, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1726.
https://doi.org/10.1182/blood-2018-99-112908
Published: 2018
Journal Articles

MDM2 and Aurora Kinase a Contribute to SETD2 Loss of Function in Advanced Systemic Mastocytosis: Implications for Pathogenesis and Treatment

Manuela Mancini, PhD, Cecilia Monaldi, Sara De Santis, Cristina Papayannidis, Michela Rondoni, MD, Luana Bavaro, Margherita Martelli, Abbenante Maria Chiara, Antonio Curti, Elisa Ficarra, Giulia Paciello, Maria Chiara Fontana, MSc, Roberta Zanotti, MD, Massimiliano Bonifacio, Luigi Scaffidi, MD, Livio Pagano, Marianna Criscuolo, Francesco Albano, MD, Fabio Ciceri, MD, Chiara Elena, MD, Patrizia Tosi, MD, Massimo Delledonne, Carla Avanzato, Luciano Xumerle, Peter Valent, Giovanni Martinelli, MD, Michele Cavo, MD, Simona Soverini, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1779.
https://doi.org/10.1182/blood-2018-99-113278
Published: 2018
Journal Articles

SETD2 Non-Genomic Loss of Function and p53 Functional Inactivation in Advanced Systemic Mastocytosis (SM): Pathogenetic and Therapeutic Implications

Manuela Mancini, PhD, Cecilia Monaldi, Sara De Santis, Cristina Papayannidis, MD, Michela Rondoni, MD, Maria Chiara Abbenante, MD, Luana Bavaro, Margherita Martelli, Elisa Ficarra, Giulia Paciello, Viviana Guadagnuolo, Maria Chiara Fontana, MSc, Marco Manfrini, Roberta Zanotti, MD, Livio Pagano, MD, Francesco Albano, MD, Fabio Ciceri, MD, Chiara Elena, Patrizia Tosi, MD, Massimo Delledonne, Peter Valent, MD, Michele Cavo, MD, Giovanni Martinelli, MD, Simona Soverini, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2944.
https://doi.org/10.1182/blood.V130.Suppl_1.2944.2944
Published: 2017
Journal Articles

Targeting WEE1 Kinase after G2/M Checkpoint Arrest Induces Apoptosis in Chronic Myeloid Leukemia Progenitors

Manuela Mancini, PhD, Sara De Santis, Cecilia Monaldi, Fausto Castagnetti, MD PhD, Luana Bavaro, Margherita Martelli, Gabriele Gugliotta, MD PhD, Gianantonio Rosti, MD, Elena Tenti, PhD, Maria Alessandr Santucci, MD, Michele Cavo, MD, Giovanni Martinelli, MD, Simona Soverini, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1588.
https://doi.org/10.1182/blood.V130.Suppl_1.1588.1588
Published: 2017
Journal Articles

Polo-like Kinase-1 and Aurora Kinase A As Novel Therapeutic Targets in Neoplastic Mast Cells

Manuela Mancini, PhD, Cecilia Monaldi, Sara De Santis, Cristina Papayannidis, MD, Michela Rondoni, MD, Maria Chiara Abbenante, MD, Luana Bavaro, Margherita Martelli, Roberta Zanotti, MD, Livio Pagano, MD, Michele Cavo, MD, Peter Valent, MD, Giovanni Martinelli, MD, Simona Soverini, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 5290.
https://doi.org/10.1182/blood.V130.Suppl_1.5290.5290
Published: 2017
Journal Articles

SETD2 Loss of Function Is a Recurrent Event in Advanced-Phase Chronic Myeloid Leukemia

Manuela Mancini, PhD, Sara De Santis, Cecilia Monaldi, Luana Bavaro, Margherita Martelli, Fausto Castagnetti, MD PhD, Gabriele Gugliotta, MD PhD, Gianantonio Rosti, MD, Alessandra Iurlo, MD PhD, Elisabetta Abruzzese, MD, Marzia Salvucci, MD, Patrizia Pregno, MD, Antonella Gozzini, MD, Monica Crugnola, MD, Francesco Albano, MD, Massimiliano Bonifacio, MD, Elisabetta Calistri, MD, Mario Tiribelli, MD, Gianni Binotto, MD, Annalisa Imovilli, MD, Elena Trabacchi, MD, Sara Galimberti, PhD MD, Claudia Baratè, MD PhD, Elena Tenti, PhD, Michele Baccarani, MD, Michele Cavo, MD, Giovanni Martinelli, MD, Simona Soverini, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 43.
https://doi.org/10.1182/blood.V130.Suppl_1.43.43
Published: 2017